Mutant p53 Activities in Mouse Tumor Models
This is the annual Margaret Pittman Lecture. Speaker Guillermina Lozano, Ph.D., is a geneticist recognized for her studies of the p53 tumor suppressor pathway, from characterizing p53 as a transcriptional activator to characterizing the physiological importance of Mdm2 and Mdm4 proteins as inhibitors of p53, and the consequences of p53 mutations on tumor development.For more information go tohttps://oir.nih.gov/walsAir date: 3/2/2022 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 24, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Control of Embryonic Morphogenesis
The Tabin Lab studies the genetic basis by which form and structure are regulated, both during embryonic development to produce the exquisite morphology of the vertebrate embryo and over evolutionary time to generate the extraordinary and beautiful diversity of animal forms on this planet. In our developmental studies we combine classical methods of experimental embryology with modern molecular, imaging, genetic and genomic techniques for interrogating and testing gene function. In our evolutionary work we have addressed question of morphological, behavioral and metabolic evolution in a variety of species using both develo...
Source: Videocast - All Events - November 24, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Reconstruction of the Pathophysiology of Chronic Pain from Genome-wide Studies
The speaker's research focuses on determining the cellular and molecular biological mechanisms by which functional genetic variations impact human pain perception and risk of development of chronic pain conditions, enabling new approaches to identify new drug targets, treatment responses to analgesics, and diagnostic.For more information go tohttps://oir.nih.gov/walsAir date: 2/9/2022 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 23, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Turning Genes into Medicines: Challenges in the Development of Gene Therapeutics
Speaker Katherine High joined AskBio in January 2021 as President, Therapeutics and member of the AskBio Board of Directors. Dr. High is responsible for driving the strategic direction and execution of the company ’ s preclinical and clinical programs. Most recently, she was a Visiting Professor at Rockefeller University. Previously, she served as President, Head of Research and Development, and a member of the Board of Directors at Spark Therapeutics, where she directed the development and regulatory approval of Luxturna ® , the first gene therapy for genetic disease to obtain regulatory approval in both the United Sta...
Source: Videocast - All Events - November 23, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Single-Molecule Studies of Homologous Recombination
Speaker Eric Greene uses single-molecule optical microscopy to study fundamental interactions between proteins and nucleic acids. " Our overall goal is to reveal the molecular mechanisms that cells use to repair, maintain, and decode their genetic information. This research combines aspects of biochemistry, physics, and nanoscale technology to answer questions about complex biological problems that cannot be easily addressed through traditional biochemical approaches. As part of our work, we have established robust experimental platforms that enable single molecule imaging of biochemical reaction mechanisms in a “ high t...
Source: Videocast - All Events - November 22, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
A Galaxy of Genius? The Enduring Dream of Controlling Human Heredity
Speaker Nathaniel Comfort, Ph.D., of Johns Hopkins University presents a history lecture, " A Galaxy of Genius? The Enduring Dream of Controlling Human Heredity " . — " What a galaxy of genius might we not create! " burbled Francis Galton in 1865, exuberant about his conception of a voluntary human breeding program, to be informed by Darwinism. Subpar intelligence, he was convinced, lay at the root of poverty, promiscuity, disease, and antisocial behavior of all kinds. A similar enthusiasm girds contemporary social and behavioral genetics, or “ sociogenomics. ” In fact, every revolution in our understanding of heredi...
Source: Videocast - All Events - October 18, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Taiwan vole
A Taiwan vole.
[Research supported by U.S. National Science Foundation grant MCB 1751372.]
Learn more in the San Francisco State University news story Study on bizarre rodent genetics solves a ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - October 1, 2021 Category: Science Source Type: video
COVID-19 Scientific Interest Group: Human Antibody Response to SARS-CoV-2 Infection and Vaccination
COVID-19 Scientific Interest Group
Michel C. Nussenzweig is the Zanvil A. Cohn and Ralph M. Steinman Professor and Investigator, Howard Hughes Medical Institute. The Nussenzweig ’ s laboratory studies the molecular aspects of the immune system ’ s innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. For work on adaptive immunity, he focuses on B lymphocytes and antibodies to HIV-1, while his studies of innate immunity focus on dendritic cells. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 coronavirus, among other viruses...
Source: Videocast - All Events - September 23, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Reconstruction of the Pathophysiology of Chronic Pain from Genome-wide Studies
Speaker Luda Diatchenko, M.D., Ph.D. is Canada Excellence Research Chair in Human Pain Genetics; Pfizer Canada Professor in Pain Research. McGill University. Her research is focused on determining the cellular and molecular biological mechanisms by which functional genetic variations impact human pain perception and risk of development of chronic pain conditions, enabling new approaches to identify new drug targets, treatment responses to analgesics, and diagnostic.For more information go tohttps://oir.nih.gov/walsAir date: 12/1/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 8, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Blood Stem Cell Clonality and the Niche
Speaker Leonard Zon, M.D., is HHMI Investigator; Grousbeck Professor of Pediatric Medicine, Harvard Medical School; Director, Stem Cell Program at Boston Children's Hospital. The Zon laboratory aims to dissect how assaults to the hematopoietic system cause severe diseases such as leukemias, lymphomas, and anemias. They investigate hematopoietic development and disease using chemical screens, genetic screens, and analysis of novel transgenic lines in zebrafish.For more information go tohttps://oir.nih.gov/walsAir date: 11/17/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 8, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Using Genetics to Unravel Amyotrophic Lateral Sclerosis (ALS) 2) Retroviral Elements in Pathophysiology and as Therapeutic Targets in Amyotrophic Lateral Sclerosis (ALS)
For more information go tohttps://cc.nih.gov/about/news/grcurrent.htmlAir date: 9/1/2021 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 17, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Genetic Modifiers: Lessons from Nervous System Disorders [Day 3]
The NIH will hold a virtual three-day workshop titled “ Genetic Modifiers: Lessons from Nervous System Disorders. ” The event is scheduled for September 21, 22, and 23 from 10 am – 2pm EST.
This workshop will bring together a diverse group of researchers with expertise in genetics, genomics, neurology, pathophysiology, and preclinical translation. Understanding genetic factors that modify the onset, progression or severity of diseases can lead to novel therapeutics, facilitate clinic al trial design, and enable precision medicine. The purpose of this workshop is to promote collaborations, confront challenges and hi...
Source: Videocast - All Events - July 2, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Genetic modifiers: Lessons from Nervous System Disorders [Day 2]
This workshop will bring together a diverse group of researchers with expertise in genetics, genomics, neurology, pathophysiology, and preclinical translation. Understanding genetic factors that modify the onset, progression or severity of diseases can lead to novel therapeutics, facilitate clinical trial design, and enable precision medicine. The purpose of this workshop is to promote collaborations, confront challenges and highlight successful strategies for genetic modifier discovery, validation, characterization, and clinical implementation as part of the NIH Blueprint mission to foster transformative discoveries in ne...
Source: Videocast - All Events - July 2, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Genetic Modifiers: Lessons from Nervous System Disorders [Day 1]
This workshop will bring together a diverse group of researchers with expertise in genetics, genomics, neurology, pathophysiology, and preclinical translation. Understanding genetic factors that modify the onset, progression or severity of diseases can lead to novel therapeutics, facilitate clinical trial design, and enable precision medicine. The purpose of this workshop is to promote collaborations, confront challenges and highlight successful strategies for genetic modifier discovery, validation, characterization, and clinical implementation as part of the NIH Blueprint mission to foster transformative discoveries in ne...
Source: Videocast - All Events - July 2, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Outbreak Preemption and Response in the Genomic and Information Age
COVID-19 Scientific Interest Group
Dr. Sabeti is a professor at Harvard University and at Harvard T.H. Chan School of Public Health, as well as a Howard Hughes Medical Institute Investigator and member of the Broad Institute of MIT and Harvard. Her lab's research areas include: developing analytical methods to detect and investigate evolution in the genomes of humans and other species; examining host and viral genetic factors driving disease susceptibility to the devastating and deadly diseases; investigating the genomes of microbes; and determining the microbial cause of undiagnosed acute febrile illness. Just as COVID-19...
Source: Videocast - All Events - June 1, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
