Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function | Science Signaling
Protein transfer through matrix-bound vesicles from CAFs enhances monocyte adhesion to endothelial cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 12, 2024 Category: Science Source Type: news

The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P | Science Signaling
The phospholipid PI4P can enhance STING activation by increasing its recruitment to the Golgi apparatus. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 12, 2024 Category: Science Source Type: news

Aging from adipose accumulation of antibodies | Science Signaling
IgG accumulation in white adipose tissue contributes to aging-associated metabolic dysfunction. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 12, 2024 Category: Science Source Type: news

Differential protein-protein interactions underlie signaling mediated by the TCR and a 4-1BB domain –containing CAR | Science Signaling
The protein-protein interactions stimulated by activation of chimeric antigen receptors in T cells are characterized. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 5, 2024 Category: Science Source Type: news

eEF1A2 promotes PTEN-GSK3 β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer | Science Signaling
PTEN and the translation factor eEF1A2 repress breast cancer cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 5, 2024 Category: Science Source Type: news

Bring in the B team | Science Signaling
ATP released by osteoblasts signals through the purinergic receptor P2RX4 to optimize plasma cell survival. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 5, 2024 Category: Science Source Type: news

Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation | Science Signaling
Breast cancer cell sensitivity to a second-generation AKT degrader correlates with basal JNK activity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 27, 2024 Category: Science Source Type: news

ALOX5 drives the pyroptosis of CD4+ T cells and tissue inflammation in rheumatoid arthritis | Science Signaling
Leukotriene-induced T cell pyroptosis drives synovial inflammation in rheumatoid arthritis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 27, 2024 Category: Science Source Type: news

A way to block TBK1 in ccRCC | Science Signaling
Targeting a driver of TBK1 kinase activity may slow the growth of kidney tumors. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 27, 2024 Category: Science Source Type: news

Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation | Science Signaling
A fusion protein called A1M that chaperones bioactive lipids is characterized in endothelial cells and mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 20, 2024 Category: Science Source Type: news

Activation of gp130 signaling in T cells drives TH17-mediated multi-organ autoimmunity | Science Signaling
Genetic activation of a cytokine receptor in T cells in mice models a STAT3-driven autoimmune syndrome. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 20, 2024 Category: Science Source Type: news

Poachers turned gamekeepers in T cells | Science Signaling
The efficacy of therapeutic T cells is enhanced by incorporating mutations associated with autoimmunity or lymphoma. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 20, 2024 Category: Science Source Type: news

Mechanisms of biased agonism by G αi/o-biased stapled peptide agonists of the relaxin-3 receptor | Science Signaling
How distinct signaling pathways are activated by the receptor for relaxin-3 is determined. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 13, 2024 Category: Science Source Type: news

GPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization | Science Signaling
Biased CXCR3 –mediated signaling depends on the location-specific recruitment of GRKs. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 13, 2024 Category: Science Source Type: news

RNAs create a sticky situation | Science Signaling
Glycated RNAs on neutrophils enable adhesion to the endothelium and extravasation to sites of inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 13, 2024 Category: Science Source Type: news