Genetics' part in the standard of care
2bPrecise CMO Joel Diamond, MD, says pharmacogenomics is a good entry point for providers in precision medicine, identifying the right medicine for better outcomes and patient satisfaction. (Source: Healthcare ITNews Videos)
Source: Healthcare ITNews Videos - May 14, 2020 Category: Information Technology Tags: Precision Medicine Quality and Safety Source Type: video

SGI Symposium
NINR ’ s Division of Intramural Research (DIR) will convene a half-day symposium to mark a milestone anniversary of its Summer Genetics Institute. The symposium will include keynote addresses, scientific presentations, a scientific panel discussion, and a research poster session. It will highlight SGI graduates ’ many accomplishments and showcase the positive impact of this program in accelerating genetics and genomics in nursing science.Air date: 6/22/2020 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - April 27, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

New evidence that modern humans and Neanderthals share a tangled genetic history.
New research from University at Buffalo and the Foundation for Research and Technology in Greece adds to growing evidence that our ancestors interbred with Neanderthals more often than we thought.This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - April 24, 2020 Category: Science Source Type: video

Demystifying Medicine - Sickle Cell Anemia: Treatable and/or Curable?
Demystifying Medicine Lecture Series Although the fundamental molecular pathophysiology of sickle cell anemia was elucidated in studies of this genetic disease starting more than 70 years ago, it is only in about the last two decades that this knowledge has led to specific therapies. Indeed in the last decade serious attention has turned to the possibility of a genetic cure of this condition. Have we finally cured sickle cell anemia? Not quite, but we may be on the cusp. Really. In a dozen clinical trials planned or underway, some at the NIH Clinical Center, researchers are applying gene therapy to cure this well-studied g...
Source: Videocast - All Events - February 27, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Clinical Neuroscience Grand Rounds: Molecular Genetics and Novel Therapeutics
Clinical Neuroscience Grand Rounds This activity is intended for Neurologists, Neuroscientists, Neurosurgeons, Neuropsychologists, and Health Care Professionals. This activity has been planned and implemented in accordance with the Essential Areas and polices of the Accreditation Council for Continuing Medical Education through the joint providership of the Johns Hopkins University School of Medicine and the National Institutes of Health (NIH). The Johns Hopkins University School of Medicine is accredited by the ACME to provide continuing medical education for physicians.Air date: 3/3/2020 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 25, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Rear Admiral (Upper Half) Richard W. Childs Flag Promotion Ceremony
The United States Public Health Service Flag Promotion ceremony for Rear Admiral (RADM) Richard W. Childs, promoted to RADM Upper Half O-8 in January 2020, is being webcast live on 3/27/2020 from Masur Auditorium. Richard Childs, MD serves as the Clinical Director of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH). He was commissioned in the USPHS Commissioned Corps as a Lieutenant in 1995 when joined the NCI as an Oncology Fellow. Following fellowship training, he was appointed a tenure-track investigator in the Hematology Branch of the NHLBI where he continues to conduct r...
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Molecular orbitals of a portion of DNA molecule
The molecular orbitals of a portion of DNA molecule, a key component of the genetic code. [Research supported by National Science Foundation grants MCB 1616590, MCB 1244570, PHY 1430124 and ACI 1713784.] Learn more about this research in the University of Illinois news story (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - February 18, 2020 Category: Science Source Type: video

Innovative Data Science Methods in Biomedical Research (Day 2)
The objectives of the workshop are to assess recent developments in statistical ML/AI methods and to identify major challenges and issues of ML/AI in biomedical research. The topics of sessions will cover decision trees, random forest, regularized regression models/AI, targeted learning, and neural networks, and show use cases for healthcare device and image. The data domain areas will include medical imaging, epidemiological cohorts, genetics, etc. The workshop will be an excellent learning opportunity for NIH investigators and program staff to enhance their knowledge of ML/AI and their application in biomedical research....
Source: Videocast - All Events - February 18, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Innovative Data Science Methods in Biomedical Research (Day 1)
The objectives of the workshop are to assess recent developments in statistical ML/AI methods and to identify major challenges and issues of ML/AI in biomedical research. The topics of sessions will cover decision trees, random forest, regularized regression models/AI, targeted learning, and neural networks, and show use cases for healthcare device and image. The data domain areas will include medical imaging, epidemiological cohorts, genetics, etc. The workshop will be an excellent learning opportunity for NIH investigators and program staff to enhance their knowledge of ML/AI and their application in biomedical research....
Source: Videocast - All Events - February 18, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Deciphering Cancer Genomes and Networks
NIH Director's Wednesday Afternoon Lecture Series Large-scale cancer genome sequencing consortia, such as TCGA, have provided a huge influx of somatic mutation data across large cohorts of patients. Understanding how these observed genetic alterations give rise to specific cancer phenotypes is a major aim of cancer genomics. This is challenging because numerous somatic mutations occur in each cancer genome, but only a subset are cancer-relevant; further, there is a high degree of mutational heterogeneity across individuals. Fortunately, the large and diverse biological datasets collected over the past few decades — i...
Source: Videocast - All Events - January 30, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Frog species Hyperolius cinnamomeoventris
This unusual-looking female reed frog was thought to be a new species until its genetics revealed it is a widespread species called Hyperolius cinnamomeoventris. [Specimens will be part of the National Science Foundation-supported iDigBio project, funded under NSF grants DBI 1115210 and ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - January 23, 2020 Category: Science Source Type: video

A Myth of Convenience: The Law Lag and Scientific Progress
NIMH Director ’ s Innovation Speaker Series For the fourteenth year, the National Institute of Mental Health is pleased to invite you to attend the fourth of a series of lectures dedicated to innovation, invention, and scientific discovery. Sheila Jasanoff is Pforzheimer Professor of Science and Technology Studies at the John F. Kennedy School of Government at Harvard University. She is affiliated with the Department of the History of Science and Harvard Law School. Previously, she was Professor of Science Policy and Law at Cornell U niversity and founding chair of Cornell ’ s Department of Science and Techno...
Source: Videocast - All Events - January 13, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Genetic and Evolutionary Dissection of the Sleep-Feeding Conflict
NIH Neuroscience Series SeminarFor more information go tohttps://neuroscience.nih.gov/ninds/Home.aspxAir date: 3/30/2020 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 3, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

Southern sea otter and baby in Moss Landing, California
A southern sea otter swims with its baby in Moss Landing, California. Researchers have found a genetic link between the deadly pathogen toxoplasmosis, which the otters are contracting, and wild and feral cats on land. [Research supported by National Science Foundation grants OCE 1065990 and OCE ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - December 30, 2019 Category: Science Source Type: video

Wild southern sea otter off Moss Landing in California
A wild southern sea otter off Moss Landing in California. Researchers have found a genetic link between the deadly pathogen toxoplasmosis, which the otters are contracting, and wild and feral cats on land. [Research supported by National Science Foundation grants OCE 1065990 and OCE ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - December 29, 2019 Category: Science Source Type: video

Teams of microbes are at work in our bodies. How can we know what they ’ re up to?
NSF-funded researchers are using their pattern-recognition algorithm to identify microbial communities in the body by sifting through volumes of genetic code. Their method could speed the development of medical treatments for microbiota-linked ailments like Crohn’s disease. This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - December 23, 2019 Category: Science Source Type: video

CC Grand Rounds: Adventures in Autoinflammatory Genetics: From Genetically Complex Syndromes to Mendelian Diseases: 1) Systemic Juvenile Idiopathic Arthritis: One Name, Many Faces and 2) The Deficiency of Adenosine Deaminase 2: A Master of Mimicry
CC Grand Rounds: Adventures in Autoinflammatory Genetics: From Genetically Complex Syndromes to Mendelian Diseases: 1) Systemic Juvenile Idiopathic Arthritis: One Name, Many Faces and 2) The Deficiency of Adenosine Deaminase 2: A Master of MimicryFor more information go tohttps://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 1/22/2020 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 20, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Mining the Unexplored Cancer Kinome for Novel Therapeutic Targets in Squamous Cell Carcinomas
NCI ’ s Center for Cancer Research (CCR) Grand Rounds Cancer genomic sequencing has significantly impacted the understanding of the temporal and spatial genetic alterations that lead to tumorigenesis. This information enables the development of targeted therapies that result in durable and less toxic responses in patients. In regard to kinases, the biomedical community has focused research efforts on approximately 200 kinases among the 538 kinases present in the human kinome, yet siRNA screens and cancer genomic studies indicate that the vast majority of these unexplored kinases (approximately 300) are implicated in ...
Source: Videocast - All Events - December 9, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Protocol Navigation Training: Submitting and Accessing Phenotype and Molecular Data from NCBI ’ s dbGaP Archive
Protocol Navigation Training Program Seminar Series The NIH Intramural Research Program ’ s Protocol Navigation Training Program presents: ubmitting and Accessing Phenotype and Molecular Data from NCBI ’ s dbGaP Archive. This presentation will feature Michael Feolo, Staff Scientist and dbGaP Team Lead with the National Center for Biotechnology Information (NCBI), National Library of Medicine (NLM). Mr. Feolo will discuss the NCBI ’ s database of Genotypes and Phenotypes (dbGaP), an NIH-sponsored data repository charged with archiving, curating, and distributing information produced by studies investigatin...
Source: Videocast - All Events - November 26, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Harnessing Genetic Interactions to Advance Precision Targeted and Immune Therapy of Cancer
CCR Grand Rounds Dr. Eytan Ruppin is a computational biologist whose research is focused on developing and harnessing data science approaches for the integration of multi-omics data to better understand the pathogenesis of cancer, its evolution and treatment. Her laboratory collaborates with many experimental cancer labs, aiming to develop and utilize computational approaches to jointly gain a network-level integrative view of the systems that the researchers study. Together with Dr. Ruppin ’ s collaborators, from a translational perspective, the researchers aim to predict and test novel drug targets and biomarkers t...
Source: Videocast - All Events - November 18, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

NIMHD Director's Seminar: Genetic Research with Alaska Native People: Lessons and Future Possibilities
The objectives of Dr. Dillard ’ s presentation will include the following:• Lessons learned over a decade of engagement with the Alaska Native community about ethical, legal and social implications of genetic research.• Findings from recent and ongoing genetic research by Southcentral Foundation, a tribal health organization in Anchorage, Alaska.• Ideas to increase participation of individuals from groups typically underrepresented in genetic research. Dr. Dillard is of Inupiaq Eskimo descent, born and raised in Alaska. She is the director of research for Southcentral Foundation, a tribal health organi...
Source: Videocast - All Events - November 5, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Neuroscience Seminar - Axon Degeneration: Molecular Mechanisms and Therapeutic Potential
NIH Neuroscience Series Seminar Dr. DiAntonio ’ s laboratory investigates molecular mechanisms that control the structure and function of neural circuits in development and disease. They combine genetic, molecular, neuroanatomical, and electrophysiological studies in both Drosophila and mouse to identify pathways required for the development, maintenance, and regeneration of axons and synapses. Axonal degeneration is a common feature of many neurological diseases including hereditary neuropathies, diabetes, glaucoma, chemotherapy-induced neurotoxicity, and neurodegenerative diseases such as Alzheimer ’ s and Pa...
Source: Videocast - All Events - November 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

The Peter Pan Syndrome: Oncohistones Stall Development in Pediatric Cancers
CCR Grand Rounds Dr. Jabado ’ s research focuses on elucidating genetic signatures of pediatric astrocytomas and examining how they compare to adults. These are deadly brain tumors that originate in the brain and include glioblastomas (GBM, the highest grade of astrocytomas), which are one of the deadliest cancers in humans. Her group uncovered that pediatric high-grade astrocytomas (HGA) are molecularly and genetically distinct from adult tumors. They also identified a new molecular mechanism driving pediatric HGA, namely recurrent somatic driver mutations in the tail of histone 3 variants (H3.3 and H3.1). These mut...
Source: Videocast - All Events - October 21, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

23andMe advancing personalized medicine
Erin Trimble of 23andMe discusses the value of polygenic risk scores, making genetic information actionable for better health and equipping primary care providers to talk with their patients about genetics. (Source: Healthcare ITNews Videos)
Source: Healthcare ITNews Videos - October 14, 2019 Category: Information Technology Tags: Precision Medicine Women In Health IT Source Type: video

Innovation by evolution: bringing new chemistry to life
NIH Director's Wednesday Afternoon Lecture Series Marshall W. Nirenberg Lecture Not satisfied with nature ’ s vast catalyst repertoire, we want to create new protein catalysts and expand the space of genetically encoded enzyme functions. I will describe how we can use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones, thereby circumventing our profound ignorance of how sequence encodes function. Using mechanistic understanding and mimicking nature ’ s evolutionary processes, we can generate whole new enzyme families that catalyze synthetically important rea...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

We are what we eat: nutrition, genes, cognition & deep learning in age-related macular degeneration
NIH Director's Wednesday Afternoon Lecture Series Age-related macular degeneration (AMD) is the leading cause of blindness in the United States and in the developed world. Two NIH-supported randomized clinical trials with 10 years of follow-up in nearly 10,000 participants demonstrated that nutritional supplements with antioxidant vitamins and minerals reduces the risk of progression to late AMD. Dietary data suggest the importance of the Mediterranean diet in reducing the risk of AMD, particularly fish consumption. The analyses of the genetic interaction with nutrition challenges the idea that you can eat away your geneti...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

A patient-scientist ’ s road toward primary prevention in genetic prion disease
NIH Director's Wednesday Afternoon Lecture Series In 2010, Sonia Vallabh watched her 52 year old mother die of a rapid, mysterious, undiagnosed neurodegenerative disease. One year later, Sonia learned that her mother's disease had been genetic prion disease, and that she herself had inherited the causal mutation, making it very likely she would suffer the same fate in 20 years' time. There was no prevention, treatment, or cure available. Despite having no prior training in biology, Sonia and her husband Eric Minikel set out to re-train themselves as scientists and devote their lives to searching for a treatment or cure for...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Bad deeds go unpunished: the vacuole guard hypothesis and pathogen intracellular growth
NIH Director ’ s Wednesday Afternoon Lecture Series Ralph Isberg has been a Professor of Molecular Biology and Microbiology at Tufts University School of Medicine for 32 years. After receiving an undergraduate degree at Oberlin College, he obtained his PhD at Harvard working on transposable genetic elements in bacteria. Throughout his career at Tufts he has primarily focused on the pathogenesis of Legionella pneumophila and enteropathogenic Yersinia, and has recently initiated projects on tackling drug resistance in nosocomial organisms. His research highlights include the identification of proteins involved in uptak...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

CRISPR/Cas9 genetic sequence with a'hairpin' lock
An artist’s representation of the CRISPR/Cas9 genetic sequence with a "hairpin" lock added to the left side of the system, a new approach created by biomedical engineers at Duke University that will improve the accuracy of the CRISPR genome editing technology by an average of 50-fold. The approach ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - October 3, 2019 Category: Science Source Type: video

Informatics for Genomics-informed Surveillance of RNA Viruses
NLM Informatics and Data Science Lecture Series Genomics-informed surveillance is now recognized as an important extension to the monitoring of rapidly evolving pathogens. Next generation sequencing has the ability to produce large amounts of data for tracking viruses of public health importance. Biomedical informatics approaches are able to facilitate the translation of these data into information for public health surveillance. Thus, epidemiologists can identify new outbreaks or monitor the course of a known epidemic by leveraging pathogen sequences (and corresponding metadata) generated from the clinical specimens of si...
Source: Videocast - All Events - October 1, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

NLM Special Lecture: Gender, Race and Power in Science
The National Library of Medicine will be hosting a special lecture by British science journalist Angela Saini in the Lister Hill Auditorium. Saini explores how prejudice can affect scientific research on race and gender and describes her efforts to uncover manipulation of evidence, abuse and wrongdoing by those in power, as well as the inadvertent and inappropriate use of race by mainstream scientific researchers in health and genetics. Drawing from themes in her two most recent books, “ Superior: The Return of Race Science ” and “ Inferior: How Science Got Women Wrong ” , she will show why research...
Source: Videocast - All Events - September 16, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Ethical & Regulatory Aspects of Clinical Research Session 7: Ethics of Genetics Research and Incidental Findings, and Ethical Issues in All of Us
The Department of Bioethics offers this seven to eight week course annually each fall. The course is designed to provide an overview of the important issues in the ethics of human subject research for clinical investigators and others who participate in the conduct of research and is open to the entire NIH community as well as to those from outside NIH. Topics include the history of human subject research ethics, principles and guidelines, study design, subject recruitment, informed consent, and international research. The course is open to the entire NIH community as well as to those from outside NIH. The recommended text...
Source: Videocast - All Events - September 16, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

NIDDK Administrative Speaker Series: Identifying the Genetic Basis of Obesity and Type 2 Diabetes in Southwest American Indians
2019 NIDDK Administrative Speaker Series The series is an opportunity for NIDDK staff to learn about the important science NIDDK conducts and supports. It is also an excellent way to inspire our administrative staff, as it allows them a chance to hear and see how their roles contribute to and/or impact the work of the scientists.Air date: 10/9/2019 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 16, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA's helix may have arisen with startling ease (Image 2)
For research on the possible origins of life chemicals on early Earth, Georgia Tech researchers used a base molecule called a proto-nucleobase (seen here next to a nucleobase), highly suspected to be precursors of nucleobases, the main components that transport genetic code in today’s RNA. [Image ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - August 19, 2019 Category: Science Source Type: video

NIA Butler-Williams Scholars Program 2019
Discussion sessions will focus on methodological approaches and interventions. The program also will include consultation on the development of research interests and advice on preparing and submitting research grant applications to NIA.Air date: 8/2/2019 10:15:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - July 3, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Neuroscience Seminar: Time to Wake Up: Regulation of Neural Stem Cell Quiescence and Reactivation
NIH Neuroscience Series Seminar Stem cell populations in tissues as varied as blood, gut and brain spend much of their time in a mitotically dormant, quiescent, state. A key point of regulation is the decision between quiescence and proliferation. The ability to reactivate neural stem cells in situ raises the prospect of potential future therapies for brain repair after damage or neurodegenerative disease. Understanding the molecular basis for stem cell reactivation is an essential first step in this quest. In Drosophila, quiescent neural stem cells are easily identifiable and amenable to genetic manipulation, making them ...
Source: Videocast - All Events - June 7, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

NIH Director's Seminar: Of humans and mice: Fundamental mechanisms of tissue-specific antifungal immunity
NIH Director's Seminar Series Over the past few decades, fungal infections have emerged as major causes of morbidity and mortality in immunosuppressed patients despite the administration of antifungal therapy. This talk will highlight recent advances in our understanding of the cellular and molecular basis of protective host immunity against mucosal and invasive fungal infections. These insights have been gained via enrollment at the NIH Clinical Center of large cohorts of patients with inherited and acquired susceptibility to fungal disease and via corroborating immunological research in clinically relevant mouse models o...
Source: Videocast - All Events - June 5, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Why don't we get more cancer: The importance of ECM Chromatin interactions in tissue-specificity and breast cancer
CCR Grand Rounds Mina J. Bissel, Ph.D., is a Distinguished Scientist, the highest rank bestowed at Lawrence Berkeley National Laboratory (LBNL) and serves as Senior Advisor to the Laboratory Director on Biology. She is also Faculty of four Graduate Groups in UC Berkeley: Comparative Biochemistry, Endocrinology, Molecular Toxicology, and Bioengineering (UCSF/UCB joint program). Having challenged several established paradigms, Bissell is a pioneer in breast cancer research and her body of work has provided much impetus for the current recognition of the significant role that extracellular matrix (ECM) signaling and microenvi...
Source: Videocast - All Events - June 3, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Of humans and mice: Fundamental mechanisms of tissue-specific antifungal immunity
NIH Director's Seminar Series Over the past few decades, fungal infections have emerged as major causes of morbidity and mortality in immunosuppressed patients despite the administration of antifungal therapy. This talk will highlight recent advances in our understanding of the cellular and molecular basis of protective host immunity against mucosal and invasive fungal infections. These insights have been gained via enrollment at the NIH Clinical Center of large cohorts of patients with inherited and acquired susceptibility to fungal disease and via corroborating immunological research in clinically relevant mouse models o...
Source: Videocast - All Events - June 3, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Watch Your Step, There Is New Chemistry Everywhere
NCCIH Integrative Medicine Research Lecture Series The National Center for Complementary and Integrative health (NCCIH) presents the Integrative Medicine Research Lecture Series. The series provides overviews of the current state of research and practice involving complementary health approaches and explores perspectives on the emerging discipline of integrative medicine. Dr. Sean Brady is Tri-Institutional Professor and Evnin Professor Head, Laboratory of Genetically Encoded Small Molecules at the Rockefeller University. Dr. Brady has developed culture-independent methods to circumvent this discovery bottleneck. He will d...
Source: Videocast - All Events - May 23, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

A new resource for breeding better tomatoes or should that be, " re-sauce? "
Researchers from Boyce Thompson Institute -- partnered with the European Research Area Network for Coordinating Action in Plant Sciences (ERA-CAPS) Program -- have created a pan-genome that captures all of the genetic information of 725 closely related wild and cultivated tomatoes. This resource of ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - May 23, 2019 Category: Science Source Type: video

Human Hereditary Deafness is Complex Yet Easy to Grasp
Beyond the Lab, Understanding Communication Disorders: Speaker Series Learn how deafness can be inherited (passed down through generations). Genetic research can improve our understanding of which gene variants are associated with human hereditary deafness. By identifying these gene variants, scientists may be able to diagnose certain forms of hereditary hearing loss earlier and more accurately. The program is part of the Beyond the Lab speaker series offered by the National Institute on Deafness and Other Communication Disorders (NIDCD). Designed for administrative and support staff as well as scientists, the speaker seri...
Source: Videocast - All Events - May 20, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

The role of mass spectrometry to implement protein biomarkers in clinical studies for precision medicine
Proteomics Interest Group Understanding cancer biology at a molecular level has dramatically changed therapeutic strategies in oncology and improved patient care. As drugs become more targeted with clearer mode of actions, it is important to implement robust biomarkers into drug development process to precisely identify the right patients for clinical trials, to deliver safer and more effective drugs, and to reduce overall developmental costs. While genetic biomarkers are widely used, implementing protein biomarkers remains challenging in part due to the lack of robust technologies fit for clinical laboratories. Recently, ...
Source: Videocast - All Events - April 26, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Opiates on the brain
NIH Director's Wednesday Afternoon Lecture Series Dr. Kieffer is a basic scientist and neurobiologist. She isolated the first gene encoding an opioid receptor, a landmark in neuroscience research to understanding molecular bases of opioid transmission and opioid-mediated mechanisms underlying pain control, mood disorders and addiction. Her team elucidated the role of each opioid receptor in both known and unknown areas of opioid physiology and behaviors using gene knockout in mice. She showed that mu receptors mediate both analgesic and addictive actions of morphine, and are responsible for drug and social reward. Her team...
Source: Videocast - All Events - April 24, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Genes, lifestyle, and risk for heart attack
NIH Director's Wednesday Afternoon Lecture Series Dr. Kathiresan leverages human genetics to understand the root causes of heart attack and to improve preventive cardiac care. Among his scientific contributions, Dr. Kathiresan has helped highlight new biological mechanisms underlying heart attack, discovered mutations that protect against heart attack risk, and developed a genetic test for personalized heart attack prevention.For more information go tohttps://oir.nih.gov/wals/2018-2019Air date: 5/22/2019 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 24, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Special Tuesday Lecture, NIH Director's Wednesday Afternoon Lecture Series
Julie Theriot is the Benjamin D. Hall Endowed Chair in Basic Life Sciences and a Howard Hughes Medical Institute investigator in the Department of Biology at the University of Washington. Her lab explores the mechanics and dynamics of how cells organize themselves to create their own structures and shapes. She studies an unusually wide variety of cell types and model systems in order to gain a broad conceptual understanding of the organizational rules that give rise to cell structure and coordinated movement. This work has important implications for understanding host-pathogen interactions, the function of immune cells, a...
Source: Videocast - All Events - April 24, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

The secret lives of cells
NIH Director's Wednesday Afternoon Lecture Series From the 17th through the 19th century, beautifully artistic micrographs of living specimens were inextricably linked to biological discovery. However, for much of the 20th century, optical microscopy took a back seat to the powerful new fields of genetics and biochemistry. Starting in the 1980s, the tables started to turn again, thanks to the widespread availability of computers, lasers, sensitive detectors, and fluorescence labeling techniques. The result has been a Cambrian explosion of new technologies with the ability to understand the findings of genetics and biochemi...
Source: Videocast - All Events - April 23, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

CC Grand Rounds: Genetic Syndromes in Diverse Populations
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 4/24/2019 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 20, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

NIGMS Director's Early-Career Investigator Lecture: Sex-Biased Genome Evolution
NIGMS Director's Early-Career Investigator Lecture 2019 If you ’ re merely counting chromosomes, men and women aren ’ t that different. We all have DNA packaged into 23 pairs of chromosomes. Just one of these pairs — the sex chromosomes known as X and Y — is inherited differently in males and females. In general, women have two X chromosomes (XX), and men have one X and one Y chromosome (XY). Today, the human X chromosome is much larger than the human Y chromosome. But that wasn ’ t always the case. Evidence indicates that, in mammals prior to about 200 million years ago, X and Y were the same...
Source: Videocast - All Events - March 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Expanding the functional and actionable genome: Insights from the study of fusion-driven tumors
CCR Grand Rounds Dr. Caplen co-discovered RNA interference (RNAi) in mammalian cells and has pioneered approaches for exploiting this gene regulatory mechanism to investigate cancer biology and treatment. Dr. Caplen applies the perturbations induced by RNA- or DNA-based technologies to interrogate specific aspects of the genetic, transcriptional, and cell-signaling alterations observed in cancer cells. These functional genetic approaches will be used to enhance our understanding of the mechanistic basis of cancer and to discover new cancer treatment strategies. Current studies are focused on the functional genetic analysis...
Source: Videocast - All Events - March 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video