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An FGF21 fix to get sober | Science Signaling
FGF21-mediated activation of noradrenergic neurons enables recovery from ethanol intoxication in mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 21, 2023 Category: Science Source Type: news
SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape | Science Signaling
Antitumor immunity against liver cancer is impaired by SUMOylation of intracellular IL-33. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2023 Category: Science Source Type: news
Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA –binding protein 1 | Science Signaling
ZBP1 induces stress granule –dependent necroptosis in cells subjected to oxidative stress. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2023 Category: Science Source Type: news
The NF- κB multidimer system model: A knowledge base to explore diverse biological contexts | Science Signaling
A consensus mathematical model of NF- κB dimers may be used to better understand NF-κB control and function. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2023 Category: Science Source Type: news
IL-6 drives hepatocyte dedifferentiation | Science Signaling
Injury-induced hepatocyte reprogramming depends on a proinflammatory cytokine from Kupffer cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 14, 2023 Category: Science Source Type: news
The kinetics of signaling through the common FcR γ chain determine cytokine profiles in dendritic cells | Science Signaling
Dendritic cell responses induced by the FcR γ subunit depend on when receptor abundance peaks. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 7, 2023 Category: Science Source Type: news
The early bird catches the IL-2 in C-type lectin receptor –dependent activation of dendritic cells | Science Signaling
Early but not delayed receptor stimulation elicits IL-2 production through the adaptor protein FcR γ (Watanabe et al., in 7 March 2023 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 7, 2023 Category: Science Source Type: news
Immunogenic Lncs to cancer therapy | Science Signaling
LncRNA-derived peptides enhance T lymphocyte responses to tumors in mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 7, 2023 Category: Science Source Type: news
Data-driven design of orthogonal protein-protein interactions | Science Signaling
A computational framework based on sequence analysis enables the generation of new protein-protein interactions. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 28, 2023 Category: Science Source Type: news
IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice | Science Signaling
The Hedgehog signaling pathway mediates the intercellular interactions that establish pregnancy in mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 28, 2023 Category: Science Source Type: news
Glia turn opioids painful | Science Signaling
Co-targeting glial cells may block the paradoxical increase in pain caused by repeated opioid use. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 28, 2023 Category: Science Source Type: news
Optogenetic decoding of Akt2-regulated metabolic signaling pathways in skeletal muscle cells using transomics analysis | Science Signaling
The insulin-induced signaling pathways that are specifically regulated by the kinase Akt2 are identified. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 21, 2023 Category: Science Source Type: news
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome | Science Signaling
The NLRP3 inflammasome senses and is activated by perturbations in endosomal trafficking. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 21, 2023 Category: Science Source Type: news
Dopamine suppresses ILC2s | Science Signaling
Dopamine reduces the allergen-induced responses of group 2 innate lymphoid cells to alleviate airway inflammation in mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 21, 2023 Category: Science Source Type: news
Catalytic site mutations confer multiple states of G protein activation | Science Signaling
The structures and activation states of G protein α-subunits are determined by a residue required for GTP hydrolysis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 14, 2023 Category: Science Source Type: news