Hematopoietic Stem Cells Aging – Mechanisms, Consequences and Interventions
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its summer seminar, featuring Dr. Emmanuelle Passegu é . Dr. Passegue is a Professor in the Department of Genetics and Development at the Columbia University Medical Center and Director of the Columbia Stem Cell Initiative (CSCI) in New York. She is widely recognized for her expertise on hematopoietic stem cell (HSC) biology. Her research over the past 10-years has focused on understanding the cellular and molecular processes controlling HSC activity during homeostasis, and addressing how these regulations are changed in myeloid malignancies and phy...
Source: Videocast - All Events - June 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Law of STAT fives, root orchestrators of lymphocyte homeostasis and function
Immunology Interest Group Seminar Series
The transcription factor STAT5 is fundamental to the mammalian immune system. Operating downstream of cytokines and growth factors, it impacts all aspects of lymphocyte biology, from general cellular processes like proliferation and apoptosis, to specialized immunological programs like effector and regulatory T cell differentiation. Genetic studies in humans underscore its widespread influence as mutations of STAT5 or upstream activators manifest varied Alejandro Villarino, NIAMS, NIHimmunological phenotypes including immunodeficiency, autoimmunity and hematological malignancies. Mo...
Source: Videocast - All Events - June 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Psychiatric Genomics in the Era of Team Science Symposium
The last decade has seen unprecedented progress in Psychiatric Genomics and for the first-time real advances have been made in delineating the genetic architecture of neuropsychiatric disorders and their underlying molecular pathophysiology. This progress has been facilitated by a convergence in the understanding of the structure and function of the human genome; the development of high throughput sequencing technologies that can be deployed across molecular scales (e.g. DNA, RNA, methylation etc.) and the creation of large bio- and data- repositories. In parallel, the team science (TS) approach has been refined as a novel...
Source: Videocast - All Events - June 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Word processor for the genome: technologies for improving our understanding and treatment of diseases
NIH Director's Wednesday Afternoon Lecture Series
Our research focuses on the development and application of novel molecular technologies for studying the nervous system. Given the complexity of the brain, it is important to develop both precise perturbation as well as quantitative readout methodologies so that we can systematically reverse-engineer how the brain is functionally organized. So far my work has focused on the development of optogenetics technologies for controlling neural activity with high temporal, spatial, and cell-type specificity; and, more recently, genome engineering technologies based on CRISPR-Cas sy...
Source: Videocast - All Events - June 8, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Repetitive DNA sequences in health and disease: gift wrappings for precision medicine
NIH Director ’ s Wednesday Afternoon Lecture Series
Dr. Ramos is recognized as a leading expert in the study of gene-gene and gene-environment interactions and genomic medicine. His research program integrates diverse approaches, ranging from molecular genetics to population-based public health studies in efforts to understand the genetic and genomic basis of human disease and to advance the goals of precision medicine. Ongoing basic science studies in his laboratory focus on repetitive genetic elements in the mammalian genome and their role in genome plasticity and disease, while his clinical work focuses on the charact...
Source: Videocast - All Events - June 8, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Translational traps: sex and aging in stroke research stroke research
NIH Wednesday Afternoon Lecture Series
Dr. McCullough ’ s research interests primarily focus on: 1) understanding sex differences in ischemic cell death 2) age related inflammation and 3) social factors in stroke recovery.
Basic molecular and animal studies in males and females have direct translational relevance, as treatments have revealed the efficacy in one sex has paradoxically shown a detrimental effect in the other sex. This is now increasingly recognized in clinical stroke populations.
Another important area of Dr. McCullough ’ s research is understanding the genetic and hormonal differences in inflammation acr...
Source: Videocast - All Events - June 6, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center: Targeting the Genetic and Metabolic Basis of Fumarate Hydratase-Deficient Kidney Cancer: Hereditary Leiomyomatosis and Renal Cell Carcinoma
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 5/31/2017 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Brave new world: recent evolution of an insect-transmitted pathogen
NIH Director's Wednesday Afternoon Lecture Series
In their natural settings microbes seldom encounter conditions that are propitious for unrestricted growth. Rather, they must survive in environments where most of the time they are faced with limiting amounts of essential nutrients, stressful stimuli and the presence of other living organisms. Since the early 1980s, Dr. Kolter ’ s laboratroy has investigated many of these survival strategies using approaches from genetics, biochemistry and ecology.For more information go tohttps://oir.nih.gov/wals/2016-2017Air date: 5/17/2017 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 11, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Epithelial molecules shaping immunosurveillance by local T cells
Immunology Interest Group Seminar Series
The thesis of conventional immunology is centralized control whereby responses to infection within tissues are decided within lymph nodes, from which effector T lymphocytes are dispatched to quell regional disturbances. But this cannot explain the observation that many tissues at steady state are T cell-rich. Do such cells simply provide responses to infection or do they provide more generalized means to sustain tissue integrity and organ function? Likewise, how are such cells able to respond to acute stress but not drive constitutive tissue inflammation? And, how do immune cell –...
Source: Videocast - All Events - May 8, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Extracellular vesicles released by glioblastoma cells: saboteurs, biomarkers and therapeutics
Xandra Breakefield, Ph.D. is a basic scientist with a strong background in molecular genetics and neuroscience. She focuses her research efforts on: gene therapy for neurologic diseases; and elucidation of the role of extracellular vesicles (EVs) released from cancer cells in tumor progression. She led early studies demonstrating mutant RNA in serum EVs from glioblastoma patients as biomarkers.For more information go tohttps://oir.nih.gov/wals/2016-2017/extracellular-vesicles-released-glioblastoma-cells-saboteurs-biomarkersAir date: 5/10/2017 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 5, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
The changing epidemiology of HPV and cervical cancer: from etiology, to validation of prevention methods, to dissemination
NIH Director's Wednesday Afternoon Lecture Series
Over three decades of studies moving from etiology to preventive methods research to guidelines development, Dr. Schiffman has learned some broad lessons about the strengths and weaknesses of epidemiology that he will describe.
He joined the Clinical Genetics Branch in October 2009 to study intensively why HPV is such a powerful carcinogenic exposure, akin to an acquired genetic trait with high penetrance for a cancer phenotype. The main studies in which Dr. Schiffman played a major role in the past 5 years, listed chronologically, include: The Portland Kaiser Cohort; the T...
Source: Videocast - All Events - May 2, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
The Contribution of Bone to Whole Organism Physiology
GeroScience Interest Group
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its spring seminar, featuring Dr. Gerard Karsenty, the Paul A. Marks M.D., Professor and Chair of the Department of Genetics and Development at Columbia University Medical Center, New York City.
Dr. Karsenty's main interest is how organs interact with one another to regulate vertebrates' various physiological functions. His research focuses on bone and, through the use of genetics, he has discovered that this organ, in addition to making bone, has remarkable endocrine functions that include the regulation of insulin secreti...
Source: Videocast - All Events - May 1, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
1) Human Brain Bank at NIMH: A New Resource for Brain Studies and 2) Psychiatric Genetics: The Genetic Architecture of Mental Disorders
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 4/19/2017 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 31, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
The gut microbiome: a master regulator of metabolism
Immunology Interest Group Seminar Series
Humans and many other animals are home to enormous numbers of beneficial bacteria that profoundly influence health. The existence of beneficial resident microorganisms was first recognized in the late 1800's by Louis Pasteur, who founded the field of medical microbiology. However, we ’ ve only recently begun to acquire a molecular understanding of how resident microorganisms contribute to our health. The Hooper lab has spent more than a decade studying how resident bacteria of the gut communicate with our own cells to shape our physiology, our development, and our ability to fight...
Source: Videocast - All Events - March 27, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Elucidating the regulation of antiviral immune responses in humans
Director's Seminar Series
Research in the laboratory headed by Dr. Su is aimed at understanding the molecular regulation of human immune responses in vivo. The laboratory aims to identify the genetic underpinnings of patients who have rare inherited immunodeficiencies that present with virus infections. These patients serve as " experiments of nature " who can more broadly inform us as to what is happening in the healthy immune system. Viruses of particular interest include those that infect the skin such as herpes simplex virus, as well as systemic viruses such as Epstein-Barr virus, and more recently respiratory tract vi...
Source: Videocast - All Events - March 14, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
