Can metformin reduce obesity in children and adolescents?
(Mary Ann Liebert, Inc./Genetic Engineering News) A new study has shown metformin -- a glucose-lowering drug commonly used to treat diabetes -- to be effective at lowering some measures of obesity in children and adolescents. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 18, 2020 Category: International Medicine & Public Health Source Type: news

Cholesterol Drugs Might Help Curb Prostate Cancers
The study couldn't prove cause and effect, but it found that statins, taken alone or with metformin, did seem associated with an increase in survival. (Source: WebMD Health)
Source: WebMD Health - February 14, 2020 Category: Consumer Health News Source Type: news

Trijardy XR (Empagliflozin, Linagliptin, and Metformin Hydrochloride Extended-release Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 14, 2020 Category: Drugs & Pharmacology Source Type: news

Statins may lower mortality in high-risk prostate cancer patients
(Thomas Jefferson University) Statin use alone or with metformin is associated with lower prostate cancer mortality from all causes, among high-risk patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

Human gut-in-a-dish model helps define 'leaky gut,' and outline a pathway to treatment
(University of California - San Diego) UC San Diego researchers use 3D human gut organoids to reveal the molecular system that keeps intestinal linings sealed, demonstrate how the system breaks down and how it can be strengthened with the diabetes drug metformin. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

FDA Not Recommending Recalls of Diabetes Drug
The FDA began testing samples of metformin for the carcinogen NDMA at the end of last year. Contamination with this substance has led to recalls of blood pressure and heartburn medications within the past 2 years. (Source: WebMD Health)
Source: WebMD Health - February 7, 2020 Category: Consumer Health News Source Type: news

FDA Not Recommending Recalls of Diabetes Drug Metformin FDA Not Recommending Recalls of Diabetes Drug Metformin
After lab tests indicated only nondetectable or low levels of NMDA in metformin in the US, FDA says it currently has no plans to recall any such products, which are used to treat type 2 diabetes.News Alerts (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - February 6, 2020 Category: Endocrinology Tags: Diabetes & Endocrinology News Alert Source Type: news

Largest ever evaluation of the cardiovascular risk of rosiglitazone published
Analysis of raw individual patient level data gives more accurate picture of drug ’s link to heart problems Related items fromOnMedica People on statins at greater risk of skin infections and diabetes Adding insulin to metformin linked to higher mortality Vitamin D does not reduce kidney damage in type 2 diabetes Raised risk of MI and mortality when starting sulfonylurea Use of DPP-4 inhibitors associated with increased risk of IBD (Source: OnMedica Latest News)
Source: OnMedica Latest News - February 6, 2020 Category: UK Health Source Type: news

Trijardy XR (Empagliflozin, Linagliptin, and Metformin Hydrochloride Extended-release Tablets) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 5, 2020 Category: Drugs & Pharmacology Source Type: news

Laboratory Tests | Metformin
FDA continues to investigate the presence of the N-Nitrosodimethylamine (NDMA) impurity in metformin approved for sale in the U.S. Metformin is a prescription drug used to control high blood sugar in patients with type 2 diabetes. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 3, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

FDA Updates and Press Announcements on NDMA in Metformin
(Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 3, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Metformin latest drug to be investigated for possible carcinogenic chemicals
(Natural News) Living with diabetes means lots of health-related worries, and if you’re taking one very popular diabetes drug, you can add cancer to your list of concerns. Metformin, which is given to many people with type 2 diabetes to control high blood sugar, has been found to contain carcinogens in other countries, prompting official... (Source: NaturalNews.com)
Source: NaturalNews.com - January 31, 2020 Category: Consumer Health News Source Type: news

Monthly News Roundup - January 2020
Trijardy XR: A Triple Drug Combo Approved for Type 2 Diabetes In January, the US Food and Drug Administration (FDA) approved once-daily Trijardy XR (empagliflozin, linagliptin, and metformin hydrochloride extended release tablets) to lower blood... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 31, 2020 Category: Pharmaceuticals Source Type: news

FDA OKs New Triple-Combo Pill, Trijardy XR, for Type 2 Diabetes FDA OKs New Triple-Combo Pill, Trijardy XR, for Type 2 Diabetes
The once-daily treatment comprises empagliflozin (Jardiance), linagliptin (Tradjenta), and extended-release metformin hydrochloride. It will be available in four different dosages.FDA Approvals (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - January 28, 2020 Category: Cardiology Tags: Diabetes & Endocrinology News Alert Source Type: news

FDA Approves Trijardy XR (empagliflozin/linagliptin/metformin) for Type 2 Diabetes in Adults
RIDGEFIELD, Conn., and INDIANAPOLIS, Jan. 27, 2020 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) has approved Trijardy XR (empagliflozin/linagliptin/metformin hydrochloride extended release tablets) to lower blood sugar in adults with... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - January 28, 2020 Category: Drugs & Pharmacology Source Type: news

Polycystic Ovary Syndrome Hikes Bipolar Disorder Risk Polycystic Ovary Syndrome Hikes Bipolar Disorder Risk
The risk of developing bipolar disorder was increased in women with PCOS, possibly because of shared inflammatory pathways, a study has found; metformin may have a protective effect.Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - January 20, 2020 Category: Psychiatry Tags: Ob/Gyn & Women ' s Health News Source Type: news

Metformin latest drug to be investigated for possible carcinogenic chemicals
(Natural News) Living with diabetes means lots of health-related worries, and if you’re taking one very popular diabetes drug, you can add cancer to your list of concerns. Metformin, which is given to many people with type 2 diabetes to control high blood sugar, has been found to contain carcinogens in other countries, prompting official... (Source: NaturalNews.com)
Source: NaturalNews.com - January 17, 2020 Category: Consumer Health News Source Type: news

Adult heart disease after childhood cancer now less likely
Efforts to cut toxicity of treatment credited for drop in heart disease risk in survivors of childhood cancer Related items fromOnMedica Only half of new cancer drugs extend or improve life Women treated for cancer have higher CHF risk in pregnancy Metformin doesn ’t help HbA1c in teens with type 1 diabetes US doctor says FDA should have withdrawn rosuvastatin Codeine not to be used for coughs and colds in children under 12 (Source: OnMedica Latest News)
Source: OnMedica Latest News - January 16, 2020 Category: UK Health Source Type: news

FDA testing metformin for traces of nitrosamines
MHRA aware of issue and advises patients to continue to taking their diabetes medicine Related items fromOnMedica People on statins at greater risk of skin infections and diabetes Raised risk of MI and mortality when starting sulfonylurea Use of DPP-4 inhibitors associated with increased risk of IBD Vitamin D does not reduce kidney damage in type 2 diabetes Use pioglitazone only in selected patients, says EMA guidance (Source: OnMedica Latest News)
Source: OnMedica Latest News - December 10, 2019 Category: UK Health Source Type: news

FDA Testing Levels of Carcinogen in Diabetes Drug Metformin
Title: FDA Testing Levels of Carcinogen in Diabetes Drug MetforminCategory: Health NewsCreated: 12/6/2019 12:00:00 AMLast Editorial Review: 12/9/2019 12:00:00 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - December 9, 2019 Category: Endocrinology Source Type: news

FDA Investigates Metformin for Possible Carcinogen
FDA Investigating Metformin for Possible Carcinogen (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - December 9, 2019 Category: General Medicine Source Type: news

FDA Testing Levels of Carcinogen in Diabetes Drug Metformin
FRIDAY, Dec. 6, 2019 -- Levels of possible cancer-causing chemicals in metformin diabetes medications are under investigation by the U.S. Food and Drug Administration. During the past year and a half, several types of drugs -- including angiotensin... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 6, 2019 Category: Pharmaceuticals Source Type: news

FDA Investigating Metformin for Possible Carcinogen FDA Investigating Metformin for Possible Carcinogen
The Food and Drug Administration has begun testing samples of metformin for NDMA. The fourth most-prescribed drug in the US, metformin is generally the first medication prescribed for type 2 diabetes.WebMD Health News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - December 6, 2019 Category: Drugs & Pharmacology Tags: Diabetes & Endocrinology News Source Type: news

Popular Diabetes Drug May Contain a Carcinogen Popular Diabetes Drug May Contain a Carcinogen
The Food and Drug Administration has begun testing samples of metformin for NDMA. The fourth most-prescribed drug in the US, metformin is generally the first medication prescribed for type 2 diabetes.WebMD Health News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 6, 2019 Category: Cancer & Oncology Tags: Diabetes & Endocrinology News Source Type: news

Regulators in Canada, Europe and U.S. probe diabetes drug metformin for carcinogen NDMA
Health Canada and FDA aware some metformin diabetes medicines in other countries were reported to have low levels of NDMA, a cancer-causing chemical that prompted a recall of a commonly used heartburn medication this year. (Source: CBC | Health)
Source: CBC | Health - December 6, 2019 Category: Consumer Health News Tags: News/Health Source Type: news

FDA Testing Levels of Carcinogen in Diabetes Drug Metformin
FRIDAY, Dec. 6, 2019 -- Levels of possible cancer-causing chemicals in metformin diabetes medications are under investigation by the U.S. Food and Drug Administration. Metformin is a prescription drug used to control high blood sugar in patients... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 6, 2019 Category: General Medicine Source Type: news

FDA probes diabetes drug metformin for carcinogen NDMA
The U.S. Food and Drug Administration is investigating whether the diabetes drug metformin had unsafe levels of a cancer-causing chemical and will recommend recalls as appropriate, the agency said on Thursday. (Source: Reuters: Health)
Source: Reuters: Health - December 6, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

Popular Diabetes Drug May Contain a Carcinogen
More than 30 million people in the U.S. have diabetes, and 90 to 95% are type 2, the CDC says, and metformin is the fourth-most prescribed drug in the United States. (Source: WebMD Health)
Source: WebMD Health - December 5, 2019 Category: Consumer Health News Source Type: news

Medical News Today: Study reveals how diabetes drug promotes healthy aging
Doctors often prescribe metformin for type 2 diabetes. A new mouse study on its liver mechanisms may explain its wider benefits for health and life span. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 5, 2019 Category: Consumer Health News Tags: Seniors / Aging Source Type: news

Glenmark Pharma gets USFDA nod for diabetes management drug
"Glenmark Pharmaceuticals Inc, USA, has been granted final approval by the United States Food& Drug Administration (USFDA) for metformin hydrochloride extended release tablets USP, 500 mg and 1000 mg, the generic version of Glumetza extended release tablets, 500 mg and 1,000 mg, of Salix Pharmaceuticals Inc," the drug maker said in a filing to BSE. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - November 26, 2019 Category: Pharmaceuticals Source Type: news

Metformin Treatment and Cancer Risk Metformin Treatment and Cancer Risk
Several studies have suggested that metformin may reduce the incidence of cancer in diabetic patients, but evidence is conflicting. This statistical analysis aimed to better evaluate the association.American Journal of Epidemiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 4, 2019 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Diabetes drugs may lower risk of dementia
Diabetes drugs such as SGLT2 inhibitors and metformin, may lower risk of dementia in patients with type 2 diabetes, according to a Danish study published in theEuropean Journal of Endocrinology.Speciality Medical Dialogues (Source: Society for Endocrinology)
Source: Society for Endocrinology - October 23, 2019 Category: Endocrinology Source Type: news

Metformin Increases Glucose Uptake in Early-Stage NSCLC
Metformin appeared to increase glucose uptake in lung cancer cells, according to results from a phase II trial. (Source: CancerNetwork)
Source: CancerNetwork - October 12, 2019 Category: Cancer & Oncology Authors: Seth Augenstein Source Type: news

Effect of Oral Contraceptive Pill and/or Metformin in PCOS Effect of Oral Contraceptive Pill and/or Metformin in PCOS
What benefits might these therapies offer to patients with PCOS? A new review examines the therapeutic impacts.Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 9, 2019 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Type 2 diabetes drug could offer hope for multiple sclerosis after a study on rats
Scientists from Cambridge University gave rats the blood-sugar lowering medication metformin for three months. They then stripped myelin from some of the nerves in the animals' brain. (Source: the Mail online | Health)
Source: the Mail online | Health - October 4, 2019 Category: Consumer Health News Source Type: news

Diabetes drug offers hope of new treatment for multiple sclerosis
Trial using rats showed the drug metformin repaired nerve damage caused by the diseaseScientists have raised hopes of a new treatment for multiple sclerosis after animal studies showed a common diabetes drug can repair nerve damage caused by the disease.The effect of the drug was so striking that doctors in Cambridge are now planning a clinical trial of MS patients next year.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - October 2, 2019 Category: Science Authors: Ian Sample Science editor Tags: Medical research Multiple sclerosis Science Society Health UK news World news Source Type: news

Metformin SR cost saving versus metformin  IR
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - October 1, 2019 Category: Drugs & Pharmacology Source Type: news

Addition of Metformin to TKI Therapy Delivers ‘Unusual’ Result in Lung Cancer
Researchers examined how metformin and TKI therapy did in combatting lung cancer. (Source: CancerNetwork)
Source: CancerNetwork - September 26, 2019 Category: Cancer & Oncology Authors: Christina Bennett, MS Source Type: news

SUSTAIN-8: Semaglutide vs Canagliflozin After Metformin in T2D SUSTAIN-8: Semaglutide vs Canagliflozin After Metformin in T2D
Reduction in HbA1c and weight loss are superior with SC semaglutide compared with canagliflozin, but treatment decisions should also consider patient comorbidities, patient preference, tolerance, and cost.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - September 23, 2019 Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news

EU Panel Votes to Expand Dulaglutide Indication Based on REWIND EU Panel Votes to Expand Dulaglutide Indication Based on REWIND
The panel also recommends approval of Qtrilmet, a fixed-dose combination of metformin hydrochloride/saxagliptin/dapagliflozin for treatment of type 2 diabetes.International Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 20, 2019 Category: Consumer Health News Tags: Diabetes & Endocrinology News Alert Source Type: news

CV Risk Lower With Metformin in T2DM & #43; Reduced Kidney Function
THURSDAY, Sept. 19, 2019 -- Treatment with metformin versus sulfonylureas is associated with a reduced risk for major adverse cardiovascular events (MACE) among patients with type 2 diabetes and reduced kidney function, according to a study... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 19, 2019 Category: Pharmaceuticals Source Type: news

Two-drug combo more effective at lowering blood sugar in diabetes patients
Prescribing metformin and vildagliptin to people newly diagnosed with type 2 diabetes reduced their long-term blood sugar levels more than single-drug therapy in a recent study. (Source: Health News - UPI.com)
Source: Health News - UPI.com - September 18, 2019 Category: Consumer Health News Source Type: news

VERIFY: Metformin + DPP-4 Inhibitor as Dual Therapy for Diabetes? VERIFY: Metformin + DPP-4 Inhibitor as Dual Therapy for Diabetes?
VERIFY suggests that initial combination therapy for type 2 diabetes with metformin plus vildagliptin is well tolerated and effective; risk for treatment failure was 50% lower than in those on monotherapy.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - September 18, 2019 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Riomet ER (Metformin Hydrochloride for Extended-release Oral Suspension) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 16, 2019 Category: Drugs & Pharmacology Source Type: news

Diabetes drug can repair brain damage and make new cells grow - but it only works in WOMEN
A new study, from the University of Toronto in Ontario, Canada, has found that the female sex hormone estradiol amplifies the effect that the drug metformin has on brain stem cells. (Source: the Mail online | Health)
Source: the Mail online | Health - September 11, 2019 Category: Consumer Health News Source Type: news

Riomet ER (Metformin Hydrochloride for Extended-release Oral Suspension) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 11, 2019 Category: Drugs & Pharmacology Source Type: news

Metformin - Postmortem fatal and non-fatal reference concentrations in femoral blood and risk factors associated with fatal intoxications - Walz L, J önsson AK, Ahlner J, Östgren CJ, Druid H.
BACKGROUND& OBJECTIVES: To improve the interpretation of fatal intoxications by establishing fatal and non-fatal reference concentrations of metformin in postmortem femoral blood and to further evaluate risk factors associated with fatal metformin intoxic... (Source: SafetyLit)
Source: SafetyLit - September 11, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Racial Differences in Metformin Use and Incident Dementia Racial Differences in Metformin Use and Incident Dementia
Does the association of metformin use with a lower risk of dementia versus sulfonylureas vary by race?Annals of Family Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 5, 2019 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

Polycystic Ovary Syndrome Awareness Month
September is   Polycystic Ovary Syndrome Awareness Month and is an excellent time to focus on the latest Cochrane evidence.Polycystic ovary syndrome (PCOS) is a very common condition affecting 8% to 13% of women. Being overweight worsens all clinical features of PCOS. These clinical features include reproductive issues such as reduced frequency of ovulation and irregular menstrual cycles, reduced fertility, polycystic ovaries onultrasound and high levels of male hormones such as testosterone, which can cause unwanted facial or body hair growth and acne. PCOS is also associated with metabolic features, withrisk factors...
Source: Cochrane News and Events - September 3, 2019 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Toxicology Rounds: Brace Yourself for Metformin-Associated Lactic Acidosis
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - September 1, 2019 Category: Emergency Medicine Tags: Toxicology Rounds Source Type: news