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USRM Reaches Key Sales Milestone of Proprietary Adipocell(TM) Product
Company Poised to Be Industry Leader in Autologous Adipose Stem Cell Treatments SUNRISE, Fla., Jan. 15, 2018 -- (Healthcare Sales & Marketing Network) -- U.S. Stem Cell, Inc. (OTC: USRM), a leader in the development of proprietary, physician-based stem... Regenerative Medicine U.S. Stem Cell, Adipocell, stem cell (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - January 15, 2018 Category: Pharmaceuticals Source Type: news

UCLA scientists make cells that enable the sense of touch
Researchers at the  Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons — the cells that give us our sense of touch. The new protocol could be a step toward stem cell–based therapies to restore sensation in paralyzed people who have lost feeling in parts of their body.The study, which was led by Samantha Butler, a UCLA associate professor of neurobiology and member of the Broad Stem Cell Research Center, was published today in the journal Stem Cell Reports.Sensory interneurons, a class of n...
Source: UCLA Newsroom: Health Sciences - January 12, 2018 Category: Universities & Medical Training Source Type: news

Upfront Stem Cell Transplant Remains Standard of Care for Newly Diagnosed Multiple Myeloma Upfront Stem Cell Transplant Remains Standard of Care for Newly Diagnosed Multiple Myeloma
Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - January 11, 2018 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news

NIDCR Autotherapies Symposium | Thurs., Jan. 25, 8:00 a.m.-12:00 p.m.
Having trouble viewing this email? View it as a Web page.   NIDCR invites you to a scientific symposium: "Autotherapies: Enhancing Our Innate Healing Capacity"  Thursday, January 25, 8:00 am-12:00 pm Lipsett Amphitheater in the NIH Clinical Center (Building 10)NIH Campus, Bethesda, Md. Autotherapies are treatments based on the body's natural ability to heal and protect itself. For example, immunotherapy harnesses the body’s immune cells to fight c...
Source: NIDCR Science News - January 11, 2018 Category: Dentistry Source Type: news

Researchers map genetic ‘switches’ behind human brain evolution
FINDINGSUCLA researchers have developed the first map of gene regulation in human neurogenesis, the process by which neural stem cells turn into brain cells and the cerebral cortex expands in size. The scientists identified factors that govern the growth of our brains and, in some cases, set the stage for several brain disorders that appear later in life.BACKGROUNDThe human brain differs from that of mice and monkeys because of its large cerebral cortex. The organ ’s most highly developed part, the cerebral cortex is responsible for thinking, perceiving and sophisticated communication. Scientists are just beginning t...
Source: UCLA Newsroom: Health Sciences - January 11, 2018 Category: Universities & Medical Training Source Type: news

Alcohol may be 'very damaging' to people with 'Asian glow'
Why does drinking alcohol boost your risk of cancer? By damaging the DNA in your stem cells, a new study suggests. And if your face flushes red after you sip half a bottle of beer, like many Asians, you could be getting way more DNA damage than other people. (Source: CBC | Health)
Source: CBC | Health - January 11, 2018 Category: Consumer Health News Tags: News/Technology & Science Source Type: news

UCLA scientists make cells that enable the sense of touch
(University of California - Los Angeles Health Sciences) Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons -- the cells that give us our sense of touch. The new protocol could be a step toward stem cell-based therapies to restore sensation in paralyzed people who have lost feeling in parts of their body. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 11, 2018 Category: International Medicine & Public Health Source Type: news

Long-lasting adaptations of the innate immune system through the bone marrow
(Radboud University Nijmegen) The immune system not only detects and destroys pathogens such as microbes but also plays a role in the onset of diseases such as arteriosclerosis. Scientists from Radboud university medical center, Bonn, Dresden and Pennsylvania, studied a new mechanism that regulates the immune system's functioning. They discovered that cholesterol inhibitors may prevent infections, that a high-fat Western diet can have a long-lasting effect on our immunity and that even our stem cells can be disrupted. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 11, 2018 Category: Infectious Diseases Source Type: news

Researchers map out genetic 'switches' behind human brain evolution
(University of California - Los Angeles) UCLA researchers have developed the first map of gene regulation in human neurogenesis, the process by which neural stem cells turn into brain cells and the cerebral cortex expands in size. The scientists identified factors that govern the growth of our brains and, in some cases, set the stage for several brain disorders that appear later in life. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 11, 2018 Category: International Medicine & Public Health Source Type: news

Stem cell-rich cord blood donations could increase by 'nudging' parents, study suggests
(University of Toronto, Rotman School of Management) A two-year study of expectant mothers in Milan, Italy, has found that cord blood donations increased significantly when parents received information about the procedure and " prompts " to indicate their interest in donating at both early and late stages of their pregnancies. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 11, 2018 Category: International Medicine & Public Health Source Type: news

Gene therapy comes of age
After almost 30 years of promise tempered by setbacks, gene therapies are rapidly becoming a critical component of the therapeutic armamentarium for a variety of inherited and acquired human diseases. Gene therapies for inherited immune disorders, hemophilia, eye and neurodegenerative disorders, and lymphoid cancers recently progressed to approved drug status in the United States and Europe, or are anticipated to receive approval in the near future. In this Review, we discuss milestones in the development of gene therapies, focusing on direct in vivo administration of viral vectors and adoptive transfer of genetically engi...
Source: ScienceNOW - January 11, 2018 Category: Science Authors: Dunbar, C. E., High, K. A., Joung, J. K., Kohn, D. B., Ozawa, K., Sadelain, M. Tags: Medicine, Diseases review Source Type: news

The epigenetic control of stemness in CD8+ T cell fate commitment
After priming, naïve CD8+ T lymphocytes establish specific heritable transcription programs that define progression to long-lasting memory cells or to short-lived effector cells. Although lineage specification is critical for protection, it remains unclear how chromatin dynamics contributes to the control of gene expression programs. We explored the role of gene silencing by the histone methyltransferase Suv39h1. In murine CD8+ T cells activated after Listeria monocytogenes infection, Suv39h1-dependent trimethylation of histone H3 lysine 9 controls the expression of a set of stem cell–related memory genes. Single-c...
Source: ScienceNOW - January 11, 2018 Category: Science Authors: Pace, L., Goudot, C., Zueva, E., Gueguen, P., Burgdorf, N., Waterfall, J. J., Quivy, J.-P., Almouzni, G., Amigorena, S. Tags: Immunology r-articles Source Type: news

Stem Cell Therapy Helps Resolve Complex Perianal Fistulas in Crohn's Disease Stem Cell Therapy Helps Resolve Complex Perianal Fistulas in Crohn's Disease
Local administration of allogeneic expanded adipose-derived stem cells (Cx601) improves resolution of complex perianal fistulas in patients with Crohn's disease, according to results from the ADMIRE CD trial.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 10, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

FDA says N.J. stem cell company marketing product without approval
The agency said the company, which has roots in South Jersey, is marketing a stem cell product without FDA approval. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - January 10, 2018 Category: Pharmaceuticals Authors: John George Source Type: news

'Decorated' stem cells could offer targeted heart repair
(North Carolina State University) 'Decorating' cardiac stem cells with platelet nanovesicles can increase the stem cells' ability to find and remain at the site of heart attack injury and enhance their effectiveness in treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 10, 2018 Category: International Medicine & Public Health Source Type: news

New stem cell method sheds light on a tell-tale sign of heart disease
(Morgridge Institute for Research) While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research unexpectedly unearthed a powerful new model for studying a hallmark of vascular disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 9, 2018 Category: Biology Source Type: news

Engineers grow functioning human muscle from skin cells
(Duke University) Duke engineers have grown the first functioning human muscle from non-muscle cells -- skin cells reverted to their primordial stem cell state. The ability to start from cellular scratch using non-muscle tissue will allow scientists to grow far more muscle cells, provide an easier path to genome editing and cellular therapies, and develop individually tailored models of rare muscle diseases for drug discovery and basic biology studies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 9, 2018 Category: International Medicine & Public Health Source Type: news

Cellular hitchhikers aid recovery from spinal cord injury
The healing effects of stem cells in spinal cord injury can be aided by their ability to move to specific anti-inflammatory cells called M2 macrophages. (Source: Yale Science and Health News)
Source: Yale Science and Health News - January 5, 2018 Category: Universities & Medical Training Source Type: news

MM: High-Dose Chemo with SCT Associated with Longer PFS (CME/CE)
(MedPage Today) -- Autologous stem cell transplant remains preferred therapy for eligible patients (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 5, 2018 Category: Primary Care Source Type: news

Researchers grow skin, with hair, from stem cells
In a first, stem cell researchers can grow hair follicles in skin, an Indiana University School of Medicine report said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - January 5, 2018 Category: Consumer Health News Source Type: news

Lab notes: from zero aliens to a whopping prime, 2018 is already racking up the digits
We ’re going to start big: with over 23m digits. That’s right, not even a week into 2018 and records have already tumbled at the discovery of thelargest prime number ever to be found - less than a year after its predecessor. It ’s exciting, it a math-sy sort of way, but for my money the most intriguing story this week was the genetic analysis of an ice age baby girl which has revealeda new group of Native Americans: the ancient Beringians. One of our experts also unpackedwhat the ancient DNA discovery tells us about Native American ancestry, and it ’s a fascinating read. A less pleasing genetic reve...
Source: Guardian Unlimited Science - January 5, 2018 Category: Science Authors: Tash Reith-Banks Tags: Science Source Type: news

Gene therapy offers long-term treatment for mice with diabetes
The newly resurgent field of gene therapy, which recently produced treatments forblood cancers andblindness, has taken a step toward fighting a scourge that is on the rise worldwide: diabetes.Inresearch reported Thursday in the journal Cell Stem Cell, scientists showed that a single infusion... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - January 5, 2018 Category: Science Authors: Melissa Healy Source Type: news

Blood sugar levels in diabetic mice restored with gene therapy
A new gene therapy approach can revert sugar levels back to normal in mice with type 1 diabetes, according to new findings published inCell Stem Cell.EurekAlert! (Source: Society for Endocrinology)
Source: Society for Endocrinology - January 5, 2018 Category: Endocrinology Source Type: news

In scientific first, IU researchers grow hairy skin in a dish
(Indiana University) Researchers at Indiana University School of Medicine have successfully developed a method to grow hairy skin from mouse pluripotent stem cells -- a discovery that could lead to new approaches to model disease and new therapies for the treatment of skin disorders and cancers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 5, 2018 Category: International Medicine & Public Health Source Type: news

Stem Cell Transplant Improves Severe Scleroderma Survival Stem Cell Transplant Improves Severe Scleroderma Survival
Among patients with severe scleroderma, stem cell transplant significantly improved survival compared with cyclophosphamide but was associated with higher mortality and short-term side effects, a study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 4, 2018 Category: Consumer Health News Tags: Rheumatology News Source Type: news

FDA warns American CryoStem Corporation of significant deviations related to its unapproved stem cell product, Atcell
FDA warns American CryoStem Corporation of significant deviations related to its unapproved stem cell product (Source: Food and Drug Administration)
Source: Food and Drug Administration - January 4, 2018 Category: American Health Source Type: news

Stem Cell Transplant Shows Promise for Immune Disorder Scleroderma
Title: Stem Cell Transplant Shows Promise for Immune Disorder SclerodermaCategory: Health NewsCreated: 1/3/2018 12:00:00 AMLast Editorial Review: 1/4/2018 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - January 4, 2018 Category: Rheumatology Source Type: news

Gene therapy restores normal blood glucose levels in mice with type 1 diabetes
(Cell Press) A study in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long-term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with type 1 diabetes. The researchers used an adeno-associated viral (AAV) vector to deliver to the mouse pancreas two proteins, Pdx1 and MafA, which reprogrammed plentiful alpha cells into functional, insulin-producing beta cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 4, 2018 Category: Biology Source Type: news

Phase III clinical trials for stem cell-based cartilage regeneration therapy have started
(Osaka University) A group of researchers at Osaka University developed a synthetic tissue using synovium-derived mesenchymal stem cells for treating damaged cartilage, which had previously been incurable and had no effective therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 4, 2018 Category: International Medicine & Public Health Source Type: news

Deep learning methods used to identify novel genes implicated in tissue regeneration and cancer
(InSilico Medicine, Inc.) The latest publication by Insilico Medicine and BioTime in Oncotarget demonstrated the first application of deep neural networks (DNNs) to the gene expression data collected during many stages of differentiation starting from several embryonic stem cell lines. Repression of COX7A1 in embryonic and cancer cells was identified as embryonic-fetal transition markers by DNN. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 4, 2018 Category: International Medicine & Public Health Source Type: news

Experts identify how alcohol raises cancer risk
Alcohol can cause damage to DNA in blood stem cells Related items fromOnMedica Government urged to stress dangers of even moderate drinking Alcohol dependency and detoxification Detox units 'putting patients at risk' Alcohol directly causes seven types of cancer England faces 135,000 alcohol-related cancer deaths by 2035 (Source: OnMedica Latest News)
Source: OnMedica Latest News - January 4, 2018 Category: UK Health Source Type: news

Stem Cell Transplant Succeeds in Scleroderma (CME/CE)
(MedPage Today) -- Significant benefits seen versus cyclophosphamide (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 3, 2018 Category: Primary Care Source Type: news

Medical Grade Soluble Collagen
This study developed a macroporous scaffold that is fabricated by weaving highly aligned collagen threads. The scaffold can deliver high density cell condensates while providing mechanical stiffness comparable to that of cartilage. The scaffold also mimicked the arcade-like orientation of collagen fibers in cartilage. A highly robust chondrogenesis was observed in this mesenchymal cell pellet delivery system. Baseline mechanical robustness of this scaffold system will enable delivery of cell pellets as early as three days. (Source: Neuromics)
Source: Neuromics - January 3, 2018 Category: Neuroscience Tags: 3-D Cell based Assays 3-D collagen scaffolds cartilage human chondrocytes Human Mesenchymal Stem Cells Source Type: news

How alcohol damages stem cell DNA and increases cancer risk
LONDON (Reuters) - Drinking alcohol produces a harmful chemical in the body which can lead to permanent genetic damage in the DNA of stem cells, increasing the risk of cancer developing, according to research published on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - January 3, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Alcohol can cause irreversible genetic damage to stem cells, says study
Link between drinking and cancer clarified by study which indicates alcohol causes cancer by scrambling DNA in cells, eventually leading to mutationsAlcohol can cause irreversible genetic damage to the body ’s reserve of stem cells, according to a study that helps explain the link between drinking and cancer.The research, using genetically modified mice, provides the most compelling evidence to date that alcohol causes cancer by scrambling the DNA in cells, eventually leading to deadly mutations.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - January 3, 2018 Category: Science Authors: Hannah Devlin Science correspondent Tags: Science Health Alcohol Cancer research Medical research Society Genetics Stem cells Source Type: news

Cellular barcoding helps scientists understand the behavior of stem cells
Use of labeling technology in mice leads to discoveries in process of natural blood formation. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - January 3, 2018 Category: American Health Source Type: news

Stem cell transplant for severe scleroderma improves survival, quality of life
NIH-funded study finds transplantation superior to treatment with immune-suppressing drug. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - January 3, 2018 Category: American Health Source Type: news

Stem Cell Transplant Shows Promise for Immune Disorder Scleroderma
WEDNESDAY, Jan. 3, 2018 -- Stem cell transplants could offer new hope for people with a severe form of scleroderma -- a debilitating and deadly condition that affects the immune system, a new study suggests. " Scleroderma hardens the skin and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 3, 2018 Category: General Medicine Source Type: news

New research shows how alcohol damages DNA and increases cancer risk
(Cancer Research UK) Scientists have shown how alcohol damages DNA in stem cells, helping to explain why drinking increases your risk of cancer, according to research part-funded by Cancer Research UK and published in Nature today. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 3, 2018 Category: Cancer & Oncology Source Type: news

Cellular barcoding helps scientists understand the behavior of stem cells
(NIH/National Heart, Lung and Blood Institute) By tagging bone marrow cells of mice with a genetic label, or barcode, researchers were able to track and describe the family tree of individual blood cells as they form in their natural environment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 3, 2018 Category: International Medicine & Public Health Source Type: news

Scientists advance stem cell therapy for a leading cause of blindness
Researchers made advances toward creating stem cell-derived retinal cells used to treat a leading cause of blindness. (Source: Health News - UPI.com)
Source: Health News - UPI.com - January 2, 2018 Category: Consumer Health News Source Type: news

NIH discovery brings stem cell therapy for eye disease closer to the clinic
Stem cell-derived retinal cells need primary cilia to support survival of light-sensing photoreceptors. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - January 2, 2018 Category: American Health Source Type: news

Frequency touts first-in-human safety study for hearing loss therapy
Frequency Therapeutics has finished a first-in-human study of its progenitor cell activation therapy, FX-322, in nine adults with severe to profound sensorineural hearing loss. The company’s candidate is a combination of small molecules that are designed to activate progenitor cells and trigger the formation of new hair cells in the inner ear. Get the full story at our sister site, Drug Delivery Business News. The post Frequency touts first-in-human safety study for hearing loss therapy appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - January 2, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Drug-Device Combinations Otolaryngology Ear, Nose & Throat Pharmaceuticals Regenerative Medicine Stem Cells Frequency Therapeutics Source Type: news

Scientists use stem cells to create hairy skin in the lab
The new skin model, developed by experts at Indiana University School of Medicine in Indianapolis, more closely resembles natural hair than any of its predecessors. (Source: the Mail online | Health)
Source: the Mail online | Health - January 2, 2018 Category: Consumer Health News Source Type: news

Baldness cure? Stem cells from MICE used to create skin in a lab
A CURE for baldness has moved a step closer after skin was created in the lab, complete with hair follicles. (Source: Daily Express - Health)
Source: Daily Express - Health - January 2, 2018 Category: Consumer Health News Source Type: news

NIH discovery brings stem cell therapy for eye disease closer to the clinic
(NIH/National Eye Institute) Scientists at the National Eye Institute report that tiny tube-like protrusions called primary cilia on cells of the retinal pigment epithelium (RPE) -- a layer of cells in the back of the eye -- are essential for the survival of the retina's light-sensing photoreceptors. The discovery has advanced efforts to make stem cell-derived RPE for transplantation into patients with geographic atrophy, otherwise known as dry age-related macular degeneration (AMD), a leading cause of blindness in the US. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 2, 2018 Category: Biology Source Type: news

Hairy skin grown from mouse stem cells
(Cell Press) Indiana University School of Medicine researchers have cultured the first lab-grown skin tissue complete with hair follicles. This skin model, developed using stem cells from mice, more closely resembles natural hair than existing models and may prove useful for testing drugs, understanding hair growth, and reducing the practice of animal testing. The work appears January 2 in the journal Cell Reports. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 2, 2018 Category: Biology Source Type: news

Scientists a step closer to mimicking way human body creates sperm
Researchers pass milestone on developmental path from stem cells to immature sperm, and hint lab-made sperm and eggs may one day be possibleScientists have come a step closer to mimicking the natural process by which the body creates sperm from stem cells in work that could ultimately provide new treatments for infertility.Speaking at theProgress Educational Trust annual conference in London this month, Azim Surani, director of germline and epigenetics research at the University of Cambridge ’s Gurdon Institute, said he and colleagues had passed a significant milestone on the path to producing sperm in the laboratory...
Source: Guardian Unlimited Science - January 1, 2018 Category: Science Authors: Hannah Devlin Science correspondent Tags: Reproduction Stem cells Science Biology Fertility problems Health Society Medical research Source Type: news

Anti-T-Cell Globulins Flop in Unrelated Stem Cell Transplants (CME/CE)
(MedPage Today) -- GVHD reduced, but so was survival (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - December 29, 2017 Category: Hematology Source Type: news

OncoBreak: Top News of 2017; Trial Recruitment Troubles; Obesity and Stem Cells
(MedPage Today) -- News, features, and commentary about cancer-related issues (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - December 28, 2017 Category: American Health Source Type: news