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Convergent activation of Ca2+ permeability in two-pore channel 2 through distinct molecular routes | Science Signaling
NAADP and a synthetic agonist stimulate a two-pore channel through distinct mechanisms. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 22, 2023 Category: Science Source Type: news

Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12 | Science Signaling
Two NAADP-binding proteins are required for evoked Ca2+ release through two-pore channels. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 22, 2023 Category: Science Source Type: news

The gliogenic switch takes teamwork | Science Signaling
A five-signal cue drives the switch to glia production in the developing fetal brain. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 22, 2023 Category: Science Source Type: news

Broadening a SARS-CoV-1 –neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution | Science Signaling
A method to change the specificity of a neutralizing antibody through engineering is developed. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 15, 2023 Category: Science Source Type: news

A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis | Science Signaling
Activation of sphingosine-1-phosphate signaling by a viral GPCR exacerbates glioblastoma progression. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 15, 2023 Category: Science Source Type: news

Bypassing ACE2 | Science Signaling
SARS-CoV-2 binds to a lysosomal transmembrane protein to enter cells independently of ACE2. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 15, 2023 Category: Science Source Type: news

Unraveling allostery within the angiotensin II type 1 receptor for G αq and β-arrestin coupling | Science Signaling
Residues located throughout a GPCR that bias the signaling output when mutated are identified. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 8, 2023 Category: Science Source Type: news

TGF- β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis | Science Signaling
TGF- β induces a distinct macrophage phenotype that promotes coagulation and worsens survival during sepsis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 8, 2023 Category: Science Source Type: news

Mitochondrial fission fueled by fasting | Science Signaling
Fasting activates mTORC2 to stimulate mitochondrial fission and support mitochondrial respiration. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 8, 2023 Category: Science Source Type: news

A spatiotemporal Notch interaction map from plasma membrane to nucleus | Science Signaling
Proteolytic liberation of the Notch intracellular domain occurs at an intracellular compartment. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 1, 2023 Category: Science Source Type: news

Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles | Science Signaling
Durability of MAPK inhibitors may be improved by impairing tumor tolerance to replication stress. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 1, 2023 Category: Science Source Type: news

Naked mole-rats slay zombies | Science Signaling
Senescent cells in naked mole-rats are eliminated by apoptosis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 1, 2023 Category: Science Source Type: news

Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice | Science Signaling
Nitrosylation sends CaMKII to neuronal synapses to support learning and memory in mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 25, 2023 Category: Science Source Type: news

Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179 | Science Signaling
The structure of the orphan GPCR GPR179 bound to the extracellular matrix component pikachurin is solved. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 25, 2023 Category: Science Source Type: news

Rescuing β cells | Science Signaling
Loss of phosphatidylinositol transfer protein alpha underlies pancreatic β cell failure. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 25, 2023 Category: Science Source Type: news