Organoids Produce Tooth Enamel Proteins
Researchers at the University of Washington School of Medicine have developed a method to create stem cell-derived organoids that can produce tooth enamel proteins. The breakthrough could pave the way for lab grown enamel that can be used in dental repairs and may even allow for living fillings or completely new living teeth that can be implanted into a patient’s jaw. The researchers studied the genetic activity that occurs during tooth development, and then used this information to steer stem cells into becoming ameloblasts, which are the cell type responsible for enamel creation. Once present in organoids, the cells ca...
Source: Medgadget - September 12, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Dentistry Genetics Materials uwsomwwami Source Type: blogs
“The Greatest Scientist of All Time” says Scientific American. Who is it?
BY MIKE MAGEE
When it comes to our earthly survival as a human species, words are often under-powered and off-the-mark. Clearer concepts, definitions and terms are required for clarity. Here are five terms that are useful and worth remembering:
Planetary Boundaries
Earth Systems
Human Perturbations
Planetary Scale Destabilization
Holocene Epoch vs. Anthropogenic Epoch
These terms all tie back to a single source – a child of World War II, only seven when his home in Amsterdam was overrun by Nazis. His father was a waiter, his mother a cook in a local hospital. He’d later recall with a sh...
Source: The Health Care Blog - September 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Chemistry Mike Magee Ozone Paul Crutzen Scientific American Source Type: blogs
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
DNA Damage and Consequent Inflammation in Heart Failure
One of the ways in which cell damage characteristic of aging can provoke inflammation is via the mislocalization of DNA. Either nuclear DNA or mitochondrial DNA can find its way to the cytosol, where it can trigger responses evolved to detect bacterial or viral infection, or severe cell damage. This creates a cascade of downstream signaling leading to an inflammatory response. In youth these events occur comparatively rarely, and in circumstances wherein immune response and potentially even cell death are beneficial. With age, however, there is a continued mild but growing level of dysfunction and consequent sustained infl...
Source: Fight Aging! - September 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Suppression of Transposable Element Activity Extends Life in Nematode Worms
There is a growing interest in the role of transposable elements in aging. These are sections of the genome, remnants of ancient viral infections, that are capable of copying themselves when active, causing mutational damage in the process. Transposable elements are suppressed in youth, their portions of the genome folded away and hidden from transcriptional machinery, but this suppression fails with age as epigenetic markers that determine the structure of the genome change. Any mechanism that increases mutational damage in large numbers of cells might be suspected to contribute to degenerative aging, but definitive proof...
Source: Fight Aging! - September 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
CRISPR-Equipped Bacteria Detect Tumors
Researchers at the University of California San Diego have created a bacterial sentinel system that can alert clinicians to the presence of tumors. The technology takes advantage of the specificity of the CRISPR system and the tendency of bacteria to uptake fragments of DNA from their environment. Termed “Cellular Assay for Targeted CRISPR-discriminated Horizontal gene transfer” (CATCH), the system has been created to detect gastrointestinal tumors in its first iteration. This involves administering the CRISPR-enabled bacteria to the gut. The bacteria have been engineered to respond to DNA fragments that encode...
Source: Medgadget - September 7, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Genetics Oncology UCSD Source Type: blogs
PU.1 Inhibition to Reduce Microglial Inflammation in the Aging Brain
Researchers here report on a drug discovery effort targeting PU.1, a gene implicated in increased inflammation of microglia in the brain. Microglia are innate immune cells of the central nervous system. Like macrophages in the rest of the body, they react to the damage and dysfunction of aging with increased inflammatory behavior, a maladaptive response that worsens pathology. Chronic, unresolved inflammation is clearly disruptive to tissue function wherever it occurs in the body. In the brain, chronic inflammation is a well-studied feature of conditions such as Alzheimer's disease. A greater population of inflammatory mic...
Source: Fight Aging! - September 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
New Research: Kidney Enzyme As A Promising Solution For High Blood Pressure
Conclusion
We’ve journeyed through a landscape of cutting-edge research, all pointing to one thing: ENPEP could be a game-changer in treating high blood pressure. This isn’t just another study; it’s a pivotal moment in medical science. The research from the University of Manchester has the potential to reshape how we approach this widespread health issue.
So, what’s the next step? Stay informed. New treatments could be just around the corner, and you’ll want to be in the know. Whether it’s following medical journals or talking to your healthcare provider, staying updated could make...
Source: The EMT Spot - September 5, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
A Discussion of Current Approaches Under Development for the Treatment of Aging
This open access paper tours a number of the present approaches under development to the treatment of aging as a medical condition, dwelling the most on therapies targeting senescent cells, either for destruction or to suppress the harmful senescence-associated secretory phenotype. We live in an exciting time of great potential, an age of accelerating progress in the capabilities of medical biotechnology, though it remains the case that too few people realize just how close we are to the widespread use of the first practical rejuvenation therapies.
Aging poses one of the greatest challenges for modern medicine, as...
Source: Fight Aging! - September 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
« Back to Top
Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
We examined whether adult neurogenesis sustains hippocampal connections cumulatively across the life span. Long-term suppression of neurogenesis as occurs during stress and aging resulted in an accelerated decline in hippocampal acetylcholine signaling and a slow and progressing emergence of profound working memory deficits.
These deficits were accompanied by compensatory reorganization of cholinergic dentate gyrus inputs with increased cholinergic innervation to the ventral hippocampus and recruitment of ventrally projecting neurons by the dorsal projection. While increased cholinergic innervation was dysfunctional...
Source: Fight Aging! - September 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Trial By Error: Professor Chris Ponting Discusses on DecodeME ’ s First Results
By David Tuller, DrPH Professor Chris Ponting is a geneticist at the University of Edinburgh. He is also the principal investigator for DecodeME, a genome wide association study. The DecodeME team recently published findings from more than 17,000 questionnaires it had collected from patients. I wrote about those findings in a post last week. In … Trial By Error: Professor Chris Ponting Discusses on DecodeME’s First Results Read More » (Source: virology blog)
Source: virology blog - August 31, 2023 Category: Virology Authors: David Tuller Tags: Uncategorized Chris Ponting DecodeME Source Type: blogs
What is intersex? What do you know about your patient ’ s sexual development?
I don’t know about you, but I learned very little about variations in sexual development during my medical education over a decade ago. Commonly presented topics were usually of a genetic nature—this person has XXY or XO chromosomes and the “abnormalities” such chromosomal variations can bring. That’s about the extent of my education regarding sex
Read more…
What is intersex? What do you know about your patient’s sexual development? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 31, 2023 Category: General Medicine Authors: Rosemary Eseh-Logue, MD Tags: Conditions Primary Care Source Type: blogs
Transferring the Naked Mole Rat Hyaluronan Synthase 2 Gene Into Mice Reduces Cancer Incidence, Extends Life
Naked mole rats live far longer than similarly sized mammals, and are near immune to cancer. One of the mechanisms of cancer resistance involves the production of a different form of high molecular weight hyaluronan, and much more of it, improving the anti-cancer mechanism of contact inhibition. In addition, other mechanisms derived from changes in hyaluronan may affect life span through improved cellular function, but this is less well explored. Researchers here take the naked mole-rat version of the gene for high molecular weight hyoluronan, hyaluronan synthase 2, and put it into mice. The result is less cancer, improved...
Source: Fight Aging! - August 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Perspective on the Coming Regulatory Shift to Approval of Drugs to Treat Aging
At some point, regulatory bodies that oversee the development of new medicine will accept that therapies can target causative mechanisms of aging in order to slow or reverse the progression of aging, and that there are viable ways to assess new treatments that treat aging. There is growing pressure from the academic community and longevity-focused biotech industry for the ability to run clinical trials to treat aging, rather than to treat one specific age-related disease.
While inevitable, this change will take some years to come to pass, and likely require greater consensus in the research community on reasonable a...
Source: Fight Aging! - August 29, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
