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The Hygiene Hypothesis: Why A Little Dirt is Good for You
CSR Learn About ScienceAir date: 2/21/2018 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 16, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

NCI Post-Treatment Surveillance Workshop - March 2018 (Day 2)
To discuss issues in post treatment surveillance given the current advances in imaging and in vitro diagnostics. Specific discussions will occur in Breast, Colon, NSCLS, Colorectal Cancer and Testicular cancer. Identify and prioritize histologies and tools that are most suitable to be evaluated in this setting, in NCTN and NCORP clinical trials.Air date: 3/27/2018 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 15, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

NCI Post-Treatment Surveillance Workshop - March 2018 (Day 1)
To discuss issues in post treatment surveillance given the current advances in imaging and in vitro diagnostics. Specific discussions will occur in Breast, Colon, NSCLS, Colorectal Cancer and Testicular cancer. Identify and prioritize histologies and tools that are most suitable to be evaluated in this setting, in NCTN and NCORP clinical trials.Air date: 3/26/2018 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 15, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

All of Us Research Program Scientific Priorities Workshop - March 2018 (Day 2)
All of Us Research Program Scientific Priorities WorkshopAir date: 3/22/2018 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 15, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

All of Us Research Program Scientific Priorities Workshop - March 2018 (Day 1)
All of Us Research Program Scientific Priorities WorkshopAir date: 3/21/2018 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 15, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Autism Awareness Month Sesame Street Workshop
Sesame Street Workshop will bring the new character Julia, an autistic Muppet that is four years old. This event will consist of a meet and greet, a panel discussion, and viewing clips of Sesame Street.For more information go tohttps://iacc.hhs.govAir date: 4/9/2018 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 15, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

NIH BRAIN Initiative Neuroethics Division Meeting: In vitro research with Human Neural Tissue
The purpose of the meeting is to assess the state of the science and consider neuroethical issues regarding research with human neural tissue, with the aim of informing how to support this type of research. Information presented and gathered at this meeting will support the development of future plans for the NIH BRAIN Initiative, set to continue until 2025.Air date: 3/28/2018 9:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 15, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Office of AIDS Research Advisory Council Meeting - March 2018
OAR Director ’ s Report; and, updates on the NIH AIDS Study Sections, the OAR Task Force on Cost-Sharing, the FY2020 Trans-NIH Plan for HIV-Related Research, and on HIV/AIDS research activities from NIH Institutes.Air date: 3/27/2018 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 15, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Robustness, Variability and Homeostasis in Neurons and Networks
NIH Neuroscience Series SeminarFor more information go tohttps://neuroscience.nih.gov/neuroseries/Home.aspxAir date: 5/21/2018 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

OD on the Move All Hands Meeting - March 2018
A meeting of the Office of the Director employees engaged in the Rockledge move led by the Deputy Director for Management. The OD on the Move All Hands meeting will feature project updates, staff resources, and a Q&A panel session.Air date: 3/13/2018 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Mechanistic basis of cancer immunotherapy
NIH Director's Wednesday Afternoon Lecture Series My group ’ s long interest in understanding the cellular mechanisms of the immune response has increasingly focused on the problem of cancer immunology and immunotherapy. We have now established an entire department devoted to this effort, and postdocs in my group seek to understand how checkpoint inhibitors (eg anti-PD-L1), vaccines, immune agonists and their combinations work to produce durable anti-cancer responses.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 4/18/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Sensing from within: how the immune system discriminates friend from foe
NIH Director's Wednesday Afternoon Lecture Series The Fitzgerald lab is focused on understanding the molecular mechanisms controlling the inflammatory response. We are interested in determining how the immune system discriminates between pathogens, resident microflora and host molecules to both protect the host from infection and avoid damaging inflammatory diseases. We employ multifaceted approaches including immunology, biochemistry, molecular biology and genetics to understand these mechanisms.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 4/25/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Cerebellar synaptic signaling as a metaphor for mentorship: how silence and speech get different deeds done
NIH Director's Wednesday Afternoon Lecture Series The cerebellum facilitates learned, coordinated movements and corrects errors. Signals to execute these functions are carried by the large neurons of the cerebellar nuclei, which form the major premotor projection from the cerebellum.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 5/2/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

The cryo-EM revolution
NIH Director's Wednesday Afternoon Lecture Series Research in the Subramaniam lab over the last decade has been guided by the vision that emerging tools in 3D electron microscopy hold great promise for imaging cells, viruses and protein complexes at high resolution in their native states, thus bridging a major gap in structural biology. In his talk, he will review examples of recent progress ranging from determination of protein structures at atomic resolution to imaging viruses, cells and tissue at nanometer resolution.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 4/11/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Of bones, brain, and fat: macrophages and the control of homeostasis
NIH Director's Wednesday Afternoon Lecture Series Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in development, homeostasis and diverse types of cancer and can either restrain or promote cancer progression and metastasis. The Geissmann lab is now building on previous work to investigate mechanisms by which tissue macrophages may control tissue growth and metabolism and whether these same mechanisms play a role in cancer initiation and development.For more information go tohttps://o...
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

LINGO proteins: a new language for the mucosal barrier
NIH Director's Wednesday Afternoon Lecture Series The Herbert lab investigates cellular and molecular mechanisms responsible for the initiation of Type 2 immunity against gastrointestinal helminths and enteropathogenic bacteria. We are focused upon identification of novel cytokine/receptor interactions that regulate the cross-talk between epithelial and myeloid compartments leading to pathogen clearance and tissue repair.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 3/21/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Foxo1 regulates commensalism via modulating goblet cell mucus secretion
Immunonology IG Seminar Dr. Wu completed his M.D. studies in China at Shanghai Jiaotong University School of Medicine, and then studied immunology and matrix biology as a graduate student at Muenster University, Germany. His main focus was T cell migration during the central nervous system (CNS) inflammation. He joined Dr. Vijay Kuchroo ’ s lab in Brigham and Women ’ s Hospital, Harvard Medical School as a postdoctoral fellow where he studied the molecular regulation of T cell differentiation during inflammation and autoimmunity. In 2017, Dr. Wu started a position as an NIH Stadtman Tenure-Track Investigator at...
Source: Videocast - All Events - February 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Gut feelings: host microbiome interactions in health and disease
NIH Director's Wednesday Afternoon Lecture Series Fiona Powrie is interested in the intestinal immune system ’ s ability to distinguish foreign microbes from the trillions of harmless bacteria that reside in our gut – and how this delicate balancing act breaks down in inflammatory bowel disease. Her work has identified suppressor ‘ regulatory T cells ’ that are crucial for gut homeostasis, as well as immune signals pivotal for chronic intestinal inflammation.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 3/14/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

NIMHD Director's Seminar Series - March 2018
The National Institute on Minority Health and Health Disparities (NIMHD) has launched the NIMHD Director ’ s Seminar Series (DSS). This forum highlights novel research discoveries by prominent researchers who are advancing the science of minority health and health disparities.Air date: 3/13/2018 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Translating from Chemistry to Clinic with Deep Learning
NLM Informatics and Data Science Lecture Series Many medicines become toxic only after bioactivation by metabolizing enzymes. Often, metabolic enzymes transformed them into chemically reactive species, which subsequently conjugate to proteins and cause adverse events. For example, carbamazepine is epoxidized by P450 enzymes in the liver, but then conjugates to proteins, causing Stevens Johnson Syndrome in some patients. The most difficult to predict drug reactions, idiosyncratic adverse drug reactions, often depend on bioactivation. Our group has been using deep learning to model the metabolism of diverse chemicals, and th...
Source: Videocast - All Events - February 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Vesicular transmission of viral populations: strength in numbers
Director's Seminar Series Using interdisciplinary approaches from cell biology to virology to immunology, we investigate the strategies exploited by viruses to successfully transmit themselves among hosts. We recently discovered a novel form of viral transmission in which viruses are transmitted among hosts, not as single infectious units, but as populations of infectious units clustered inside vesicles. We have found this type of en masse transmission to be widespread in nature, taking place both within as well as between hosts and notably leading to enhanced viral infectivity, suppression of host immune responses and the...
Source: Videocast - All Events - February 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Towards Minimally-invasive or Non-invasive Approaches to Assess Tissue Oxygenation Pre- and Post-Transfusion Workshop (Day 2)
The goal of this workshop is to discuss potential next steps to facilitate the development of new technologies and/or biomarker panels to assess tissue oxygenation in a minimally to non-invasive fashion pre- and post-transfusion of Red Blood Cells (RBCs). The 2015 Transfusion Symposium identified tissue oxygenation assessment as a priority area. The development of minimally to non-invasive procedures to accurately measure tissue oxygenation are needed 1) pre-transfusion to predict who would benefit from RBC transfusions, and (2) post-transfusion to determine if the patient did benefit (and to be able to test the differenti...
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Towards Minimally-invasive or Non-invasive Approaches to Assess Tissue Oxygenation Pre- and Post-Transfusion Workshop (Day 1)
The goal of this workshop is to discuss potential next steps to facilitate the development of new technologies and/or biomarker panels to assess tissue oxygenation in a minimally to non-invasive fashion pre- and post-transfusion of Red Blood Cells (RBCs). The 2015 Transfusion Symposium identified tissue oxygenation assessment as a priority area. The development of minimally to non-invasive procedures to accurately measure tissue oxygenation are needed 1) pre-transfusion to predict who would benefit from RBC transfusions, and (2) post-transfusion to determine if the patient did benefit (and to be able to test the differenti...
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

HPV VLPs: Nature ’ s Nanoparticles for Prevention and Treatment of Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds Dr. John Schiller graduated from the University of Wisconsin-Madison with a B.S. in molecular biology in 1975. In 1982, he received a Ph.D. from the Department of Microbiology of the University of Washington in Seattle, then joined the NCI Laboratory of Cellular Oncology as a National Research Service Award postdoctoral fellow in 1983. Dr. Schiller became a senior staff fellow in the Laboratory of Cellular Oncology in 1986 and a senior investigator in 1992. He became chief of the Neoplastic Disease Section of the lab in 1998, deputy lab chief in 2000 and designate...
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Mitochondria control of physiology and disease: beyond ATP
NIH Director ’ s Wednesday Afternoon Lecture Series For decades, the mitochondria have been primarily viewed as biosynthetic and bioenergetic organelles generating metabolites for the production of macromolecules and ATP, respectively. Our work has elucidated that mitochondria have a third distinct role whereby they release reactive oxygen species (ROS) and metabolites such as L-2-hydroxyglutarate to initiate physiological and pathological processes including hypoxic activation of HIFs, cellular differentiation, T cell activation and cancer cell proliferation. Thus, mitochondria function as signaling organelles.For m...
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Race, risk, and resilience: understanding racial differences in cognitive aging and brain pathology
NIH Director ’ s Wednesday Afternoon Lecture Series Dr. Barnes' research focus is on racial disparities in chronic diseases of aging, with a particular focus on Alzheimer ’ s disease and cognitive decline.For more information go tohttps://oir.nih.gov/wals/2017-2018Air date: 2/28/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Hematopoietic stem cells in stress, disease, and aging
NIH Director ’ s Wednesday Afternoon Lecture Series Dr. Passagu é 's research investigates the biology of blood-forming hematopoietic stem cells in normal and deregulated contexts such as development of hematological malignancies and physiological aging.For more information go tohttps://oir.nih.gov/wals/2017-2018Air date: 2/21/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Sugar and the beating heart: the conundrum of heart failure in diabetes
NIH Director ’ s Wednesday Afternoon Lecture Series Dr. Abel's current research interests focus on elucidating the molecular mechanisms leading to cardiac dysfunction in diabetes and the regulation of myocardial growth and metabolism by insulin signaling.For more information go tohttps://oir.nih.gov/wals/2017-2018/sugar-beating-heart-conundrum-heart-failure-diabetesAir date: 2/7/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

The Growing Promise of Gene Therapy Approaches (Day 2)
This two-day workshop will bring together research, regulatory, industry and patient perspectives on the growing emergence of gene therapies and the information necessary to optimize their development and the potential benefits that these new therapies may have for monogenic and rare diseases.Air date: 9/11/2018 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 1, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

The Growing Promise of Gene Therapy Approaches (Day 1)
This two-day workshop will bring together research, regulatory, industry and patient perspectives on the growing emergence of gene therapies and the information necessary to optimize their development and the potential benefits that these new therapies may have for monogenic and rare diseases.Air date: 9/10/2018 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 1, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 12/17/2019 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 11/19/2019 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 10/15/2019 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 9/17/2019 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 6/18/2019 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 5/13/2019 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 4/26/2019 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 3/19/2019 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 2/19/2019 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 1/15/2019 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 12/18/2018 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 11/20/2018 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 10/16/2018 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Joseph Leiter NLM/MLA Lectureship 2018
The Joseph Leiter NLM/MLA Lectureship was established in 1983 to stimulate intellectual liaison between the Medical Library Association (MLA) and the National Library of Medicine (NLM. The lectureship is hosted at NLM every other year.Air date: 5/9/2018 1:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

DNA Repair
Interest Group videoconferenceAir date: 9/11/2018 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

A comprehensive repertoire of mutational signatures in human cancer
DNA Repair Interest Group videoconferenceAir date: 6/19/2018 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Proteogenomics of Breast Cancer
NCI's Center for Cancer Research (CCR) Grand Rounds Dr. Matthew Ellis ’ s clinical and basic research focuses on breast cancer. He has developed neoadjuvant endocrine therapy as an alternative to chemotherapy for promoting breast-conserving therapy in postmenopausal women with ER+ HER2- stage 2 and 3 disease. He developed and validated the Ki67 proliferation marker-based Preoperative Endocrine Prognostic Index which is now undergoing a large validation study (the ALTERNATE study). These clinical studies have provided the clinical context and tumor specimens for seminal investigations into the ER+ breast cancer somati...
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Repair-resistant Aristolochic acid-derived DNA adducts
DNA Repair Interest Group videoconferenceAir date: 5/15/2018 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 29, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

ATR/Chk1 axis controls replication origin firing;
DNA Repair Interest Group videoconferenceAir date: 4/24/2018 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 29, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Persistent nuclear DNA damage reprograms cellular stress responses to drive aging
DNA Repair Interest Group videoconferenceAir date: 3/20/2018 12:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 29, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video