Genes, networks and variations of the immune response
Nir Hacohen is currently Associate Professor of Medicine at Harvard/MGH and Senior Associate Member of the Broad Institute of Harvard and MIT. He earned a Ph.D. in biochemistry from Stanford and was trained in physics, mathematics and computer science from his undergraduate studies at Harvard University. He joined Harvard/MGH as an assistant professor in 2003 after leading his own lab as an independent Whitehead Fellow at the Whitehead Institute. His honors include the NIH Director’s New Innovator Award, the Sandler Memorial first prize PhD thesis award, and a Helen Hay Whitney Fellowship with David Baltimore. Nir ...
Source: Videocast - All Events - April 13, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

CC Grand Rounds: Gaucher Disease and Parkinsonism: Using Induced Pluripotent Stem Cells to Probe the Link Between a Rare and a Common Disorder and Clinical and Molecular Characteristics of Erdheim-Chester Disease
CC Grand Rounds: Gaucher Disease and Parkinsonism: Using Induced Pluripotent Stem Cells to Probe the Link Between a Rare and a Common Disorder and Clinical and Molecular Characteristics of Erdheim-Chester DiseasePresented by: Ellen Sidransky, MD, Senior Investigator and Chief, Section on Molecular Neurogenetics, Medical Genetics Branch, NHGRI, NIH and Juvianee Estrada-Veras, MD, Staff Clinician, Human Biochemical Genetics Section, Medical Genetics Branch, NHGRI, NIHCategory: Clinical Center Grand RoundsAired date: 03/25/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - March 26, 2015 Category: Journals (General) Tags: Past Events Source Type: video

The mammalian virome in genetic analysis of health and disease pathogenesis
The Annual R. E. Dyer Lecture For more information go to http://wals.od.nih.govAir date: 4/22/2015 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 25, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Use of spherical nucleic acid nanoconjugates to accelerate closure of diabetic wounds
NIH Director's Wednesday Afternoon Lecture Series The Paller lab studies the role of gangliosides (sphingolipids), which regulate lipid raft-based signaling, in skin, particularly in diabetic wound healing and skin cancer. The lab uses DNA- and RNA-nanoconjugates as topical gene therapy to treat diabetic ulcers, psoriasis, skin cancer and other skin overgrowth disorders, and rare genetic skin problems. Dr. Paller is the PI of Northwestern's Skin Disease Research Center, which includes 3 Cores dedicated to providing service to researchers of skin biology. As a pediatric dermatologist, Dr. Paller specializes in genetic (esp...
Source: Videocast - All Events - March 25, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Genomics of amyotrophic lateral sclerosis
NIH Director's Seminar Series Amyotrophic lateral sclerosis (ALS; Lou Gehrig’s disease) is a fatal neurodegenerative disorder that leads to rapidly progressive paralysis and respiratory failure. ALS is the third most common neurodegenerative disease in the Western World, and there are currently no effective therapies. Frontotemporal dementia (FTD) is the most common form of dementia in the population under the age of 65. An overlap between these two clinically distinct neurological diseases has long been recognized, but the molecular basis of this intersection was unknown. Recently, the Laboratory of Neurogenet...
Source: Videocast - All Events - March 16, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Cortisol Dysregulation and Alcoholism: Consequence, Correlation or Causality
7th Annual Jack Mendelson Honorary Lecture NIAAA established the Jack Mendelson Honorary Lecture Series as a tribute to Dr. Jack Mendelson, who made remarkable scientific contributions to the field of clinical alcohol research. The purpose of this honorary lecture series is to highlight clinical/human research in the alcohol field by an outstanding investigator who has made significant and long-term contributions to our understanding of alcoholism susceptibility, alcohol’s effects on the brain and other organs, and the prevention and treatment of alcohol use disorders. NIAAA is pleased to present this series of scie...
Source: Videocast - All Events - March 16, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Burkitt lymphoma: a model of polymicrobial carcinogenesis and global oncology
NIH Director's Seminar It has been just over 50 years since the description of Burkitt Lymphoma (BL) as an unusual tumor affecting jaws of African children. Seminal discoveries linked to BL includ Epstein-Barr virus, the first human virus linked to a human cancer, the linkage of BL to Plasmodium falciparum malaria, chromosomal translocations involving c-myc and immunoglobulin promoter elements, and demonstration of rapid and curative response to chemotherapy. Dubbed the Rosetta stone of cancer, BL became a complex model for carcinogenesis involving poly-microbes, immunity and host-genetics. Fifty years later, many fundam...
Source: Videocast - All Events - February 24, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Optimizing FDA's Regulatory Oversight of Next Generation Sequencing Diagnostic Tests
The purpose of this workshop is to discuss and receive feedback from the community on FDA’s regulatory approach to diagnostic tests for human genetics or genomics using Next Generation Sequencing (NGS) technology.Air date: 2/20/2015 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 12, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Tracing the Evolution of Adaptive Immunity
NIH Director's Wednesday Afternoon Lecture A search for the origin of our adaptive immune system has revealed that the jawed vertebrates and jawless vertebrates (lampreys and hagfish) use different strategies for generating large repertoires of lymphocyte receptors for antigens. Whereas lymphocytes in jawed vertebrates undergo RAG-mediated recombinatorial assembly of immunoglobulin V, D, and J gene segments to generate diverse T-cell receptor (TCR) and B-cell receptor (BCR) repertoires, lymphocytes in jawless vertebrates employ leucine-rich repeat (LRR) gene segments as templates to complete the assembly of variable lymp...
Source: Videocast - All Events - February 2, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Telomere DNA Repair and Joint Molecule Resolution
NIH Director's Seminar Series Telomeres are chromosome end capping structures. Critical shortening or over-lengthening of telomeres leads to a DNA damage response or delays in DNA replication, resulting in genome instability. It is believed that owing to its G-rich sequence, telomeres are especially susceptible to oxidative DNA damage, and also to formation of alternative DNA forms, both of which may impact telomere maintenance. We investigate the hypothesis that oxidative DNA damage, inadequate DNA repair and aberrant DNA intermediate resolution would impact telomere maintenance and function. Using a combination of m...
Source: Videocast - All Events - January 29, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

CNVs conferring risk of autism or schizophrenia affect cognition in controls
Presented by: Hreinn Stefansson, Ph.D., Head of CNS Division, deCODE GeneticsCategory: NeuroscienceAired date: 01/26/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - January 27, 2015 Category: Journals (General) Tags: Past Events Source Type: video

CNVs conferring risk of autism or schizophrenia affect cognition in controls
Neuroscience Seminar Series Dr. Stefansson has a PhD in biochemistry from the University of Lund, Sweden and has worked on the genetics of psychiatric disorders as Head of the CNS Division at deCODE since 2000. His work has included large scale sequencing projects, expression analysis and analysis of structural variants and rearrangements. Dr. Stefansson is the IC Chairperson (Exploitation Manager) of the Neuromics project.Air date: 1/26/2015 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 23, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Bringing Genetics and Epigenetics to the Fetal-Adult Hemoglobin Switch
Presented by: Stuart H. Orkin, M.D., Chairman of the Department of Pediatric Oncology, Dana Farber Cancer Institute; Professor of Pediatric Medicine, Harvard Medical School; Investigator, Howard Hughes Medical InstituteCategory: WALS - Wednesday Afternoon LecturesAired date: 01/21/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - January 22, 2015 Category: Journals (General) Tags: Past Events Source Type: video

A Tribute to Marshall Nirenberg
On Tuesday, March 17, 2015, the National Library of Medicine (NLM) hosts a public program in the Lister Hill Auditorium entitled “A Tribute to Marshall Nirenberg.” The occasion will mark the NLM’s acquisition of Marshall Nirenberg’s Nobel Prize and certificate through a generous donation from Dr. Myrna Weissman, who will offer remarks at the event. The program will also recognize the publication of Dr. Frank Portugal’s new book about Dr. Nirenberg, “The Least Likely Man: Marshall Nirenberg and the Discovery of the Genetic Code” (MIT Press, February 2015) with a talk by the author, ...
Source: Videocast - All Events - January 20, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

How Shelterin Solves the Telomere End-Protection Problem
Presented by: Titia de Lange, Ph.D., Leon Hess Professor, Laboratory of Cell Biology and Genetics, The Rockefeller UniversityCategory: HHS OnlyAired date: 01/14/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - January 15, 2015 Category: Journals (General) Tags: Past Events Source Type: video

Bringing Genetics and Epigenetics to the Fetal-Adult Hemoglobin Switch
Wednesday Afternoon Lecture SeriesAir date: 1/21/2015 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 8, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

The extraordinary bacterial Type VI secretion machine
Presented by: John Mekalanos, Ph.D., Adele H. Lehman Professor of Microbiology and Molecular Genetics; Chair, Department of Microbiology and Molecular Genetics; and Professor, Department of Microbiology and Molecular Genetics at Harvard Medical SchoolCategory: WALS - Wednesday Afternoon LecturesAired date: 12/10/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - December 11, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Genetics of Aging Phenotypes over the Life Course: A Population Perspective
Presented by: Dr. Joanne Murabito, Director, Clinic at the Framingham Heart Study, Associate Professor of Medicine at Boston University School of MedicineCategory: GeroscienceAired date: 12/04/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - December 4, 2014 Category: Journals (General) Tags: Past Events Source Type: video

CC Grand Rounds: (1) Measurable Residual Disease in Acute Myeloid Leukemia and (2) Rare Disorders Informing Cancer Biology: Lessons Learned From Dyskeratosis Congenita
Presented by: (1) Christopher Hourigan, MD, DPhil, Assistant Clinical Investigator, Myeloid Malignancies Section, Hematology Branch, NHLBI, NIH and (2) Sharon A. Savage, MD, Senior Investigator and Chief, Clinical Genetics Branch, Division of Cancer Epidemiology aCategory: Clinical Center Grand RoundsAired date: 12/03/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - December 4, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Pathogenic pathways in allergy gleaned from monogenic disease
Presented by: Joshua D. Milner, MD Chief, Genetics and Pathogenesis of Allergy Section, NIAID, NIHCategory: NIH Director's SeminarsAired date: 11/14/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - November 14, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Genetics of Aging Phenotypes over the Life Course: A Population Perspective
The Trans-NIH GeroScience Interest Group (GSIG) cordially invites you to its fall seminar, featuring Dr. Joanne Murabito. Dr. Murabito is Director of the Clinic at the Framingham Heart Study, and she is an Associate Professor of Medicine at Boston University School of Medicine. Dr. Murabito’s research goals have focused on aging and reproductive traits in the Framingham Heart study and beyond. Specifically, her research program focuses on using the tools of epidemiology and high-throughput genetic platforms to better understand the natural history of aging and to detect novel pathways and mechanisms for aging-related...
Source: Videocast - All Events - November 14, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Ethics and Genetics Research
Presented by: Sara Chandros Hull, PhD, NHGRI, NIH and Clinical Center, NIH, Ben Berkman, JD, NHGRI, NIH and Clinical Center, NIH Category: BioethicsAired date: 11/12/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - November 13, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Contemporary Clinical Medicine: Great Teachers: Clinical Genomics and Genetic Mechanisms for Disease
Presented by: James R. Lupski, MD, PhD, DSc (hon), Cullen Professor of Molecular and Human Genetics and Professor of Pediatrics, Baylor College of MedicineCategory: Clinical Center Grand RoundsAired date: 11/05/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - November 7, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Secretary's Advisory Committee on Human Research Protections (SACHRP) - October 2014 (Day 2)
Presented by: Jerry Menikoff, MDCategory: Secretary's Advisory Committee Genetics, Health & SocietyAired date: 10/30/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - November 4, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Secretary's Advisory Committee on Human Research Protections (SACHRP) - October 2014 (Day 1)
Presented by: Jerry Menikoff, MDCategory: Secretary's Advisory Committee Genetics, Health & SocietyAired date: 10/29/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - November 3, 2014 Category: Journals (General) Tags: Past Events Source Type: video

NICHD Structural Birth Defects Working Group Meeting - December 2014
The mission of the Birth Defects Initiative is to capitalize on genomic and other biomedical discoveries to further understanding of the mechanisms responsible for structural birth defects, which affect almost 4% of all live births in the United States each year. The ultimate goal is the development of new, innovative, and valuable strategies for the molecular diagnosis, treatment, and prevention of human structural birth defects. The Initiative and the related NICHD Structural Birth Defects Working Group were founded in 2000 by the NICHD and is coordinated by the Developmental Biology and Structural Variations Branch (DB...
Source: Videocast - All Events - November 3, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Contemporary Clinical Medicine: Great Teachers: Clinical Genomics and Genetic Mechanisms for Disease
For more information go to http://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 11/5/2014 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 29, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Pathogenic pathways in allergy gleaned from monogenic disease
NIH Director's Seminar Series Monogenic diseases can be highly instructive in uncovering basic pathways whose perturbations lead to specific symptoms. Monogenic diseases associated with allergy present an opportunity to define pathways critical for preventing allergic disease. Previous studies of such diseases have understandably focused on the more severe associated phenotypes such as infection, autoimmunity or neoplasms. Our lab wishes to mechanistically understand how these mutations lead to the allergic phenotype, in order to learn globally important lessons in allergy pathogenesis. Additionally, we seek to define ne...
Source: Videocast - All Events - October 28, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

The Mechanisms of Cytoskeletal Motor Proteins
Wednesday Afternoon Lecture Series The Annual DeWitt Stetten, Jr., Lecture Movement is a fundamental property of living organisms. The contraction of muscles, beating of cilia and flagella, segregation of genetic material during mitosis, and intracellular transport of membranes, proteins and mRNAs are driven by molecular motor proteins that move along cytoskeletal filaments. Dr. Vale's laboratory, whose research is funded by NIH, has studied kinesin and dynein, the two types of motors that move along microtubule tracks. The mechanism of kinesin is reasonably well understood through measurements of its single molecule ...
Source: Videocast - All Events - October 27, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Genetic approaches to understanding visual circuit development, function and repair
Presented by: Andrew Huberman, Ph.D., University of California, San DiegoCategory: NeuroscienceAired date: 10/20/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - October 21, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Genetic risk for Alzheimer's disease: an emerging role for rare variants
Neuroscience Seminar SeriesAir date: 5/11/2015 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 20, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Genetic approaches to understanding visual circuit development, function and repair
Neuroscience Seminar Series Air date: 10/20/2014 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 7, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Ethics Rounds: Whole Exome Sequencing in the Clinical Setting: Implications for Research
Presented by: Jeffrey R. Botkin, MD, MPH, Professor of Pediatrics and Medical Ethics and Associate Vice President for Research, University of Utah and Case Presenter: Julie Sapp, ScM, Certified Genetic Counselor, Medical Genomics and Metabolic Genetics Branch, NHGCategory: Clinical Center Grand RoundsAired date: 10/01/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - October 2, 2014 Category: Journals (General) Tags: Past Events Source Type: video

A multiscale biology approach for dissecting the complex processes underlying aging and aging-related phenotypes
Presented by: Eric Schadt, Ph.D., Director, Icahn Institute for Genomics and Multiscale Biology; Chair of the Department of Genetics and Genomic Sciences Jean C. and James W. Crystal Professor of Genomics Icahn School of Medicine at Mount SinaiCategory: WALS - Wednesday Afternoon LecturesAired date: 10/01/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - October 2, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Ethics Rounds: Whole Exome Sequencing in the Clinical Setting: Implications for Research
Ethics Rounds “Whole Exome Sequencing in the Clinical Setting: Implications for Research” The use of whole exome sequencing in the clinical setting has the potential to significantly increase the amount of information available to patients. When this information conflicts with information obtained in the research setting, investigators are faced with the question of whether they should pursue follow-up testing. Please join us to discuss to what extent researchers are responsible for their subjects’ clinical care and to what extent researchers should conduct testing for clinical purposes The prog...
Source: Videocast - All Events - September 29, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Ethics Rounds: Genetic Results of Uncertain Significance
For more information go to http://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 10/1/2014 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 23, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Ethics and Genetics Research
Ethical and Regulatory Aspects of Clinical Research - Session 7 The Department of Bioethics offers this seven to eight week course annually each fall. The course is designed to provide an overview of the important issues in the ethics of human subject research for clinical investigators and others who participate in the conduct of research and is open to the entire NIH community as well as to those from outside NIH. Topics include the history of human subject research ethics, principles and guidelines, study design, subject recruitment, informed consent, and international research. The course is open to the entire NIH com...
Source: Videocast - All Events - September 2, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

The Epigenetic Basis of Common Human Disease
Wednesday Afternoon Lecture Series Although epigenetic changes in the cancer genome have been known for three decades, the role of epigenetics in common human disease and its relationship to genetic variation has only recently begun to be explored. The Feinberg lab has been developing whole-genome approaches to the epigenetic analysis of human disease and contributing to a new field of epigenetic epidemiology that integrates genetic, epigenetic, and environmental factors. One of the most exciting developments in this recent work is the idea that epigenetic plasticity under genetic control may confer a survival advantage i...
Source: Videocast - All Events - August 28, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Age-by-Disease interactions in the Human Brain: Evidence & Model
GeroScience Interest Group (GSIG) Summer Seminar The Trans-NIH GeroScience Interest Group (GSIG) cordially invites you to its summer seminar, featuring Dr. Etienne Sibille. Dr. Sibille is the Campbell Family chair in Clinical Neuroscince, in the Campbell Family Mental Health Research Institute , Centre for Addiction and Mental Health (CAMH), in the Department of Psychiatry at the University of Toronto. Dr. Sibille’s research goals have consistently focused on translational research aimed at identifying the cellular and molecular bases of depression, and specifically of the mood and affect dysregulation components of...
Source: Videocast - All Events - August 18, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

A brief mindfulness-based preventive intervention improves self-control and neuroplasticity: brain mechanisms and applications to mental disorders
The National Center for Complementary and Alternative Medicine (NCCAM) presents the Integrative Medicine Research Lecture series.The series provides overviews of the current state of research and practice involving complementary health therapies, and explores perspectives on the emerging discipline of integrative medicine. Dr. Yi-Yuan Tang is a professor of Psychological Sciences, Presidential Endowed Chair in Neuroscience at Texas Tech University and founding Director of Texas Tech Neuroimaging Institute. Dr. Tang is also Adjunct Professor of Internal Medicine at TTU Health Science Center, Adjunct Professor, Dept. of Psyc...
Source: Videocast - All Events - August 15, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center: CARs for Kids: Lessons Learned from Targeting Lymphoblastic Leukemia with Genetically Engineered T Cells
Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center: CARs for Kids: Lessons Learned from Targeting Lymphoblastic Leukemia with Genetically Engineered T CellsPresented by: Daniel Lee, MD, Assistant Clinical Investigator, Pediatric Oncology Branch, NCI, NIHCategory: Clinical Center Grand RoundsAired date: 06/04/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - June 4, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center: CARs for Kids: Lessons Learned from Targeting Lymphoblastic Leukemia with Genetically Engineered T Cells
Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center: CARs for Kids: Lessons Learned from Targeting Lymphoblastic Leukemia with Genetically Engineered T CellsFor more information go to http://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 6/4/2014 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - June 3, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

(1) Pediatric Bipolar Disorder, Irritability, and New Approaches to Psychiatric Diagnosis (2) When Does Bipolar Disorder Begin? Genetic Approaches to Age At Onset
Presented by: (1) Ellen Leibenluft, MD, Chief, Section on Bipolar Spectrum Disorders Co-Chief, Emotion and Development Branch, NIMH (2) David T. Chen, MD, Clinical Fellow, Human Genetics Branch, NIMHCategory: Clinical Center Grand RoundsAired date: 05/21/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - May 21, 2014 Category: Journals (General) Tags: Past Events Source Type: video

Drosophila as a model for alcoholism: An interplay of nature and nurture
Alcohol is one of the most widely used and abused drugs in the world, with devastating medical and social consequences. The estimated prevalence of Alcohol Use Disorders is 8.5 percent in the United States, thus affecting more than 17 million Americans. The difficulty and cost of human studies have led to the development of animal models to investigate the genetic, molecular, and neural mechanisms underlying both the short- and long-term effects of ethanol. Rodent models have been most widely used and have provided important insights into these mechanisms. More recently, the fruit fly Drosophila melanogaster has been devel...
Source: Videocast - All Events - May 1, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

(1) Pediatric Bipolar Disorder, Irritability, and New Approaches to Psychiatric Diagnosis (2) When Does Bipolar Disorder Begin? Genetic Approaches to Age At Onset
For more information go to http://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 5/21/2014 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 29, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Epigenetic Regulation by Long Noncoding RNAs
Presented by: Jeannie T. Lee, M.D., Ph.D., Professor of Genetics and of Pathology at Harvard Medical School and Massachusetts General Hospital; Investigator, Howard Hughes Medical InstituteCategory: Wednesday Afternoon LecturesAired date: 04/03/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - April 4, 2014 Category: Journals (General) Tags: Past Events Source Type: video

A Mitochondrial Etiology of Metabolic and Degenerative Diseases, Cancer and Aging
Wednesday Afternoon Lecture Series For half a millennium Western medicine has focused on anatomy and for the past century on nuclear DNA (nDNA), Mendelian, genetics. While these concepts have permitted many biomedical advances, they have proven insufficient for understanding the common "complex" diseases. Life requires energy, 90 percent of which comes from the mitochondrion. The mitochondrial genome consists of thousands of copies of the maternally inherited mitochondrial DNA (mtDNA) plus 1,000–2,000 nDNA genes. The mtDNA has a very high mutation rate, but the most deleterious mutations are removed by an...
Source: Videocast - All Events - March 31, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Gene Selection and Sample Classification with Applications to TCGA Data
NIH Director's Seminar Earlier we developed a computational algorithm, GAKNN, for assessing the importance of genes for sample classification based on expression data. GAKNN combines a genetic algorithm (GA) and the k-nearest neighbor (KNN) method to identify many predictive sets of genes, each of which jointly can distinguish two classes of samples based on a training set. The relative importance of a gene for sample classification can then be assessed based on the proportion of predictive sets that contain that gene. Now, we have extended the algorithm to account for multiple classes in the data. Furthermore, instead of...
Source: Videocast - All Events - March 26, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

CANCELED - Neural Circuit Dynamics During Virtual Navigation
Neuroscience Seminar Series Dr. Tank Lab’s current focus is on persistent neural activity, a form of neural circuit dynamics that is associated with short-term memory. Persistent neural activity is a sustained increase or suppression of action potential firing elicited by a brief sensory stimulus or motor command. Across the population of participating neurons, the pattern of sustained changes in action potential firing is correlated with the information held in short term memory, while disruption of persistent activity produces deficits in memory-guided behavior. These characteristics suggest that the memory is act...
Source: Videocast - All Events - March 17, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

Genetic Basis of Protozoan Pathogan Emergence and Disease
Presented by: Michael Grigg, Ph.D. Chief, Molecular Parasitology Section, Laboratory of Parasitic Diseases, NIAID, NIH Category: NIH Director's SeminarsAired date: 03/07/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - March 11, 2014 Category: Journals (General) Tags: Past Events Source Type: video