Of mice and men: what we can learn about human cancer by studying mouse models
NIH Director's Wednesday Afternoon Lecture Series
The research in Cory Abate-Shen ’ s laboratory is focused on understanding basic mechanisms of transcriptional regulation and differentiation, and how these become dysregulated in cancer. The laboratory takes a multi-disciplinary approach to investigate genitourinary malignancies, which includes using mechanism-based studies, analyses of genetically-engineered mouse models (GEMMs), and state-of-the-art systems biology approaches.For more information go tohttps://oir.nih.gov/walsAir date: 12/19/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Standing on the shoulders of mice: adventures in human immunology
NIH Director's Wednesday Afternoon Lecture Series
While inbred mice have been a very powerful model for analyzing the immune system, recent advances, both technological and conceptual, have begun to make direct studies of the human immune system possible. This is vitally important from a translational perspective, as mouse models of disease have not been as productive as hoped for in producing “ actionable intelligence ” with which to diagnose and treat patients. Another benefit is that human work is almost unexplored territory for immunologists in our present time, where asking basic questions often results in unexpec...
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Wednesday Afternoon Lecture Series – Special Tuesday Lecture
NIH Director's Wednesday Afternoon Lecture Series
The major interest of Dr. Hotamisligil's laboratory is to study the regulatory pathways, which control glucose and lipid metabolism. His lab's biochemical and genetic studies focus on signal transduction using cultured mammalian cells as well as transgenic animals to identify specific abnormalities in these pathways, which are involved in human metabolic and inflammatory diseases including obesity, diabetes, fatty liver disease, atherosclerosis, and asthma.For more information go tohttps://oir.nih.gov/walsAir date: 11/13/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
What Makes America Great
NIH Director's Wednesday Afternoon Lecture Series
Dr. Gahl studies the natural history, diagnosis, and treatment of rare genetic disorders such as cystinosis, Hermansky-Pudlak Syndrome, sialic acid storage diseases, GNE myopathy, and disorders of platelets and pigmentation. He also investigates undiagnosed disorders under the aegis of the NIH Undiagnosed Diseases Program and Network, and pursues new disease discovery.For more information go tohttps://oir.nih.gov/walsAir date: 11/7/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series
NIH Directors Seminar Series
Dr. Xu ’ s Laboratory of Molecular Genetics, Systems Biology Center, NHLBI is interested in the basic mechanism guiding the transmission of our second genome- mitochondrial DNA. Mutations in mitochondrial genome have emerged as important factors compromising human health. Although mitochondrial genome is prone to accumulating mutations due to the high spontaneous mutation frequency and a lack of repair mechanisms, the crippling mitochondrial mutation is exceedingly rare in populations. It is puzzling how mothers are able to restrict the transmission of damaging mutations to the next generatio...
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Understanding the source of regenerative ability in animals
NIH Director ’ s Wednesday Afternoon Lecture Series
DeWitt Stetten Jr. Lecture
Established by NIGMS in 1982 and presented annually in honor of Dr. Stetten, the third NIGMS director, this annual lecture is part of the Wednesday Afternoon Lecture Series.
Salamanders and starfish might be “ simpler ” than humans, but they far surpass us in one major way — the ability to regenerate tissues and regrow lost limbs. Dr. S á nchez Alvarado studies regeneration using the flatworm planaria Schmidtea mediterranea. Remarkably, when halved or quartered (even by high school students) this organism can clone itself from the piece...
Source: Videocast - All Events - October 4, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Living in the Cold -- Adaptations in Hibernation
NIH Neuroscience Series Seminar
Dr. Li ’ s lab studies the structure and function of retinal synapses and circuits. Although they know the basic structure and major cell types of the retina, it remains much of a " black box " in terms of the connections and functions of these neurons. Their long-term research goal is to understand how the neuronal circuits are wired in this " black box " under normal conditions and how the circuits are altered during pathological processes. Both pieces of information will be crucial for the design of biological and/or prosthetic interventions aiming to restore vision in many types of bli...
Source: Videocast - All Events - September 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Staghorn coral
(A. millepora). A recent study suggests that corals in the Great Barrier Reef have enough genetic variation to adapt to and survive rising ocean temperatures for at least another century.
More about this image
Using genetic samples and computer simulations, ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - September 13, 2018 Category: Science Source Type: video
Boosting bacteria's productivity
Chemical engineers have designed a genetic switch that allows them to dramatically boost bacteriaÂs production of useful chemicals.
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Massachusetts Institute of Technology (MIT) chemical engineers have designed a novel genetic switch that allows them to ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - September 13, 2018 Category: Science Source Type: video
NIH Research Festival - Plenary Session II
During this session, we will hear about recent research advances in the areas of immunodeficiency, rare diseases, genetic disorders, and membrane proteins.For more information go tohttps://researchfestival.nih.gov/2018/plenary-sessionsAir date: 9/13/2018 10:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - September 7, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Base editing: chemistry on a target nucleotide in the genome of living cells
NIH Director's Wednesday Afternoon Lecture Series
Marshall W. Nirenberg Lecture
Dr. Liu ’ s research integrates chemistry and evolution to illuminate biology and enable next-generation therapeutics. His major research interests include the engineering, evolution, and in vivo delivery of genome editing proteins such as base editors to study and treat genetic diseases; the evolution of proteins with novel therapeutic potential using phage-assisted continuous evolution (PACE); and the discovery of bioactive synthetic small molecules and synthetic polymers using DNA-templated organic synthesis and DNA-encoded libraries.For m...
Source: Videocast - All Events - August 28, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS Lecture - Base editing: chemistry on a target nucleotide in the genome of living cells
Dr. Liu ’ s research integrates chemistry and evolution to illuminate biology and enable next-generation therapeutics. His major research interests include the engineering, evolution, and in vivo delivery of genome editing proteins such as base editors to study and treat genetic diseases; the evolution of proteins with novel therapeutic potential using phage-assisted continuous evolution (PACE); and the discovery of bioactive synthetic small molecules and synthetic polymers using DNA-templated organic synthesis and DNA-encoded libraries.For more information go tohttps://oir.nih.gov/wals/2018-2019/base-editing-chemistry-t...
Source: Videocast - All Events - August 27, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Genomics & Health Disparities Lecture: Towards Understanding the Role of Population Diversity in Cancer Genome Science
Genomics and Health Disparities Lecture Series
John Carpten, PhD is Professor and Chair for the Department of Translational Genomics. His training and professional experiences include postdoctoral training at the National Human Genome Research Institute/NIH, and serving as Deputy Director of Research at the Translational Genomics Research Institute (TGen). Dr. Carpten ’ cancer research program spans multiple disciplines including germline genetics for disease risk and predisposition, somatic cancer genomics, health disparities research, cell biology, functional genomics, and precision medicine. The primary focus of his r...
Source: Videocast - All Events - August 15, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
A newly engineered bacteria could help deliver nitrogen gas to plants, reducing the need for costly,
To enable plants to take advantage of Earth's nitrogen-rich atmosphere -- and reduce the need for fertilizer -- scientists have genetically engineered bacteria that can make use of nitrogen gas, a process called nitrogen fixation. If scientists can apply this engineering method -- in which ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - August 4, 2018 Category: Science Source Type: video
A feat of reverse engineering!
NSF funded researchers @tuftsu have developed a genetically modified yeast that can more efficiently consume a sugar called xylose. Changing the menu for yeast from glucose to xylose can lead to many advances including biofuel production. For more information: (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - June 14, 2018 Category: Science Source Type: video
