Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A man in his 70s with weakness and syncope
DiscussionBrugada Type 1 ECG changes are associated with sudden cardiac death (SCD) and the occurrence of ventricular dysrhythmias. Patients that develop a Type 1 pattern without any precipitating or provoking factors have a risk of SCD of 0.5-0.8% per year. In patients that only have this pattern induced by a sodium channel blocking agent have a lower rate of SCD (0 - 0.35% per year)[1]. Drugs that have been associated with Brugada ECG patterns include tricyclic antidepressants, anesthetics, cocaine, methadone, antihistamines, electrolyte derangements, and even tramadol. [2]. Our patient had a Brugada Type ...
Source: Dr. Smith's ECG Blog - July 22, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
Reduced APRT Expression Extends Life in Killifish
Researchers here note that reducing APRT expression affects extends life in short-lived killifish via mechanisms likely related to the calorie restriction response. This regulation of the pace of aging in response to nutrient availability is arguably the most well studied aspect of the biology of aging, but the production of calorie restriction mimetic strategies (such as this one) seems unlikely to result in meaningful therapies for humans. Short-lived species exhibit a much greater extension of life span in response to a low calorie diet than occurs in long-lived species like our own. Mice can live as much as 40% longer ...
Source: Fight Aging! - July 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Further Work on Small Molecules that Can Induce Cell Reprogramming
In this study, we developed and utilized novel screening methods including a quantitative nucleocytoplasmic compartmentalization assay (NCC) that can readily distinguish between young, old, and senescent cells. We identify a variety of novel chemical cocktails capable of rejuvenating cells and reversing transcriptomic age to a similar extent as OSK overexpression. Thus, it is possible to reverse aspects of aging without erasing cell identity using chemical rather than genetic means. (Source: Fight Aging!)
Source: Fight Aging! - July 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
CRISPR-Cas13 Test Inexpensively and Rapidly Reveals HIV Viral Load
Scientists at Penn State have developed an assay that lets them to directly measure HIV viral load in a drop of blood. The technology is also faster and less expensive than current approaches. At present, RT-PCR is typically used to assess HIV levels in a patient’s blood, requiring genetic material to be amplified before it can be measured. This is time-consuming and does not provide a direct measurement of viral loads, but rather a close estimate. This new technology, called Self-digitization Through Automated Membrane-based Partitioning (STAMP), aims to directly measure viral levels in just a drop of blood. It involves...
Source: Medgadget - July 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Public Health Source Type: blogs
Pulmonary Arterial Hypertension: Unraveling Its Impact On Heart And Lungs
Conclusion
Navigating the complexities of Pulmonary Arterial Hypertension (PAH) might seem daunting. However, with the right knowledge and proactive approach, it’s possible to manage the condition and maintain a good quality of life.
PAH, a unique type of high blood pressure affecting the arteries in the lungs, can put extra strain on the heart. Over time, this can lead to heart failure. The condition’s root cause may vary, from genetic factors to other health issues like heart defects, liver disease, or autoimmune diseases. Remember, sometimes the cause remains unknown, resulting in idiopathic pulmonary ...
Source: The EMT Spot - July 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
A Small Molecule to Reduce Mitochondrial Generation of Oxidative Stress
Researchers here report on an improved version of compounds known to reduce the generation of oxidizing molecules by mitochondria. Mitochondrial dysfunction can produce sustained oxidative stress that changes cell behavior for the worse, contributing to aspects of aging. That targeting antioxidants to the mitochondria or upregulating natural antioxidant molecules can produce some benefit to health suggests that the size of the contribution is meaningful. The details matter, however, and as cells use mild mitochondrial oxidative stress to trigger beneficial maintenance activities, with the metabolic response to exercise bei...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pre-A & P: A Refresher for Student Success in Anatomy & Physiology | TAPP 140
In episode 140, we introduce the development of thepre-A&P course and theA&P1 Supplement course. These coursesaddress the challenges faced by A&P students and improve theirreadiness and comprehension. In this first of two episodes, we focus on the pre-A&P course. It focuses on filling subject knowledge gaps with 10 modules and cumulative tests. Student surveys and studies show its effectiveness inachieving higher grades in the A&P 1 course. Implementing these nontraditional coursesrequires collaboration and support from advisors and faculty members. Together, we aim tobridge the gap in subject pre...
Source: The A and P Professor - July 18, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Primary Hypertension: The Unseen Risk For Healthy People
Conclusion
In conclusion, even the healthiest individuals can develop primary hypertension, a condition that affects a significant portion of the U.S. adult population. With its roots often hidden in our genetic makeup and influenced by various lifestyle factors, hypertension can quietly disrupt our wellbeing, earning its nickname as the “silent killer.”
Real-life experiences, such as Martin Cassels’, highlight that maintaining an active, healthy lifestyle doesn’t render one immune to this condition. However, it underscores the importance of regular health check-ups and the value of a second o...
Source: The EMT Spot - July 13, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Towards Depletion of Microglia as a Treatment for Alzheimer's Disease
In recent years, increasing attention has been given to the role of microglia in neurodegenerative conditions. Microglia are innate immune cells of the central nervous system, analogous to macrophages elsewhere in the body, but which also participate in the organization of synaptic connections in addition to the other roles one might expect from immune cells. Microglia in the aging brain become more inflammatory and overactive with age. Some become senescent. This contributes to the chronic inflammation of brain tissue observed in older individuals, and which contributes to the onset and progression of neurodegenerative co...
Source: Fight Aging! - July 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Recombinant Klotho Treatment Improves Cognitive Function in Old Rhesus Macaques
Klotho is one of the few genuinely longevity-associated genes, in that greater than normal expression increases life span in mice, while lower than normal expression shortens life span in mice. In humans, greater levels of circulating soluble klotho correlate with greater longevity. Klotho is thought to operate in the kidneys, in some way that is protective against the mechanisms of age-related decline, but there is a great deal of evidence for greater circulating klotho to improve cognitive function. At the same time, it seems unclear as to whether klotho is actually doing anything in the brain; it may be that the benefit...
Source: Fight Aging! - July 12, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing Efforts to Use Cells and Scaffolds to Regenerate the Heart
The heart is one of the least regenerative tissues in the body. Damage resulting from loss of blood flow during a heart attack leads to scarring and loss of function, rather than any meaningful degree of regeneration. While preventing the atherosclerosis that causes occlusion of blood vessels is the most desirable goal, finding ways to repair a damaged heart is also a high priority for the research community. Many groups have worked towards regenerative therapies based on delivery of cells and scaffolding material, even layers of artificial tissue made by combining the two, but progress has been frustratingly slow.
...
Source: Fight Aging! - July 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Uncovering the truth about genetic mutations and weight loss
“I do not feel full even after I eat” is what I heard from so many of my patients. Even after bariatric surgery, this feeling of fullness would go away initially but then it would come back, and they found themselves again overindulging. Why does this happen? Brain studies have shown that obesity impairs the
Read more…
Uncovering the truth about genetic mutations and weight loss originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 10, 2023 Category: General Medicine Authors: Franchell Hamilton, MD Tags: Conditions Obesity Source Type: blogs
Mobilization for Truth, or Survival?
Scott Frickel, of my own university, and Fernando Tormos-Aponte of the University of Pittsburgh,have recently reviewed studies of what they call " science activism " and find that it is " surging, " which they refer to as a " culture shift " among scientists. They write:Science activism has long been considered taboo, as many in the field fear thatpoliticizing science undermines its objectivity.
Even so, scientist-activists have still managed to shape the U.S.
political landscape throughout history. Over the past century, for
example, scientists have protestedthe atomic bomb,pesticides,wars in Southeast Asia,genet...
Source: Stayin' Alive - July 10, 2023 Category: American Health Source Type: blogs
