Nanorattles for Rapid Detection of Multiple mRNA Cancer Biomarkers
Scientists at Duke University have developed a ‘nanorattle’ system that allows for the detection of mRNA biomarkers of cancer. The tiny structures consist of gold nanospheres with a surrounding silver nanocage, forming the so-called rattle. The nanorattles are also loaded with light scattering dyes called Raman reporters. When illuminated with a laser, the rattles emit significant amounts of light. The researchers developed the technology so that they could detect mRNA biomarkers of cancer, which will bind to the nanorattles if present in a patient sample. The researchers can then use a laser to illuminate the nanoratt...
Source: Medgadget - September 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Nanomedicine Oncology Pathology Duke Source Type: blogs

Algae-Based Microrobots Deliver Antibiotics within Lungs
Researchers at the University of California San Diego have developed a microrobot system to treat bacterial pneumonia. The microrobots consist of living algal cells that can swim very effectively in biological fluids, allowing them to navigate throughout the lungs and deliver drugs to difficult-to-reach areas. The algal cells are studded with antibiotic-loaded polymer spheres that are coated with cell membranes from neutrophils, which help them to neutralize inflammatory molecules that are released by bacteria in the lungs, providing a localized anti-inflammatory effect. In tests in mice with bacterial pneumonia, the micro...
Source: Medgadget - September 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Critical Care Materials Medicine Nanomedicine UCSD Source Type: blogs

Microfluidic Device Mimics Embryonic Heartbeat to Stimulate Stem Cell Development
Scientists at the University of New South Wales in Australia have developed a method to produce human blood stem cell precursors from human pluripotent stem cells. The method may have use in treating cancer patients who require high doses of such blood stem cells to help replenish endogenous populations that have been destroyed by chemotherapy. The researchers exploited the tendency of cells to respond to mechanical stimuli and cultured the pluripotent stem cells in a microfluidic device that mimicked the pulsatile flow of the embryonic heartbeat. Given that human blood stem cells naturally form during embryonic develo...
Source: Medgadget - September 26, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Oncology UniSouthWales UNSW Source Type: blogs

Face Mask Detects Respiratory Viruses, Alerts User
Scientists at Shanghai Tongji University in China have created a face mask that can alert the wearer to the presence of respiratory viruses in the surrounding environment, including the viruses behind COVID-19 and influenza. The mask includes aptamers, which are short sequences of DNA or RNA that can bind to protein targets. When viral particles bind to the aptamers, ion-gated transistors boost the signal so that the mask can sensitively detect small amounts of virus. The mask sends a message to the wearer’s smartphone within 10 minutes of detecting the virus. The technology could be very valuable for healthcare staff or...
Source: Medgadget - September 22, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Public Health Source Type: blogs

Smartphone Camera Measures Blood Oxygen
At the University of Washington a research team has developed a smartphone system that can measure blood oxygen levels. The technology uses the camera and flash of the phone to take the measurement, and the system is so easy to use that it may be well suited for at-home use. A person presses their finger over the camera, which gets illuminated by the flash, and the camera measures how much light from the flash the finger absorbs, which a deep-learning algorithm can then correlate with blood oxygen levels. The system could be useful for COVID-19 patients who wish to monitor their progress at home and receive early warning o...
Source: Medgadget - September 21, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Anesthesiology Cardiology Diagnostics Emergency Medicine Telemedicine UW Source Type: blogs

3D Printed Light Sensor for Light-Sensitive Disease
At the University of Minnesota a team of researchers has developed a 3D printed light sensing wearable that can help people with light-sensitive diseases, such as lupus, to understand more about the types of light that can exacerbate their symptoms. Many people with lupus are sensitive to light, such as sunlight or even regular indoor light, but they may not know what specific light conditions are likely to cause flare-ups. This new device aims to provide such people with more information, so that they can learn more about their flare-ups and take steps to avoid or reduce them. The technology could lead to more personalize...
Source: Medgadget - September 19, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Dermatology Diagnostics Medicine UMNews Source Type: blogs

Soft Robot Biodegrades Inside Body
Researchers at the City University of Hong Kong have developed a magnetic soft millirobot that can grab and release objects, and move around by rolling. The device can be controlled using magnetic fields, and consists of a biodegradable gelatin and iron oxide microparticles. The technology has significant potential as a minimally invasive drug delivery system, perhaps in the gastrointestinal tract, and may even lead to soft robots that can carry out surgical procedures within the body. One of the nicest features of the device is its rapid biodegradation over the space of a couple of days, which means that it may not ha...
Source: Medgadget - September 19, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Surgery CityUHongKong microrobotics microrobots millirobot Source Type: blogs

Alveoli on a Chip to Reveal Airflow Characteristics in Disease and Drug Delivery
Researchers at the Harbin Institute of Technology in China have developed a microfluidic-style chip that models the alveoli present in our airways. The tiny air sacs in our lungs are crucial for gas exchange, but they can be difficult to study and model. A better understanding of airflow patterns in these structures could be very useful in informing the design of inhalable medications, understanding respiratory threats in the form of inhaled particulate pollutants, and also in understanding respiratory diseases. This new device models a branching point of the airways using a flexible polymer that has been molded into small...
Source: Medgadget - September 13, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Materials Medicine Source Type: blogs

3D Printed Tablets for Controlled Drug Release
Researchers at the University of the Basque Country have developed a technique that allows them to 3D print pharmaceutical tablets using different types of starch. By modifying the types of starch used and the shape of the tablets, the team can fine-tune drug release to be either rapid or slow. This includes full release of the encapsulated drug in as little as ten minutes to as long as six hours, providing significant scope to address a wide variety of therapeutic situations. The technique could allow for more personalized medicine for patient cohorts who require specialized dosing regimens, such as young children and eld...
Source: Medgadget - September 12, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine upvehu Source Type: blogs

Granular Hydrogels for Improved Bioinks
Researchers at Penn State have developed a granular hydrogel that contains both hydrogel microparticles and self-assembling nanoparticles, and which could be highly suited for bioprinting purposes. The concept involves the nanoparticles becoming adsorbed onto the hydrogel microparticles and reversibly adhering the microparticles together, providing a printed gel structure that is porous enough to permit cell viability, but which maintains a desired shape and mechanical properties. Unlike conventional hydrogels, which consist of long polymer strands that are interlinked and surrounded by water, and which require a substanti...
Source: Medgadget - September 12, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Surgery upenn Source Type: blogs

Motion Sensors to Detect Age-Related Disease
Researchers at the University of Bern in Switzerland have developed a motion tracking system that is intended to assist in detecting age-related disease in elderly people. The system could be installed in someone’s home or in assisted-living facilities, and consists of a series of motion sensors that can monitor for signs of unusual movement. The system can inform caregivers if an emergency arises, such as a fall, which can be detected when someone does not return to their bed at night or is stationary for a long period, for example. However, the researchers also envisage it as helping to provide early detection for a va...
Source: Medgadget - September 9, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Geriatrics Rehab unibern Source Type: blogs

Wearable Pneumatic Assistive Tech with Logic Gate Control
Researchers at Rice University have developed a textile control system, free of any electronics, for pneumatic wearable technology that is designed to be helpful for people with limited mobility. Medgadget recently covered the pneumatic ‘gripper’ developed by Rice researchers. Now, they have created a textile control system for such wearables, that consists of tubes through which compressed air can pass and a series of logic gates, similar to those used in computer systems, that can control the passage and pressure of the compressed air. The system would allow someone to direct the energy in the system, in the form of ...
Source: Medgadget - September 9, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Rehab riceuniversity Source Type: blogs

Surface Coating Rapidly Kills Pathogens, Lasts Months
A team at the University of Michigan has developed a coating for frequently touched surfaces that can rapidly kill a wide array of pathogens, including MRSA and SARS-CoV-2. The technology incorporates polyurethane that contains crosslinked compounds from essential oils with wide-spectrum anti-microbial action. The researchers fine-tuned the crosslinking process so that the oils were available to kill microbes but not sufficiently free to evaporate rapidly. Unlike anti-microbial surface coatings that are based on metals, such as copper or zinc, the new coating can kill microbes quite fast, in as little as two minutes. Howev...
Source: Medgadget - September 6, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Public Health umich Source Type: blogs

Pneumatic Assistive Device for People with Disabilities
Researchers at Rice University have developed a pneumatic assistive device for people with disabilities. The technology includes an air pump that is mounted in the wearer’s shoe, providing pneumatic power with each step. This power is stored in a wearable belt that includes an “arm” that can reach out and grip items when activated. The device may be very practical for people with arm weakness who struggle to lift objects. The research team also developed a shirt with a bellows mechanism in the armpit that lets a wearer pick up an object that weighs 10 pounds. The researchers are exploring the possibility of u...
Source: Medgadget - September 6, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Rehab riceuniversity Source Type: blogs

AI Device Monitors Breathing to Diagnose Parkinson ’s
Researchers at MIT have developed an AI system that can diagnose Parkinson’s disease and track its progression, simply by monitoring someone’s breathing patterns as they sleep. The device looks like an internet router and can be mounted on the wall in a bedroom. It emits radio waves and then a neural network analyzes the reflected waves to assess breathing patterns. Crucially, the technology may be able to assist in diagnosing Parkinson’s disease much earlier than many conventional techniques and it is highly convenient and non-invasive compared with traditional diagnostics. It may also be particularly beneficial in ...
Source: Medgadget - September 6, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Telemedicine mit parkinsons Source Type: blogs