Outbreak Response in the Genomic and Information Age
Sabeti is a computational geneticist whose lab develops powerful methods and tools for advancing genome biology and medicine. She has created some of the most widely used algorithms to mine our genome for instances of human adaptation, and created powerful molecular tools to elucidate their underlying biology. She has contributed to widely varying fields — such as viral sequencing, information theory, rural disease surveillance, and education efforts in West Africa — to create comprehensive approaches for detecting, containing, and treating deadly infectious diseases.For more information go tohttps://oir.nih.go...
Source: Videocast - All Events - April 30, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Demystifying Medicine - Parkinson ’ s Disease: Advances and Challenges
Demystifying Medicine Lecture Series Parkinson's is a long-term degenerative disorder of the central nervous system that causes tremors, slowness of movement, rigidity, and postural instability. The disease may also lead to depression, anxiety, and, in the advanced stages of the disease, dementia. The cause remains unknown, and there is no cure. However, treatment to ameliorate symptoms has advanced in promising ways over the past decade. Ellen Sidransky, M.D., is an NIH senior investigator and chief of the NHGRI Medical Genetics Branch and Section on Molecular Neurogenetics. Her lab aims to understand and to optimize trea...
Source: Videocast - All Events - April 26, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Lasker Scholar lecture: Cell Therapy for Epithelial Cancers
Lasker Scholar lecture Cell therapy is an emerging treatment modality that is highly effective in hematological cancers. Research by Dr. Hinrichs ’ s team has demonstrated the potential to extend cell therapy to the treatment of common epithelial cancers. Treatment of patients with human papillomavirus (HPV)-associated cancers with tumor-infiltrating lymphocytes showed durable, complete tumor responses, apparently curing some patients with metastatic cancer. A more “ off the shelf ” approach with peripheral blood T cells genetically engineered to target the HPV E7 antigen also demonstrated robust clinical...
Source: Videocast - All Events - April 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Gene-Targeted Therapies: Early Diagnosis and Equitable Delivery [Day 3]
Currently, technological developments are offering the hope of new therapies for individuals with rare disease at a pace that has the potential for significantly challenging the existing infrastructure for efficient, effective, and equitable delivery. It is important therefore, to plan and be prepared for these challenges. Changes need to be implemented to improve the process of getting more treatments to more patients, more quickly. Gene-targeted therapies have the ability to provide treatments to multiple disorders rapidly. Gene-targeted therapeutics, such as virus-mediated gene replacement, somatic genome editing and ol...
Source: Videocast - All Events - April 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Gene-Targeted Therapies: Early Diagnosis and Equitable Delivery [Day 2]
Currently, technological developments are offering the hope of new therapies for individuals with rare disease at a pace that has the potential for significantly challenging the existing infrastructure for efficient, effective, and equitable delivery. It is important therefore, to plan and be prepared for these challenges. Changes need to be implemented to improve the process of getting more treatments to more patients, more quickly. Gene-targeted therapies have the ability to provide treatments to multiple disorders rapidly. Gene-targeted therapeutics, such as virus-mediated gene replacement, somatic genome editing and ol...
Source: Videocast - All Events - April 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Gene-Targeted Therapies: Early Diagnosis and Equitable Delivery [Day 1]
Currently, technological developments are offering the hope of new therapies for individuals with rare disease at a pace that has the potential for significantly challenging the existing infrastructure for efficient, effective, and equitable delivery. It is important therefore, to plan and be prepared for these challenges. Changes need to be implemented to improve the process of getting more treatments to more patients, more quickly. Gene-targeted therapies have the ability to provide treatments to multiple disorders rapidly. Gene-targeted therapeutics, such as virus-mediated gene replacement, somatic genome editing and ...
Source: Videocast - All Events - April 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Demystifying Medicine: Suicide and Depression in Time of COVID-19
Demystifying Medicine Lecture Series The COVID-19 pandemic has brought profound stress into our lives — from social isolation and hectic work schedules, to grief over the loss of those who have died from COVID-19 and the inability to fully gather together to mourn them. Populations with underlying depression and addiction disorders are particularly vulnerable to self-harm during these trying times. While depression, suicide and COVID clearly are associated in terms of public health, are they also linked mechanistically, particularly in regard to neurobiology? Are there genetic factors or biomarkers for susceptibility...
Source: Videocast - All Events - April 9, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

A Brief History of Eugenics in America: Implications for Medicine in the 21st Century
The eugenics movement in early 20th century America was based on a limited understanding of human heredity, and culminated in a nationwide program of forced sterilization of those deemed unfit to reproduce. A related aspect of the eugenics movement was exclusion of undesirable immigrants who were of “ bad blood. ” What lessons can we learn from America ’ s eugenics movement that will help us answer the difficult questions raised by striking advances in biomedicine in the 21st century? In vitro fertilization, preimplantation genetic diagnosis, non-invasive prenatal fetal screening, gene replacement, genome...
Source: Videocast - All Events - March 24, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Contemporary Clinical Medicine: Great Teachers: Chasing Genetics of Susceptibility to Cancer: An Engaging and Revealing Odyssey
For more information go tohttps://cc.nih.gov/about/news/grcurrent.htmlAir date: 4/14/2021 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 17, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

CC Grand Rounds: Physiologic and Genetic Studies of Diabetes in the Akimel O ’ odham (Pima Indians)
CC Grand Rounds: Physiologic and Genetic Studies of Diabetes in the Akimel O ’ odham (Pima Indians)For more information go tohttps://cc.nih.gov/about/news/grcurrent.htmlAir date: 4/28/2021 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 17, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Accelerating Progress in Celiac Disease Research Workshop (Day 1)
Celiac disease is an autoimmune disease that occurs in genetically susceptible individuals who develop an immune response to ingested gluten. This disease affects greater than 1% of the US population, and incidence appears to have been increasing over the last several decades. The only known treatment is life-long strict avoidance of all forms of wheat, rye, and barley. Although a gluten-free diet is an effective treatment in many individuals, recent research has revealed that up to 50% of individuals following a gluten-free diet are inadvertently exposed to gluten, and a substantial minority develop persistent or recurren...
Source: Videocast - All Events - March 11, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Accelerating Progress in Celiac Disease Research Workshop (day 2)
Celiac disease is an autoimmune disease that occurs in genetically susceptible individuals who develop an immune response to ingested gluten. This disease affects greater than 1% of the US population, and incidence appears to have been increasing over the last several decades. The only known treatment is life-long strict avoidance of all forms of wheat, rye, and barley. Although a gluten-free diet is an effective treatment in many individuals, recent research has revealed that up to 50% of individuals following a gluten-free diet are inadvertently exposed to gluten, and a substantial minority develop persistent or recurren...
Source: Videocast - All Events - March 10, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Accelerating Progress in Celiac Disease Research Workshop
Celiac disease is an autoimmune disease that occurs in genetically susceptible individuals who develop an immune response to ingested gluten. This disease affects greater than 1% of the US population, and incidence appears to have been increasing over the last several decades. The only known treatment is life-long strict avoidance of all forms of wheat, rye, and barley. Although a gluten-free diet is an effective treatment in many individuals, recent research has revealed that up to 50% of individuals following a gluten-free diet are inadvertently exposed to gluten, and a substantial minority develop persistent or recurren...
Source: Videocast - All Events - March 10, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Quasi-species Suppression of Viral Drug Resistance
NIH Director ’ s Wednesday Afternoon Lecture Series This is the annual George Khoury Lecture, which honors the memory of Dr. George Khoury (1943 – 1987), a highly regarded NIH virologist and caring mentor of the postdoctoral fellows in his laboratory. Dr. Karla Kirkegaard, Ph.D., is the Violetta L. Horton Research Professor of Genetics at the Stanford University School of Medicine. Her laboratory focuses on identification of dominant drug targets for antiviral design, such as small molecules that stabilize oligomeric assemblages. A past recipient of the NIH Director's Pioneer Award, Dr. Kirkegaard combines her ...
Source: Videocast - All Events - March 1, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

NIDCR Clinical Research Fellowship Grand Rounds, Women in Science series
Dear Colleagues,Please join us for the NIDCR Clinical Research Fellowship Grand Rounds, Women in Science seriesLecture Title: " Human Cell Atlas: Mapping the Human Body One Cell at a Time " Presenter: Dr. Sarah TeichmannDate: 3/5/2021Time: 10:00am -11:00amLocation: WebcastOverview:The Human Cell Atlas (HCA) is an ambitious global initiative aiming to create comprehensive reference map of all human cells — the fundamental units of life — as a basis for both understanding human health and diagnosing, monitoring, and treating disease. Co-founded by Dr Sarah Teichmann from the Wellcome Sanger Institute in...
Source: Videocast - All Events - March 1, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Cell Therapy for Epithelial Cancers
Cell therapy is an emerging treatment modality that is highly effective in hematological cancers. Research by Dr. Hinrichs ’ s team has demonstrated the potential to extend cell therapy to the treatment of common epithelial cancers. Treatment of patients with human papillomavirus (HPV)-associated cancers with tumor-infiltrating lymphocytes showed durable, complete tumor responses, apparently curing some patients with metastatic cancer. A more “ off the shelf ” approach with peripheral blood T cells genetically engineered to target the HPV E7 antigen also demonstrated robust clinical activity with extensiv...
Source: Videocast - All Events - February 18, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Using Peripheral Blood to Understand Recovery from Brain Injuries
Dr. Gill ’ s presentation will provide evidence of how fluid biomarkers relate to recovery from brain injuries, including the role of proteins during acute recovery. Mild brain injuries are often difficult to diagnose, thus, having biomarkers that identify individuals with even subtle injuries are important to improve care. Further, identification of biomarkers that predict recovery are essential to provide preventative interventions to mitigate risk, including the additive risk for lasting symptoms and deficits that are now being observed in our studies of military personnel, Veterans and athletes. Fluid biomarkers ...
Source: Videocast - All Events - February 18, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Neurobiology of Social Behavior Circuits
This is a special NIH Director's Lecture in the WALS series. Speaker Catherine DuLac, Ph.D., Harvard University, employs genetic manipulation of pheromone signaling, which has led to a novel assessment of the respective roles of the vomeronasal organ (VNO) and the main olfactory epithelium (MOE) in pheromone-mediated behaviors. She discovered that, in contrast to previous thinking, VNO activity is not required for the initiation of male-female mating behavior in the mouse, and instead, ensures sex discrimination among conspecifics. In contrast, MOE signaling appears essential to trigger mating in the mouse.For more informa...
Source: Videocast - All Events - February 11, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

CFTR, the Odd ABC Transporter Responsible for Cystic Fibrosis
Speaker Jue Chen, Ph.D., of The Rockefeller University, studies ATP-binding cassette (ABC) transporters, a diverse group of membrane proteins integral to almost every biological process. In prokaryotes, these proteins are critical for survival. In humans, ABC transporters make up one of the largest gene families, and more than a dozen genetic diseases have been traced to ABC transporter defects. ABC transporters are also central to multidrug resistance in many pathogenic bacteria and in tumor cells.For more information go tohttps://oir.nih.gov/walsAir date: 4/28/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 10, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Advancing Therapies for Children and Adults with Rare Tumors or Genetic Tumor Predisposition Syndromes
This is the annual G. Burroughs Mider Lecture. Speaker Brigitte Widemann, M.D., is the chief of the National Cancer Institute ’ s Pediatric Oncology Branch. Trained as a pediatric oncologist with expertise in drug development and early clinical trials for children with refractory cancers she applied her expertise to study genetic tumor predisposition syndromes (GTPS), in particular neurofibromatosis type 1 (NF1) and very rare pediatric and adult solid tumors.For more information go tohttps://oir.nih.gov/walsAir date: 4/21/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 10, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Special Tuesday WALS Lecture - Three (Formerly) Blind Mice: Reprogramming Tissues to Be Young Again
Special Tuesday WALS Lecture Dr. Sinclair is a professor of genetics, Blavatnik Institute, and co-director of the Paul F. Glenn Center for Biology of Aging Research, at Harvard Medical School. His lab seeks to understand why we age and whether we can extend human health and longevity. The Sinclair laboratory has demonstrated that it is possible to epigenetically reprogram cells to safely reverse aging in vivo and regain eyesight. This research, conducted with support from the National Institute on Aging and National Eye Institute, was recently published in Nature (PMID: 33268865; doi: 10.1038/s41586-020-2975-4) and will b...
Source: Videocast - All Events - February 4, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Cell Atlases as Roadmaps in Health and Disease
Wednesday Afternoon Lecture Series Dr. Regev is Executive Vice President of Research and Early Development at Genentech, a subsidiary of Roche. She has earned praise for creating technologies to expand understanding of biological processes, such as assays for sequencing RNA in single cells and associated machine learning algorithm s. She also co-leads the Human Cell Atlas project, which aims to describe all cell types in the human body. She is currently on leave from her longstanding positions at MIT and at the Broad Institute. Cells are the basic unit of life and form a key intermediate between genotype and phenotype, wh...
Source: Videocast - All Events - February 1, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Young Blood for Old Brains
Speaker Tony Wyss-Coray's laboratory studies the role of immune and injury responses in neurodegeneration and Alzheimer ’ s disease. We seek to understand how immune responses and injury pathways may modulate neurodegeneration and age-related changes in the brain. We study these pathways in vivo and in cell culture using a number of genetic and proteomic tools. We have been particularly interested in the TGF-beta signaling pathway as a major regulator of biological processes and we are developing genetic and pharmacological agents to manipulate this pathway.For more information go tohttps://oir.nih.gov/walsAir date: ...
Source: Videocast - All Events - January 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Innate Immunity for Bacteria Against Phage
My lab has a long-standing interest in the signaling pathways and regulatory networks that enable bacteria to sense and respond to their environments. Most recently, we have focused on toxin-antitoxin systems, which are abundant, but still poorly understood genetic modules found throughout the bacterial kingdom. We study the mechanisms of action of the toxins, the coevolution of toxins and antitoxins, and the role of toxin-antitoxin systems in providing bacteria immunity to some classes of bacteriophage, which will be the topic of my seminar.For more information go tohttps://oir.nih.gov/walsAir date: 3/17/2021 3:00:00 PM (...
Source: Videocast - All Events - January 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

These Viruses Are Forever: Consequences of Retroviral DNA Integration to Aids and Evolution
Our research interests revolve around obtaining a better understanding of the interaction of retroviruses with their host cells and organisms. We use simple retroviruses (avian and murine viruses) as well as HIV to elucidate the nature of the retrovirus-receptor interaction; control of viral gene expression; mechanism of retroviral genetic variation; and evolution of the host-virus relationship, as revealed by the fossil record provided by endogenous proviruses found in the normal DNA of all vertebrates and many other species.For more information go tohttps://oir.nih.gov/walsAir date: 3/16/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 15, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

RNA Antics in Viral Drug Resistance and host immunosuppression
This is the annual George Khoury Lecture. Speaker Karla Kirkegaard, Ph.D., deciphers the genetics of RNA viruses and their mammalian hosts, with the goal of suppressing drug resistance and excessive inflammation during viral infections.For more information go tohttps://oir.nih.gov/walsAir date: 3/3/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 15, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Three (Formerly) Blind Mice: Reprogramming Tissues to Be Young Again
Speaker David A. Sinclair, Ph.D., a professor in the Department of Genetics, Blavatnik Insitute, and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney, in 1995 and did his postdoctoral research at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability and aging. In 1999 he moved to Harvard Medical S...
Source: Videocast - All Events - January 15, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video

Colliding Ribosomes Function as a Sentinel for Cellular Distress
The ribosome is a complex molecular machine that translates the genetic code into functional polypeptides. We are interested in how this machine catalyzes and coordinates the molecular events of translation and its regulation. Work in the Green lab ranges all the way from translational initiation mechanisms in bacteria to ribosome homeostasis in human disease. In all of our projects, we rely on genetic and biochemical approaches to explore the biology of the system in bacterial, yeast and mammalian systems. Most projects in the lab also incorporate ribosome profiling and other high throughput genome-wide approaches to leve...
Source: Videocast - All Events - December 11, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

OHSRP Education Series: The NIH Genomic Data Sharing Policy: applicability to IRP investigators; components; and required protocol and consent content
The next OHSRP Education Series session will be held on Tuesday, December 1st from 3-4 PM via live NIH videocast at https://videocast.nih.gov/ and will be archived During this session, Kathleen Calzone, PhD, RN, AGN-BC, FAAN, will present The NIH Genomic Data Sharing Policy: applicability to the IRP; components; and required protocol and consent content. Dr. Calzone is a Research Geneticist in the Genetics Branch of the Center for Cancer Research at the National Cancer Institute. She is also the National Institutes of Health Genomic Data Sharing Policy Genomic Program Administrator for the NCI Center for Cancer Research. O...
Source: Videocast - All Events - November 17, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Gaucher Disease: How a Rare Disease Provides a Window into Common Neurodegenerative Disorders
WALS Astute Clinician Lecture The speaker, Dr. Ellen Sidransky, is the Branch Chief of the Medical Genetics Branch and is a pediatrician and geneticist in the National Human Genome Research Institute at National Institutes of Health (NIH). Her research interests include both clinical and basic aspects of Gaucher disease and Parkinson disease, studies of genotype/phenotype correlation and genetic modifiers, insights from mouse models, and novel treatment strategies. She played a lead role in establishing the association between glucocerebrosidase and parkinsonism. The author of over 200 publications, she continues to focus ...
Source: Videocast - All Events - October 20, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Genetic Studies Illuminating Pathways Important for Controlling COVID Disease
We are interested in new inherited defects of innate immunity that can cause increased susceptibility to virus infections, especially those targeting the respiratory tract. One example is our discovery of human MDA5 deficiency in a patient who had recurrent severe rhinovirus and other respiratory viruses. The patient ’ s loss of MDA5 demonstrated the physiological importance of this cytosolic viral nucleic acid sensor for immunity against the common cold virus. The extent to which MDA5 physiologically contributes in humans to protect against other respiratory viruses is being studied. For more information about this ...
Source: Videocast - All Events - October 5, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

3D rendering of genetically targeted chemical assembly of functional materials
The golden color in this 3D rendering depicts biocompatible materials attached to neurons, materials deposited using a process called genetically targeted chemical assembly (GTCA). In GTCA, researchers use genetic information to target cells and precisely deposit polymers, sparing the neighboring ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - October 1, 2020 Category: Science Source Type: video

Ethical & Regulatory Aspects of Clinical Research Session 4: Genetics
The Department of Bioethics offers this seven week course annually each fall. The course is designed to provide an overview of the important issues in the ethics of human subject research for clinical investigators and others who participate in the conduct of research and is open to the entire NIH community as well as to those from outside NIH. Topics include the history of human subject research ethics, principles and guidelines, study design, subject recruitment, informed consent, and international research. The course is open to the entire NIH community as well as to those from outside NIH. The recommended textbook is E...
Source: Videocast - All Events - September 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Human antibody responses to SARS-CoViD-2
NIH Director's Wednesday Afternoon Lecture Series Annual William E. Paul Lecture – – Dr. Nussenzweig ’ s laboratory studies the molecular aspects of the immune system ’ s innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. For work on adaptive immunity, he focuses on B lymphocytes and antibodies to HIV-1, while his studies of innate immunity focus on dendritic cells. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 coronavirus, among other viruses.For more information go tohttps://oir.nih.gov/wals/about...
Source: Videocast - All Events - September 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair Interest Group Seminar: The Sensing and Repair of DNA Strand Breaks and Human Genetic Disease
DNA Repair Interest Group SeminarAir date: 10/20/2020 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

From Mechanisms to Medicines: Realizing the DREAM of an Alzheimer's Cure
NIH Director's Seminar Series The repeated failures of disease-modifying treatments for Alzheimer ’ s disease (AD) have increased the urgency to identify novel therapeutic targets and biomarkers for AD and related dementias (ADRD). Dr. Thambisetty's Clinical and Translational Neuroscience Section has applied a systems biology approach leveraging deep molecular phenotyping by multi-OMICs methods in brain and blood in combination with multi-modal neuroimaging and epidemiological analyses to identify abnormal metabolic pathways in ADRD associated with severity of pathology and expression of clinical symptoms. These stud...
Source: Videocast - All Events - September 2, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

NIH Director's Seminar Series
The repeated failures of disease-modifying treatments for Alzheimer ’ s disease (AD) have increased the urgency to identify novel therapeutic targets and biomarkers for AD and related dementias (ADRD). Dr. Thambisetty's Clinical and Translational Neuroscience Section has applied a systems biology approach leveraging deep molecular phenotyping by multi-OMICs methods in brain and blood in combination with multi-modal neuroimaging and epidemiological analyses to identify abnormal metabolic pathways in ADRD associated with severity of pathology and expression of clinical symptoms. These studies have added to a growing bo...
Source: Videocast - All Events - September 2, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Nucleic Acid Delivery Systems for RNA Therapy and Gene Editing
NIH COVID-19 SIG Lecture Series High throughput, combinatorial approaches have revolutionized small-molecule drug discovery. Dan Anderson will describe his work on the combinatorial development of nanoparticulate, intracellular delivery systems for RNA therapy and gene editing. Libraries of degradable polymers and lipid-like materials have been synthesized, formulated, and screened for their ability to deliver macromolecular payloads inside of cells. These nanoformulations facilitate in vivo delivery, enabling gene suppression with small-interfering RNA, gene expression with messenger RNA, or permanent genetic editing usin...
Source: Videocast - All Events - June 5, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Genetics' part in the standard of care
2bPrecise CMO Joel Diamond, MD, says pharmacogenomics is a good entry point for providers in precision medicine, identifying the right medicine for better outcomes and patient satisfaction. (Source: Healthcare ITNews Videos)
Source: Healthcare ITNews Videos - May 14, 2020 Category: Information Technology Tags: Precision Medicine Quality and Safety Source Type: video

SGI Symposium
NINR ’ s Division of Intramural Research (DIR) will convene a half-day symposium to mark a milestone anniversary of its Summer Genetics Institute. The symposium will include keynote addresses, scientific presentations, a scientific panel discussion, and a research poster session. It will highlight SGI graduates ’ many accomplishments and showcase the positive impact of this program in accelerating genetics and genomics in nursing science.Air date: 6/22/2020 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - April 27, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

New evidence that modern humans and Neanderthals share a tangled genetic history.
New research from University at Buffalo and the Foundation for Research and Technology in Greece adds to growing evidence that our ancestors interbred with Neanderthals more often than we thought.This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - April 24, 2020 Category: Science Source Type: video

Demystifying Medicine - Sickle Cell Anemia: Treatable and/or Curable?
Demystifying Medicine Lecture Series Although the fundamental molecular pathophysiology of sickle cell anemia was elucidated in studies of this genetic disease starting more than 70 years ago, it is only in about the last two decades that this knowledge has led to specific therapies. Indeed in the last decade serious attention has turned to the possibility of a genetic cure of this condition. Have we finally cured sickle cell anemia? Not quite, but we may be on the cusp. Really. In a dozen clinical trials planned or underway, some at the NIH Clinical Center, researchers are applying gene therapy to cure this well-studied g...
Source: Videocast - All Events - February 27, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Clinical Neuroscience Grand Rounds: Molecular Genetics and Novel Therapeutics
Clinical Neuroscience Grand Rounds This activity is intended for Neurologists, Neuroscientists, Neurosurgeons, Neuropsychologists, and Health Care Professionals. This activity has been planned and implemented in accordance with the Essential Areas and polices of the Accreditation Council for Continuing Medical Education through the joint providership of the Johns Hopkins University School of Medicine and the National Institutes of Health (NIH). The Johns Hopkins University School of Medicine is accredited by the ACME to provide continuing medical education for physicians.Air date: 3/3/2020 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 25, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Rear Admiral (Upper Half) Richard W. Childs Flag Promotion Ceremony
The United States Public Health Service Flag Promotion ceremony for Rear Admiral (RADM) Richard W. Childs, promoted to RADM Upper Half O-8 in January 2020, is being webcast live on 3/27/2020 from Masur Auditorium. Richard Childs, MD serves as the Clinical Director of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH). He was commissioned in the USPHS Commissioned Corps as a Lieutenant in 1995 when joined the NCI as an Oncology Fellow. Following fellowship training, he was appointed a tenure-track investigator in the Hematology Branch of the NHLBI where he continues to conduct r...
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Molecular orbitals of a portion of DNA molecule
The molecular orbitals of a portion of DNA molecule, a key component of the genetic code. [Research supported by National Science Foundation grants MCB 1616590, MCB 1244570, PHY 1430124 and ACI 1713784.] Learn more about this research in the University of Illinois news story (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - February 18, 2020 Category: Science Source Type: video

Innovative Data Science Methods in Biomedical Research (Day 2)
The objectives of the workshop are to assess recent developments in statistical ML/AI methods and to identify major challenges and issues of ML/AI in biomedical research. The topics of sessions will cover decision trees, random forest, regularized regression models/AI, targeted learning, and neural networks, and show use cases for healthcare device and image. The data domain areas will include medical imaging, epidemiological cohorts, genetics, etc. The workshop will be an excellent learning opportunity for NIH investigators and program staff to enhance their knowledge of ML/AI and their application in biomedical research....
Source: Videocast - All Events - February 18, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Innovative Data Science Methods in Biomedical Research (Day 1)
The objectives of the workshop are to assess recent developments in statistical ML/AI methods and to identify major challenges and issues of ML/AI in biomedical research. The topics of sessions will cover decision trees, random forest, regularized regression models/AI, targeted learning, and neural networks, and show use cases for healthcare device and image. The data domain areas will include medical imaging, epidemiological cohorts, genetics, etc. The workshop will be an excellent learning opportunity for NIH investigators and program staff to enhance their knowledge of ML/AI and their application in biomedical research....
Source: Videocast - All Events - February 18, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Deciphering Cancer Genomes and Networks
NIH Director's Wednesday Afternoon Lecture Series Large-scale cancer genome sequencing consortia, such as TCGA, have provided a huge influx of somatic mutation data across large cohorts of patients. Understanding how these observed genetic alterations give rise to specific cancer phenotypes is a major aim of cancer genomics. This is challenging because numerous somatic mutations occur in each cancer genome, but only a subset are cancer-relevant; further, there is a high degree of mutational heterogeneity across individuals. Fortunately, the large and diverse biological datasets collected over the past few decades — i...
Source: Videocast - All Events - January 30, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Frog species Hyperolius cinnamomeoventris
This unusual-looking female reed frog was thought to be a new species until its genetics revealed it is a widespread species called Hyperolius cinnamomeoventris. [Specimens will be part of the National Science Foundation-supported iDigBio project, funded under NSF grants DBI 1115210 and ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - January 23, 2020 Category: Science Source Type: video

A Myth of Convenience: The Law Lag and Scientific Progress
NIMH Director ’ s Innovation Speaker Series For the fourteenth year, the National Institute of Mental Health is pleased to invite you to attend the fourth of a series of lectures dedicated to innovation, invention, and scientific discovery. Sheila Jasanoff is Pforzheimer Professor of Science and Technology Studies at the John F. Kennedy School of Government at Harvard University. She is affiliated with the Department of the History of Science and Harvard Law School. Previously, she was Professor of Science Policy and Law at Cornell U niversity and founding chair of Cornell ’ s Department of Science and Techno...
Source: Videocast - All Events - January 13, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video