Heart Transplant Listing Decisions in the Modern Era Heart Transplant Listing Decisions in the Modern Era
Gaming the system or doing what's best for your patient? The author examines the difficult ethical balance faced by physicians during the heart transplant allocation process.Circulation (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - February 14, 2020 Category: Transplant Surgery Tags: Cardiology Journal Article Source Type: news

Heart transplant list could be slashed after hope of keeping donated organ alive for 24 hours
But by pumping fluid through its blood vessels, and using pulses of oxygen which mimic a heartbeat, scientists have been able to keep five pigs' hearts for 24 hours. (Source: the Mail online | Health)
Source: the Mail online | Health - February 14, 2020 Category: Consumer Health News Source Type: news

Isolated Extramedullary Relapse in Acute Lymphoblastic Leukemia: What Can We Do Before and After Transplant?
The case of a 43-year-old male with a history of B-cell acute lymphoblastic leukemia. (Source: CancerNetwork)
Source: CancerNetwork - February 13, 2020 Category: Cancer & Oncology Authors: Santiago Riviello-Goya, MD, Aldo A. Acosta-Medina, MD, Sergio I. Inclan-Alarcon, MD, Sofia Garcia-Miranda, MD, Christianne Bourlon, MD, MHSc Source Type: news

Virtual Crossmatching Allows Faster Kidney Transplantation Virtual Crossmatching Allows Faster Kidney Transplantation
Kidney transplantation can be safely performed with virtual crossmatching of donor and recipient without the need for a prospective physical crossmatch, according to a retrospective review.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - February 13, 2020 Category: Transplant Surgery Tags: Transplantation News Source Type: news

Transcription factor AP2 controls cnidarian germ cell induction
Clonal animals do not sequester a germ line during embryogenesis. Instead, they have adult stem cells that contribute to somatic tissues or gametes. How germ fate is induced in these animals, and whether this process is related to bilaterian embryonic germline induction, is unknown. We show that transcription factor AP2 (Tfap2), a regulator of mammalian germ lines, acts to commit adult stem cells, known as i-cells, to the germ cell fate in the clonal cnidarian Hydractinia symbiolongicarpus. Tfap2 mutants lacked germ cells and gonads. Transplanted wild-type cells rescued gonad development but not germ cell induction in Tfap...
Source: ScienceNOW - February 13, 2020 Category: Science Authors: DuBuc, T. Q., Schnitzler, C. E., Chrysostomou, E., McMahon, E. T., Febrimarsa, , Gahan, J. M., Buggie, T., Gornik, S. G., Hanley, S., Barreira, S. N., Gonzalez, P., Baxevanis, A. D., Frank, U. Tags: Development, Evolution r-articles Source Type: news

Survival Similar for Hemodialysis, Peritoneal Dialysis
WEDNESDAY, Feb. 12, 2020 -- Peritoneal dialysis (PD) and in-center hemodialysis (HD) carry similar survival benefits, according to a review published online Jan. 28 in Nephrology Dialysis Transplantation. Mohamed E. Elsayed, M.B.B.S., from... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 12, 2020 Category: Pharmaceuticals Source Type: news

Tackling the Weight List Problem Tackling the Weight List Problem
Laparoscopic sleeve gastrectomy may help improve kidney transplant candidacy among morbidly obese patients, but important questions remain.American Journal of Transplantation (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - February 12, 2020 Category: Surgery Tags: Transplantation Journal Article Source Type: news

AHA News: Baby Born With 'One-of-a-Kind' Heart Receives Transplant
Title: AHA News: Baby Born With 'One-of-a-Kind' Heart Receives TransplantCategory: Health NewsCreated: 2/11/2020 12:00:00 AMLast Editorial Review: 2/12/2020 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - February 12, 2020 Category: Cardiology Source Type: news

SGLT2 Inhibition: A New Avenue to Protect the Kidney SGLT2 Inhibition: A New Avenue to Protect the Kidney
Could SGLT2 inhibitors have a role in the management of patients with kidney disease? What are the benefits of these agents?Nephrology Dialysis Transplantation (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - February 12, 2020 Category: Surgery Tags: Nephrology Journal Article Source Type: news

FDA Lifts Clinical Hold for MultiTAA T-Cell Therapy Trial in Acute Myeloid Leukemia
The planned trial will investigate the safety and efficacy of the novel multi-tumor associated antigen T-cell therapy in patients with post-transplant acute myeloid leukemia. (Source: CancerNetwork)
Source: CancerNetwork - February 12, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

What would it take to make FMT mainstream? Two publications consider the opportunities
(Cell Press) Fecal microbiota transplant treatment for most microbiome-associated diseases has not been rigorously studied in humans--and any such studies would be subject to regulation by the Food and Drug Administration. In a pair of forums publishing February 12 in the journal Cell Host& Microbe, clinicians and an FDA scientist detail some areas of FMT research that could facilitate the development of safe and effective FMT therapies for patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 12, 2020 Category: International Medicine & Public Health Source Type: news

Cardiovascular Functional Reserve Improves After Kidney Transplant Cardiovascular Functional Reserve Improves After Kidney Transplant
Improved cardiovascular reserve was seen 1 year after kidney transplantation in the absence of significant alterations in left ventricular muscle mass in the CAPER study.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - February 12, 2020 Category: Cardiology Tags: Cardiology News Source Type: news

Novel Vaccine May Help Prevent CMV-Related Complications in Transplant Patients Novel Vaccine May Help Prevent CMV-Related Complications in Transplant Patients
Patients who underwent an allogeneic hematopoietic stem cell transplant (HCT) experienced fewer cytomegalovirus (CMV)-related complications after Triplex vaccine injections in a phase-2, randomized, placebo-controlled trial.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - February 12, 2020 Category: Allergy & Immunology Tags: Transplantation News Source Type: news

Virtual Cross-Matching May Speed Kidney Transplant Process
TUESDAY, Feb. 11, 2020 -- Virtual cross-matching may reduce cold ischemia time (CIT) for donor organs in kidney transplants, according to a study published online Feb. 5 in the Journal of the American College of Surgeons. Vinayak S. Rohan, M.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 11, 2020 Category: Pharmaceuticals Source Type: news

How Lifesaving Organs for Transplant Go Missing in Transit How Lifesaving Organs for Transplant Go Missing in Transit
Scores of organs -- mostly kidneys -- are trashed each year, and many more become critically delayed while being shipped on commercial airliners, a new investigation finds.Kaiser Health News (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 11, 2020 Category: Intensive Care Tags: Transplantation News Source Type: news

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Scores of organs -- mostly kidneys -- are trashed each year, and many more become critically delayed while being shipped on commercial airliners, a new investigation finds.Kaiser Health News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - February 11, 2020 Category: Surgery Tags: Transplantation News Source Type: news

AHA News: Baby Born With'One-of-a-Kind' Heart Receives Transplant
TUESDAY, Feb. 11, 2020 (American Heart Association News) -- When a test showed a dangerous drop in the heart rate of Courtney Agnoli's unborn daughter, the doctor who urgently admitted her to the hospital said, " You aren't leaving here without a... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 11, 2020 Category: General Medicine Source Type: news

Janssen Announces Submission to U.S. FDA for New DARZALEX ® (Daratumumab)-Based Combination Regimen for Patients with Relapsed/Refractory Multiple Myeloma
RARITAN, NJ, February 10, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the submission of a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) seeking approval of DARZALEX® (daratumumab) in combination with Kyprolis® (carfilzomib) and dexamethasone (DKd) for relapsed/refractory multiple myeloma. The sBLA is supported by results from the Phase 3 CANDOR study, which compared treatment with DKd to carfilzomib and dexamethasone (Kd) in patients with multiple myeloma who relapsed after one to three prior lines of therapy. “W...
Source: Johnson and Johnson - February 10, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Triplex reduces cytomegalovirus complications by half and induces immunity in stem cell transplant
(American College of Physicians) The novel Triplex vaccine reduced rates of cytomegalovirus (CMV) complications in patients undergoing allogeneic hematopoietic stem cell transplant (HCT) by half and induced immunity to the virus. No vaccine-associated safety concerns were identified. Findings from a phase 2 randomized clinical trial are published in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 10, 2020 Category: Infectious Diseases Source Type: news

City of Hope's Triplex vaccine reduces rate of CMV complications in transplant recipients
(City of Hope) Patients who underwent a stem cell transplant and received the Triplex vaccine to prevent a type of herpes virus -- cytomegalovirus (CMV) -- from duplicating out of control were 50% less likely to develop health complications related to the virus than patients who did not take Triplex, according to a City of Hope-led study published today in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 10, 2020 Category: Infectious Diseases Source Type: news

Assisted suicide in Canada has created a glut of organ donations
(Natural News) The Canadian newspaper Ottawa Citizen is celebrating the legalization of assisted suicide in Canada because now there are a whole lot more organs and tissues available for desperate patients. Because Ontario’s transplant waiting list is usually around 1,600 patients at any given time, according to the paper, this abundance of new organs and tissues is decreasing... (Source: NaturalNews.com)
Source: NaturalNews.com - February 7, 2020 Category: Consumer Health News Source Type: news

Roche to present new data on Tecentriq in combination with Avastin that shows improvement in overall survival for Chinese patients with the most common form of liver cancer
Basel, 7 February 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that additional data will be presented from a cohort of Chinese patients in the Phase III IMbrave150 study that evaluated Tecentriq ® (atezolizumab) in combination with Avastin® (bevacizumab) as a treatment for people with unresectable hepatocellular carcinoma (HCC) who have not received prior systemic therapy. Data from 194 Chinese patients who took part in the IMbrave150 study were consistent with the global results, that showed a statistically significant and clinically meaningful improvement in overall survival (OS) and progression-free...
Source: Roche Investor Update - February 7, 2020 Category: Pharmaceuticals Source Type: news

Effect of kidney transplant on balance and fall risk - Tekkarismaz N, Doruk Analan P, Ozelsancak R, Torun D, Caliskan K, Haberal M.
This study aimed to compare balance and fall risk between kidney transplant recipients and healthy adults and to determine th... (Source: SafetyLit)
Source: SafetyLit - February 6, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Economic Burden of Kidney Transplant Graft Failure Quantified
WEDNESDAY, Feb. 5, 2020 -- Kidney transplant graft failure is associated with additional medical costs of $78,079 for the average patient and a loss of 1.66 quality-adjusted life years (QALYs), according to a study published online Feb. 5 in the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 5, 2020 Category: Pharmaceuticals Source Type: news

The economic burden of kidney transplant failure in the United States
(Wiley) A recent analysis published in the American Journal of Transplantation estimates that for the average US patient who has undergone kidney transplantation, failure of the transplanted organ (graft failure) will impose additional medical costs of $78,079 and a loss of 1.66 quality-adjusted life years. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 5, 2020 Category: International Medicine & Public Health Source Type: news

Short Learning Curve in Robot-Assisted Kidney Transplantation Short Learning Curve in Robot-Assisted Kidney Transplantation
Surgeons need to complete only about three dozen robot-assisted kidney transplantations to reach reproducibility in terms of performance and outcomes, according to new findings.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - February 4, 2020 Category: Surgery Tags: Transplantation News Source Type: news

Some hospitals wary as new liver transplant rules begin
A rule that will more broadly share donated livers goes into effect Tuesday. (Source: ABC News: Health)
Source: ABC News: Health - February 3, 2020 Category: Consumer Health News Tags: Health Source Type: news

Biopsy Kidneys From Live Donors to Predict Transplant Success Biopsy Kidneys From Live Donors to Predict Transplant Success
Features in kidneys from living donors not detectable by standard evaluation modestly contribute to predicting later graft failure in transplant recipients, new research suggests.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 3, 2020 Category: Consumer Health News Tags: Nephrology News Source Type: news

Liver Transplant for Hepatocellular Carcinoma in the U.S. Liver Transplant for Hepatocellular Carcinoma in the U.S.
How have the patterns and outcomes for HCC-related liver transplants evolved over the last thirty years? A new study examines the trends.American Journal of Transplantation (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - February 3, 2020 Category: Surgery Tags: Transplantation Journal Article Source Type: news

Innovations in high-risk heart failure treatments: transplants and technology
Leading medical centers, including Temple University Hospital, are finding new ways to approve more people for heart transplants, including those with coexisting health conditions. An estimated 6 million Americans — nearly equal to the population of the Delaware Valley — are living with a heart failure diagnosis. The life-threatening condition develops when the heart becomes too weak to pump adequate blood supply to support other organs in the body. Heart failure is co mmonly associated with… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - February 1, 2020 Category: Biotechnology Authors: Erin Bernall Source Type: news

Hepatitis C no longer an obstacle for transplant recipients
Sharon Price had come to grips with the notion that dialysis would soon be part of his life. Facing a long wait for a new kidney, he was 73 years old and his condition had grown progressively over two years. He was ready to begin the treatment, but first had a request for his doctors at Atrium Health’s Carolinas Medical Center. “I was going to do it [dialysis], no ifs and or buts,” Price says. “But I wanted to put it off for two months because it was summer, and I wanted to do spend time… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - February 1, 2020 Category: Biotechnology Authors: Atrium Health Source Type: news

Innovations in high-risk heart failure treatments: transplants and technology
Leading medical centers, including Temple University Hospital, are finding new ways to approve more people for heart transplants, including those with coexisting health conditions. An estimated 6 million Americans — nearly equal to the population of the Delaware Valley — are living with a heart failure diagnosis. The life-threatening condition develops when the heart becomes too weak to pump adequate blood supply to support other organs in the body. Heart failure is co mmonly associated with… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 1, 2020 Category: Pharmaceuticals Authors: Erin Bernall Source Type: news

Hepatitis C no longer an obstacle for transplant recipients
Sharon Price had come to grips with the notion that dialysis would soon be part of his life. Facing a long wait for a new kidney, he was 73 years old and his condition had grown progressively over two years. He was ready to begin the treatment, but first had a request for his doctors at Atrium Health’s Carolinas Medical Center. “I was going to do it [dialysis], no ifs and or buts,” Price says. “But I wanted to put it off for two months because it was summer, and I wanted to do spend time… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 1, 2020 Category: Pharmaceuticals Authors: Atrium Health Source Type: news

Teen who received double lung transplant shares warning
A Michigan teenager who received what ’s believed to be the first double lung transplant shares a warning for people addicted to vaping, including his own brother. 17-year-old Daniel Ament tells Dean Reynolds why he feels lucky to be alive. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - February 1, 2020 Category: Consumer Health News Source Type: news

Teen warns about vaping after double-lung transplant
Daniel Ament remembers vaping last September — and then waking up more than a month later after the emergency surgery. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - January 31, 2020 Category: Consumer Health News Source Type: news

The Teenager Who Needed a Double Lung Transplant Because He Vaped Has Something to Say
Daniel Ament went to sleep one day and woke up months later with a new set of lungs. Ament, 17 and a high school junior in Grosse Pointe, Mich., (anonymously) made headlines this past fall after becoming the first person to receive a double lung transplant due to what doctors attribute to vaping-related damage. But Ament—who spent more than a month critically ill and hospitalized before his surgery—doesn’t remember any of it. “I was trying to think of the last thing I could remember, and it was summer,” says Ament, talking on the record for the first time. [When I woke up,] it was almost snowi...
Source: TIME: Health - January 31, 2020 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized E-Cigarettes public health Source Type: news

Outcomes After Bone Marrow Transplants Continue to Improve Outcomes After Bone Marrow Transplants Continue to Improve
The downward trajectory in mortality rates first documented in the early 2000s continues among bone marrow transplant recipients due to small, additive steps that collectively have improved outcomes.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 31, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Teen warns about vaping after after double-lung transplant
Daniel Ament remembers vaping last September — and then waking up more than a month later after the emergency surgery. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - January 31, 2020 Category: Consumer Health News Source Type: news

Teen warns others about vaping after double-lung transplant
The first person to receive a double-lung transplant after his lungs were damaged by vaping is now warning others. The teen remembers vaping last September, and then waking up more than a month later. Dean Reynolds reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - January 31, 2020 Category: Consumer Health News Source Type: news

Drug-induced liver injury caused by phenprobamate: strong probability due to repeated toxicity - Duzenli T, Tanoglu A, Akyol T, Kara M, Yazgan Y.
Drug-induced liver injury (DILI) is an important cause of morbidity and mortality. DILI can even cause acute liver failure and the need for liver transplantation. Identifying DILI may be particularly difficult because it is actually an exclusion diagnosis ... (Source: SafetyLit)
Source: SafetyLit - January 30, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Promoting Mixed Chimerism Promising in Kidney Transplants
THURSDAY, Jan. 30, 2020 -- For patients undergoing living kidney transplants, persistent mixed chimerism can be achieved to allow complete or partial withdrawal of immunosuppressive drugs, according to a study published in the Jan. 29 issue of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 30, 2020 Category: Pharmaceuticals Source Type: news

Bone Marrow Transplants Less Risky Now
Title: Bone Marrow Transplants Less Risky NowCategory: Health NewsCreated: 1/29/2020 12:00:00 AMLast Editorial Review: 1/30/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - January 30, 2020 Category: Cancer & Oncology Source Type: news

HKUST researchers find that regulating lipid metabolism in neurons helps axon regeneration
(Hong Kong University of Science and Technology) Regenerative medicine is the study of repairing tissue and organ function that is lost due to injury, aging, or disease. Although many tissues and organs can be restored via either drug treatment or surgical transplantation, repairing the damaged central nervous system (CNS) is still a daunting medical problem. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 30, 2020 Category: International Medicine & Public Health Source Type: news

Fighting infections with fungi: Transgenic fungus successfully kills malaria mosquitoes, report researchers
This study, published in the journal Science, had a research team describe their trial for a transgenic approach to combating malaria. By definition, transgenic is when genetic material is transplanted into... (Source: NaturalNews.com)
Source: NaturalNews.com - January 29, 2020 Category: Consumer Health News Source Type: news

Bone Marrow Transplants Less Risky Now
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - January 29, 2020 Category: Cancer & Oncology Tags: Family Medicine, Nursing, Oncology, Organ Transplants, News, Source Type: news

Bone Marrow Transplants Less Risky Now
WEDNESDAY, Jan. 29, 2020 -- The risks faced by U.S. bone marrow transplant patients have dropped sharply, a new study shows. While this type of transplant can be lifesaving for patients with blood cancers (such as leukemia) and other diseases,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 29, 2020 Category: General Medicine Source Type: news

Outcomes Positive With National Kidney Paired Donation Program
WEDNESDAY, Jan. 29, 2020 -- A nationalized kidney paired donation program results in equivalent outcomes compared with control living kidney donor transplant, according to a study published online Jan. 28 in the Clinical Journal of the American... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 29, 2020 Category: Pharmaceuticals Source Type: news

GFR: When To Measure and in Which Patients? GFR: When To Measure and in Which Patients?
Which CKD patients may need measured GFR -- and why? A new review examines the question.Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 29, 2020 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

LVAD Outcomes Similar With Bridging Vs Destination Therapy LVAD Outcomes Similar With Bridging Vs Destination Therapy
The clinical outcomes of treatment with a left ventricular assist device (LVAD) are similar whether or not patients are heart transplant candidates, according to findings from the MOMENTUM 3 randomized clinical trial.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - January 29, 2020 Category: Intensive Care Tags: Cardiology News Source Type: news

Magdi Habib Yacoub receives Bakken Scientific Achievement Award
(The Society of Thoracic Surgeons) Legendary heart-lung transplant surgeon, researcher, and professor Sir Magdi Habib Yacoub, MD, today was honored with the 2020 Earl Bakken Scientific Achievement Award from The Society of Thoracic Surgeons. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 28, 2020 Category: International Medicine & Public Health Source Type: news