NIMHD Director's Seminar: Genetic Research with Alaska Native People: Lessons and Future Possibilities
The objectives of Dr. Dillard ’ s presentation will include the following:• Lessons learned over a decade of engagement with the Alaska Native community about ethical, legal and social implications of genetic research.• Findings from recent and ongoing genetic research by Southcentral Foundation, a tribal health organization in Anchorage, Alaska.• Ideas to increase participation of individuals from groups typically underrepresented in genetic research.
Dr. Dillard is of Inupiaq Eskimo descent, born and raised in Alaska. She is the director of research for Southcentral Foundation, a tribal health organization which ...
Source: Videocast - All Events - November 5, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Neuroscience Seminar - Axon Degeneration: Molecular Mechanisms and Therapeutic Potential
NIH Neuroscience Series Seminar
Dr. DiAntonio ’ s laboratory investigates molecular mechanisms that control the structure and function of neural circuits in development and disease. They combine genetic, molecular, neuroanatomical, and electrophysiological studies in both Drosophila and mouse to identify pathways required for the development, maintenance, and regeneration of axons and synapses.
Axonal degeneration is a common feature of many neurological diseases including hereditary neuropathies, diabetes, glaucoma, chemotherapy-induced neurotoxicity, and neurodegenerative diseases such as Alzheimer ’ s and Parkinson ...
Source: Videocast - All Events - November 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
The Peter Pan Syndrome: Oncohistones Stall Development in Pediatric Cancers
CCR Grand Rounds
Dr. Jabado ’ s research focuses on elucidating genetic signatures of pediatric astrocytomas and examining how they compare to adults. These are deadly brain tumors that originate in the brain and include glioblastomas (GBM, the highest grade of astrocytomas), which are one of the deadliest cancers in humans. Her group uncovered that pediatric high-grade astrocytomas (HGA) are molecularly and genetically distinct from adult tumors. They also identified a new molecular mechanism driving pediatric HGA, namely recurrent somatic driver mutations in the tail of histone 3 variants (H3.3 and H3.1). These mutatio...
Source: Videocast - All Events - October 21, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
23andMe advancing personalized medicine
Erin Trimble of 23andMe discusses the value of polygenic risk scores, making genetic information actionable for better health and equipping primary care providers to talk with their patients about genetics. (Source: Healthcare ITNews Videos)
Source: Healthcare ITNews Videos - October 14, 2019 Category: Information Technology Tags: Precision Medicine Women In Health IT Source Type: video
Innovation by evolution: bringing new chemistry to life
NIH Director's Wednesday Afternoon Lecture Series
Marshall W. Nirenberg Lecture
Not satisfied with nature ’ s vast catalyst repertoire, we want to create new protein catalysts and expand the space of genetically encoded enzyme functions. I will describe how we can use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones, thereby circumventing our profound ignorance of how sequence encodes function. Using mechanistic understanding and mimicking nature ’ s evolutionary processes, we can generate whole new enzyme families that catalyze synthetically important reactions n...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
We are what we eat: nutrition, genes, cognition & deep learning in age-related macular degeneration
NIH Director's Wednesday Afternoon Lecture Series
Age-related macular degeneration (AMD) is the leading cause of blindness in the United States and in the developed world. Two NIH-supported randomized clinical trials with 10 years of follow-up in nearly 10,000 participants demonstrated that nutritional supplements with antioxidant vitamins and minerals reduces the risk of progression to late AMD. Dietary data suggest the importance of the Mediterranean diet in reducing the risk of AMD, particularly fish consumption. The analyses of the genetic interaction with nutrition challenges the idea that you can eat away your geneti...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
A patient-scientist ’ s road toward primary prevention in genetic prion disease
NIH Director's Wednesday Afternoon Lecture Series
In 2010, Sonia Vallabh watched her 52 year old mother die of a rapid, mysterious, undiagnosed neurodegenerative disease. One year later, Sonia learned that her mother's disease had been genetic prion disease, and that she herself had inherited the causal mutation, making it very likely she would suffer the same fate in 20 years' time. There was no prevention, treatment, or cure available. Despite having no prior training in biology, Sonia and her husband Eric Minikel set out to re-train themselves as scientists and devote their lives to searching for a treatment or cure for...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Bad deeds go unpunished: the vacuole guard hypothesis and pathogen intracellular growth
NIH Director ’ s Wednesday Afternoon Lecture Series
Ralph Isberg has been a Professor of Molecular Biology and Microbiology at Tufts University School of Medicine for 32 years. After receiving an undergraduate degree at Oberlin College, he obtained his PhD at Harvard working on transposable genetic elements in bacteria. Throughout his career at Tufts he has primarily focused on the pathogenesis of Legionella pneumophila and enteropathogenic Yersinia, and has recently initiated projects on tackling drug resistance in nosocomial organisms. His research highlights include the identification of proteins involved in uptake of...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
CRISPR/Cas9 genetic sequence with a'hairpin' lock
An artistÂs representation of the CRISPR/Cas9 genetic sequence with a "hairpin" lock added to the left side of the system, a new approach created by biomedical engineers at Duke University that will improve the accuracy of the CRISPR genome editing technology by an average of 50-fold. The approach ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - October 2, 2019 Category: Science Source Type: video
Informatics for Genomics-informed Surveillance of RNA Viruses
NLM Informatics and Data Science Lecture Series
Genomics-informed surveillance is now recognized as an important extension to the monitoring of rapidly evolving pathogens. Next generation sequencing has the ability to produce large amounts of data for tracking viruses of public health importance. Biomedical informatics approaches are able to facilitate the translation of these data into information for public health surveillance. Thus, epidemiologists can identify new outbreaks or monitor the course of a known epidemic by leveraging pathogen sequences (and corresponding metadata) generated from the clinical specimens of si...
Source: Videocast - All Events - October 1, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
NLM Special Lecture: Gender, Race and Power in Science
The National Library of Medicine will be hosting a special lecture by British science journalist Angela Saini in the Lister Hill Auditorium. Saini explores how prejudice can affect scientific research on race and gender and describes her efforts to uncover manipulation of evidence, abuse and wrongdoing by those in power, as well as the inadvertent and inappropriate use of race by mainstream scientific researchers in health and genetics. Drawing from themes in her two most recent books, “ Superior: The Return of Race Science ” and “ Inferior: How Science Got Women Wrong ” , she will show why researchers need to be c...
Source: Videocast - All Events - September 16, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Ethical & Regulatory Aspects of Clinical Research Session 7: Ethics of Genetics Research and Incidental Findings, and Ethical Issues in All of Us
The Department of Bioethics offers this seven to eight week course annually each fall. The course is designed to provide an overview of the important issues in the ethics of human subject research for clinical investigators and others who participate in the conduct of research and is open to the entire NIH community as well as to those from outside NIH. Topics include the history of human subject research ethics, principles and guidelines, study design, subject recruitment, informed consent, and international research. The course is open to the entire NIH community as well as to those from outside NIH. The recommended text...
Source: Videocast - All Events - September 16, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDDK Administrative Speaker Series: Identifying the Genetic Basis of Obesity and Type 2 Diabetes in Southwest American Indians
2019 NIDDK Administrative Speaker Series
The series is an opportunity for NIDDK staff to learn about the important science NIDDK conducts and supports. It is also an excellent way to inspire our administrative staff, as it allows them a chance to hear and see how their roles contribute to and/or impact the work of the scientists.Air date: 10/9/2019 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 16, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
DNA's helix may have arisen with startling ease (Image 2)
For research on the possible origins of life chemicals on early Earth, Georgia Tech researchers used a base molecule called a proto-nucleobase (seen here next to a nucleobase), highly suspected to be precursors of nucleobases, the main components that transport genetic code in todayÂs RNA. [Image ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - August 19, 2019 Category: Science Source Type: video
NIA Butler-Williams Scholars Program 2019
Discussion sessions will focus on methodological approaches and interventions. The program also will include consultation on the development of research interests and advice on preparing and submitting research grant applications to NIA.Air date: 8/2/2019 10:15:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - July 3, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
