NHLBI Obesity, Nutrition, and Physical Activity Seminar: Cardiovascular Health in the Peripartum Period: Drivers and Determinants
In this one-hour webinar, Dr. Sadiya S. Khan, MD, MSc, will present an overview of “ Cardiovascular Health in the Peripartum Period: Drivers and Determinants. ” She will discuss how cardiovascular health in the peripartum period is associated with adverse pregnancy outcomes with short- and long-term implications for the birthing adult and offspring. Dr. Khan will also share how upstream drivers, including social, psychological, and lifestyle factors, offer opportunities for intervention to improve cardiovascular health. Finally, she will discuss why interventions should include individual-, health-system, community, an...
Source: Videocast - All Events - April 17, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
the NHLBI-NIDCR Shared Anniversary Virtual Symposium
The National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Dental and Craniofacial Research (NIDCR) invite you to a joint 75th anniversary symposium, Celebrating the Science That Unites Us. This virtual event will be on Thursday, May 16, 2024, from 12:30 p.m. – 3 p.m. EST. The symposium is virtual, free, and open to the public.The NHLBI ’ s 75th anniversary celebrates numerous achievements and collaborations in heart, blood, lung, and sleep research; millions of lives saved and improved; and the many scientific pioneers who have worked tirelessly to improve public health and to save lives.In it...
Source: Videocast - All Events - April 17, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: Harnessing Mechanistic Insights into microRNA Function for Cancer Therapy
As a class of small non-coding RNAs, microRNAs (miRNAs) function as master gene regulators. My laboratory studies how miRNAs themselves are regulated and their applications in cancer treatment. Despite the success of using miRNAs including their isoforms (isomiRs) as disease biomarkers, development of miRNA-based cancer treatments was somewhat lagging behind mainly due to the difficulty in identifying tumor-driver miRNA variations. In this talk, I will discuss our endeavor in addressing this challenge by investigating the mechanisms of miRNA biogenesis and function. I will demonstrate how the addition of sequences at their...
Source: Videocast - All Events - April 1, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Center Grand Rounds: Great Teachers Distinguished Clinical Research Scholar and Educator in Residence Lecture - Genetics & Genomics of Neuropsychiatric Disorders
Genetics& Genomics of Neuropsychiatric DisordersDaniel Geschwind MD PhDGordon and Virginia MacDonald Distinguished Professor of Human GeneticsNeurology and PsychiatrySenior Associate Dean and Associate Vice Chancellor of Precision HealthInstitute for Precision HealthUniversity of California Los AngelesFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 4/10/2024 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 1, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS: A History of the North American Buffalo in Three Acts
Beth Alison Shapiro is a professor in the Department of Ecology and Evolutionary Biology at the University of California, Santa Cruz. Shapiro's work has centered on the analysis of ancient DNA. She was awarded a MacArthur Fellowship in 2009 and a Royal Society University Research Fellowship in 2006. Research Interests My research aims to better understand how populations and species change through time, in particular in in response to environmental and other changes to their habitat. To address this, my group uses the latest experimental and computational approaches to analyze genetic information isolated from fossil and a...
Source: Videocast - All Events - March 5, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS NIH Director's Lecture: The Future of CRISPR: What ’ s Ahead for Genome Editing
Jennifer Doudna is a Nobel Laureate in Chemistry, and a Professor of Biochemistry, Biophysics and Structural Biology. Her research focuses on RNA as it forms a variety of complex globular structures, some of which function like enzymes or form functional complexes with proteins. Her lab's research into RNA biology led to the discovery of CRISPR-Cas9 as a tool for making targeted changes to the genome. In bacteria, CRISPR systems preserve invading genetic material and incorporate it into surveillance complexes to achieve adaptive immunity. Crystal structures of diverse Cas9 proteins reveal RNA-mediated conformational activa...
Source: Videocast - All Events - February 12, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Center Grand Rounds: Breast Cancer ’ s Uncharted Pathway: Stromal Disruption in Multistep Mammary Carcinogenesis
Mustapha Abubakar, MD, PhDEarl Stadtman InvestigatorIntegrative Tumor Epidemiology BranchDivision of Cancer Epidemiology& Genetics National Cancer Institute, NCIFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 2/21/2024 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 2, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - A new molecular regulatory pathway revealed by studying a human immunodysregulatory disorder
Our laboratory aims to elucidate molecular mechanisms regulating the human immune system and delineate how their derangements cause disease. As will be exemplified in the talk, our approach is to study patients with rare and poorly characterized inherited inborn errors of immunity who are followed at the NIH Clinical Center. By carefully investigating these “ experiments of nature ” we can draw inferences about molecular functions based on patient phenotypes. Our program broadly integrates the patients ’ clinical evaluations, assessments of their immune function, genetic and biochemical analyses to gain insights into...
Source: Videocast - All Events - February 2, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Dr. Manu Platt Seminar, Strokes with sickle cell disease: Dynamic interplay between biomechanical and biochemical stimuli
Strokes with sickle cell disease: Dynamic interplay between biomechanical and biochemical stimuli of children born with sickle cell disease, 11% will have a major stroke by age 16, and 30-35% will have a silent stroke impairing cognitive abilities. Later in life, risk for hemorrhagic stroke increases, suggesting an age-related component to arterial damage. Significantly higher velocities measured with transcranial Doppler in cerebral arteries implicates children at risk for strokes with disturbed cerebral hemodynamics. Cathepsins are a family of proteases containing the most potent human elastases and collagenases that we ...
Source: Videocast - All Events - January 3, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine — Cognitive Loss, Dementia, and Neurodegenerative Disorders: Vascular and Genetic Factors
The Demystifying Medicine Series, jointly sponsored by FAES and NIH, includes presentations on pathology, diagnosis, and therapy in the context of major disease problems and current research. Primarily directed toward PhD students, clinicians and program managers, this series is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, trainees, fellows, and staff are welcome to participate.For more information go tohttps://demystifyingmedicine.od.nih.govAir date: 4...
Source: Videocast - All Events - December 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine — Behavioral Genetics: Man Meets Dog
The Demystifying Medicine Series, jointly sponsored by FAES and NIH, includes presentations on pathology, diagnosis, and therapy in the context of major disease problems and current research. Primarily directed toward PhD students, clinicians and program managers, this series is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, trainees, fellows, and staff are welcome to participate.For more information go tohttps://demystifyingmedicine.od.nih.govAir date: 3...
Source: Videocast - All Events - December 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine — Parkinson's Disease: From Genetic Breakthroughs to Therapeutic Targets
The Demystifying Medicine Series, jointly sponsored by FAES and NIH, includes presentations on pathology, diagnosis, and therapy in the context of major disease problems and current research. Primarily directed toward PhD students, clinicians and program managers, this series is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, trainees, fellows, and staff are welcome to participate.For more information go tohttps://demystifyingmedicine.od.nih.govAir date: 3...
Source: Videocast - All Events - December 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine — Progeria: A Genetic and Therapeutic Adventure
The Demystifying Medicine Series includes presentations on pathology, diagnosis, and therapy in the context of major disease problems and current research. Primarily directed toward PhD students, clinicians and program managers, this series is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, trainees, fellows, and staff are welcome to participate.For more information go tohttps://demystifyingmedicine.od.nih.govAir date: 1/23/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS Lecture: Leveraging Genetics and Cell Signaling to Decipher Disorders of Excitability
Presentation Objectives: To understand how genetic testing illuminates the causes of a devastating disease, Sudden Unexpected Death in Childhood, and identifies dysfunctional calcium signaling as a major cause; To chart a course for how genetic analysis of neuropsychiatric disorders such as schizophrenia, Major Depressive Disorder and Bipolar Disorder will spur understanding the impact of non-coding variations in key signaling proteins; To appreciate how genetics highlights underappreciated signaling molecules that coordinate excitatory and inhibitory synaptic strength and provide a target for cannabidiol (CBD) action in e...
Source: Videocast - All Events - December 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH ProtIG Seminar: The role of long-lived proteins in aging and Alzheimer ’ s disease
Loss of proteostasis is a hallmark of aging, and aging is the greatest risk factor for Alzheimer's disease (AD). Deterioration in function and accumulation of damage to the proteome are largely repaired by protein turnover. These turnover mechanisms are particularly important in long-lived postmitotic neurons, which cannot dilute toxic proteins through cell division. We aimed to identify extremely long-lived proteins (ELLP) that persist for several months or longer across the aging continuum in wild-type mice and in genetic AD mouse models. We hypothesize that these ELLPs represent key points of vulnerability to the declin...
Source: Videocast - All Events - November 30, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
