MITF in the Regulation of Schwann Cell Nerve Repair Activity
The peripheral nervous system is far more capable of self-repair than the central nervous system. Nonetheless, nerve damage typically results in far less functional regeneration than is the case for other tissues. The research community is thus interested in finding ways to enhance existing repair processes. Here, researchers investigate a portion of the regulatory mechanisms that control the activity of Schwann cells in nerve repair, in search of targets for drug development programs aimed at enhancing regeneration of nerve damage, both in the peripheral nervous system, and also potentially in the central nervous system.
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Source: Fight Aging! - December 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The State Of CRISPR Clinical Trials And Their Future Potentials
CRISPR, short for “Clustered Regularly Interspaced Short Palindromic Repeats” – and more specifically CRISPR–Cas9 – relates to a gene-editing method that gained popularity in the past decade; and not for trivial reasons. Being the most efficient and accurate method to edit a cell’s genome, CRISPR holds potentials that range from treating conditions such as HIV to finding new drug targets.
While such potentials are real and are being actively investigated, you might be curious about more practical examples of CRISPR applications. By taking the US Clinical Trials registry as an example, we consider lis...
Source: The Medical Futurist - December 7, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF CRISPR therapy clinical trials gene editing Source Type: blogs
Award-Winning Safety Training Videos Showcase Inclusivity in the Lab
Virginia Commonwealth University’s (VCU’s) Center on Health Disparities and safety and risk management department in Richmond teamed up to develop a series of six lab safety training videos with supplemental funding to their NIGMS-funded Initiative for Maximizing Student Development (IMSD) program. The videos cover topics such as safety culture, biosafety, chemical safety, and emergency response, but what sets them apart is how they showcase diversity and inclusion in the lab.
The first video in the safety training series describes the importance of maintaining positive safety culture, which includes people’s p...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 6, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cool Videos Training Source Type: blogs
The Most Overhyped Technologies in Healthcare
The hype about technological development in healthcare should not blind us in terms of the probabilities and possibilities of today’s healthcare and the future of medicine. To remain objective and conscious but still optimistic, let’s look at the most overhyped technologies and keep in mind the realistic development opportunities in healing.
You know the saying: the pessimist says the glass is half empty, the optimist says it is half full, and, well, the cynic asks who drank the other half? I’m truly an optimist – especially when it comes to the future of medicine and healthcare, but we need to ask the uncom...
Source: The Medical Futurist - December 5, 2023 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine 3d printing robotics virtual reality wearables GC1 hype organs Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Can you try these two questions on Amyloid ?
Is it a physiological molecule ?
1.Yes, It is a physiological molecule.
2.No, Amyloid is always pathological.
Where does it gets deposited ?
A .Extracellular*
B. Intracellular
C. Both
Answer : Q 1: A / Q 2: C. It is indeed a physiological molecule in small amounts that help carry hormones across the blood. In pathology, it accumulates in huge amounts. It is a disorder of protein folding, making them thick, stiff , sheets of peptide, hence mis-behaving with adjacent cells, injuring them in the process. This is responsible for the systemic nature of disorder right from the brain to peripheral nerves, H...
Source: Dr.S.Venkatesan MD - December 1, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Alzheimer disease amyloidosis ttr amyloid what is amyloid Source Type: blogs
What Do We Need To Have AI-Equipped Nanobots In Medicine
Disease, noun [archaic]: A historical term used to describe various physical and mental ailments that affected organisms, primarily humans, in an era before the advent of comprehensive nanomedical and genetic interventions. In the technologically primitive past, diseases were common causes of discomfort, dysfunction, and mortality, often requiring medical treatment and care. Modern advances and nanobots in medicine have rendered this term obsolete, as conditions previously classified as diseases are now either preventable or entirely curable at the molecular level.
Are we on the brink of a brave new world where disease...
Source: The Medical Futurist - November 30, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Future of Medicine Nanotechnology nanobots nanobots in medicine AI Source Type: blogs
Associations Between Gut Microbiome and Risk of Age-Related Neurodegenerative Disease
It is becoming clear that there are correlations between the composition of the gut microbiome and risk of suffering neurodegenerative conditions such as Parkinson's disease and Alzheimer's disease. The gut microbiome changes with age, the populations of inflammatory microbes growing in size, while microbes that create beneficial metabolites are diminished in number. Even only considering the effects of additional chronic inflammation in later life, it is clear that a more inflammatory gut microbiome is harmful. There may be other ways in which gut-resident microbes can contribute to neurodegenerative conditions, however. ...
Source: Fight Aging! - November 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
AI ’ s Unforeseen Medical Discoveries: The Curious Case Of Unusual Associations
Artificial intelligence can do a plethora of astonishing things, which has been discussed thoroughly in the past year. We train models to assist medical work, from administration to image analysis, from triage to mental health support. And every now and then AI has curious medical discoveries, detecting things that – to the best of our human knowledge – should not be detectable from the input data. Like knowing the race of the patient from chest X-rays alone. These unusual associations present brand-new challenges to medical professionals.
In these cases, the medical detective work has a new aim: to understa...
Source: The Medical Futurist - November 28, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Artificial Intelligence in Medicine digital health Healthcare technology AI Source Type: blogs
Genetic testing may help cure or condemn those who suffer from addiction
In a recently published study, it was found that a set of 4 genes (JUN, CEBPB, PRKCB, ENO2, or CEBPG) was shown to predict the diagnosis of heroin addiction with an accuracy rate of around 85 percent. This is an amazing development and could open the door to knowing who is at high risk of
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Genetic testing may help cure or condemn those who suffer from addiction originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 26, 2023 Category: General Medicine Authors: L. Joseph Parker, MD Tags: Conditions Genetics Source Type: blogs
Revolutionizing patient care: the convergence of AI and personalized medicine
In the dynamic realm of health care, two revolutionary forces are converging to redefine patient care: artificial intelligence (AI) and personalized medicine. This synergy transforms how we understand, diagnose, and treat diseases, tailoring health care to each patient’s needs. The emergence of personalized medicine Personalized medicine, at its core, is about understanding the unique genetic,
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Revolutionizing patient care: the convergence of AI and personalized medicine originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 25, 2023 Category: General Medicine Authors: Harvey Castro, MD, MBA Tags: Tech Health IT Source Type: blogs
An Aging Clock Derived from Images of the Lens of the Eye
In this study, we used informative lens photographs to generate LensAge as an innovative indicator to reveal aging status of lens based on deep learning (DL) models. Under ideal physiological conditions (both genetic and environmental), biological age should be synchronized with chronological age. While in reality, there are almost always differences between biological age and chronological age, which is considered to result from individually different aging processes. Therefore, we measured the difference between LensAge and chronological age as the LensAge index to assess an individual's aging rate relative to peers, and...
Source: Fight Aging! - November 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Therapy to Reduce Lipoprotein(a) Levels
The research and development community is ever in search of the next statin drug, and a way to reduce lipoprotein(a) levels looks very much like an alternative statin. Statins reduce the amount of cholesterol carried by LDL particles in the bloodstream. Lipoprotein(a) is a carrier of cholesterol, like LDL, and research has shown that high levels correlate with the development of atherosclerotic lesions, as is the case for LDL-cholesterol. That being so, one can't be all that optimistic that a treatment to reduce lipoprotein(a) will actually do much for disease risk. Statins reduce risk of stroke and heart attack resulting ...
Source: Fight Aging! - November 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Will We All Have To Become Biologically Enhanced Superhumans?
Okay, hands up who can tell who’s the most famous biologically enhanced superhuman in the world? True, it’s a quite close call between Captain America and The Incredible Hulk (sorry Spidey, you’re not even close). But are human-invented superhumans just a thing of a Stan Lee comic, or is it an actual scientific idea from a real laboratory?
As a matter of fact, enhancing human capabilities has been on the minds of people for ages, but it has come a long way from ancient training methods to exoskeletons. Enhancing our abilities, be it permanently or temporarily is a tempting but risky matter. Will it be possibl...
Source: The Medical Futurist - November 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Forecast Artificial Intelligence in Medicine Augmented Reality Bioethics Biotechnology Cyborgization Digital Health Research E-Patients Genomics Health Sensors & Trackers Healthcare Policy Medical Education Robotics Science Ficti Source Type: blogs
Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
