FDA Panel Endorses Islet Cell Treatment for Type 1 Diabetes FDA Panel Endorses Islet Cell Treatment for Type 1 Diabetes
Voting 12-4 to support approval, panel members expressed concern about toxicity of long-term immunosuppression, particularly given the advances in diabetes technology that now offer improved control.Medscape Medical News (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - April 16, 2021 Category: Transplant Surgery Tags: Diabetes & Endocrinology News Source Type: news

Organ Harvesting's Troubled Past — and Complicated Present Organ Harvesting's Troubled Past — and Complicated Present
With the rise of organ transplantation came difficult ethical questions on race, economics, and the meaning of life.Undark (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - April 15, 2021 Category: Transplant Surgery Tags: Transplantation Commentary Source Type: news

Scientists Have Created Embryos That Are Part Human, Part Monkey
The long-term goal is to grow organs for human transplantation. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - April 15, 2021 Category: Pharmaceuticals Authors: Robert Hart, Forbes Staff Tags: Business /business Innovation /innovation Healthcare /healthcare Science /science Breaking breaking-news Editors' Pick editors-pick Source Type: news

Scientists Create Embryos With Cells From Monkeys, Humans
THURSDAY, April 15, 2021 -- Researchers have successfully introduced human stem cells into monkey embryos in the lab, creating short-lived hybrid organisms that could prove an important step in growing human transplant organs from livestock or... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 15, 2021 Category: General Medicine Source Type: news

Scientists Report Creating the First Embryo With Human and Non-Human Primate Cells
In a ground-breaking experiment, researchers have successfully created the first human-monkey chimera. The work, published in the journal Cell, describes the the first embryo containing both human and monkey cells that was cultured for 20 days. Led by Juan Carlos Izpisua Belmonte, the study represents the culmination of decades of work in understanding early embryo development in non-human species, which Belmonte hopes will now apply to humans. But it is bound to raise serious ethical questions about the implications of combining human cells with those from a different species (even if it is a closely related one), and the...
Source: TIME: Health - April 15, 2021 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Source Type: news

The effect of a microbial ecosystem therapeutic (MET-2) on recurrent Clostridioides difficile infection: a phase 1, open-label, single-group trial, The lancet
This study is registered with ClinicalTrials.gov, NCT02865616 FINDINGS: Between Sept 19, 2018, and Feb 28, 2020, we enrolled 19 adult patients with at least two episodes of mild to moderate C difficile infection (median age 65 years [IQR 56-67]; 12 women [63%], seven men [37%]). Recurrent C difficile infection was absent at day 40 in 15 (79%) of 19 patients after initial treatment, increasing to 18 (95%) 40 days after retreatment. No mortality associated with C difficile infection, infections associated with MET-2 treatment, or other serious adverse events were observed. The most common self-limited, mild to moderate sympt...
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news

Scientists Create Early Embryos That Are Part Human, Part Monkey
An international team has put human cells into monkey embryos in hopes of finding new ways to produce organs for transplantation. But some ethicists still worry about how such research could go wrong.(Image credit: Weizhi Ji/Kunming University of Science and Technology) (Source: NPR Health and Science)
Source: NPR Health and Science - April 15, 2021 Category: Consumer Health News Authors: Rob Stein Source Type: news

Personalized Cancer Vaccine Shows Early Promise Across Tumor Types Personalized Cancer Vaccine Shows Early Promise Across Tumor Types
In a phase 1 trial, the vaccine, called PGV-001, was well tolerated. It was given to 13 patients with multiple myeloma who had a high risk of recurrence after surgery or autologous stem cell transplant.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 15, 2021 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Sudden Cardiac Death in Dialysis Patients Sudden Cardiac Death in Dialysis Patients
What factors may contribute to sudden cardiac death in in end-stage kidney disease patients receiving dialysis -- and what strategies may help prevent these events?Nephrology Dialysis Transplantation (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - April 15, 2021 Category: Intensive Care Tags: Nephrology Journal Article Source Type: news

The Costs of Human Uterus Transplantation The Costs of Human Uterus Transplantation
This study aimed to estimate the total societal cost of a live donor uterus transplant in a European setting.Human Reproduction (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 14, 2021 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news

Tiny wireless implant detects oxygen deep within the body
(University of California - Berkeley) Engineers at the University of California, Berkeley, have created a tiny wireless implant that can provide real-time measurements of tissue oxygen levels deep underneath the skin. The device, which is smaller than the average ladybug and powered by ultrasound waves, could help doctors monitor the health of transplanted organs or tissue and provide an early warning of potential transplant failure. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 14, 2021 Category: International Medicine & Public Health Source Type: news

Physical inactivity is linked to more severe coronavirus infection, death, says new study
The study, published in the British Journal of Sports Medicine, showed that physical inactivity was surpassed only by advanced age and a history of organ transplant as a risk factor for severe disease. (Source: The Economic Times)
Source: The Economic Times - April 14, 2021 Category: Consumer Health News Source Type: news

Physical Inactivity Linked To More Severe Covid-19 Infection And Death
Surpassed only by advanced age and organ transplant as a risk factor, large study shows. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - April 13, 2021 Category: Pharmaceuticals Authors: Misha Gajewski, Contributor Tags: Healthcare /healthcare Innovation /innovation Source Type: news

Closer to human -- Mouse model more accurately reproduces fatty liver disease
(Baylor College of Medicine) Researchers have developed a novel mouse model that reproduces many key features of human non-alcoholic fatty liver disease (NAFLD), a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

Researchers awarded $500,000 to test novel strategies using mitochondria therapy
(University of Tennessee Health Science Center) Researchers from the University of Tennessee Health Science Center have received a $500,000 grant over three years from the Department of Defense to test a novel strategy using mitochondria transplantation therapy for restoration of neuromuscular structure and function after injury. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 12, 2021 Category: International Medicine & Public Health Source Type: news

Deep Learning model developed at UHN to maximize lifespan after liver transplant  
(University Health Network) Researchers from University Health Network have developed and validated an innovative deep learning model to predict a patient's long-term outcome after receiving a liver transplant. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 12, 2021 Category: International Medicine & Public Health Source Type: news

First Living Donor Transplant of Lung Tissue to COVID - 19 Patient Announced
Female recipient received lung tissue donated by her husband and son (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - April 10, 2021 Category: Respiratory Medicine Tags: Infections, Pulmonology, Surgery, Institutional, Source Type: news

Stool transplants treat bowel infection by boosting bowel-protecting cells, study finds
Stool transplants effectively treat bacterial infections in the colon by boosting levels of specific molecules that help protect bowel cells, according to a study published Friday by Gastroenterology. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 9, 2021 Category: Consumer Health News Source Type: news

First Living Donor Transplant of Lung Tissue to COVID-19 Patient Announced
FRIDAY, April 9, 2021 -- The world's first transplant of lung tissue from living donors to a COVID-19 patient with severe lung damage was announced Thursday by doctors in Japan. In the 11-hour operation at Kyoto University on Wednesday, the female... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 9, 2021 Category: Pharmaceuticals Source Type: news

Social Factors Affect Treatment for Mantle Cell Lymphoma
Unmarried, less - educated patients less likely to receive autologous hematopoietic cell transplantation (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 9, 2021 Category: Cancer & Oncology Tags: Oncology, Pathology, Journal, Source Type: news

Transplant Saves Selected Patients With Irreversible COVID-19 Lung Disease Transplant Saves Selected Patients With Irreversible COVID-19 Lung Disease
Double lung transplants are the only known way to save the lives of people with acute respiratory distress syndrome and irreversible lung damage from COVID-19, a new study shows.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - April 9, 2021 Category: Intensive Care Tags: Infectious Diseases News Source Type: news

Mortality Risk Up for Dialysis Patients in March to July 2020
FRIDAY, April 9, 2021 -- Patients undergoing dialysis and those with kidney transplants had increased mortality risk in 2020 compared with 2017 to 2019, according to a study published online April 8 in the Journal of the American Society of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 9, 2021 Category: Pharmaceuticals Source Type: news

Social Factors Affect Treatment for Mantle Cell Lymphoma
FRIDAY, April 9, 2021 -- Autologous hematopoietic cell transplantation (AHCT) is associated with a lower likelihood of death among adult mantle cell lymphoma (MCL) patients, but certain sociodemographic factors may affect the selection of candidates... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 9, 2021 Category: Pharmaceuticals Source Type: news

COVID-19 Patient Receives Lung Transplant From Living Donors
TOKYO — Doctors in Japan announced Thursday they have successfully performed the world’s first transplant of lung tissue from living donors to a patient with severe lung damage from COVID-19. The recipient, identified only as a woman from Japan’s western region of Kansai, is recovering after the nearly 11-hour operation on Wednesday, Kyoto University Hospital said in a statement. It said her husband and son, who donated parts of their lungs, are also in stable condition. The university said it was the world’s first transplant of lung tissue from living donors to a person with COVID-19 lung damage. T...
Source: TIME: Health - April 9, 2021 Category: Consumer Health News Authors: MARI YAMAGUCHI / AP Tags: Uncategorized COVID-19 overnight wire Source Type: news

A new international consortium to promote stem cell-based therapy for Huntington's disease
(University of Barcelona) The Stem Cells for Huntington's Disease (SC4HD) is a new international consortium created to promote advanced therapy medicinal product (ATMP) through cell transplantation studies on Huntington's Disease. The entity, made up of twenty-eight renowned researchers from ten countries, has been officially presented in a recent publication in the Journal of Huntington's Disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 9, 2021 Category: International Medicine & Public Health Source Type: news

Moderna vaccine antibodies last at least 6 months; lung transplant can save some COVID-19 survivors
​​Earlier this month, Pfizer Inc and partner BioNTech SE said their vaccine using similar messenger RNA (mRNA) technology remained highly effective for at least six months. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 9, 2021 Category: Pharmaceuticals Source Type: news

New Research Models Offer Promise for Understanding the Human Brain and Finding Pathways to Therapies, But Also Raise Profound Ethical Questions
New models for studying the human brain — human neural organoids, transplants, and chimeras — show promise for advancing understanding of the brain and laying the groundwork for new therapeutic approaches to brain diseases that have so far proved hard to treat, says a new report from the National Academies of Sciences, Engineering, an d Medicine. (Source: News from the National Academies)
Source: News from the National Academies - April 8, 2021 Category: Science Source Type: news

Diabetes Diagnosis Varies Among People of African Descent Diabetes Diagnosis Varies Among People of African Descent
The relationship between A1c and glycemia appears to differ across African, African American, and Afro-Caribbean populations.Medscape Medical News (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - April 8, 2021 Category: Transplant Surgery Tags: Diabetes & Endocrinology News Source Type: news

COVID-19 patient receives lung transplant from living donors
Doctors in Japan say they have successfully performed the world’s first transplant of lung tissue from living donors to a patient with severe lung damage from COVID-19 (Source: ABC News: Health)
Source: ABC News: Health - April 8, 2021 Category: Consumer Health News Tags: Health Source Type: news

GI Symptoms and Fecal Microbiota Transplant in COVID-19 GI Symptoms and Fecal Microbiota Transplant in COVID-19
Might fecal microbiota transplantation be a potential therapeutic and rehabilitative intervention for treatment of COVID-19 gastrointestinal disturbances?Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 8, 2021 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
Liquid biopsies that analyze cell-free DNA in blood plasma are used for noninvasive prenatal testing, oncology, and monitoring of organ transplant recipients. DNA molecules are released into the plasma from various bodily tissues. Physical and molecular features of cell-free DNA fragments and their distribution over the genome bear information about their tissues of origin. Moreover, patterns of DNA methylation of these molecules reflect those of their tissue sources. The nucleosomal organization and nuclease content of the tissue of origin affect the fragmentation profile of plasma DNA molecules, such as fragment size and...
Source: ScienceNOW - April 8, 2021 Category: Science Authors: Lo, Y. M. D., Han, D. S. C., Jiang, P., Chiu, R. W. K. Tags: Medicine, Diseases, Online Only review Source Type: news

OCS Heart System Earns Hard-Won Backing of FDA Panel OCS Heart System Earns Hard-Won Backing of FDA Panel
The nonbinding vote moves forward the device, which advocates hailed as a potentially transformative step for heart transplantation.Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 7, 2021 Category: Surgery Tags: Cardiology News Source Type: news

Estimating costs of uterine transplantation
(University of Gothenburg) Sweden's acclaimed research on uterine transplants has taken a new step forward: into the field of health economics. Now, for the first time, there is a scientifically based estimate of how much implementing the treatment costs. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 7, 2021 Category: International Medicine & Public Health Source Type: news

First U.S. Trachea Transplant Patient Breathing Freely
So far, patient has not had any complications or signs of rejection (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - April 7, 2021 Category: Respiratory Medicine Tags: Pulmonology, Surgery, Institutional, Source Type: news

The Water Was Bad Before COVID, Now Trust Is Hard to Win Back The Water Was Bad Before COVID, Now Trust Is Hard to Win Back
A $28.5 million settlement to clean the water in a rural county of Alabama came through right before the pandemic hit, but can the still-recovering community trust health workers to help?Medscape Medical News (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - April 6, 2021 Category: Transplant Surgery Tags: Medscape Today News Source Type: news

First U.S. Trachea Transplant Patient Breathing Freely
TUESDAY, April 6, 2021 -- A woman who received the first trachea transplant in the United States could be a model for other patients, including those with birth defects, those with untreatable airway diseases, and COVID-19 survivors left with... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 6, 2021 Category: Pharmaceuticals Source Type: news

Woman Takes A Deep Breath After First Successful Tracheal Transplant
A 56-year-old woman with a history of severe asthma has successfully received a donor tracheal transplant. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - April 6, 2021 Category: Pharmaceuticals Authors: Nina Shapiro, Contributor Tags: Healthcare /healthcare Innovation /innovation Source Type: news

Woman Recovering After Rare Windpipe Transplant From Donor Woman Recovering After Rare Windpipe Transplant From Donor
Doctors say the drastic operation could potentially help other people left with serious windpipe damage from ventilators, including patients with COVID-19.Associated Press (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 6, 2021 Category: Surgery Tags: Pulmonary Medicine News Source Type: news

‘There Was Nothing Anybody Could Do for These Patients.’ Now There Is.
The first successful direct transplant of a trachea is a medical milestone that could help thousands of people with airways damaged by ventilators and other causes. (Source: NYT Health)
Source: NYT Health - April 6, 2021 Category: Consumer Health News Authors: Pam Belluck Tags: Trachea Medical Devices Surgery and Surgeons Transplants Organ Donation Mount Sinai Medical Center Macchiarini, Paolo Genden, Eric M Sr your-feed-science Neck Source Type: news

First US trachea transplant offers hope to Covid patients with windpipe damage
Social worker, 56, treated at Mt Sinai hospital in New YorkSome patients left with serious damage from ventilatorsSurgeons in New York City have performed the first windpipe transplant in the US, giving a woman who suffered severe asthma a new trachea, the tube that transports air from the mouth to the lungs.Doctors say such operations could help Covid-19 patients left with serious windpipe damage from breathing machines.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - April 6, 2021 Category: Science Authors: Associated Press in New York Tags: Medical research Science US healthcare US news Source Type: news

Woman recovering after rare windpipe transplant from donor
Doctors say a woman is breathing freely again after undergoing a windpipe transplant from a donor (Source: ABC News: Health)
Source: ABC News: Health - April 6, 2021 Category: Consumer Health News Tags: Health Source Type: news

New Real-World Observational Analysis of UPTRAVI ® (selexipag) Underscores the Importance of Risk Assessment for Treating Pulmonary Arterial Hypertension (PAH) Patients
SOUTH SAN FRANCISCO, CA – April 6, 2021 – Findings from an analysis of the first 500 patients enrolled in the SPHERE registry (SelexiPag: tHe usErs dRug rEgistry) found more than three-quarters (76%) of pulmonary arterial hypertension (PAH) patients treated with UPTRAVI® (selexipag) either maintained (56%) or reduced (20%) their one-year mortality risk score. The SPHERE results were published in the April issue of the Journal of Heart and Lung Transplantation (JHLT). SPHERE is an ongoing real-world, observational, user registry using two different risk assessment methods that describes the clinical characte...
Source: Johnson and Johnson - April 6, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Woman Gets New Windpipe In Groundbreaking Transplant Surgery
A medical team in New York City says it has performed the first complete surgical transplant of a trachea. These kinds of transplants are one of the last big transplant challenges.(Image credit: Claudia Paul/Mount Sinai Health System) (Source: NPR Health and Science)
Source: NPR Health and Science - April 6, 2021 Category: Consumer Health News Authors: Richard Harris Source Type: news

Is COVID-19 More Severe in Kidney Transplant Recipients? Is COVID-19 More Severe in Kidney Transplant Recipients?
A new study examines the question of whether kidney transplant recipients may realize worse COVID-19 outcomes compared with nontransplant patients.American Journal of Transplantation (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - April 6, 2021 Category: Transplant Surgery Tags: Transplantation Journal Article Source Type: news

First Successful Trachea Transplant a Medical Milestone
The first successful direct transplant of a trachea is a medical milestone that could help thousands of people with airways damaged by ventilators and other causes. (Source: NYT Health)
Source: NYT Health - April 6, 2021 Category: Consumer Health News Authors: Pam Belluck Tags: Trachea Medical Devices Surgery and Surgeons Transplants Organ Donation Mount Sinai Medical Center Macchiarini, Paolo Genden, Eric M Sr your-feed-science Neck Source Type: news

Liver Transplant Emerges for Hepatic Mets in Colorectal Cancer Liver Transplant Emerges for Hepatic Mets in Colorectal Cancer
A new indication for a scarce resource?Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 5, 2021 Category: Surgery Tags: Hematology-Oncology News Source Type: news

NIH scientists develop breath test for methylmalonic acidemia
Test for rare genomic condition measures disease severity and success of liver transplantation for patients. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - April 5, 2021 Category: American Health Source Type: news

NIH scientists develop breath test for methylmalonic acidemia
(NIH/National Human Genome Research Institute) Researchers at the National Institutes of Health have developed a breath test that measures how well patients with methylmalonic acidemia (MMA) respond to receiving liver or combined liver and kidney transplantation. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 5, 2021 Category: Biology Source Type: news

Researchers develop a technique to produce transplantable livers in the laboratory
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) An extracellular matrix obtained by controlled decellularization is used to reconstruct the liver with human-like characteristics (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 5, 2021 Category: Biology Source Type: news

Sharing Mayo Clinic: Daughter quits smoking to donate liver to her mom
When she learned that a liver transplant could save her mom's life, April Wilson didn't hesitate to stop smoking and say yes to being a living donor. April Wilson smoked for 25 years and tried many times to quit, but nothing seemed to work. "I tried everything," April says. "I used every replacement therapy, Chantix, [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 4, 2021 Category: Databases & Libraries Source Type: news