Structural, Functional, and Genetic Changes Surrounding Electrodes Implanted in the Brain
Acc Chem Res. 2024 Apr 17. doi: 10.1021/acs.accounts.4c00057. Online ahead of print.ABSTRACTConspectusImplantable neurotechnology enables monitoring and stimulating of the brain signals responsible for performing cognitive, motor, and sensory tasks. Electrode arrays implanted in the brain are increasingly used in the clinic to treat a variety of sources of neurological diseases and injuries. However, the implantation of a foreign body typically initiates a tissue response characterized by physical disruption of vasculature and the neuropil as well as the initiation of inflammation and the induction of reactive glial states...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Bhavna Gupta Akash Saxena Mason L Perillo Lauren C Wade-Kleyn Cort H Thompson Erin K Purcell Source Type: research
Late-onset Familial Hemophagocytic Lymphohistiocytosis in a survivor of Hodgkin's Lymphoma
Leuk Res Rep. 2023 Nov 7;21:100394. doi: 10.1016/j.lrr.2023.100394. eCollection 2024.ABSTRACTHemophagocytic Lymphohistiocytosis is an inflammatory condition which results in over activation of the immune system. It could be either sporadic or familial. The familial subtype is linked with various genetic mutations and is commonly a disease of the young. Here we report a case of HLH in an adult, occurring in the background of a successfully treated hematological malignancy. Upon workup, he was also found to have pathogenic STXBP2 mutation, suggesting HLH of familial origin. To date, only few cases of adult-onset familial HLH...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Mirza Rameez Samar Daania Shoaib Nida E Zehra Munira Moosajee Source Type: research
Case series of retinal vein occlusions showing early recovery using oral l-methylfolate
Ther Adv Ophthalmol. 2024 Apr 15;16:25158414241240687. doi: 10.1177/25158414241240687. eCollection 2024 Jan-Dec.ABSTRACTThis case series describes the aggregate rate of recovery in five consecutive subjects (six eyes) with retinal vein occlusion (RVO) who received l-methylfolate and other vitamins via Ocufolin®, a medical food. Subjects were followed for 10-33 months by a single ophthalmologist. Ocufolin® was prescribed at the time of diagnosis and subjects remained on the regimen throughout the time of observation. Examinations were performed in an un-masked fashion at 3-month intervals with recording of best corrected ...
Source: Adv Data - April 17, 2024 Category: Epidemiology Authors: Steven Baker Dylan Baker Robert Baker Craig J Brown Source Type: research
Spirulina (Arthrospira platensis) supplementation: Impact on growth, metabolism, and antioxidant status in zebrafish
In conclusion, this study indicates that SP supplementation has substantial potential as a growth promoter, positively influencing lipid metabolism and antioxidant enzyme activity without affecting zebrafish survival. (Source: Journal of Animal Physiology and Animal Nutrition)
Source: Journal of Animal Physiology and Animal Nutrition - April 17, 2024 Category: Zoology Authors: Aline Pereira Coli,
William Franco Carneiro,
Kiara C ândido Duarte da Silva,
Tássia Flávia Dias Castro,
João Paulo Lima de Oliveira,
Moisés Silvestre Azevedo de Martins,
Luis David Solis Murgas Tags: ORIGINAL ARTICLE Source Type: research
Netherton syndrome —A therapeutic challenge in childhood
We describe an 8-year-old boy with genetically proven NS treated with intravenous immunoglobulin for recurrent skin and systemic infections from infancy, growth retardation, and associated erythroderma. Under this therapy, his skin status, infectious exacerbations, and quality of life all improved. Knowledge of the cytokine-mediated pathogenesis of NS and the development of new biologic drugs open new possibilities for NS patients. However, the different therapeutic options have been applied in a limited number of cases, and variable responses have been shown. Randomized controlled trials with a sufficient number of patien...
Source: Clinical Case Reports - April 17, 2024 Category: General Medicine Authors: Polina Kostova,
Guergana Petrova,
Martin Shahid,
Vera Papochieva,
Dimitrinka Miteva,
Ivelina Yordanova,
Kossara Drenovska,
Irena Bradinova,
Camila K. Janniger,
Robert A. Schwartz,
Snejina Vassileva Tags: CASE REPORT Source Type: research
Serum Folate and Vitamin B12 Modify the Associations of N6AMT1 Genetic Variants with Gestational Diabetes Mellitus: A Cross-Sectional Study in Chinese Pregnant Women
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 17, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
GSE262041 RNASeq analysis of CC011, CC074, Trimko, and Trim wt female mice on 3dpi and 6dpi after infection with Ebola virus
Contributors : Alexandra Schaefer ; Nicholas Catanzaro ; Cameron NguyenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGene expression changes in the liver was studied by RNAseq Results: Strong differences in the liver-specific responses between CC011 and CC074 mice (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE262518 Acute multi-level response to defective de novo chromatin assembly in S-phase
Contributors : Giulia Ricci ; Vivek Bhardwaj ; Jeroen van den Berg ; Francesca MattiroliSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensLong-term perturbation of de novo chromatin assembly during DNA replication has profound effects on epigenome maintenance and cell fate. The early mechanistic origin of these defects is unknown. Here, we combine acute degradation of Chromatin Assembly Factor 1 (CAF-1), a key player in de novo chromatin assembly, with single-cell genomics, quantitative proteomics, and live-microscopy to uncover these initiating mechanisms in h...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE262759 Shared Transcriptomic Signatures of Inflammaging Among Diverse Strains of Drosophila melanogaster
Contributors : Sabrina I Perna ; Weihao Tang ; Andrew Li ; Sydney D Blimbaum ; Lei ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterBackground: A prominent hallmark of aging is inflammaging —the increased expression of innate immune genes without identifiable infection. Model organisms with shorter lifespans, such as the fruit fly, provide an essential platform for probing the mechanisms of inflammaging. Multiple groups have reported that, like mammalian models, old flies have signif icantly higher levels of expression of anti-microbial peptide genes. However, wheth...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research
GSE261920 Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response
Contributors : Kristen John ; Ian Huntress ; Ethan Smith ; Hsuan Chou ; Tammy S Tollison ; Sergio Covarrubias ; Elisa Crisci ; Susan Carpenter ; Xinxia PengSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensLong noncoding RNAs (lncRNAs) are a newer class of noncoding transcripts identified as key regulators of biological processes. Here we aimed to identify novel lncRNA targets that play critical roles in major human respiratory viral infections by systematically mining large-scale transcriptomic datasets. Using bulk RNA-sequencing (RNA-seq) analysis, we identified a previous...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE261688 Expression data from adipose tissue macrophages of mice with or without moderate aerobic exercise
Contributors : Fei Qin ; Wenbai HuangSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculus ; synthetic constructATMs, which can constitute up to 50% of the cells in adipose tissue of obese mice 5, play a pivotal role in both metabolic and immune regulation of adipose tissue. This is particularly evident in both healthy states and in conditions associated with metabolic syndrome.To delve into the precise mechanisms of the ATMs in response to exercise, we utilized exercise-induced primary ATMs and miRNAs microarray to investigate the effects of an 8-week aerobic exercise training on ATMs. Following the exe...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Mus musculus synthetic construct Source Type: research
GSE261672 Serum cytokine and chemokine analysis of patients with treatment-na ïve unresectable hepatocellular carcinoma and cancer-free chronic liver disease.
Contributors : Ryoichi Miura ; Hikaru Nakahara ; Atsushi OnoSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensA total of 116 patients, 96 with treatment-na ïve unresectable hepatocellular carcinoma (uHCC) and 20 chronic liver disease without any cancer, were analysed for 17 cytokines and chemokines from serum and analysed for oncological features. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Protein profiling by protein array Homo sapiens Source Type: research
GSE261283 Bioinformatics and single-cell CRISPRi-based screen reveals effector genes and implicates multi-tissue etiology for BMD [scCRISPR screen]
Contributors : Mitchell Conery ; James A Pippin ; Matthew C Pahl ; Struan F GrantSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensTo nominate identify tissues relevant to the etiology of bone mineral density we generated ATAC-seq in pediatric hMSC-osteoblasts, hFOB 1.19 cells (hFOBs), osteoclasts, and primary chondrocytes. Leveraging the results of this experiment, we designed a CRISPRi screen in hFOBs with scRNA-seq expression read out. The targets selected for the screen were informed by newly generated Capture-C and bulk RNA-seq from hFOBs. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE261284 Bioinformatics and single-cell CRISPRi-based screen reveals effector genes and implicates multi-tissue etiology for BMD
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE261508 Identification of mesenchymal cell populations during neonatal lung development
Contributors : Yongjun Yin ; Jeffrey R Koenitzer ; David M Ornitz ; Debabrata Patra ; Sabine DietmannSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlveologenesis is the final stage of lung development in which the internal surface area of the lung is increased to facilitate efficient gas exchange in the mature organism. The first phase of alveologenesis involves the formation of septal ridges (secondary septae) which are covered by alveolar type 1 (AT1) and alveolar type 2 (AT2) cells and contain mesenchymal cells, capillaries, and an elastin rich extracellular matrix (ECM). The ...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
