NCI Support for Cancer Immunology
Immunonology IG Seminar
Norman E. “ Ned ” Sharpless, M.D., was officially sworn in as the 15th director of the National Cancer Institute (NCI) on October 17, 2017. Prior to his appointment, Dr. Sharpless served as the director of the University of North Carolina (UNC) Lineberger Comprehensive Cancer Center, a position he held since January 2014. Dr. Sharpless was a Morehead Scholar at UNC – Chapel Hill and received his undergraduate degree in mathematics. He went on to pursue his medical degree from the UNC School of Medicine, graduating with honors and distinction in 1993. He then completed his internal medicine res...
Source: Videocast - All Events - June 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Exploring adult brain plasticity following adverse developmental conditions
NIH Wednesday Afternoon Lecture Series
Adverse conditions during development, including stress in early life or the presence of a neurodevelopmental disorder, can set the stage for enduring behavioral impairments that last a lifetime. While it would be ideal to prevent or reverse such occurrences during the developmental period, in the absence of these options, approaches designed to modify residual plasticity in the adult brain may help to optimize function and mitigate problematic behaviors. Using rodent models of early life stress-induced anxiety and hyperactivity, as well as those of autism spectrum disorder (ASD), Dr....
Source: Videocast - All Events - June 11, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
B cells in Autoimmune diseases: Focus on Sj ö gren's Syndrome
NIDCR Clinical Research Fellowship Grand Rounds
B cells play a complex role in the development of systemic autoimmune diseases, especially in primary Sj ö gren's syndrome, a progressive condition that damages saliva and tear glands and leads to dry mouth, dry eyes, and other symptoms. Dr. Jacques-Olivier Pers will outline growing evidence that regulatory B lymphocytes (Breg) may blunt the pathogenesis of systemic autoimmune disease, and thus may be potential targets for treatment. Studies of distinct B cell subsets that play differing roles in autoimmune diseases are providing new insights into Breg development and immune...
Source: Videocast - All Events - April 11, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: New Findings in Genetic Bone Diseases 1) X-linked Form of Osteogenesis Imperfecta Caused by Defective Intramembrane Proteolysis and 2) Cracking the " Tough Nut " : Somatic Mutations in the Candle Wax Bone Disease Melorheostosis
CC Grand Rounds:New Findings in Genetic Bone Diseases " 1) X-linked Form of Osteogenesis Imperfecta Caused by Defective Intramembrane Proteolysis and 2) Cracking the " Tough Nut " : Somatic Mutations in the Candle Wax Bone Disease MelorheostosisFor more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 4/25/2018 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 26, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Rapid, genetically tailored N-of-1 neurotherapeutics: a case study in Batten disease
NIH Neuroscience Series Seminar
Dr. Yu ’ s laboratory leads genome-wide searches for rare single-gene causes of autism to reveal ASD ’ s underlying genomic architecture, to understand its neurobiological causes, and to illuminate possible treatments. For instance, they are studying whole exome sequencing data from a large cohort of patients recruited via the Autism Sequencing Consortium, and have uncovered a striking enrichment of gene knockouts, especially in girls, and several dozen novel candidate genes, including several of special neurobiological interest responsible for glutamatergic and serotonergic signaling.
T...
Source: Videocast - All Events - March 23, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
PD-1 Cancer Immunotherapy
NCI Center for Cancer Research Eminent Lecture Series
Gordon J. Freeman, PhD works in the Department of Medical Oncology at Dana-Farber Cancer Institute and is Professor of Medicine at Harvard Medical School. Dr. Freeman earned his BA in Biochemistry and Molecular Biology, and PhD in Microbiology and Molecular Genetics from Harvard University. His research has identified the major pathways that control the immune response by inhibiting T cell activation (PD-1/PD-L1 and B7-2/CTLA-4) or stimulating T cell activation (B7-2/CD28).
In 2000, Dr. Freeman discovered PD-L1 and PD-L2, and showed they were ligands for PD-1, thus def...
Source: Videocast - All Events - March 16, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
From Germline Genetics to Function: Making Sense of Genome-Wide Association Studies for Pancreatic Cancer Risk
NIH Directors Seminar Series
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States and the seventh world-wide. This seminar will discuss results from genome-wide association studies (GWAS), conducted within the NCI-led Pancreatic Cancer Cohort Consortium. This collaborative effort has identified over 20 common pancreatic cancer risk loci. Genomic and functional characterization of a subset of these loci will be presented. These examples highlight different molecular mechanisms underlying cancer risk and genes found to be important for a wide range of processes incl...
Source: Videocast - All Events - March 1, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Under Your Skin: Molecules and Cells for Touch and Pain
The National Center for Complementary and Integrative Health (NCCIH) presents the integrative Medicine Research Lecture Series. The series provides overviews of the current state of research and practice involving complementary health approaches and explores perspectives on the emerging discipline of integrative medicine. Dr. Alexander Chesler, Ph.D., Principal Investigator, Section on Sensory Cells and Circuits Intramural Lab, NCCIH, is our guest speaker for this lecture.
The somatosensory system enables us to detect touch, temperature and painful stimuli. By studying patients with a rare, inherited disease, Alexander Che...
Source: Videocast - All Events - February 26, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Biowulf Seminar Series: How to build a dog in 2,392,715,236 simple steps
Biowulf Seminar Series
The Biowulf seminar series continues with talks by Biowulf users. The first such seminar features Heidi Parker, the Senior Staff Scientist for the Dog Genome Project at NHGRI
The NHGRI Dog Genome Project at NIH and focuses on the genetics of health and body structure in the domestic dog. We are particularly interested in the variation represented in individual dog breeds, which allows us to focus on locating genes involved in both canine cancer and the morphologic traits. Our research yields not only an understanding of how genes interact to create the modern dog breeds we see today and how we can ke...
Source: Videocast - All Events - February 16, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Sensing from within: how the immune system discriminates friend from foe
NIH Director's Wednesday Afternoon Lecture Series
The Fitzgerald lab is focused on understanding the molecular mechanisms controlling the inflammatory response. We are interested in determining how the immune system discriminates between pathogens, resident microflora and host molecules to both protect the host from infection and avoid damaging inflammatory diseases. We employ multifaceted approaches including immunology, biochemistry, molecular biology and genetics to understand these mechanisms.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 4/25/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Preclinical cancer-target validation: How not to be wrong
Wednesday Afternoon Lecture Series
Published and unpublished studies by investigators in the pharmaceutical industry indicate that a disturbingly high number of academic laboratories' reports nominating potential new cancer-drug targets are either non-reproducible or, if reproducible, are not sufficiently robust to form the basis for drug-discovery efforts. The reasons are likely multifactorial, including the ubiquitous use of " down " assays in cancer biology (e.g. decreased cell proliferation, decreased tumor growth, etc.) that incorporate chemical and genetic perturbants that are prone to cause off-target effects, failu...
Source: Videocast - All Events - January 23, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Who knew mosquitoes could go on diets? This species is foregoing human blood for floral nectar
Most mosquitoes in a species called Wyeomyia smithii refuse blood meals in favor of sweet floral nectar. New research is helping to explain the evolutionary genetics of the switch from blood sucker to flower fanatic.This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - January 12, 2018 Category: Science Source Type: video
Single cell analysis of the effector T cell transcriptome
Immunonology IG Seminar
Dr. Thomas Ciucci is a post-doctoral fellow in Dr. R é my Bosselut ’ s group within the Laboratory of Immune Cell Biology (LICB). He received a Ph.D. in Genetics and Immunology from the University of Nice, France in 2012. His doctoral research work investigated the relationship between inflammatory immune cells, the tumor environment and bone tissue. Dr. Ciucci joined Dr. Bosselut ’ s group in 2013 to pursue his interests in the regulation of T cell responses. His research has focused on two aspects of T cell differentiation during the immune response. The first, identified a previously unrecog...
Source: Videocast - All Events - January 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Genetic Compensation and Transcriptional Adaptation
NCI's Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians.Air date: 1/19/2018 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 3, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Secrets of butterfly wings revealed!
How do genes shape and color a butterflys wings? George Washington University evolutionary geneticist Arnaud Martin is using CRISPR Cas9, a gene editing technique, to determine how changes in the 'painting gene' WntA result in different wing shapes and patterns in butterflies. This research ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - December 21, 2017 Category: Science Source Type: video
