Mesenchymal Stem Cell Therapy Produces Thymus Regrowth in Old Non-Human Primates
Thymocytes generated in the bone marrow migrate to the thymus, near the heart, where they mature into T cells of the adaptive immune system. Unfortunately, the thymus atrophies with age. Most people have little active thymus tissue left by the time they are in their 50s. Absent a robust supply of new T cells, the adaptive immune system becomes ever more made up of malfunctioning, senescent, and other problematic cells, lacking the naive T cells needed to respond to new threats. Regeneration of the thymus is thus an important goal. There are some indications that the thymus is more plastic than thought, given that mild calo...
Source: Fight Aging! - April 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
TLR2 Important in the Dysfunction of Hair Follicles
Dysfunction in hair follicles and loss of the capacity for hair growth is a perhaps surprisingly complex aspect of aging and disease. For all the the basic mechanisms of hair growth are well-investigated, the hair follicle is a complex structure, and hair growth involves the collaboration of many cell types, activities, and signaling that shifts over time as the follicle progresses through the stages of growth. It has proven to be hard to pin down any one specific mechanism as vital, and it may turn out to be the case that no one specific mechanism is the key to preventing loss of hair with advancing age and other circumst...
Source: Fight Aging! - April 12, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Long-Lived RNA that is Never Replaced in Neurons
The question of whether there are long-lived molecules in long-lived neurons in the brain is an interesting one. Are there specific molecules in the brain that never get replaced across a lifetime, and thus might be vulnerable to damage in the form of modifications that disrupt function? This remains a somewhat hypothetical concern, in the sense that there is no direct demonstration that this is a significant source of dysfunction in late life. Researchers have found evidence for long-lived nuclear pore proteins, however, and here another group presents evidence for long-lived RNA molecules.
Most cells in the huma...
Source: Fight Aging! - April 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Survey of MicroRNAs Shown to be Relevant to Muscle Aging
RNA molecules are produced in the cell nucleus by transcription machinery that reads gene sequences from the genome. MicroRNAs are among the varieties of RNA molecule that are not translated by a ribosome to produce proteins. Instead they directly participate in cell functions, often by altering the expression of other genes. Many microRNAs appear to be important players in the regulation of specific cell behaviors and tissue functions, such as regeneration and maintenance of tissues.
In today's open access paper, the authors provide an overview of some of the microRNAs that have been identified as important or pote...
Source: Fight Aging! - April 4, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reversing Myeloid Bias by Selective Destruction of Hematopoietic Cells
The hematopoietic cell populations of the bone marrow are responsible for producing red blood cells and immune cells. With advancing age, the production of immune cells shifts to bias myeloid cells of the innate immune system versus lymphocyte cells of the adaptive immune system. This is thought to be an important aspect of immune aging. Researchers here attempt to reverse this myeloid bias in immune cell production by selectively destroying some of the myeloid-focused hematopoietic cells, an interesting idea. The results are positive and intriguing.
During aging, the number of hematopoietic stem cells (HSCs) that...
Source: Fight Aging! - April 3, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Stem Cell Secretome Treatment Improves Measures of Health in Old Mice
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 1, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Interview with Stefany Shaheen: Revolutionizing diabetes care through cell therapies
I had the extraordinary opportunity to chat with Stefany Shaheen, the Chief Strategy Officer of Advanced Regenerative Manufacturing Institute (ARMI) and BioFab USA, about the transformative potential of cell therapies for individuals living with diabetes. Stefany shared her remarkable journey, insights on cell therapies’ current status, approval challenges, and how the diabetes community can contribute to advancing research in this field.
A few months before this discussion with Stefany, I had the opportunity to hear Dean Kamen speak at the recent ...
Source: Scott's Diabetes Blog - April 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Skeptical View of the Role of Nuclear DNA Damage in Aging
It is evident and settled that stochastic nuclear DNA damage contributes to cancer. The more of it that you have, the worse your risk. What is still very much debated is whether nuclear DNA damage contributes meaningfully to degenerative aging, and how it does so. Most mutational damage to DNA occurs in regions that are inactive, in cells that have comparatively few divisions remaining before reaching the Hayflick limit. Even if damage alters the function of such a cell, in some non-cancerous way, it is unclear as to how this could amount to a meaningful contribution to loss of tissue function.
The one school of tho...
Source: Fight Aging! - March 28, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Lipid Droplets in Microglia Involved in Alzheimer's Pathology
Microglia are innate immune cells resident in the central nervous system. Microglial dysfunction is clearly a contributing factor in the onset and progression of age-related neurodegenerative conditions, including Alzheimer's disease, as well as the accompanying chronic inflammation of brain tissue. As to why microglia become problematic and inflammatory, there are any number of possible contributing mechanisms to consider. Cellular senescence, mitochondrial dysfunction, reactions to cell debris or the presence of persistent viral infections, and more. In this vein, researchers here discuss excessive lipid accumulation in ...
Source: Fight Aging! - March 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Human Exosomes Harvested from Stem Cells in Urine Produce Rejuvenation in Mice
In this study, we further analyzed these data and found that a class of USC-EVs-enriched proteins have been previously shown to possess anti-aging function, such as tissue inhibitor of metalloproteinases 1 (TIMP1), plasminogen activator urokinase (PLAU), insulin-like growth factor binding protein 5, senescence marker protein-30, and connective tissue growth factor. Thus, we hypothesized that USC-EVs might be capable of rejuvenating old organs from aging via transferring of anti-aging proteins.
Here, we tested the effects of USC-EVs on cellular senescence in vitro and on the aging-related phenotypes in different orga...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
