Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection | Science Signaling
A protein with protective effects during antiviral responses promotes infection by Mycobacterium tuberculosis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 4, 2022 Category: Science Source Type: news

The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET | Science Signaling
The kinase PLK1 fuels lung cancer growth by amplifying tumorigenic MAPK signaling. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 4, 2022 Category: Science Source Type: news

Mutations in protein kinase C γ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition | Science Signaling
Biochemical characterization of mutations that cause a neurodegenerative disease provides pathological insight. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 27, 2022 Category: Science Source Type: news

TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22 | Science Signaling
The adaptor protein TRAF3 prevents a tyrosine phosphatase from blocking type I interferon signaling in T cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 27, 2022 Category: Science Source Type: news

Extracellular vesicles as central regulators of blood vessel function in cancer | Science Signaling
How extracellular vesicles released from cancer cells reprogram endothelial cells is discussed. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 27, 2022 Category: Science Source Type: news

Stress with ketamine tackles depression | Science Signaling
A stress hormone enables the antidepressant action of ketamine. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 27, 2022 Category: Science Source Type: news

Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport | Science Signaling
Coordination of mucus secretion with ion transport drives small intestinal crypt flushing. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 20, 2022 Category: Science Source Type: news

The HIV-1 protein Nef activates the Tec family kinase Btk by stabilizing an intermolecular SH3-SH2 domain interaction | Science Signaling
A lentiviral protein induces the dimerization of a host tyrosine kinase to stimulate its activity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 20, 2022 Category: Science Source Type: news

Expand, push, break, release, repair: A unique way to secrete macromolecules | Science Signaling
A unique secretory modality in the small intestine is discovered (Dolan et al., in 20 September 2022 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 20, 2022 Category: Science Source Type: news

Telomeres to go | Science Signaling
By acquiring telomeres from antigen-presenting cells, some T cells are protected from senescence. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 20, 2022 Category: Science Source Type: news

Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition | Science Signaling
Repairs to ruptures in the amniotic sac may involve EMT elicited by fetal macrophages. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 13, 2022 Category: Science Source Type: news

Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex | Science Signaling
An adhesion complex required for brush border formation in the intestine is identified. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 13, 2022 Category: Science Source Type: news

Pathogenic putrescine | Science Signaling
Urea metabolism in astrocytes that produce putrescine leads to memory impairment in Alzheimer ’s disease. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 13, 2022 Category: Science Source Type: news

c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile | Science Signaling
Cyclic di-AMP degradation protects Clostridioides difficile from osmotic and bile salt stresses and promotes host colonization. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 6, 2022 Category: Science Source Type: news

Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP | Science Signaling
Biological roles for c-di-AMP in C. difficile are revealed (Oberkampf et al., in 6 September 2022). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 6, 2022 Category: Science Source Type: news