Bruker Wins NanoString Auction
NanoString declaring bankruptcy on the eve of 2024's edition of AGBT was a shock to many at the meeting and then there was confusion: would one of the sponsors have a dark booth? The aggressive 10X Genomics legal strategy that forced the bankruptcy raised a degree of polite ire. But NanoString marketing carried on and CSO Joe Beecham delivered a fiery speech saying"we're not going anywhere". Then an investment firm, Patient Square Capital, appeared to be the front runner for acquiring the assets, with speculation they would combine NanoString with their other spatial omics portfolio company, Resolve Biosc...
Source: Omics! Omics! - April 23, 2024 Category: Bioinformatics Authors: Keith Robison Source Type: blogs
Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Update on Reversal of Atherosclerosis at Repair Biotechnologies
As some of you know, Repair Biotechnologies is the company I co-founded with Bill Cherman back in 2018. We've been working on an approach to reverse atherosclerosis for much of that time, and matters have progressed through the stage of great data in mice to present preparations for a pre-IND meeting with the FDA. While excess cholesterol has long been understood to be important to the development of atherosclerosis, it turns out that circulating cholesterol bound to LDL particles is less important than the amount of localized excess cholesterol in the liver and blood vessel walls.
Any localized excess of cholestero...
Source: Fight Aging! - April 11, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
8 Mindblowing Examples Of Technology Innovation In Healthcare
Medical innovations often conjure images of sterile labs, high-tech equipment, and complex procedures. But every now and then, remarkable breakthroughs come with a dash of ‘why didn’t I think of that?’ ingenuity. From reimagined everyday objects to solutions inspired by the natural world, these innovations prove that effective healthcare doesn’t always need to be complicated.
Let’s see some medical innovations that are as surprising as they are effective. We collected eight of our favorites that show how a little out-of-the-box thinking is leading to big changes in healthcare.
1. Zip-up ...
Source: The Medical Futurist - April 9, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF creative healthcare healthcare innovation Source Type: blogs
Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How microplastics harm your health
The New England Journal of Medicine recently published a paper titled “Microplastics and Nanoplastics in Atheromas and Cardiovascular Events,” which detected the presence of microplastics and nanoplastics (MNPs) in carotid artery plaque, with a higher risk of a composite of myocardial infarction, stroke, or death from any cause at 34 months follow-up than those in
Read more…
How microplastics harm your health originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 5, 2024 Category: General Medicine Authors: Neha Pidatala, MD Tags: Conditions Cardiology Source Type: blogs
Using mRNA to Generate Therapeutic Antibodies in the Brain
It may turn out to be cost-effective to replace delivery of therapeutic monoclonal antibodies with delivery of messenger RNA (mRNA), encapsulated in a lipid nanoparticle or linked to a cell penetrating molecule of some sort in order to reach the desired tissues and be taken up into the cytoplasm. Researchers here consider this in the context of treating Alzheimer's disease, where the primary thrust of therapeutic development involves the use of antibodies targeting the various protein aggregates thought to contribute to disease progression.
Monoclonal antibodies have emerged as a leading therapeutic agent for the ...
Source: Fight Aging! - April 4, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Inhibiting P16 in Microglia Reduces Amyloid Plaques in Mice
Researchers here show that targeting microglia in a mouse model of Alzheimer's disease to suppress p16 expression can reduce amyloid-β plaques. This appears to be a way to interfere in a maladaptive reaction to amyloid-β on the part of microglia, innate immune cells responsible for clearing molecular debris from brain tissue. P16 is a marker of cellular senescence, though may also be characteristic of non-senescent but still problematic, pro-inflammatory microglia. There is a good amount of evidence to suggest that both senescent and overly active microglia are important to the progression of neurodegenerative conditions...
Source: Fight Aging! - March 28, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Human Exosomes Harvested from Stem Cells in Urine Produce Rejuvenation in Mice
In this study, we further analyzed these data and found that a class of USC-EVs-enriched proteins have been previously shown to possess anti-aging function, such as tissue inhibitor of metalloproteinases 1 (TIMP1), plasminogen activator urokinase (PLAU), insulin-like growth factor binding protein 5, senescence marker protein-30, and connective tissue growth factor. Thus, we hypothesized that USC-EVs might be capable of rejuvenating old organs from aging via transferring of anti-aging proteins.
Here, we tested the effects of USC-EVs on cellular senescence in vitro and on the aging-related phenotypes in different orga...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Microplastics, Major Problem
By KIM BELLARD
It’s been almost four years since I first wrote about microplastics; long story short, they’re everywhere. In the ground, in the oceans (even at the very bottom), in the atmosphere. More to the point, they’re in the air you breathe and in the food you eat. They’re in you, and no one thinks that is a good thing. But we’re only starting to understand the harm they cause.
The Washington Post recently reported:
Scientists have found microplastics — or their tinier cousins, nanoplastics — embedded in the human placenta, in blood, in the heart and in the liver and bowels. In one re...
Source: The Health Care Blog - March 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Kim Bellard Microplastics Source Type: blogs
Using ChatGPT Offline: How Small Language Models Can Aid Healthcare Professionals
By now, you might have come across the term large language models (LLMs), which is a type of generative artificial intelligence (GenAI). If not, you have likely encountered GenAI applications that are based on LLMs. This includes the likes of ChatGPT, Google Bard and Microsoft Copilot. While such models have proved useful, in the healthcare setting, they come with new sets of regulatory, ethical and privacy concerns.
Recently, another type of language model has been gaining attention in the GenAI field: the small language model (SLM). It even holds the promise of addressing some of the challenges with integrating LLMs i...
Source: The Medical Futurist - March 12, 2024 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF large language models small language models SLM Source Type: blogs
Micro and Nanoplastics and Cardiovascular Events – Recent Study
Use of plastics in daily life is currently on the increase and it is a well known pollutant in our water bodies like rivers, ponds, lakes and ocean. Plastics can be degraded into microplastics which are smaller than 5 mm and nanoplastics which are smaller than 1000 nanometer [1]. Microplastics and nanoparticles can trigger toxicologic effects in the body [2]. Both microplastics and nanoplastics can enter our body through ingestion, inhalation and even by topical exposure on the skin. According to a webpage from United States National Oceanic and Atmospheric Administration (NOAA), microbeads which are a type of microplastic...
Source: Cardiophile MD - March 8, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
What Scares Healthcare Like EVs Scare Detroit
By KMI BELLARD
I’m thinking about electric vehicles (EVs)…and healthcare.
Now, mind you, I don’t own an EV. I’m not seriously thinking about getting one (although if I’m still driving in the 2030’s I expect it will be in one). To be honest, I’m not really all that interested in EVs. But I am interested in disruption, so when Robinson Meyer warned in The New York Times “China’s Electric Vehicles Are Going to Hit Detroit Like a Wrecking Ball,” he had my attention. And when on the same day I also read that Apple was cancelling its decade-long effort to build an EV, I was definitely paying attention.
...
Source: The Health Care Blog - March 6, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Health Tech Biden Detroit EVs Hospitals Kim Bellard Source Type: blogs
What Does an Immunologist Do?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed.
Immunology is the study of the immune system, including all the cells, tissues, and organs that work together to protect you from germs. A person who studies immunology is called an immunologist, and there are three types:
Researchers, who study the immune system in the laboratory to understand how it works or how it can go awry and find new treatments for immune system-related diseases
Doctors, who diagnose and care for patients with diseases related to the immune system, such as ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 12, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Injury and Illness Immunology Miniseries Infectious Diseases Medicines Microbes Research Roundup Source Type: blogs
