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Pharma Technology Focus – Issue 64
In this issue: Using drugs after their expiration dates have passed, treating lactose intolerance, a closer look at CARB-X ’s work on antibacterial R&D, helping nanomedicines reach their target, radioactive isotopes battling cancer, and more. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - October 20, 2017 Category: Pharmaceuticals Source Type: news

Rockville-based cancer therapy company Cytimmune Sciences in fundraising mode
The company is working on a therapy for pancreatic cancer using nanotechnology. (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - October 20, 2017 Category: Health Management Authors: Tina Reed Source Type: news

Flash Nano: CNT technology energizes clean power
Company marries “clean” and “nano” technology to produce a battery boasting enhanced storage, charge/discharge speeds and stability. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 20, 2017 Category: Nanotechnology Authors: Anna Demming Source Type: news

Novel diabetes treatment developed in Desai Lab to power SF-area startup
An insulin-generating implant that utilizes nanotechnology developed in theDesai Lab is closer to becoming a real treatment for diabetes, after being acquired by a San Francisco-based startup.The biotechnology company Encellin acquired exclusive worldwide rights to the technology, originally developed in the laboratory ofTejal Desai, PhD, chair of theDepartment of Bioengineering and Therapeutic Sciences, a joint department of... (Source: UCSF School of Pharmacy News)
Source: UCSF School of Pharmacy News - October 19, 2017 Category: Universities & Medical Training Authors: Paula Joyce Source Type: news

Polymer nanoparticles make good afterglow agents
They could be used for high-contrast, real-time bio-imagingin vivo. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 19, 2017 Category: Nanotechnology Authors: Belle Dum é Source Type: news

Chaos-assisted broadband momentum transformation in optical microresonators
We report broadband momentum transformations of light in asymmetric whispering gallery microresonators. Assisted by chaotic motions, broadband light can travel between optical modes with different angular momenta within a few picoseconds. Efficient coupling from visible to near-infrared bands is demonstrated between a nanowaveguide and whispering gallery modes with quality factors exceeding 10 million. The broadband momentum transformation enhances the device conversion efficiency of the third-harmonic generation by greater than three orders of magnitude over the conventional evanescent-wave coupling. The observed broadban...
Source: ScienceNOW - October 19, 2017 Category: Science Authors: Jiang, X., Shao, L., Zhang, S.-X., Yi, X., Wiersig, J., Wang, L., Gong, Q., Loncar, M., Yang, L., Xiao, Y.-F. Tags: Physics reports Source Type: news

Slow light on the nanoscale
(Source: ScienceNOW)
Source: ScienceNOW - October 19, 2017 Category: Science Authors: Osborne, I. S. Tags: Physics twis Source Type: news

Ultraslow waves on the nanoscale
There has recently been a surge of interest in the physics and applications of broadband ultraslow waves in nanoscale structures operating below the diffraction limit. They range from light waves or surface plasmons in nanoplasmonic devices to sound waves in acoustic-metamaterial waveguides, as well as fermions and phonon polaritons in graphene and van der Waals crystals and heterostructures. We review the underlying physics of these structures, which upend traditional wave-slowing approaches based on resonances or on periodic configurations above the diffraction limit. Light can now be tightly focused on the nanoscale at ...
Source: ScienceNOW - October 19, 2017 Category: Science Authors: Tsakmakidis, K. L., Hess, O., Boyd, R. W., Zhang, X. Tags: Online Only, Physics review Source Type: news

MOF-derived cobalt nanoparticles catalyze a general synthesis of amines
The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chemical research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobalt-diamine-dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atmosphere. The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples). The reaction coupl...
Source: ScienceNOW - October 19, 2017 Category: Science Authors: Jagadeesh, R. V., Murugesan, K., Alshammari, A. S., Neumann, H., Pohl, M.-M., Radnik, J., Beller, M. Tags: Chemistry r-articles Source Type: news

A liquid metal reaction environment for the room-temperature synthesis of atomically thin metal oxides
Two-dimensional (2D) oxides have a wide variety of applications in electronics and other technologies. However, many oxides are not easy to synthesize as 2D materials through conventional methods. We used nontoxic eutectic gallium-based alloys as a reaction solvent and co-alloyed desired metals into the melt. On the basis of thermodynamic considerations, we predicted the composition of the self-limiting interfacial oxide. We isolated the surface oxide as a 2D layer, either on substrates or in suspension. This enabled us to produce extremely thin subnanometer layers of HfO2, Al2O3, and Gd2O3. The liquid metal–based re...
Source: ScienceNOW - October 19, 2017 Category: Science Authors: Zavabeti, A., Ou, J. Z., Carey, B. J., Syed, N., Orrell-Trigg, R., Mayes, E. L. H., Xu, C., Kavehei, O., OMullane, A. P., Kaner, R. B., Kalantar-zadeh, K., Daeneke, T. Tags: Chemistry, Materials Science reports Source Type: news

Bucks biopharm firm signs licensing deal with California onco-immunology company
Arbutus BioPharma Corp., a Bucks County company developing treatments to cure hepatitis B infections, has entered into a collaboration and licensing deal with a California biopharmaceutical company developing personalized cancer immunotherapies. Under the terms of this license agreement, Gritstone Oncology of Emeryville, Calif., gets worldwide access to Arbutus’ portfolio of proprietary and clinically validated lipid nanoparticle [LNP] products and associated intellectual property. Gritstone will… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - October 18, 2017 Category: Pharmaceuticals Authors: John George Source Type: news

New hope for old antibiotics: Scientists have found a way to supercharge them for increased effectiveness against superbugs
(Natural News) Quantum dots are light-activated, nano-sized crystals with unique structures made from semiconductors. They’re highly tunable and can be precisely controlled for all sorts of applications, some of which lie in the field of medicine. While they’ve been used in place of organic dyes in biological analysis, researchers from the University of Colorado Boulder... (Source: NaturalNews.com)
Source: NaturalNews.com - October 18, 2017 Category: Consumer Health News Source Type: news

Researchers watch in real time as fat-encased drug nanoparticles invade skin cells
(University of Colorado Anschutz Medical Campus) A University of Colorado Cancer Center study published today in the journal ACS Nano describes the use of cutting-edge microscopy technology to visualize how liposomes escape from blood vessels into surrounding cells in a living mouse, offering clues that may help researchers design better drug delivery systems. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 18, 2017 Category: Cancer & Oncology Source Type: news

Stiff fibers spun from slime
(Max-Planck-Gesellschaft) Nanoparticles from the secretion of velvet worms form recyclable polymer fibers. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 18, 2017 Category: Biology Source Type: news

How a 'Star Wars' parody turned into a tool for scientific discovery (video)
(American Chemical Society) Science has long inspired the arts, but examples of the reverse scenario are sparse. Now scientists who set out to produce a 'Star Wars' parody have inadvertently created such an example. Incorporating animation techniques from the film industry, the researchers developed a robust new modeling tool that could help spur new molecular discoveries. Their project, reported in ACS Nano, resulted in a short film about fertilization called 'The Beginning.' For a look behind-the-scenes, watch ACS' Headline Science video. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 18, 2017 Category: Biology Source Type: news

Conductance measurements optimize atomic layer deposition automatically
Monitoring technique characterizes nanoscale deposition in real time, guiding a genetic algorithm and resulting in more efficient deposition cycles. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 18, 2017 Category: Nanotechnology Authors: Marric Stephens Source Type: news

MIPT scientists revisit optical constants of ultrathin gold films
(Moscow Institute of Physics and Technology) The authors of the paper provide reference data on the optical constants of gold for a wide range of wavelengths for films that are 20 to 200 nanometers thick. These findings will be of use to researchers working on various nanophotonic devices and metamaterials. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 17, 2017 Category: Biology Source Type: news

New Patent Issued to Nanomedical Diagnostics for Use of Graphene...
Ability to apply the highly sensitive and affordable technology for non-invasive tumor-specific DNA detection brings the holy grail of early cancer detection one step closer.(PRWeb October 17, 2017)Read the full story at http://www.prweb.com/releases/nanomedical_diagnostics/DNA_probe_patent_issued/prweb14810978.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - October 17, 2017 Category: Pharmaceuticals Source Type: news

New Patent Granted to Nanomedical Diagnostics for Use of Graphene...
Ability to apply the highly sensitive and affordable technology for non-invasive tumor-specific DNA detection brings the holy grail of early cancer detection one step closer.(PRWeb October 17, 2017)Read the full story at http://www.prweb.com/releases/nanomedical_diagnostics/DNA_probe_patent_issued/prweb14810978.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - October 17, 2017 Category: Pharmaceuticals Source Type: news

Magnetic particle imaging could help monitor stroke patients
Results from experiments on mice with cerebral ischemia are promising and produce blood-flow images that are comparable to those obtained with MRI, but in real time. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 16, 2017 Category: Nanotechnology Authors: Belle Dum é Source Type: news

NanOlogy takes nanoparticle tech into Phase II trials
In the last two weeks, NanOlogy has launched trials evaluating its cancer-fighting paclitaxel nanoparticle suspension in patients with prostate cancer and in patients with ovarian cancer. The Texas-based company’s nanoparticle tech is based on a production process that cuts the size of chemotherapy crystals by up to 400 times, creating stable nanoparticles with increased surface area and unique geometry, NanOlogy explained. The particles do not require coating agents for stability and are suspended prior to use. Get the full story at our sister site, Drug Delivery Business News. The post NanOlogy takes nano...
Source: Mass Device - October 16, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Oncology Pharmaceuticals nanology Source Type: news

Nanoantenna arrays power a new generation of fluorescence-based sensors
Researchers from the Universities of Bristol and Bedfordshire, in collaboration with multinational company ABB, have designed and tested a series of plasmonic nanoantenna arrays that could lead to the development of a new generation of ultrasensitive and low-cost fluorescence sensors that could be used to monitor water quality. (Source: University of Bristol news)
Source: University of Bristol news - October 16, 2017 Category: Universities & Medical Training Tags: International, Research; Faculty of Engineering, Faculty of Engineering, School of Computer Science, Electrical and Electronic Engineering, and Engineering Maths, Faculty of Science, Faculty of Science, School of Physics; Press Release Source Type: news

Major advance in nanopore detection of peptides and proteins
(University of Groningen) Nanopore technology, which is used to sequence DNA, is cheap, hand-held and works in the jungle and in space. The use of this technology to identify peptides or proteins is now a step closer. University of Groningen scientists have used a patented nanopore to identify the fingerprints of proteins and peptides, and it can even detect polypeptides differing by one amino acid. The results were published on 16 October in the journal Nature Communications. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 16, 2017 Category: Biology Source Type: news

Nanosheet actuators lift 150 times their own weight
Lifting devices based on molybdenum disulphide nanosheets are powerful, fast and robust. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 14, 2017 Category: Nanotechnology Authors: Peter Griffin Source Type: news

3 UCLA faculty receive National Institutes of Health research awards
Three researchers from the David Geffen School of Medicine at UCLA have received National Institutes of Health Director ’s Awards for 2017, highlighting the game-changing potential of the research at UCLA. The awards, which total more than $10 million, are part of the High-Risk, High-Reward Research Program supporting creative scientists who propose innovative, high-risk or unconventional biomedical research projects with the potential for unusually broad impact.“I continually point to this program as an example of the creative and revolutionary research NIH supports,” NIH Director Dr. Fran...
Source: UCLA Newsroom: Health Sciences - October 13, 2017 Category: Universities & Medical Training Source Type: news

Liquid metal-organic frameworks remain porous
MOFs retain their exceptional porosity even when melted, a surprising finding that could lead to many new industrial applications. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 13, 2017 Category: Nanotechnology Authors: Belle Dum é Source Type: news

Light travels freely in new zero-index silicon waveguide
Structure might come in useful for a host of applications in nonlinear optics, quantum optics and waveguide coupling. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 13, 2017 Category: Nanotechnology Authors: Belle Dum é Source Type: news

Spearheading Advancements in Surgical Sealants
Surgeons and clinicians have used surgical sealants for closing or reconnecting ruptured tissues, or as an adjunct to sutures and staples, for years. However, advancements in technology have led general surgeons and specialists to consider sealants for a wider range of applications and with increased frequency. Increasing Ease of Use Surgical sealants aren't as easy to use as a tube of Crazy Glue. Surgeons must mix and use some agents precisely and promptly to be effective. Delivery systems vary from a syringe, proprietary applicator, or through an endoscope. Most require special training. Sylys®, an elastic, resorbabl...
Source: MDDI - October 13, 2017 Category: Medical Devices Authors: Heather R. Johnson Tags: Implants Source Type: news

Double-walled carbon nanotubes get sorted
Technique separates DWCNTs according to both their inner- and outer-wall electronic types for the first time. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 12, 2017 Category: Nanotechnology Authors: Belle Dum é Source Type: news

Press release: Inspiralia makes strategic investment in Israeli Nanotech Company SP Nano
(Source: Nanotechweb.org Your News)
Source: Nanotechweb.org Your News - October 12, 2017 Category: Nanotechnology Source Type: news

International team reconstructs nanoscale virus features from correlations of scattered X-rays
(DOE/Lawrence Berkeley National Laboratory) Berkeley Lab researchers contributed key algorithms which helped scientists achieve a goal first proposed more than 40 years ago -- using angular correlations of X-ray snapshots from non-crystalline molecules to determine the 3-D structure of important biological objects. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 12, 2017 Category: Biology Source Type: news

NJIT's Kamalesh Sirkar wins coveted Award for Membrane Science and Technology Innovation
(New Jersey Institute of Technology) Kamalesh Sirkar, a chemical engineer acclaimed for his innovations in industrial membrane technology used to separate and purify air, water and waste streams and to improve the quality of manufactured products such as pharmaceuticals, solvents and nanoparticles, won the 2017 Alan S. Michaels Award for Innovation in Membrane Science and Technology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 12, 2017 Category: International Medicine & Public Health Source Type: news

Johns Hopkins scientists develop experimental 'nano-chemo' particle to treat bladder cancer
(Johns Hopkins Medicine) Working with mice and rats, Johns Hopkins researchers have developed a way to successfully deliver nano-sized, platinum-based chemotherapy drugs to treat a form of bladder cancer called nonmuscle-invasive that is found in the lining of the organ and has not invaded deeper into bladder tissue. The tiny drug-infused particles, they say, potentially offer a less toxic clinical alternative to standard chemotherapy delivered intravenously or through a catheter inserted into the bladder. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 12, 2017 Category: Cancer & Oncology Source Type: news

Aqueous Au-Pd colloids catalyze selective CH4 oxidation to CH3OH with O2 under mild conditions
The selective oxidation of methane, the primary component of natural gas, remains an important challenge in catalysis. We used colloidal gold-palladium nanoparticles, rather than the same nanoparticles supported on titanium oxide, to oxidize methane to methanol with high selectivity (92%) in aqueous solution at mild temperatures. Then, using isotopically labeled oxygen (O2) as an oxidant in the presence of hydrogen peroxide (H2O2), we demonstrated that the resulting methanol incorporated a substantial fraction (70%) of gas-phase O2. More oxygenated products were formed than the amount of H2O2 consumed, suggesting that the ...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Agarwal, N., Freakley, S. J., McVicker, R. U., Althahban, S. M., Dimitratos, N., He, Q., Morgan, D. J., Jenkins, R. L., Willock, D. J., Taylor, S. H., Kiely, C. J., Hutchings, G. J. Tags: Chemistry reports Source Type: news

Hanbury Brown and Twiss interferometry of single phonons from an optomechanical resonator
Nano- and micromechanical solid-state quantum devices have become a focus of attention. Reliably generating nonclassical states of their motion is of interest both for addressing fundamental questions about macroscopic quantum phenomena and for developing quantum technologies in the domains of sensing and transduction. We used quantum optical control techniques to conditionally generate single-phonon Fock states of a nanomechanical resonator. We performed a Hanbury Brown and Twiss–type experiment that verified the nonclassical nature of the phonon state without requiring full state reconstruction. Our result establis...
Source: ScienceNOW - October 12, 2017 Category: Science Authors: Hong, S., Riedinger, R., Marinkovic, I., Wallucks, A., Hofer, S. G., Norte, R. A., Aspelmeyer, M., Gröblacher, S. Tags: Physics reports Source Type: news

EPA announces new reporting rules on nano-sized particles manufactured in the United States
(Natural News) As of Aug. 14, 2017, the Environmental Protection Agency (EPA) put into effect a working guidance for the eighth section of the Toxic Substances Control Act (TSCA) about the Nanotechnology Reporting and Recordkeeping Requirements Rule. According to Nanowerk.com, this rule necessitates manufacturers and importers to provide a one-time reporting and record-keeping of certain chemicals.... (Source: NaturalNews.com)
Source: NaturalNews.com - October 11, 2017 Category: Consumer Health News Source Type: news

Nacre-like graphene composite is stronger and tougher
Brick-and-mortar architecture leads to much improved mechanical properties. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 10, 2017 Category: Nanotechnology Authors: Belle Dum é Source Type: news

Scanning tunnelling microscope creates all-graphene p –n junctions
Varying the tip voltage produces either electron traps or waveguides, integrating electronics and photonics on the same device. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 10, 2017 Category: Nanotechnology Authors: Matthew Holwill Source Type: news

NanoValent Pharmaceuticals Announces Exclusive Global Licensing...
- NanoValent Pharmaceuticals and Children's Hospital Los Angeles (CHLA) Sign Exclusive Licensing Agreement --- Initial Wave of Financing Places Company in Position to Initiate Investigational New...(PRWeb October 10, 2017)Read the full story at http://www.prweb.com/releases/2017/10/prweb14783967.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - October 10, 2017 Category: Pharmaceuticals Source Type: news

NanOlogy starts enrolment in Phase II trial of NanoPac for ovarian cancer
US-based pharmaceutical firm NanOlogy has started patient enrolment in a Phase II clinical trial of intraperitoneal (IP) NanoPac (nanoparticle paclitaxel) sterile suspension to treat ovarian cancer. (Source: Drug Development Technology)
Source: Drug Development Technology - October 9, 2017 Category: Pharmaceuticals Source Type: news

Strengthening UK-Italian research ties
A delegation representing UK research in quantum technologies headed out to Capri last week for a bilateral high level research meeting with Italian counterparts. (Source: University of Bristol news)
Source: University of Bristol news - October 9, 2017 Category: Universities & Medical Training Tags: Business and Enterprise, International; Faculty of Science, Faculty of Science, School of Physics, Faculty of Science, The Bristol Centre for Nanoscience and Quantum Information, Institutes, Institutes, Bristol Quantum Information Institute; Press Release Source Type: news

Thermoresponsive polymer helps graphene fold into 3D shapes
Origami-inspired technique could be used to make new types of devices from carbon sheet. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 9, 2017 Category: Nanotechnology Authors: Belle Dum é Source Type: news

Novel patch can better deliver polio vaccines: Study
Kendall said,"ease of administration, coupled with dose reduction observed in this study suggests that the Nanopatch could facilitate inexpensive vaccination of inactivated poliovirus vaccines." (Source: The Economic Times)
Source: The Economic Times - October 9, 2017 Category: Consumer Health News Source Type: news

Light polarization modulated rapidly by gold nanorods
Effect could be used to make better pharmaceuticals. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 9, 2017 Category: Nanotechnology Authors: Tim Wogan Source Type: news

Bacteria self-organize to build working sensors
(Duke University) By programming bacteria with a synthetic gene circuit that can recruit gold nanoparticles to the surface of their colony, Duke researchers can build functional devices. A proof-of-concept study appearing in Nature Biotechnology uses this technique to build dome-shaped pressure sensors with the help of living bacteria. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 9, 2017 Category: Biology Source Type: news

Light polarization modulated rapidly by gold nanorods
Effect could be used to make better pharmaceuticals (Source: PhysicsWeb News)
Source: PhysicsWeb News - October 7, 2017 Category: Physics Authors: Tim Wogan Source Type: news

Quantum Čerenkov effect makes graphene glow
Characterizing the location and spectra of light emitted from graphene field-effect transistors rules out other mechanisms. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - October 7, 2017 Category: Nanotechnology Authors: Marric Stephens Source Type: news

Three quarters of honey samples contain pesticide traces
Conclusion As the researchers made clear, the concentrations of neonicotinoid pesticides measured were far below the maximum level allowed in food products. Some previous studies have suggested these levels could harm bees and other pollinators that directly harvest the nectar, but we are not small insects. There's no evidence that the level of pesticides reported in this study would pose any harm to human health. There are two other points to note, if you are concerned: No particular brands or varieties of honey were found to be more at risk than others: it was a global sweep of honey samples. Before singling out honey...
Source: NHS News Feed - October 6, 2017 Category: Consumer Health News Tags: Food/diet Source Type: news

A dash of gold improves microlasers
(University of Southern California) By attaching gold nanoparticles to the surface of a microlaser, researchers in the USC Viterbi School of Engineering demonstrated a frequency comb that takes up less space and requires 1000 times less power than current comb technology. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 6, 2017 Category: Biology Source Type: news