Quasi-species Suppression of Viral Drug Resistance
NIH Director ’ s Wednesday Afternoon Lecture Series
This is the annual George Khoury Lecture, which honors the memory of Dr. George Khoury (1943 – 1987), a highly regarded NIH virologist and caring mentor of the postdoctoral fellows in his laboratory.
Dr. Karla Kirkegaard, Ph.D., is the Violetta L. Horton Research Professor of Genetics at the Stanford University School of Medicine. Her laboratory focuses on identification of dominant drug targets for antiviral design, such as small molecules that stabilize oligomeric assemblages. A past recipient of the NIH Director's Pioneer Award, Dr. Kirkegaard combines her interest...
Source: Videocast - All Events - March 1, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDCR Clinical Research Fellowship Grand Rounds, Women in Science series
Dear Colleagues,Please join us for the NIDCR Clinical Research Fellowship Grand Rounds, Women in Science seriesLecture Title: " Human Cell Atlas: Mapping the Human Body One Cell at a Time " Presenter: Dr. Sarah TeichmannDate: 3/5/2021Time: 10:00am -11:00amLocation: WebcastOverview:The Human Cell Atlas (HCA) is an ambitious global initiative aiming to create comprehensive reference map of all human cells — the fundamental units of life — as a basis for both understanding human health and diagnosing, monitoring, and treating disease. Co-founded by Dr Sarah Teichmann from the Wellcome Sanger Institute in the UK, and Dr Av...
Source: Videocast - All Events - March 1, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Cell Therapy for Epithelial Cancers
Cell therapy is an emerging treatment modality that is highly effective in hematological cancers. Research by Dr. Hinrichs ’ s team has demonstrated the potential to extend cell therapy to the treatment of common epithelial cancers. Treatment of patients with human papillomavirus (HPV)-associated cancers with tumor-infiltrating lymphocytes showed durable, complete tumor responses, apparently curing some patients with metastatic cancer. A more “ off the shelf ” approach with peripheral blood T cells genetically engineered to target the HPV E7 antigen also demonstrated robust clinical activity with extensive tumor regr...
Source: Videocast - All Events - February 18, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Using Peripheral Blood to Understand Recovery from Brain Injuries
Dr. Gill ’ s presentation will provide evidence of how fluid biomarkers relate to recovery from brain injuries, including the role of proteins during acute recovery. Mild brain injuries are often difficult to diagnose, thus, having biomarkers that identify individuals with even subtle injuries are important to improve care. Further, identification of biomarkers that predict recovery are essential to provide preventative interventions to mitigate risk, including the additive risk for lasting symptoms and deficits that are now being observed in our studies of military personnel, Veterans and athletes. Fluid biomarkers that...
Source: Videocast - All Events - February 18, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Neurobiology of Social Behavior Circuits
This is a special NIH Director's Lecture in the WALS series. Speaker Catherine DuLac, Ph.D., Harvard University, employs genetic manipulation of pheromone signaling, which has led to a novel assessment of the respective roles of the vomeronasal organ (VNO) and the main olfactory epithelium (MOE) in pheromone-mediated behaviors. She discovered that, in contrast to previous thinking, VNO activity is not required for the initiation of male-female mating behavior in the mouse, and instead, ensures sex discrimination among conspecifics. In contrast, MOE signaling appears essential to trigger mating in the mouse.For more informa...
Source: Videocast - All Events - February 11, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
CFTR, the Odd ABC Transporter Responsible for Cystic Fibrosis
Speaker Jue Chen, Ph.D., of The Rockefeller University, studies ATP-binding cassette (ABC) transporters, a diverse group of membrane proteins integral to almost every biological process. In prokaryotes, these proteins are critical for survival. In humans, ABC transporters make up one of the largest gene families, and more than a dozen genetic diseases have been traced to ABC transporter defects. ABC transporters are also central to multidrug resistance in many pathogenic bacteria and in tumor cells.For more information go tohttps://oir.nih.gov/walsAir date: 4/28/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 10, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Advancing Therapies for Children and Adults with Rare Tumors or Genetic Tumor Predisposition Syndromes
This is the annual G. Burroughs Mider Lecture. Speaker Brigitte Widemann, M.D., is the chief of the National Cancer Institute ’ s Pediatric Oncology Branch. Trained as a pediatric oncologist with expertise in drug development and early clinical trials for children with refractory cancers she applied her expertise to study genetic tumor predisposition syndromes (GTPS), in particular neurofibromatosis type 1 (NF1) and very rare pediatric and adult solid tumors.For more information go tohttps://oir.nih.gov/walsAir date: 4/21/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 10, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Special Tuesday WALS Lecture - Three (Formerly) Blind Mice: Reprogramming Tissues to Be Young Again
Special Tuesday WALS Lecture
Dr. Sinclair is a professor of genetics, Blavatnik Institute, and co-director of the Paul F. Glenn Center for Biology of Aging Research, at Harvard Medical School. His lab seeks to understand why we age and whether we can extend human health and longevity.
The Sinclair laboratory has demonstrated that it is possible to epigenetically reprogram cells to safely reverse aging in vivo and regain eyesight. This research, conducted with support from the National Institute on Aging and National Eye Institute, was recently published in Nature (PMID: 33268865; doi: 10.1038/s41586-020-2975-4) and will b...
Source: Videocast - All Events - February 4, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Cell Atlases as Roadmaps in Health and Disease
Wednesday Afternoon Lecture Series
Dr. Regev is Executive Vice President of Research and Early Development at Genentech, a subsidiary of Roche. She has earned praise for creating technologies to expand understanding of biological processes, such as assays for sequencing RNA in single cells and associated machine learning algorithm s. She also co-leads the Human Cell Atlas project, which aims to describe all cell types in the human body. She is currently on leave from her longstanding positions at MIT and at the Broad Institute. Cells are the basic unit of life and form a key intermediate between genotype and phenotype, wh...
Source: Videocast - All Events - February 1, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Young Blood for Old Brains
Speaker Tony Wyss-Coray's laboratory studies the role of immune and injury responses in neurodegeneration and Alzheimer ’ s disease. We seek to understand how immune responses and injury pathways may modulate neurodegeneration and age-related changes in the brain. We study these pathways in vivo and in cell culture using a number of genetic and proteomic tools. We have been particularly interested in the TGF-beta signaling pathway as a major regulator of biological processes and we are developing genetic and pharmacological agents to manipulate this pathway.For more information go tohttps://oir.nih.gov/walsAir date: 3/31...
Source: Videocast - All Events - January 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Innate Immunity for Bacteria Against Phage
My lab has a long-standing interest in the signaling pathways and regulatory networks that enable bacteria to sense and respond to their environments. Most recently, we have focused on toxin-antitoxin systems, which are abundant, but still poorly understood genetic modules found throughout the bacterial kingdom. We study the mechanisms of action of the toxins, the coevolution of toxins and antitoxins, and the role of toxin-antitoxin systems in providing bacteria immunity to some classes of bacteriophage, which will be the topic of my seminar.For more information go tohttps://oir.nih.gov/walsAir date: 3/17/2021 3:00:00 PM (...
Source: Videocast - All Events - January 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
These Viruses Are Forever: Consequences of Retroviral DNA Integration to Aids and Evolution
Our research interests revolve around obtaining a better understanding of the interaction of retroviruses with their host cells and organisms. We use simple retroviruses (avian and murine viruses) as well as HIV to elucidate the nature of the retrovirus-receptor interaction; control of viral gene expression; mechanism of retroviral genetic variation; and evolution of the host-virus relationship, as revealed by the fossil record provided by endogenous proviruses found in the normal DNA of all vertebrates and many other species.For more information go tohttps://oir.nih.gov/walsAir date: 3/16/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 15, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
RNA Antics in Viral Drug Resistance and host immunosuppression
This is the annual George Khoury Lecture. Speaker Karla Kirkegaard, Ph.D., deciphers the genetics of RNA viruses and their mammalian hosts, with the goal of suppressing drug resistance and excessive inflammation during viral infections.For more information go tohttps://oir.nih.gov/walsAir date: 3/3/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 15, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Three (Formerly) Blind Mice: Reprogramming Tissues to Be Young Again
Speaker David A. Sinclair, Ph.D., a professor in the Department of Genetics, Blavatnik Insitute, and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney, in 1995 and did his postdoctoral research at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability and aging. In 1999 he moved to Harvard Medical S...
Source: Videocast - All Events - January 15, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Colliding Ribosomes Function as a Sentinel for Cellular Distress
The ribosome is a complex molecular machine that translates the genetic code into functional polypeptides. We are interested in how this machine catalyzes and coordinates the molecular events of translation and its regulation. Work in the Green lab ranges all the way from translational initiation mechanisms in bacteria to ribosome homeostasis in human disease. In all of our projects, we rely on genetic and biochemical approaches to explore the biology of the system in bacterial, yeast and mammalian systems. Most projects in the lab also incorporate ribosome profiling and other high throughput genome-wide approaches to leve...
Source: Videocast - All Events - December 11, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
