Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

mTORC1 Inhibition in Neurons Only Extends Life in Nematode Worms
General inhibition of mTOR slows aging, a calorie restriction mimetic effect, but comes with a range of side-effects, given that mTOR is a regulator of growth and development. mTOR forms two different protein complexes, mTORC1 and mTORC2. In recent years, work to produce drugs based on mTOR inhibition has focused on selectively inhibiting mTORC1 in order to reduce side-effects. Researchers here report further reduction in side-effects in short-lived nematode worms by restricting mTORC1 inhibition to neurons only. mTORC1 (mechanistic target of rapamycin complex 1) is a metabolic sensor that promotes growth when nut...
Source: Fight Aging! - October 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Towards More Selective Senolytic Drugs to Clear Senescent Cells from Aged Tissues
Cells enter a senescent state constantly throughout life, largely as a result of reaching the Hayflick limit on cellular replication, but also due to damage and stress. Senescent cells cease to replicate and begin to secrete pro-inflammatory, pro-growth signals. This attracts the immune system to sites of potential concern, and in the case of physical injuries to tissue the signaling of senescent cells helps to coordinate repair. Senescent cells are normally cleared from tissues fairly quickly, being destroyed either by immune cells, or via programmed cell death mechanisms. With age, however, the pace of clearance slows an...
Source: Fight Aging! - October 4, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

What is Known of the Mechanisms of Age-Related Hearing Loss
Hearing loss is prevalent in older individuals, either involving the destruction of sensory hair cells in the inner ear, or the axonal connections between those hair cells and the brain, or both. Hair cells do not normally regenerate to any great degree in adults, which has led to efforts to grow patient matched replacement cells, or reprogram native cells to convince them to produce new hair cells. Despite promising advances, it is not as yet a solved problem. Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly people worldwide. It typically presents as progressive, irreversible...
Source: Fight Aging! - October 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Gene Stewards: Rethinking Genome Governance
Shelly Simana (Stanford Law School), Gene Stewards: Rethinking Genome Governance, 14 UC Irvine L. Rev. (forthcoming 2024): Various entities, such as genetic testing and biotech companies, biobanks, research institutions, and government agencies, collect, analyze, and share human genetic material and... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - October 4, 2023 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs

8 Practical Predictions For The Near Future Of Healthcare
This article aims to bridge that gap, providing a condensed overview beneficial for healthcare professionals and users alike. 1) Patients will become the point of care In the pursuit of more streamlined and patient-centric healthcare, traditional hospital frameworks are under reassessment. The stereotypical scenes of long waiting lines, overwhelming paperwork, and sterile, uninviting corridors symbolize a dated workflow. The evolution towards modernity beckons a shift from this conventional setup, ushering in an era where patients, armed with digital health tools, become the focal point of care, reducing the dependen...
Source: The Medical Futurist - October 3, 2023 Category: Information Technology Authors: Andrea Koncz Tags: Future of Medicine AI artificial intelligence digital health Source Type: blogs

Case Western Reserve University ’s Law-Medicine Center Presents: When Doctors Become Cops; 12:00PM – 1:00PM on Monday, October 16th, 2023.
The lines between law enforcement and health care are blurring. Police lean on doctors to provide them with genetic samples, prescription... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - October 2, 2023 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs

Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension. « Back to Top A Relationship Between the Gut Microbiome and Bone Density https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/ Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Critical Perspective of Misappropriation of Human Genetic Materials Through Patents
Chinenye Eze (University of British Columbia), A Critical Perspective of Misappropriation of Human Genetic Materials Through Patents (2023): In this paper, I examine the problem of misappropriating human genetic materials through patents using the critical intellectual property perspective. There is... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - October 1, 2023 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs

Unraveling the complex enigma of obesity [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! We sit down with Franchell Hamilton, a bariatric surgeon, to explore the intriguing link between genetics, brain function, and obesity. She shares her insights into why many patients don’t feel full even after eating, even post-bariatric surgery. We delve into the role of dopamine Read more… Unraveling the complex enigma of obesity [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 30, 2023 Category: General Medicine Authors: Tags: Podcast Obesity Source Type: blogs

Beta Cell Senescence in Multiple Forms of Diabetes
The growing focus on cellular senescence as a contributing cause of aging has identified senescent cells as important agents in a range of conditions, age-related and otherwise. Interestingly, the pathology of both type 1 and type 2 diabetes appears to be mediated by senescent beta cells in the pancreas. Clearing senescent cells has been shown to be beneficial in animal models of these conditions, but it remains to be seen as to whether human patients will benefit. There are many conditions that might be treated with senolytic therapies to selectively destroy senescent cells, and only so many research groups and companies ...
Source: Fight Aging! - September 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

In Search of Cancer Resistance Strategies in Large Cetaceans
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension. Link: https://doi.org/10.24272/j.issn.2095-8137.2023.058 (Source: Fight Aging!)
Source: Fight Aging! - September 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Diversity Supplement Program Paves the Way for Talented Researchers
“I hope that one day I’m able to increase our understanding of evolution, and I also hope to increase access to research. I want others to know that this space is open to people who look like me, who come from disadvantaged backgrounds, and who are underrepresented in the sciences,” says Nkrumah Grant, Ph.D., a postdoctoral research associate (postdoc) in microbiology and molecular genetics at Michigan State University (MSU) in East Lansing. Dr. Grant’s work receives support from the NIGMS Diversity Supplement Program (DSP), which is designed to improve the recruitment and training of promising researchers from ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 27, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Diseases Microbes Profiles Training Source Type: blogs

Having Tackled Workflows and Image Enhancement, Generative AI Targets Diagnostics
The following is a guest article by Morris Panner, President at Intelerad Medical Systems By 2034, the U.S. could face a shortage of up to 124,000 physicians due, in part, to burnout. In the medical imaging field, specifically, this challenge isn’t exactly new – but the technology that could help remedy the problem is. The usage of this potential solution in the imaging space has been delayed due to the perception it’s a bit of a rule-breaker. A fairly recent arrival to radiology, Generative AI has emerged as a powerful resource, showing promise in a variety of tasks, from supporting streamlined workflows to syntheti...
Source: EMR and HIPAA - September 26, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Ambulatory Clinical Health IT Company Healthcare IT Hospital - Health System Clinical Workflow Generative AI Intelerad Medical Systems Medical Images Morris Panner Physician Burnout Physician Shortage Radiolog Source Type: blogs

CD44 Expression Correlates with Species Longevity
The study of large differences in longevity between otherwise similar species has produced interesting insights into how biochemical and genetic differences might contribute to species life span. As of yet, the field has failed to produce much in the way of actionable insights, however. The recent transfer of a gene from naked mole rats to mice was notable for being one of only a few such exercises conducted with increased life span as a goal. Still, the wheel turns, and we may expect to see an increasing application of what is known of the genetics of species longevity in the decades ahead. The naked mole rat (N...
Source: Fight Aging! - September 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs