Molecular Arms Races Shape the Evolution and Function of Antiviral Proteins
The Malik lab studies the causes and consequences of genetic conflicts that take place between different genomes (e.g., host-virus interactions, mitochondrial conflicts with nuclear genomes) or between components of the same genome (e.g., chromosomal competition at centromeric regions). We are interested in understanding these " molecular arms races " and how they drive recurrent genetic innovation, from the perspective of both evolutionary biology and human disease. Malik and his colleagues have used an evolutionary lens to dissect and discover both primate antiviral as well as viral adaptation strategies. This lecture wi...
Source: Videocast - All Events - April 25, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NHLBI Reproductive Health in Women and Girls with SCD: Gaps to Solutions (Day 2)
Sickle cell disease (SCD) complicates reproductive health for affected individuals. Girls and women with SCD confront challenges associated with menstruation, contraception, infertility risks, and high-risk pregnancy. This workshop assumes a lifespan approach to reproductive health in people with ovaries and sickle cell disease and engages questions related to pathophysiology, clinical care, and structural disparities that need to be addressed to fulfill the promise of high quality, individualized, comprehensive care for girls and women with SCD.
During the workshop ’ s first day, the major themes will be ovarian reser...
Source: Videocast - All Events - April 17, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NHLBI Reproductive Health in Women and Girls with SCD: Gaps to Solutions (Day 1)
Sickle cell disease (SCD) complicates reproductive health for affected individuals. Girls and women with SCD confront challenges associated with menstruation, contraception, infertility risks, and high-risk pregnancy. This workshop assumes a lifespan approach to reproductive health in people with ovaries and sickle cell disease and engages questions related to pathophysiology, clinical care, and structural disparities that need to be addressed to fulfill the promise of high quality, individualized, comprehensive care for girls and women with SCD.
During the workshop ’ s first day, the major themes will be ovarian reser...
Source: Videocast - All Events - April 17, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Tropical lizard species Puerto Rican crested anole
A Puerto Rican crested anole (Anolis cristatellus). These tropical lizards have unique genetic markers that distinguish their urban populations from neighboring forest populations.
[Research supported by U.S. National Science Foundation grants DEB 1354044, DEB 1927194 and DEB 1701706 ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - April 14, 2023 Category: Science Source Type: video
CCR Grand Rounds: Studying Precision Oncology Past by Mining a Clinical Trials Database and Identifying Future Opportunities from Single-Cell Analysis
CCR Grand Rounds“ Studying Precision Oncology Past by Mining a Clinical Trials Database and Identifying Future Opportunities from Single-Cell Analysis ”
Alejandro A. Sch ä ffer, Ph.D.
Staff Scientist, Cancer Data Science Laboratory
Center for Cancer Research, NCI
Friday, March 31, 2023
12:00 – 1:00 p.m.
Lipsett Amphitheater
(Masks required)
Also available to view via NIH Videocast.
Alejandro Sch ä ffer, Ph.D., was born in Montevideo, Uruguay, and emigrated with his parents to the United States. He received his B.S. in Applied Mathematics and his M.S. in Mathematics from Carnegie Mellon University in 1983. He re...
Source: Videocast - All Events - March 24, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Joram Piatigorsky Basic Science Lecture and Award
The Foundation for the National Institutes of Health (FNIH) and the National Eye Institute (NEI) are pleased to announce that Dan-Eric Nilsson, Ph.D., from Lund University in Sweden, will deliver the inaugural lecture in the Joram Piatigorsky Basic Science Lecture and Award series, which is managed by the FNIH and bestowed at the NEI.
Made possible by the generous philanthropic support of Lona and Joram Piatigorsky, this endowed series brings attention to notable basic sciences contributions by eye and vision scientists to a diverse general scientific audience, such as experts in molecular biology, genetics, developmenta...
Source: Videocast - All Events - March 21, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
4th NCI Symposium on Cancer Health Disparities - Day 2
Cancer health disparities affect millions of people across the United States and globally. Disparities in cancer burden are evident by geography, race/ethnicity, genetic ancestry, immigrant status, culture, gender, sexual orientation (LGBTQ+), and socioeconomic class, among other factors. Cancer disparities are not only due to barriers in access to health care, but also due to cultural barriers, structural racism and environmental disadvantage, ancestry-related risk factors, persistent co-morbidities, and chronic stress exposure because of discrimination and social isolation. The challenge of reducing and eliminating healt...
Source: Videocast - All Events - March 20, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
4th NCI Symposium on Cancer Health Disparities
Cancer health disparities affect millions of people across the United States and globally. Disparities in cancer burden are evident by geography, race/ethnicity, genetic ancestry, immigrant status, culture, gender, sexual orientation (LGBTQ+), and socioeconomic class, among other factors. Cancer disparities are not only due to barriers in access to health care, but also due to cultural barriers, structural racism and environmental disadvantage, ancestry-related risk factors, persistent co-morbidities, and chronic stress exposure because of discrimination and social isolation. The challenge of reducing and eliminating healt...
Source: Videocast - All Events - March 20, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
ECHO/NIH Return of Individual Research Results to Participants Workshop
Purpose: Identify best practices for large-sample studies of pregnancy and childhood to ethically and feasibly return individual research results to participants.Crosscutting Themes:How should recommendations differ for returning individual results to pregnant people and children versus those of other adults?Most research on returning individual results focuses on genetics results; how can we broaden to include environmental data from bioassays, physical measures, and self-reports?How can the workshop guide facilitation of equity in return of individual results?For more information go tohttps://cvent.me/ErbowlAir date: 3/1...
Source: Videocast - All Events - March 6, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
ECHO/NIH Return of Individual Research Results to Participants Workshop [Day 2]
Purpose: • Identify best practices for large-sample studies of pregnancy and childhood to ethically and feasibly return individual research results to participants.
Crosscutting Themes: • How should recommendations differ for returning individual results to pregnant people and children versus those of other adults? • Most research on returning individual results focuses on genetics results; how can we broaden to include environmental data from bioassays, physical measures, and self-reports? • How can the workshop guide facilitation of equity in return of individual results?For more information go tohttps://cvent....
Source: Videocast - All Events - March 6, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Nobel Prizes and the Emerging Gene Concept
Join us for our next talk in the Office of NIH History lecture series. Erling Norrby, M.D., Ph.D., of the Royal Swedish Academy of Sciences will speak about the changing concept of the gene through the lens of Nobel Prizes awarded in the past century. Dr. Norrby is former chair at the Karolinska Institute in Stockholm, where he served as dean of the Faculty of Medicine and was involved in the selection process for the Nobel Prize in Physiology or Medicine for 20 years. After leaving the Institute, he became Permanent Secretary of the Royal Swedish Academy of Sciences. In this role, he had overriding responsibility for the ...
Source: Videocast - All Events - February 10, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director ’ s Seminar: The Power and Potential of the Microenvironment in Cancer Metastasis
NIH Director ’ s Seminar
The tumor microenvironment – cellular and molecular changes in non-cancer cells and tissues – drive cancer progression. The pre-metastatic niche is the microenvironment important for metastatic initiation that is established at distant sites in response to primary tumor factors during cancer progression. We first characterized this microenvironment, which involves changes in both stromal and immune populations, in the pre-metastatic lungs of tumor-bearing mice. We have identified unique changes in these pre-metastatic sites by flow cytometry and RNA sequencing approaches, defining a gene sign...
Source: Videocast - All Events - February 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director ’ s Seminar Series: The Power and Potential of the Microenvironment in Cancer Metastasis
Although genetic including epigenetic alterations are the driving events in cancer, the tumor microenvironment, the cellular and molecular changes in non-cancer cells and tissues are altered during cancer progression. The microenvironment is involved in multiple aspect of cancer progression. Tumor metastasis is a critical step in the progression of solid tumors that is associated with patient mortality, and the metastatic microenvironment is a key regulator of this process. The pre-metastatic niche is the microenvironment important for metastatic initiation that is established at distant sites in response to primary tumor ...
Source: Videocast - All Events - February 7, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar - Addressing evolving and emerging public health questions with descriptive epidemiology
NIH Director's Seminar Series
Well-conducted surveillance studies have long informed hypotheses related to the causes of cancer, highlighted the population-level impact of exposures and interventions and guided additional research, prevention efforts and public health resources. The Division of Cancer Epidemiology and Genetics (DCEG) at the National Cancer Institute (NCI) has been generating etiologic clues from monitoring cancer trends and mapping cancer mortality for decades. In this lecture, Dr. Shiels will describe her research program, which utilizes a combination of innovative contemporary approaches to confront high...
Source: Videocast - All Events - January 19, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Lineage tracking in rhesus macaques: new insights into natural killer cells and tissue-resident myeloid cells.
Dr. Dunbar ’ s research focuses on understanding the process of hematopoiesis in vivo, as well as on optimizing and improving the safety of gene transfer into primary hematopoietic cells for therapeutic purposes. Her goals are synergistic: insight into the control of hematopoiesis is required to successfully manipulate and genetically modify hematopoietic cells; conversely, genetic marking of hematopoietic stem and progenitor cells has provided novel insights into lineage relationships, stem cell dynamics, and stem cell numbers in vivo that are applicable to gene therapy, stem cell transplantation, and other clinical int...
Source: Videocast - All Events - January 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
