Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension | Science Signaling
TSC2 limits mechanosensitive and cell growth signaling that drives pulmonary hypertension. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 6, 2022 Category: Science Source Type: news

Synaptic activity –dependent changes in the hippocampal palmitoylome | Science Signaling
The dynamics of palmitoylation of synaptic and nonsynaptic proteins supports neuronal plasticity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 6, 2022 Category: Science Source Type: news

Gut bugs on drugs | Science Signaling
Targeting the effects of cocaine on the gut microbiome may be a way to treat addiction. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 6, 2022 Category: Science Source Type: news

VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney | Science Signaling
The lipid kinase VPS34 limits nutrient loss but enables viral entry in renal proximal tubule cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 29, 2022 Category: Science Source Type: news

Quantal leaps in understanding Ca2+ signaling: A “Taylored” approach | Science Signaling
The organizers of a symposium honoring the contributions of Colin Taylor to calcium signaling research summarize the presentations. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 29, 2022 Category: Science Source Type: news

CMTM4 makes IL-17 signaling more complex | Science Signaling
A transmembrane protein promotes the plasma membrane localization and signaling mediated by an IL-17 receptor subunit. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 29, 2022 Category: Science Source Type: news

Characterization of TGF- β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth | Science Signaling
A human skin model reveals requirements for distinct TGF- β signaling pathways in epidermal development and homeostasis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 22, 2022 Category: Science Source Type: news

Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability | Science Signaling
Neutrophil migration through tight spaces is facilitated by chemokine-dependent enhancement of nuclear pliability. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 22, 2022 Category: Science Source Type: news

Mechanisms of mosquito magnetism | Science Signaling
Some of the skin-derived compounds that make humans attractive to mosquitoes are identified. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 22, 2022 Category: Science Source Type: news

The type II TGF- β receptor phosphorylates Tyr182 in the type I receptor to activate downstream Src signaling | Science Signaling
Ligand-induced tyrosine phosphorylation of the type I TGF- β receptor drives Src activation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 15, 2022 Category: Science Source Type: news

M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease | Science Signaling
Prion-like neurodegenerative diseases could be treated by allosterically activating acetylcholine M1 receptors. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 15, 2022 Category: Science Source Type: news

A bacterial hydrolase gives the NOD2 tolerance | Science Signaling
A bacterial endopeptidase that generates NOD2 ligands suppresses colitis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 15, 2022 Category: Science Source Type: news

An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice | Science Signaling
A compound that blocks TNF signaling and improves inflammatory arthritis in mice is identified. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 8, 2022 Category: Science Source Type: news

An evolutionarily conserved coronin-dependent pathway defines cell population size | Science Signaling
A mechanism that enables T cells and amoebae to maintain appropriate population sizes is revealed. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 8, 2022 Category: Science Source Type: news

Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment | Science Signaling
Metabolites mediate oncogenic cellular cross-talk in the tumor microenvironment. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 8, 2022 Category: Science Source Type: news