A 6-year review of acute post-streptococcal glomerulonephritis at a public children ’s hospital in Cape Town, South Africa
ConclusionsChildhood APSGN remains an important health problem in South Africa (SA) with favourable outcomes in most, apart from those with crescentic glomerulonephritis who progressed to kidney failure.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Extramedullary relapsed acute lymphoblastic leukemia presenting as asymptomatic acute kidney injury after hematopoietic stem cell transplantation
AbstractAcute kidney injury (AKI) is a common complication in children with hematological malignancies. Although AKI due to infiltration of tumor cells in children is rare, it negatively impacts treatment outcomes and increases the risk of mortality. We introduce a case of a child with acute lymphoblastic leukemia (ALL) who experienced kidney relapse resulting in asymptomatic AKI after remission from treatment, to remind clinicians not to overlook the primary disease in clinical judgment. In cases of unexplained AKI, kidney biopsy should be performed when feasible to get an accurate diagnosis and scientific treatment. In b...
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Use of a donor kidney with known autosomal dominant polycystic kidney disease in a highly sensitised paediatric recipient
We report the use of an autosomal-dominant polycystic kidney disease (ADPKD) donor kidney in a paediatric recipient. A 14-year-old boy on haemodialysis for 4 years following loss of a first kidney transplant, highly sensitised, and with limited vascular options for ongoing dialysis access, was offered a deceased brain death donor transplant from a mid-30s donor with known ADPKD but normal kidney function and negligible proteinuria. After extensive discussion with the patient and family, discussing all alternative options and review of available literature, the kidney was accepted and implanted. Graft function was immediate...
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Editors ’ Picks
Cutaneous T-cell lymphomas (CTCLs) comprise an incurable form of non-Hodgkin lymphoma, and advanced-stage forms of this disease, mycosis fungoides and Sezary syndrome, have poor prognosis. Previous case series documented long-lasting remission due to a graft-versus-lymphoma effect in patients treated with allogeneic hematopoietic stem cell transplantation (HSCT). In these studies, lymphoma relapse was common, and treatment-related morbidity and mortality were noted, leading to weaker recommendations for HSCT in this patient population. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Tags: Editors' Picks Source Type: research
Coadministration of fluconazole to boost subtherapeutic sirolimus concentrations: A case report
During a toxoplasmosis infection in a patient with hematopoietic stem cell transplantation, sirolimus concentrations fell into the subtherapeutic range and therapeutic concentrations could not be achieved despite dose escalation. This was finally achieved by CYP3A4 inhibition with fluconazole (pharmacoenhancement) and twice-daily (off-label) administration of sirolimus. AbstractIndividual sirolimus whole blood concentrations are highly variable, critically influenced by the concomitant use of cytochrome P450 (CYP) 3A inducers or inhibitors, and also modulated by food. Therapeutic drug monitoring is therefore recommended, e...
Source: Pharmacology Research and Perspectives - April 19, 2024 Category: Drugs & Pharmacology Authors: Camilo Scherkl,
Andreas D. Meid,
Sven E. Cuntz,
Laura Classen,
Johanna Weiss,
David Czock,
Walter E. Haefeli Tags: SHORT REPORT Source Type: research
Supporting Parents in the Prenatal Period in Their Choice to Donate Organs Following the Death of Their Newborn.
1. Understand the potential diagnoses in the newborn period that could potentially contribute to the pool of organs or tissue available for transplant.2. Understand the potential benefit to families who pursue the donation of organs and/or tissue from their newborn. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Terri Weinman, Katie Lawrence Source Type: research
Optimizing Palliative Medicine Support for Liver Transplant Candidates
1. Participants will be able to identify how a quality approach can be successfully used to improve access to palliative medicine for liver transplant candidates.2. Participants will be able to define methods which can be employed to improve collaboration between teams and alleviate quality gaps among unique patient populations. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Richard Guthrie, Rolland Dickson, David M H Chascsa, Matthew Martin, Beth Perry, Sue Weinhold, Kathleen Minner Source Type: research
GSE263911 AML1-ETO and CCND2 overexpression ¬ cooperate to drive acute myeloid leukemia initiation and progression
In conclusion, we confirmed that introduction of the CCND2 gene into the AML/ETO pre-leukemia mice can trigger the development of leukemia. We also confirmed that CCND2 overexpression resulted in the upregulation of the mTOR pathway and inhibiting the pathway may be a therapeutic agent for this subtype of leukemia. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus Source Type: research
A pig kidney supporting human physiology
Because of the global shortage of donor kidneys, xenotransplantation emerges as a potential solution for individuals with kidney failure who face challenges in securing a suitable donor kidney. A study featured in this month ’s issue of Kidney International assesses the kidney physiology of a porcine kidney transplanted into a brain-dead human with kidney failure, demonstrating life-sustaining physiological function for 7 days. Together with preclinical nonhuman primate studies, decedent models provide complementary d ata for development of clinical kidney xenotransplantation. (Source: Kidney International)
Source: Kidney International - April 18, 2024 Category: Urology & Nephrology Authors: Stuart J. Knechtle, Joseph M. Ladowski, Jean Kwun Tags: Commentary Source Type: research
Potential application of mesenchymal stromal cells as a new therapeutic approach in acute respiratory distress syndrome and pulmonary fibrosis
Respir Res. 2024 Apr 18;25(1):170. doi: 10.1186/s12931-024-02795-1.ABSTRACTWhile the COVID-19 outbreak and its complications are still under investigation, post-inflammatory pulmonary fibrosis (PF) has already been described as a long-term sequela of acute respiratory distress syndrome (ARDS) secondary to SARS-CoV2 infection. However, therapeutical strategies for patients with ARDS and PF are still limited and do not significantly extend lifespan. So far, lung transplantation remains the only definitive treatment for end-stage PF. Over the last years, numerous preclinical and clinical studies have shown that allogeneic mes...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Giulia Gazzaniga Marta Voltini Alessandro Carletti Elisa Lenta Federica Meloni Domenica Federica Briganti Maria Antonietta Avanzini Patrizia Comoli Mirko Belliato Source Type: research
Coadministration of fluconazole to boost subtherapeutic sirolimus concentrations: A case report
Pharmacol Res Perspect. 2024 Jun;12(3):e1198. doi: 10.1002/prp2.1198.ABSTRACTIndividual sirolimus whole blood concentrations are highly variable, critically influenced by the concomitant use of cytochrome P450 (CYP) 3A inducers or inhibitors, and also modulated by food. Therapeutic drug monitoring is therefore recommended, especially at treatment start or in circumstances that can influence sirolimus exposure. In this case report, we highlight the challenge of achieving therapeutic sirolimus concentrations and present pragmatic solutions with regimen adaptions, pharmacokinetic enhancement (use of a drug-drug interaction), ...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Camilo Scherkl Andreas D Meid Sven E Cuntz Laura Classen Johanna Weiss David Czock Walter E Haefeli Source Type: research
Extracorporeal membrane oxygenation (ECMO) during aplasia: A bridge towards myopericarditis recovery after autologous hematopoietic stem cell transplant for systemic sclerosis and recent Coronarovirus disease (COVID-19) vaccination
This report illustrates, for the first time to our knowledge, that ECMO can be indicated despite aplasia during aHSCT and successfully used as a bridge towards heart function recovery in highly selected and fragile AD patients. We review the factors that may contribute to endothelial and myocardial stunning and acute reversible cardiac failure in SSc and aggravate intrinsic endothelial injury during the aHSCT procedure. These classically include: cyclophosphamide drug toxicity, viral infections and autoimmune activation with disease flair per se. In the COVID-19 pandemic times, acute myocarditis due to recent viral infecti...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Carlotta Cacciatore Mathilde Baudet Estelle Jean Simona Presente Marylou Para Romain Sonneville Dimitri Arangalage Nassim Ait Abdallah Flore Sicre de Fontbrune Pedro Henrique Prata Benjamin Crichi Baptiste Hervier Nathalie Parquet Gilles Soulat Elie Mouss Source Type: research
Overcoming Methodological Challenges for Advancing Stem Cell Therapies in Parkinson's Disease
Cell Transplant. 2024 Jan-Dec;33:9636897241246355. doi: 10.1177/09636897241246355.ABSTRACTThe quest for new and improved therapies for Parkinson's disease (PD) remains of paramount importance, despite previous trial failures. There is a current debate regarding the potential of stem cell research as a therapeutic approach for PD. The studies of dopaminergic fetal stem cells for PD treatment, their design, and the results of the initial surgical placebo-controlled trials were reviewed in this study. Some of the fundamental methodological challenges and possible strategies to resolve them were proposed. In this article, we a...
Source: Cell Transplantation - April 18, 2024 Category: Cytology Authors: Stephen Polgar David I Finkelstein Leila Karimi Source Type: research
Is social deprivation associated with the peritoneal dialysis outcomes? A cohort study with REIN registry data
CONCLUSION: In PD patients, social deprivation was not associated with death or the composite event of death or transfer to HD. Socially deprived individuals had a greater risk of transfer to HD and lower access to kidney transplantation in the competing risk analysis.PMID:38632672 | DOI:10.1177/08968608241237685 (Source: Peritoneal Dialysis International)
Source: Peritoneal Dialysis International - April 18, 2024 Category: Urology & Nephrology Authors: Steve Biko Tobada Val érie Chatelet Clemence Bechade Antoine Lanot Annabel Boyer C écile Couchoud Fatouma Toure Sabrina Boime Thierry Lobbedez Mathilde Beaumier Source Type: research
Randomized clinical trial of non-antibiotic prophylaxis with d-Mannose plus Proanthocyanidins vs. Proanthocyanidins alone for urinary tract infections and asymptomatic bacteriuria in de novo kidney transplant recipients: The Manotras study
CONCLUSIONS: Non-antibiotic therapy is an unmet need to prevent UTI after kidney transplantation; however, the use of d-Mannose plus PAC does not seem capable to prevent it.PMID:38637262 | DOI:10.1016/j.nefroe.2024.02.011 (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - April 18, 2024 Category: Urology & Nephrology Authors: Melissa Rau Adrian Santelli Sara Mart í Mar ía Isabel Díaz Nuria Sab é Mar ía Fiol Luis Riera Bego ña Etcheverry Sergi Codina Ana Coloma Anna Carreras-Salinas Carmen Ardanuy Josep M Cruzado Edoardo Melilli Source Type: research
