Neuroscience Seminar: Time to Wake Up: Regulation of Neural Stem Cell Quiescence and Reactivation
NIH Neuroscience Series Seminar
Stem cell populations in tissues as varied as blood, gut and brain spend much of their time in a mitotically dormant, quiescent, state. A key point of regulation is the decision between quiescence and proliferation. The ability to reactivate neural stem cells in situ raises the prospect of potential future therapies for brain repair after damage or neurodegenerative disease.
Understanding the molecular basis for stem cell reactivation is an essential first step in this quest. In Drosophila, quiescent neural stem cells are easily identifiable and amenable to genetic manipulation, making them ...
Source: Videocast - All Events - June 7, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar: Of humans and mice: Fundamental mechanisms of tissue-specific antifungal immunity
NIH Director's Seminar Series
Over the past few decades, fungal infections have emerged as major causes of morbidity and mortality in immunosuppressed patients despite the administration of antifungal therapy. This talk will highlight recent advances in our understanding of the cellular and molecular basis of protective host immunity against mucosal and invasive fungal infections. These insights have been gained via enrollment at the NIH Clinical Center of large cohorts of patients with inherited and acquired susceptibility to fungal disease and via corroborating immunological research in clinically relevant mouse models o...
Source: Videocast - All Events - June 5, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Why don't we get more cancer: The importance of ECM Chromatin interactions in tissue-specificity and breast cancer
CCR Grand Rounds
Mina J. Bissel, Ph.D., is a Distinguished Scientist, the highest rank bestowed at Lawrence Berkeley National Laboratory (LBNL) and serves as Senior Advisor to the Laboratory Director on Biology. She is also Faculty of four Graduate Groups in UC Berkeley: Comparative Biochemistry, Endocrinology, Molecular Toxicology, and Bioengineering (UCSF/UCB joint program). Having challenged several established paradigms, Bissell is a pioneer in breast cancer research and her body of work has provided much impetus for the current recognition of the significant role that extracellular matrix (ECM) signaling and microenvi...
Source: Videocast - All Events - June 3, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Of humans and mice: Fundamental mechanisms of tissue-specific antifungal immunity
NIH Director's Seminar Series
Over the past few decades, fungal infections have emerged as major causes of morbidity and mortality in immunosuppressed patients despite the administration of antifungal therapy. This talk will highlight recent advances in our understanding of the cellular and molecular basis of protective host immunity against mucosal and invasive fungal infections. These insights have been gained via enrollment at the NIH Clinical Center of large cohorts of patients with inherited and acquired susceptibility to fungal disease and via corroborating immunological research in clinically relevant mouse models o...
Source: Videocast - All Events - June 3, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Watch Your Step, There Is New Chemistry Everywhere
NCCIH Integrative Medicine Research Lecture Series
The National Center for Complementary and Integrative health (NCCIH) presents the Integrative Medicine Research Lecture Series. The series provides overviews of the current state of research and practice involving complementary health approaches and explores perspectives on the emerging discipline of integrative medicine.
Dr. Sean Brady is Tri-Institutional Professor and Evnin Professor Head, Laboratory of Genetically Encoded Small Molecules at the Rockefeller University. Dr. Brady has developed culture-independent methods to circumvent this discovery bottleneck. He will d...
Source: Videocast - All Events - May 23, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
A new resource for breeding better tomatoes or should that be, " re-sauce? "
Researchers from Boyce Thompson Institute -- partnered with the European Research Area Network for Coordinating Action in Plant Sciences (ERA-CAPS) Program -- have created a pan-genome that captures all of the genetic information of 725 closely related wild and cultivated tomatoes. This resource of ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - May 23, 2019 Category: Science Source Type: video
Human Hereditary Deafness is Complex Yet Easy to Grasp
Beyond the Lab, Understanding Communication Disorders: Speaker Series
Learn how deafness can be inherited (passed down through generations). Genetic research can improve our understanding of which gene variants are associated with human hereditary deafness. By identifying these gene variants, scientists may be able to diagnose certain forms of hereditary hearing loss earlier and more accurately. The program is part of the Beyond the Lab speaker series offered by the National Institute on Deafness and Other Communication Disorders (NIDCD).
Designed for administrative and support staff as well as scientists, the speaker seri...
Source: Videocast - All Events - May 20, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
The role of mass spectrometry to implement protein biomarkers in clinical studies for precision medicine
Proteomics Interest Group
Understanding cancer biology at a molecular level has dramatically changed therapeutic strategies in oncology and improved patient care. As drugs become more targeted with clearer mode of actions, it is important to implement robust biomarkers into drug development process to precisely identify the right patients for clinical trials, to deliver safer and more effective drugs, and to reduce overall developmental costs. While genetic biomarkers are widely used, implementing protein biomarkers remains challenging in part due to the lack of robust technologies fit for clinical laboratories. Recently, ...
Source: Videocast - All Events - April 26, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Opiates on the brain
NIH Director's Wednesday Afternoon Lecture Series
Dr. Kieffer is a basic scientist and neurobiologist. She isolated the first gene encoding an opioid receptor, a landmark in neuroscience research to understanding molecular bases of opioid transmission and opioid-mediated mechanisms underlying pain control, mood disorders and addiction. Her team elucidated the role of each opioid receptor in both known and unknown areas of opioid physiology and behaviors using gene knockout in mice. She showed that mu receptors mediate both analgesic and addictive actions of morphine, and are responsible for drug and social reward. Her team...
Source: Videocast - All Events - April 24, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Genes, lifestyle, and risk for heart attack
NIH Director's Wednesday Afternoon Lecture Series
Dr. Kathiresan leverages human genetics to understand the root causes of heart attack and to improve preventive cardiac care. Among his scientific contributions, Dr. Kathiresan has helped highlight new biological mechanisms underlying heart attack, discovered mutations that protect against heart attack risk, and developed a genetic test for personalized heart attack prevention.For more information go tohttps://oir.nih.gov/wals/2018-2019Air date: 5/22/2019 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 24, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Special Tuesday Lecture, NIH Director's Wednesday Afternoon Lecture Series
Julie Theriot is the Benjamin D. Hall Endowed Chair in Basic Life Sciences and a Howard Hughes Medical Institute investigator in the Department of Biology at the University of Washington. Her lab explores the mechanics and dynamics of how cells organize themselves to create their own structures and shapes. She studies an unusually wide variety of cell types and model systems in order to gain a broad conceptual understanding of the organizational rules that give rise to cell structure and coordinated movement. This work has important implications for understanding host-pathogen interactions, the function of immune cells, a...
Source: Videocast - All Events - April 24, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
The secret lives of cells
NIH Director's Wednesday Afternoon Lecture Series
From the 17th through the 19th century, beautifully artistic micrographs of living specimens were inextricably linked to biological discovery. However, for much of the 20th century, optical microscopy took a back seat to the powerful new fields of genetics and biochemistry. Starting in the 1980s, the tables started to turn again, thanks to the widespread availability of computers, lasers, sensitive detectors, and fluorescence labeling techniques. The result has been a Cambrian explosion of new technologies with the ability to understand the findings of genetics and biochemi...
Source: Videocast - All Events - April 23, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: Genetic Syndromes in Diverse Populations
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 4/24/2019 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 20, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
NIGMS Director's Early-Career Investigator Lecture: Sex-Biased Genome Evolution
NIGMS Director's Early-Career Investigator Lecture 2019
If you ’ re merely counting chromosomes, men and women aren ’ t that different. We all have DNA packaged into 23 pairs of chromosomes. Just one of these pairs — the sex chromosomes known as X and Y — is inherited differently in males and females. In general, women have two X chromosomes (XX), and men have one X and one Y chromosome (XY). Today, the human X chromosome is much larger than the human Y chromosome. But that wasn ’ t always the case. Evidence indicates that, in mammals prior to about 200 million years ago, X and Y were the same size and contained ...
Source: Videocast - All Events - March 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Expanding the functional and actionable genome: Insights from the study of fusion-driven tumors
CCR Grand Rounds
Dr. Caplen co-discovered RNA interference (RNAi) in mammalian cells and has pioneered approaches for exploiting this gene regulatory mechanism to investigate cancer biology and treatment. Dr. Caplen applies the perturbations induced by RNA- or DNA-based technologies to interrogate specific aspects of the genetic, transcriptional, and cell-signaling alterations observed in cancer cells. These functional genetic approaches will be used to enhance our understanding of the mechanistic basis of cancer and to discover new cancer treatment strategies. Current studies are focused on the functional genetic analysis...
Source: Videocast - All Events - March 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
