A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo | Science Signaling
Cilia isolated from the olfactory sensory neurons of transgenic mice can be used to profile human odorant receptors. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Functional and biological heterogeneity of KRASQ61 mutations | Science Signaling
Comparison of Gln61 (Q61) mutations in KRAS reveals a potential therapeutic opportunity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Heterogeneity in RAS mutations: One size does not fit all | Science Signaling
The distinct biochemistry and biology of KRAS Gln61 mutants are revealed (Huynh et al., in 09 August 2022 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Hungry in the sun | Science Signaling
Ultraviolet exposure elicits the production of an appetite-stimulating hormone in males but not in females. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Antibiotic-induced inflammation | Science Signaling
Bacterial stress caused by antibiotics increases a second messenger that directly stimulates host inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 2, 2022 Category: Science Source Type: news

Antibiotic-induced inflammation
Bacterial stress caused by antibiotics increases a second messenger that directly stimulates host inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 2, 2022 Category: Science Source Type: news

CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness
A subset of extracellular vesicles from the tumor stroma may enhance pancreatic cancer progression. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 2, 2022 Category: Science Source Type: news

Stemming metabolic stress | Science Signaling
Inhibition of a zinc transporter improves the maturation and survival of β cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 26, 2022 Category: Science Source Type: news

Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target | Science Signaling
Drugs that target IL-6 effectors may be useful for osteoarthritis therapy (Liao et al., in 26 July 2022 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 26, 2022 Category: Science Source Type: news

Intravital calcium imaging in myeloid leukocytes identifies calcium frequency spectra as indicators of functional states
Decoding intracellular calcium signals in immune cells in live mice reveals their functional status during inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 26, 2022 Category: Science Source Type: news

Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner
IL-6 drives joint degeneration and pain in osteoarthritis in male mice, but not in female mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 26, 2022 Category: Science Source Type: news

Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target
Drugs that target IL-6 effectors may be useful for osteoarthritis therapy (Liao et al., in 26 July 2022 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 26, 2022 Category: Science Source Type: news

Stemming metabolic stress
Inhibition of a zinc transporter improves the maturation and survival of β cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 26, 2022 Category: Science Source Type: news

Sex-dependent signaling of social isolation | Science Signaling
The neurological effects of social isolation stress differ between males and females. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 19, 2022 Category: Science Source Type: news

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1 –mediated adhesion in T cells
T cell adhesion induced by the integrin LFA-1 is repressed by the GTPase-activating protein RASA3. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 19, 2022 Category: Science Source Type: news