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PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs | Science Signaling
A mechanism by which the inhibitory receptor PD-1 suppresses T cell activation is revealed. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 28, 2023 Category: Science Source Type: news

PI3K-C2 β limits mTORC1 signaling and angiogenic growth | Science Signaling
PI3K-C2 β restrains endothelial cell size and vessel growth by suppressing the activity of mTORC1. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 28, 2023 Category: Science Source Type: news

Actin ’ off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse | Science Signaling
The mechanisms by which PD-1 inhibits immunological synapse formation are discussed (Paillon et  al., in 28 November 2023 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 28, 2023 Category: Science Source Type: news

Stress granules plug holes | Science Signaling
Ruptures in lysosomal membranes stimulate the formation of stress granules that plug the holes to enable repair. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 28, 2023 Category: Science Source Type: news

Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells | Science Signaling
Plant MDL proteins can modulate the response of human cells to the proinflammatory cytokine MIF. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 21, 2023 Category: Science Source Type: news

Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors | Science Signaling
Glia-to-neuron signals in inflamed gut underlie abdominal pain. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 21, 2023 Category: Science Source Type: news

Beige is the color of keeping weight off | Science Signaling
A monocyte population induced by weight loss promotes white fat beiging to limit weight regain. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 21, 2023 Category: Science Source Type: news

Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure | Science Signaling
Activation of an anion channel in endothelial cells induces arterial relaxation and decreases blood pressure. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 14, 2023 Category: Science Source Type: news

Impaired intracellular Ca2+ signaling contributes to age-related cerebral small vessel disease in Col4a1 mutant mice | Science Signaling
Mutant collagen accumulation perturbs the Ca2+-dependent myogenic response of cerebral arteries. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 14, 2023 Category: Science Source Type: news

The TMEM16A anion channel as a versatile regulator of vascular tone | Science Signaling
TMEM16A has diametrically opposed effects on vascular contractility in a cell type –specific fashion (Mata-Daboin et al., in 14 November 2023 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 14, 2023 Category: Science Source Type: news

Proinflammatory apoptosis | Science Signaling
Apoptotic cells that cannot be expelled from the epithelium provoke inflammation by releasing ATP. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 14, 2023 Category: Science Source Type: news

Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans | Science Signaling
Differential interactions with glycosaminoglycans fine-tune the localization of chemokines expressed in similar patterns. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 7, 2023 Category: Science Source Type: news

A conserved mechanism for JNK-mediated loss of Notch function in advanced prostate cancer | Science Signaling
Analysis of Notch signaling suggests a tumor-suppressive role for Notch in Drosophila tumors and in advanced prostate cancer. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 7, 2023 Category: Science Source Type: news

Axon, “axoff” | Science Signaling
Demyelination by microglia reduces the likelihood of axonal degeneration in a model of cytotoxic T cell –driven myelin perturbation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 7, 2023 Category: Science Source Type: news

Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis | Science Signaling
Integrin-dependent redox signaling at endosomes stimulates chondrocytes to produce a matrix-degrading protease. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 31, 2023 Category: Science Source Type: news