Signal Transduction Knowledge Environment 
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Adrenergic receptor stimulation improves cancer immunotherapy in a range of immune-competent tumor models. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 20, 2023 Category: Science Source Type: news
Adhesion to laminin-1 and collagen IV induces the formation of Ca2+ microdomains that sensitize mouse T cells for activation | Science Signaling
Ca2+ signaling triggered by adhesion to specific extracellular matrix proteins facilitates T cell activation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 20, 2023 Category: Science Source Type: news
The lncRNA LETS1 promotes TGF- β–induced EMT and cancer cell migration by transcriptionally activating a TβR1-stabilizing mechanism | Science Signaling
A TGF- β–induced lncRNA potentiates TGF-β signaling by inhibiting ubiquitination of the TGF-β type I receptor. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 20, 2023 Category: Science Source Type: news
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein | Science Signaling
How the domains in the kinase PDK1 are arranged determines the subset of substrates that can be phosphorylated. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 13, 2023 Category: Science Source Type: news
Delayed engagement of host defenses enables SARS-CoV-2 viremia and productive infection of distal organs in the hamster model of COVID-19 | Science Signaling
Systemic interferon signaling induced by the lungs prevents SARS-CoV-2 dissemination to other organs. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 13, 2023 Category: Science Source Type: news
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity | Science Signaling
Allosteric intramolecular communication directs the selectivity of PDK1 toward specific subsets of substrates (Sacerdoti et al., in 13 June 2023 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 13, 2023 Category: Science Source Type: news
Missing signals from Fragile astrocytes | Science Signaling
The loss of a secreted factor from astrocytes may underlie neuronal pathology in Fragile X syndrome. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 13, 2023 Category: Science Source Type: news
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke | Science Signaling
Stroke activates a cation-dependent cascade that results in cellular edema in astrocytes and brain swelling. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 6, 2023 Category: Science Source Type: news
The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN | Science Signaling
ISGylation of a PI3K-signaling suppressor enables macrophages to respond to tuberculosis infection. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 6, 2023 Category: Science Source Type: news
Arrestins lie in wait | Science Signaling
Preassociation of β-arrestins with the plasma membrane facilitates their interactions with GPCRs. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 6, 2023 Category: Science Source Type: news
The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration | Science Signaling
Liver regeneration in mice depends on the suppression of cholesterol biosynthesis by the ubiquitin ligase Uhrf2. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 30, 2023 Category: Science Source Type: news
Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation | Science Signaling
Hepatic stellate cell –derived neurotrophin-3 is critical for homeostatic proliferation of hepatocytes. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 30, 2023 Category: Science Source Type: news
Hepatic stellate cells: From bad reputation to mediators of liver homeostasis | Science Signaling
Hepatic stellate cells are critical for liver size maintenance (Trinh et al., in 30 May 2023 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 30, 2023 Category: Science Source Type: news
Switching off the bat signal | Science Signaling
Bat ASC2 inhibits inflammasome activation by preventing ASC speck formation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 30, 2023 Category: Science Source Type: news
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow | Science Signaling
The barrier function and quiescence of the endothelium are supported by transmembrane protein NRP1. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 23, 2023 Category: Science Source Type: news
