Job: Assistant Professor in Fungal Biology – Cornell University
Assistant Professor; Fungal Biology; tenure track, academic year appointment (9-month) https://academicjobsonline.org/ajo/jobs/15107 The search is looking for someone with research interests and expertise in the biology of plant-associated fungi and are particularly interested in learning of talented postdoctoral scholars or junior faculty who are or identify with underrepresented groups in science, representing diversity in its broadest sense. The School of Integrative Plant Science at Cornell University (https://sips.cals.cornell.edu) invites applications for a tenure track position at the Assistant Profe...
Source: Fungal Genomes and Comparative Genomics - October 21, 2019 Category: Genetics & Stem Cells Authors: Jason Stajich Tags: fungi Source Type: blogs

Help the SENS MitoMouse Rejuvenation Research Project Hit Its Crowdfunding Stretch Goals
The latest crowdfunded research project undertaken by the SENS Research Foundation involves using the genetically engineered maximally modifiable mouse lineage in order to demonstrate the ability to copy a version of the ATP8 mitochondrial gene into the cell nucleus, a process known as allotopic expression, and thus prevent mutational damage to this gene from degrading mitochondrial function. This is a modest step on the road towards bringing this class of genetic engineering project to the point of readiness for commercial development, when a biotech startup company could be created to carry it forward. In just a f...
Source: Fight Aging! - October 21, 2019 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Chlamydia Biology
Ming Tan, Johannes H. Hegemann and Christine Sütterlin present a new book on Chlamydia Biology: From Genome to Disease This book provides an up-to-date review of the clinical infections caused by the two main human pathogens C. trachomatis and C. pneumoniae, as well as chapters on veterinary Chlamydia species and Chlamydia-related bacteria. Multiple chapters cover cutting-edge developments in Chlamydia research, from the basic biology of the intracellular chlamydial infection to the host immune response and work towards a Chlamydia vaccine. Also highlighted are recent advances in chlamydial genetics and genomics, whic...
Source: Microbiology Blog: The weblog for microbiologists. - October 21, 2019 Category: Microbiology Source Type: blogs

TWiV 570: Aarhus viral
At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS. Click arrow to play Download TWiV 570 (61 MB .mp3, 101 min) Subscribe (free): iTunes, Google Podcasts, RSS, email […] (Source: virology blog)
Source: virology blog - October 20, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology Aarhus University AIDS AIDS cure cGAS DNA sensor herpes simplex virus HIV-1 HIV-1 latent reservoir host genetics polIII polio poliomyelitis poliovirus STING TLR9 varicella-zoster virus viral viruse Source Type: blogs

Fight Aging! Newsletter, October 21st 2019
In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was 44.44% vs. 17.46% in non-PAD volunteers. In addition, analysis showed that AT1-AAs level was positively correlated with PAD. To reveal the causal relationship between AT1-AAs and vascular aging, an AT1-AAs-positive rat model was established by active immunization. The carotid pulse wave velocity was higher, and the aortic endothelium-dependent vasodilatation was attenuated significantly in the immunized rats. Morphological staining showed thickening of the aortic wall. Histological examination showe...
Source: Fight Aging! - October 20, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

When Politics Meets Genomics In the US
DNA collection from migrants who cross the US-Mexico border might be put in place soon, and the information will feed a large criminal database operated by the FBI, announced headlines early October. We’ve come a long way since the first direct-to-consumer (DTC) company, 23andme, started to offer ancestry DNA testing kits online. It seems as it was decades ago – while in fact, we’re speaking about 10-12 years. How has DTC genetic testing culminated in population genomics – and what can we expect in the future to come? In the second part of our article series about genomics and politics, we’ll ...
Source: The Medical Futurist - October 19, 2019 Category: Information Technology Authors: nora Tags: Genomics American biotechnology dna testing ethics future genes genetics policy-making politics regulation science US USA Source Type: blogs

Improving Medical AI Safety by Addressing Hidden Stratification
Jared Dunnmon Luke Oakden-Rayner By LUKE OAKDEN-RAYNER MD, JARED DUNNMON, PhD Medical AI testing is unsafe, and that isn’t likely to change anytime soon. No regulator is seriously considering implementing “pharmaceutical style” clinical trials for AI prior to marketing approval, and evidence strongly suggests that pre-clinical testing of medical AI systems is not enough to ensure that they are safe to use.  As discussed in a previous post, factors ranging from the laboratory effect to automation bias can contribute to substantial disconnects between pre-clinical performance of AI sys...
Source: The Health Care Blog - October 18, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Artificial Intelligence Data Health Tech Health Technology AI Jared Dunnmon Luke Oakden-Rayner machine learning Source Type: blogs

HUMM Releases First Affordable Patch for Improving Working Memory: Exclusive Interview
We previously interviewed Humm, a San Francisco-based neuroscience company, when they had first released their Edge headset – an electrical stimulation device that helped users by boosting their working memory. Humm is focused on helping people continue to learn and grow throughout their lives. The idea behind their innovations is that through stimulation of the prefrontal cortex—a crucial area of the brain for decision making and learning—people’s ability to process and store information will be improved. Humm uses a safe and proven method of electrical stimulation called tACS (transcranial alterna...
Source: Medgadget - October 18, 2019 Category: Medical Devices Authors: Alice Ferng Tags: Exclusive Neurology Psychiatry Sports Medicine Source Type: blogs

Addressing gene editing with “thin” bioethics
Yesterday’s post on this blog, by Steve Phillips, warned that a narrow, “rules limited” approach to bioethics reduces ethics in science and medicine to matters of regulatory compliance and risks making thoroughly logical conclusions based on faulty premises that are adopted without regarding “deeper ethical thinking” for which scientists’ thinking must be brought under the … Continue reading "Addressing gene editing with “thin” bioethics" (Source: blog.bioethics.net)
Source: blog.bioethics.net - October 18, 2019 Category: Medical Ethics Authors: Jon Holmlund Tags: Genetics Health Care bioethics biotechnology enhancement syndicated Source Type: blogs

Amazon Pays Costs for Its Employees to Seek Specialized, Early Cancer Care
Employers are becoming increasingly active in providing special health services to their employees. Such an employee/employer cohort is being called a aSmart Health Community, the activities of which are beneficial to both parties (see:Smart health communities and the future of health). Now comes news that Amazon is assisting its employees in getting high quality cancer care from a specified cancer hospital (see:Amazon Joins Trend of Sending Workers Away for Health Care). Below is an excerpt from the article:Employers are increasingly going the distance to control health spending, paying to send workers across the cou...
Source: Lab Soft News - October 17, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Cost of Healthcare Diagnostics Healthcare Innovations Medical Consumerism Public Health Radiology Source Type: blogs

Podcast: Clutter vs. Hoarding- What ’ s the Difference?
We all have a friend or family member who just can’t seem to get out from under their accumulation of stuff. Their garage, guest bedroom and basement are packed, and you can’t see the top of the kitchen table. But when does “cluttered” become “hoarded?” We have all seen the sensationalized TV depictions of filthy homes that need to be condemned. But is that what hoarding really looks like?  And why can’t those folks just throw it all out? Today’s guest explains myths surrounding hoarding, treatment strategies and why we all might be at risk. SUBSCRIBE & REVIEW Gue...
Source: World of Psychology - October 17, 2019 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: Brain and Behavior Disorders General Interview LifeHelper Mental Health and Wellness Podcast Psychiatry Psychology The Psych Central Show Source Type: blogs

Increased Insulin Sensitivity is Not Required for Extension of Healthy Life Span in Mice via Calorie Restriction
The biochemistry surrounding insulin and insulin signaling is very well studied in the context of aging. A number of ways to slow aging in laboratory species involve directly manipulating these signaling pathways. Calorie restriction, like a number of other methods of slowing aging, improves insulin sensitivity, and the consensus in the research community has been that some fraction of the benefits to health and longevity that result from a restricted calorie intake are derived from this change to insulin metabolism. Today's open access paper provides evidence to suggest, surprisingly, that this is not in fact the case. It...
Source: Fight Aging! - October 16, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Cycles of DNA Damage and Repair as a Cause of Age-Related Epigenetic Drift
Researchers have recently proposed that the normal operation of DNA repair contributes to the epigenetic change that is observed to occur with age. This is an interesting concept, and we'll see how it progresses in the years ahead, particularly as therapies based on alteration of epigenetic markers emerge as an area of active medical research and development. Epigenetic decorations to DNA are a part of the complex regulatory system controlling the amounts and timing of protein production carried out by a cell. Cells react to changing circumstances with changes to epigenetic markers such as DNA methylation. Some of t...
Source: Fight Aging! - October 15, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Peptide Particles Ferry Drugs Across Blood-Brain Barrier
Most drugs, genetic materials, and other therapeutic agents are very difficult to use inside the brain because of the blood-brain barrier. There have been attempts to use ultrasound and microbubbles to create temporary passages through the barrier, including as a possible therapy for Alzheimer’s disease, but this is approach is not easy or ideal. Now, researchers from Newcastle University in the U.K. have used a peptide (chain of amino acids) to create drug-loaded nanoparticles, about the size of viruses, that can autonomously cross the blood-brain barrier. The new particles can be loaded with nucleic acid-ba...
Source: Medgadget - October 15, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Medicine Nanomedicine Neurology Neurosurgery Source Type: blogs

Humanoid Mass Production
Henry Ford would be proud. We now have the ability to mass produce humanoids, embryonic cells derived from human embryonic stem cells or induced pluripotent stem cells (the latter can be made from adult cells). These cells are specifically designed by researchers to have some but not all of the necessary elements to be fully … Continue reading "Humanoid Mass Production" (Source: blog.bioethics.net)
Source: blog.bioethics.net - October 15, 2019 Category: Medical Ethics Authors: Mark McQuain Tags: Genetics Health Care Stem Cells bioethics biotechnology human dignity syndicated Source Type: blogs

Antibiotic-resistant urinary tract infections are on the rise
There is a global crisis of antibiotic resistance, and urinary tract infections (UTIs) may be the canary in the coal mine. UTIs are one of the most common types of infections; at least one in two women and one in 10 men will experience a UTI in their lifetime. Like many human infections, UTIs are usually caused by bacteria living on or in our bodies, and require treatment with antibiotics. What’s alarming the medical community now is that UTIs are becoming ever harder to treat with common antibiotics. Antibiotic overuse leads to antibiotic resistance At some point, most people have taken a course of trimethoprim/sulf...
Source: Harvard Health Blog - October 14, 2019 Category: Consumer Health News Authors: Lisa Bebell, MD Tags: Drugs and Supplements Health Infectious diseases Kidney and urinary tract Women's Health Source Type: blogs

What sperm banks could learn from Fox ’s ‘Almost Family’ and ‘The Handmaid’s Tale’ sequel ‘The Testaments’
This article was originally featured on the Genetic Literacy Project on October 1, 2019. This article, along with more information and additional links can be found at: https://geneticliteracyproject.org/2019/10/01/foxs-almost-family-vs-the-handmaidens-tale-sequel-the-testaments-different-takes-on-the-dangers-of-sperm-bank-donations/ .  ** I'm dreading the debut of the Fox TV series Almost Family on October 2. In it, Julia Bechley discovers that her dying dad, a famous fertility doctor, had made dozens of personal DNA donations that are now millennials, at least two of whom have unknowingly h...
Source: blog.bioethics.net - October 14, 2019 Category: Medical Ethics Authors: Bioethics Today Tags: Genetics Health Care syndicated Source Type: blogs

Fight Aging! Newsletter, October 14th 2019
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/ Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought...
Source: Fight Aging! - October 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Box-tree Moth, Cydalima perspectalis
The Box-tree Moth, Cydalima perspectalis, is an Asian species of moth (usually seen in (Japan, China, Taiwan, Korea, the Russian Far East, and India), that is gradually spreading, presumably with the advent of box hedges on new housing estates, across the South East of England. Box-tree Moth, Cydalima perspectalis (Walker, 1859), to actinic light Jul 2019, VC29 It would’ve arrived as eggs/larvae on imported box (Buxus), first recorded here in 2007. Its larvae can destroy a box hedge. Another reason to go native when it comes to planting…probably too late for native box now though. I saw my first one in the tra...
Source: David Bradley Sciencebase - Songs, Snaps, Science - October 13, 2019 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

The Future Of Hearing: How Technology Might Turn Us Into Superheroes
The objective of medical tools for personal use started to go beyond measuring health parameters and vital signs, offering accurate, as well as easy and patient-friendly measurements. Lately, they are also coupled with aesthetic appearance. Elements of design thinking and UX become an ever more organic part of product development – and that’s also visible when looking at hearables. The trend also allows getting rid of societal stigmas bound with medical devices. Millions of people don’t want to wear hearing aids because it’s connected to aging and is perceived as being more dependent while signal...
Source: The Medical Futurist - October 12, 2019 Category: Information Technology Authors: nora Tags: Future of Medicine app artificial artificial intelligence ear hearing hearing aid hearing technology medical specialty otoscope smartphone superhero Source Type: blogs

iRhythm-Verily Partnership: Interview with iRhythm CEO Kevin King
iRhythm and Verily announced a partnership last month to “co-develop solutions intended to provide early warning, diagnosis and management for patients, particularly for those with silent or undiagnosed AF.” We spoke with iRhythm CEO Kevin King to understand how the two companies complement each other and how they can solve the problem together. Ben Ouyang, Medgadget: Tell us about yourself. Kevin King: I’ve been CEO of iRhythm now for seven years, since the very early days when our company was private. I’ve led the company’s growth and expansion to where we are today. By way of back...
Source: Medgadget - October 11, 2019 Category: Medical Devices Authors: Ben Ouyang Tags: Cardiology Diagnostics Exclusive irhythm verily Source Type: blogs

An Ambitious Vision for Bioethics – Some Reflections on Professor Jing-Bao Nie’s St Cross Seminar
Written by Ben Davies Many readers of the Practical Ethics blog will remember the astounding announcement last November by Chinese researcher He Jiankui that he had used CRISPR-cas9 technology to edit into two healthy embryos a resistance to developing HIV, later resulting in the birth of twins Lulu and Nana. As Professor Julian Savulescu expressed […] (Source: blog.bioethics.net)
Source: blog.bioethics.net - October 11, 2019 Category: Medical Ethics Authors: Ben Davies Tags: Ethics Genetics Health Care Science bioethics Children and Families China CRISPR Current Affairs eugenics genetic engineering medical ethics Pluralism Reflections regulation syndicated Source Type: blogs

Why do perfect IVF cycles fail?
Often an IVF cycle goes perfectly , and the doctor is happy with the medical process. He has transferred a top quality blastocyst; the transfer was smooth; and the endometrium was 8 mm and trilaminar.However, even though everything seems to be perfect, the IVF cycle may still fail.Patients then feel cheated and upset ! After all, if the cycle was perfect and the doctor was so happy and hopeful, then why didn't it work?What they forget is that when we call a cycle perfect, we only refer to the medical tangibles which we can measure. Our technology is still not good enough to allow us to assess all the hundreds of ...
Source: Dr.Malpani's Blog - October 11, 2019 Category: Reproduction Medicine Source Type: blogs

Lipid Metabolism in Aging and Age-Related Disease
Lipids are everywhere in our biochemistry. Where they are present in cell structures and molecular mechanisms that are important to any specific age-related disease, or are among the underlying root causes of aging, it will tend to be the case that differences between species (and possibly individuals) can lead to changes in the pace of aging and disease. For example, lipid composition determines resistance to oxidative damage to cell membranes. A range of evidence supports the membrane pacemaker hypothesis of aging, in that longer-lived species tend to have more resilient cell membranes, based on their lipid composition. ...
Source: Fight Aging! - October 10, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Gene testing to guide antidepressant treatment: Has its time arrived?
Depressive disorders are among the most common conditions that disrupt lives. Fortunately, medications, psychotherapies, and lifestyle changes are usually successful in treating depression and related disorders, even if symptoms are not entirely eliminated. Sometimes people don’t gain sufficient relief from treatment, or must try several medications before finding one that works well. In an age of exciting advances, including brain imaging and genetic testing, many doctors and patients reasonably hope that new technologies will offer answers. And in fact, for antidepressant choice, several companies sell genetic test...
Source: Harvard Health Blog - October 9, 2019 Category: Consumer Health News Authors: Bruce M. Cohen, MD, PhD Tags: Anxiety and Depression Health Mental Health Tests and procedures Source Type: blogs

Deletion of p38 α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice
Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought that the loss of stem cell activity with age, throughout the body and not just in the brain, is an evolved response to rising levels of damage that serves to reduce the risk of cancer that arises from the activity of damaged cells. The cost, however, is a slow decline into dysfunction and tissue failure. There are many therapeutic approaches under development in labs and startups that involve ways to force stem cell populations to go back to work, overriding their normal reaction...
Source: Fight Aging! - October 9, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

3D Microenvironments to Grow Brain Tumors in Lab
Clinical researchers are constantly thwarted by the inability to quickly and easily try new therapies in tumors and other disease targets. Tumors within the brain are particularly hard to study because of the difficulty with access and the incredible fragility of nearby tissues. Researchers at Tufts University have just developed a way to create an environment that closely mimics that of the brain and were able to grow pediatric and adult tumors within it. The microenvironment allows for non-invasive imaging of the tumors and for easy manipulation of the cells growing within. The model tumors were grown in the presence ...
Source: Medgadget - October 8, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Neurosurgery Oncology Source Type: blogs

Combining Strategies to Slow Aging to Increase Life Span in Flies by 48%
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Link: https://doi.org/10.1073/pnas.1913212116 (Source: Fight Aging!)
Source: Fight Aging! - October 8, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Medicare Fraud — Again
Today’s Miami Herald [limited access] is reporting that there are on-going scams targeting the elderly by doing unnecessary DNA tests on them, with the intent of committing Medicare fraud. The article states, “Genetic testing . . . has become so corrupted by racketeers that the Justice Department recently unveiled its first nationwide take-down of 35 suspects … Continue reading "Medicare Fraud — Again" (Source: blog.bioethics.net)
Source: blog.bioethics.net - October 7, 2019 Category: Medical Ethics Authors: Neil Skjoldal Tags: Health Care bioethics syndicated Source Type: blogs

10 foods that may impact your risk of dying from heart disease, stroke, and type 2 diabetes
Could just 10 foods substantially impact your risk of dying from a cardiometabolic disease (CMD) like type 2 diabetes, heart disease, or stroke? Maybe. A study published in JAMA provides some insight into the degree to which 10 specific foods and nutrients affect the risk of dying from CMD. The study found that in 2012, eating suboptimal levels of 10 foods or nutrients — too much of some and not enough of others — was associated with more than 45% of deaths due to type 2 diabetes, heart disease, and stroke. 10 foods associated with nearly half of CMD deaths The researchers developed a risk assessment model that...
Source: Harvard Health Blog - October 7, 2019 Category: Consumer Health News Authors: Katherine D. McManus, MS, RD, LDN Tags: Diabetes Health Healthy Eating Heart Health Hypertension and Stroke Nutrition Source Type: blogs

How to Prevent Your Anxiety from Rubbing Off On Your Child
You're reading How to Prevent Your Anxiety from Rubbing Off On Your Child, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Sometimes, it seems like our kids aren’t learning anything from us—but that’s simply not the case. Kids absorb all the information around them and learn by example. While that can be a good thing, it can also be a problem if you don’t want to pass on certain behaviors you’re modeling for them, like anxiety. If you’re struggling with anxiety, first remember that...
Source: PickTheBrain | Motivation and Self Improvement - October 7, 2019 Category: Consumer Health News Authors: SarahDaren Tags: depression family featured psychology self improvement Source Type: blogs

Fight Aging! Newsletter, October 7th 2019
In conclusion, our findings link the calcification of the vascular tissue with the expression of FGF23 in the vessels and with the elevation of circulating levels this hormone. Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance https://www.fightaging.org/archives/2019/09/permanently-boosting-levels-of-natural-killer-cells-in-mice-to-increase-cancer-resistance/ Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the ...
Source: Fight Aging! - October 6, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Using the Apple Ecosystem to Support Health Research and Clinical Trials
In a recent note, I discussed how23andMe was beginning to recruit clinical trial subjects as a new business opportunity (see:23andMe Moving into Clinical Trial Recruitment, a Potential Source of New Income). I emphasized in the note that this was a lucrative new enterprise because drug companies offer high reimbursement for recruiting research subjects. Subsequent to posting this note, I came across another article that speculates that Apple has been eyeing the medical research market with the potential to radically change some aspects of it (see:Apple Is Going After The Healthcare Industry, Starting With Personal Health D...
Source: Lab Soft News - October 4, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Electronic Health Record (EHR) Genomic Testing Health Wearable Healthcare Information Technology Lab Industry Trends Medical Research Point-of-Care Testing Test Kits and Home Testing Source Type: blogs

The Moral Choices on CRISPR Babies
This post is presented in collaboration with the American Journal of Bioethics. You can read the entire issue by clicking here. by Sheldon Krimsky In late November 2018, Chinese scientist Dr. He Jiankui announced at the Second International Summit on Human Genome Editing in Hong Kong that he had used CRISPR/Cas 9 gene editing on two female embryos that were brought to term through an in vitro fertilization (IVF) pregnancy. The world scientific community was ill-prepared for the announcement since the moral issues surrounding the editing of human embryos were under discussion but hardly resolved.… (Source: blog.bioethics.net)
Source: blog.bioethics.net - October 3, 2019 Category: Medical Ethics Authors: Blog Editor Tags: Editorial-AJOB Featured Posts Genetics Reproductive Ethics gene editing Source Type: blogs

Screening that benefits the screener
I teach it course on human diseases for students in a public health program. One of the things that we talk about is asymptomatic disease. If a disease has no symptoms the only way that we can detect it is by screening. For screening to be beneficial it needs to be able to detect asymptomatic … Continue reading "Screening that benefits the screener" (Source: blog.bioethics.net)
Source: blog.bioethics.net - October 2, 2019 Category: Medical Ethics Authors: Steve Phillips Tags: Genetics Health Care bioethics biotechnology Health Care Practice syndicated Source Type: blogs

Arguing that People are Emotionally Fragile, and thus Should be Prevented from Using Metrics that Correlate with Age
In conclusion, we have not reached the point when it is ethical and scientifically valid to use biomarkers to predict longevity. Like: https://www.the-scientist.com/news-opinion/opinion--biomarkers-of-longevity-not-ready-for-the-clinic--66497 (Source: Fight Aging!)
Source: Fight Aging! - October 1, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

If you have migraines, put down your coffee and read this
During medical school, a neurologist taught me that the number one cause of headaches in the US was coffee. That was news to me! But it made more sense when he clarified that he meant lack of coffee. His point was that for people who regularly drink coffee, missing an early morning cup, or even just having your first cup later than usual, can trigger a caffeine withdrawal headache. And considering how many daily coffee drinkers there are (an estimated 158 million in the US alone), it’s likely that coffee withdrawal is among the most common causes of headaches. Later in my neurology rotation, I learned that caffeine i...
Source: Harvard Health Blog - September 30, 2019 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Headache Health Source Type: blogs

Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance
Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the immune system for the entire life span of the mouse. Even if this class of treatment is not actually permanent in the same way in humans, and merely long-lasting, it still seems a promising step towards enhancing the immune system at any age, not just trying to repair it when it fails in later life. They've been called the "special forces" of the immune system: invariant natural killer T cells. Alth...
Source: Fight Aging! - September 30, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, September 30th 2019
In conclusion, older adults exhibited decreased markers of UPR activation and reduced coordination with autophagy and SC-associated gene transcripts following a single bout of unaccustomed resistance exercise. In contrast, young adults demonstrated strong coordination between UPR genes and key regulatory gene transcripts associated with autophagy and SC differentiation in skeletal muscle post-exercise. Taken together, the present findings suggest a potential age-related impairment in the post-exercise transcriptional response that supports activation of the UPR and coordination with other exercise responsive pathways (i.e....
Source: Fight Aging! - September 29, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

What Happens When Genomics Meets Politics?
The number of people having their genomes sequenced could reach more than 100 million by 2025, researchers estimated. Policy-makers around the world started to realize the incredible potential in genomics for population health in the last 3-5 years, but there are huge question marks whether they can manage the use of this incredibly useful pool of data in an appropriate framework, with well-thought-out means, for the right purposes, meaning for the well-being of humans and communities in the present and the future. Here, we launched an article series to look at the countries with the most experience. Let’s start with...
Source: The Medical Futurist - September 28, 2019 Category: Information Technology Authors: nora Tags: Future of Medicine Genomics Healthcare Policy data data privacy data security Estonia ethics Gene genetic genetics Genome genome sequencing health data personal genomics Personalized medicine population population genomic Source Type: blogs

23andMe Moving into Clinical Trial Recruitment, a Potential Source of New Income
I have been blogging about23andMe for about six years (see:Update on 23andMe; Time for a Review of FDA Definition of Medical Devices). During that time, I have seen the company evolve from the first major consumer genomics enterprise to a clinical laboratory authorized by the FDA to perform testing for ten diseases or conditions. These are the first direct-to-consumer (DTC) tests authorized by the FDA that provide information about an individual ’s genetic predisposition to certain medical diseases or conditions (see:FDA allows marketing of first direct-to-consumer tests that provide genetic risk information for...
Source: Lab Soft News - September 27, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Food and Drug Administration Genomic Testing Healthcare Information Technology Healthcare Innovations Lab Industry Trends Lab Regulation Lab Standards Medical Consumerism Medical Research Pharmaceutical Industry Source Type: blogs

A Skeptical Review of the Evidence for Metformin
This review paper more or less leans towards my thoughts on metformin as a treatment to slow aging: the animal data is not great, the human data is a single study, the effect size on life span is far too small to care about, and the detrimental side effects are large in comparison to that effect size. The strategy of upregulating stress response mechanisms via drugs such as metformin is a poor strategy for long-lived species, as we clearly don't exhibit the sizable gains in life span that occur in short lived species such as mice under these circumstances. Metformin, in turn, is a low performance example of this strategy, ...
Source: Fight Aging! - September 27, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Why doesn't every perfect IVF cycle end up in a pregnancy?
Often patients have a medically perfect embryo transfer when they do an IVF cycle. The embryo is a top quality blastocyst, the endometrium is 8 mm and trilaminar and the embryo transfer was technically smooth.When patients hear that everything went perfectly, they are obviously very optimistic , and are very sure that they're going to get pregnant.However, when the cycle fails, they can't understand what went wrong.And that's the first question they ask, "What went wrong? Did I do something wrong? Was I too anxious? Didn't I rest enough? Didn't I take enough medications?"There is often quite a bit of blaming the ...
Source: Dr.Malpani's Blog - September 26, 2019 Category: Reproduction Medicine Source Type: blogs

Why do we do this?
Many of the posts on this blog involve cautions that there are things in medicine which we are capable of doing and which some want to do that we should not do. Much of the time those cautions go unheeded by our society. For fifty years we have been saying that we should not perform … Continue reading "Why do we do this?" (Source: blog.bioethics.net)
Source: blog.bioethics.net - September 26, 2019 Category: Medical Ethics Authors: Steve Phillips Tags: Genetics Health Care abortion bioethics biotechnology Ethical Method / Grounding reproduction syndicated Source Type: blogs

Job: Professor of Biomedical Informatics and Digital Health
The University of Sydney, School of Medical Sciences in Australia have established a new Discipline of Biomedical Informatics and Digital Health. They are seeking a Head of this discipline: Professor of Biomedical Informatics and Digital Health. (Source: Fungal Genomes and Comparative Genomics)
Source: Fungal Genomes and Comparative Genomics - September 25, 2019 Category: Genetics & Stem Cells Authors: Jason Stajich Tags: jobs australia biomedical informatics head Source Type: blogs

Implantable Nanolasers for Tissue Imaging, Neurotherapy
A variety of imaging techniques and technologies, such as optogenetics, could benefit from devices that can emit visible laser light from inside tissues. Conventional lasers are too large, while nanolasers tend to be inefficient, heating up too much, and typically require damaging ultraviolet light to power them. Now, researchers at Northwestern and Columbia Universities have developed a nanolaser that can be powered by deep-penetrating and safe infrared light while emitting visible light. The device, less than 150 nanometers in width, uses upconversion to capture multiple low-energy (infrared) photons and turn them...
Source: Medgadget - September 25, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Neurology Radiology Source Type: blogs

What donor offspring seek when they do DNA testing
I wrote previously about parents who fear that their donor-conceived children might uncover long-held secrets through DNA testing. Many were unsettled by Dani Shapiro’s memoir Inheritance, which told of how a DNA test done for no particular reason dismantled a family story. Now let’s consider reasons why some people who know they were donor-conceived might pursue DNA testing. Why might people who were donor-conceived seek DNA testing? Donor-conceived adults who embark upon DNA testing may, like Shapiro, stumble upon information accidentally. Their experience with DNA testing is not explored in this post, which ...
Source: Harvard Health Blog - September 25, 2019 Category: Consumer Health News Authors: Ellen S. Glazer, LICSW Tags: Infertility Mental Health Relationships Source Type: blogs

Data of the dead participant: what ’s the right thing to do?
by Marieke Bak, MSc, MA, PhD(c) When people die nowadays, they no longer leave behind only physical assets. Their estate includes large amounts of personal data that remain in existence after they pass away. Creating a digital will may be a sensible way to posthumously control digital assets like Facebook pages or Google search histories. However, a recent survey found that the vast majority of us never discuss what should happen to our data after death. When it comes to medical data, particularly those collected in the context of research, the situation is similar.… (Source: blog.bioethics.net)
Source: blog.bioethics.net - September 24, 2019 Category: Medical Ethics Authors: Marieke Bak Tags: Decision making Featured Posts Genetics Human Subjects Research & IRBs Privacy Research Ethics Science Source Type: blogs

Conversion of Glial Cells into Neurons as an Approach to Regeneration in the Brain
The authors of today's research report on success in use of a gene therapy to convert glial cells into neurons in a living mouse brain, and thereby improve the normally limited recovery that takes place following brain injury, such as that caused by a stroke. A number of research groups are investigating this class of approach to enhance regeneration in the brain, an organ that has little capacity to repair itself. The capacity that does exist is generated by neural stem cells that, arguably, continue to produce new neurons at some pace throughout life. As for all stem cell populations, activity declines with age, however....
Source: Fight Aging! - September 23, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Is the DEA Branching Out Into Regulating Medicine?
Jeffrey A. SingerThe Drug Enforcement Administration, having virtually eliminated the diversion of prescription pain relievers into the underground market for nonmedical users, appears to be setting its sights on regulating the medical management of pain, a mission not suited for law enforcement. Acting under the authority of the Substance Use-Disorder Prevention that Promotes Opioid Recovery and Treatment for Patients and Communities Act (SUPPORT Act), the DEA  announced a proposal to reduce, once again, the national production quotas for fentanyl, morphine, hydromorphone (Dilaudid), oxycodone, and oxymorphone, ...
Source: Cato-at-liberty - September 23, 2019 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs