Fight Aging! Newsletter, September 4th 2023

In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.

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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/

Neurogenesis is the process by which new neurons are created by neural stem cells, thereafter maturing and integrating into existing neural circuits. This is most studied in the hippocampus, where continual change in the circuits of the brain is essential to memory. With age, the pace of neurogenesis declines, as one might expect given what is known of the progressive loss of stem cell activity in later life. This is thought to contribute to cognitive decline in general, and to loss of memory function specifically.

In today's open access paper, researchers report on a study in which they disabled neurogenesis in mice to observe the resulting loss of memory function. Along the way they found evidence for a compensatory process that operates when neurogenesis falters, but operates poorly. The process can be dramatically improved by provoking a greater secretion of stored acetylcholine. This prevents loss of memory function, desp...

Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs