With CEO hire, this biotech boasts an all-women C-suite
Three months after publicly launching, Kojin Therapeutics has named a managing partner at the Dana-Farber Cancer Institute as its first CEO. With the addition of Luba Greenwood's, Kojin now boasts an executive team made up entirely of women — a rarity in the male-dominated field of life sciences. Johnson& Johnson (NYSE: JNJ) veteran Kay Ahn is the startup's chief scientific officer, Lynn Abel is vice president of biochemistry and founder Vasanthi Viswanathan has stayed on as head of discovery … (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 16, 2021 Category: American Health Authors: Rowan Walrath Source Type: news

Collaborative COVID-19 lockdown effort delivers major boost for vaccine innovation in Bristol
Faster vaccine development could be a step closer thanks to £ 4 million investment to Imophoron Ltd, a Bristol University biotech start-up developing a novel, next generation rapid-response vaccine platform called ADDomer ™ . Imophoron will use the investment to bring ADDomer vaccines to clinical stage, initially targeting three viruses, RSV (respiratory syncytial virus), COVID-19, and mosquito-borne Chikungunya. (Source: University of Bristol news)
Source: University of Bristol news - October 7, 2021 Category: Universities & Medical Training Tags: Announcements, Business and Enterprise, Grants and Awards, Health, International, Research; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School, Faculty of Life Sciences, Faculty of Life Sciences, School of Biochemistry, Faculty Source Type: news

Oxford Covid biotech firm makes stellar debut on London stock market
Shares of Oxford Nanopore close up 44%, giving co-founder paper fortune of £63mSee all our coronavirus coverageOxford Nanopore, whose DNA sequencing technology has been essential in tracking Covid-19 variants globally, has made a stellar stock market debut in London. A rise in its share price of as much as 47% has left the firm valued at almost £5bn.The flotation of the Oxford University spin-out has given its chief executive and co-founder, Gordon Sanghera, a fortune on paper of £63m.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - September 30, 2021 Category: Science Authors: Julia Kollewe Tags: IPOs FTSE Stock markets Nanotechnology Biochemistry and molecular biology Science University of Oxford Business UK news Source Type: news

Bristol retains Strategic Partnership with the BBSRC and ranks fourth for bioscience research funding  
The   BBSRC, one of the UK ’ s largest UK bioscience funders, has announced Bristol will retain its Strategic Partnership (SP) status. The decision was announced this month following   BBSRC ’ s SP member triannual review. Bristol is one of only ten top-funded university   partners with this status – which it has retained since 2012 recognising the University ’ s long-term record for excellence in biosciences research.   (Source: University of Bristol news)
Source: University of Bristol news - September 30, 2021 Category: Universities & Medical Training Tags: Grants and Awards, Business and Enterprise, Research; Faculty of Life Sciences, Faculty of Life Sciences, School of Biological Sciences, Faculty of Life Sciences, School of Biochemistry, Faculty of Life Sciences, School of Cellular and Molecular Medicine, Source Type: news

Antibodies in breast milk remain for 10 months after Covid infection – study
Exclusive: Researchers believe such antibodies could be used to treat people with severe coronavirusCoronavirus – latest updatesSee all our coronavirus coverageBreastfeeding women who have been infected with Covid-19 continue to secrete virus-neutralising antibodies into their milk for up to 10 months, data suggests.Besides emphasising the important role breastfeeding could play in helping to protect infants from the disease, researchers believe that such antibodies could be used to treat people with severe Covid-19, preventing their condition from getting worse.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - September 27, 2021 Category: Science Authors: Linda Geddes Tags: Breastfeeding Coronavirus Science Infectious diseases Microbiology Immunology World news Medical research Biochemistry and molecular biology Source Type: news

Major advance in race for SARS-CoV-2 inhibitor drugs
A new advance towards the development of drugs specifically designed to inhibit a key SARS-CoV-2 enzyme is reported in the Royal Society of Chemistry's leading journal, Chemical Science. The international team, led by scientists from the Universities of Oxford and Bristol, has designed new peptide molecules and shown that they block (inhibit) the virus ’ s main protease [Mpro] - a prominent SARS-CoV-2 drug target. (Source: University of Bristol news)
Source: University of Bristol news - September 20, 2021 Category: Universities & Medical Training Tags: International, Research; Faculty of Science, Faculty of Science, School of Chemistry, Faculty of Life Sciences, Faculty of Life Sciences, School of Biochemistry; Press Release Source Type: news

Oxford Covid biotech firm plans £2.4bn flotation on LSE
Business founded in 2005 has won contracts worth £144m from the UK government during pandemicOxford Nanopore, whose Covid-19 technology wassnapped up by the UK government and used to track variants of the virus globally, has unveiled its plans to float in one of the biggest London debuts this year.The company, a startup spun out from Oxford University, hopes to exceed a £2.4bn valuation achieved at a fundraising round in May. It has laid out plans to tap into the growing genomic sequencing market, estimated to be worth $5.7bn globally. Its revenues more than doubled to £114m last year, from £52m in ...
Source: Guardian Unlimited Science - September 9, 2021 Category: Science Authors: Julia Kollewe Tags: IPOs Biochemistry and molecular biology Coronavirus Nanotechnology University of Oxford Business Stock markets Science Infectious diseases Source Type: news

Neuroscience and the misperception of reality | Letter
As living creatures, we are exquisitely evolved to interact with the world through perception, saysDavid HughesGaia Vince, reviewing Anil Seth ’s Being You: A New Science of Consciousness (The exhilarating new science of consciousness, 25 August), extols the thesis that because our perception of the world is a complex physical process, perception is itself a “hallucination” and “a big lie created by our deceptive brains”. But when we consider that dogs hear sounds we don’t, flies look through compound eyes, birds navigate using inbuilt GPS, it does seem perverse to claim that the very ph...
Source: Guardian Unlimited Science - September 3, 2021 Category: Science Authors: Letters Tags: Neuroscience Psychology Science and nature books Consciousness Source Type: news

Edmond Fischer, Biochemist and Nobel Laureate, Dies at 101
Fischer was recognized for his work with reversible protein phosphorylation. (Source: The Scientist)
Source: The Scientist - August 31, 2021 Category: Science Tags: News & Opinion Source Type: news

Henry Higgs Named the John La Porte Given Professor in Cytology
Henry N. Higgs, PhD, a nationally known researcher and professor of biochemistry and cell biology at Dartmouth’s Geisel School of Medicine, has been named the John La Porte Given Professor in Cytology. (Source: News at Dartmouth Medical School)
Source: News at Dartmouth Medical School - August 11, 2021 Category: Hospital Management Authors: Timothy Dean Tags: News Henry Higgs professorship Source Type: news

Community-acquired bacterial meningitis
Progress has been made in the prevention and treatment of community-acquired bacterial meningitis during the past three decades but the burden of the disease remains high globally. Conjugate vaccines against the three most common causative pathogens (Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae) have reduced the incidence of disease, but with the replacement by non-vaccine pneumococcal serotypes and the emergence of bacterial strains with reduced susceptibility to antimicrobial treatment, meningitis continues to pose a major health challenge worldwide. In patients presenting with bacterial m...
Source: Current Awareness Service for Health (CASH) - July 28, 2021 Category: Consumer Health News Source Type: news

A.I. Predicts the Shapes of Molecules to Come
DeepMind has given 3-D structure to 350,000 proteins, including every one made by humans, promising a boon for medicine and drug design. (Source: NYT Health)
Source: NYT Health - July 22, 2021 Category: Consumer Health News Authors: Cade Metz Tags: Proteins Artificial Intelligence Computers and the Internet Genetics and Heredity Biology and Biochemistry Human Genome Project your-feed-science your-feed-health Source Type: news

Revolutionary mosquito researchers receive $2.7 million grant
(Virginia Tech) " Mosquitoes are sometimes described as the deadliest animal on Earth, " said Cl é ment Vinauger, principal investigator on the project and assistant professor from the Department of Biochemistry in the College of Agriculture and Life Sciences. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 16, 2021 Category: International Medicine & Public Health Source Type: news

Thomas Rando named director of UCLA Broad Stem Cell Research Center
Dr. Thomas Rando, a renowned neurologist and stem cell biologist, has been named director of the  Eli and Edythe Broad Center of  Regenerative Medicine and Stem Cell Research at UCLA.Rando, who was chosen after an international search, is currently a professor of neurology and neurological sciences at the medical school at Stanford University, where he also serves as director of the Glenn Center for the Biology of Aging and deputy director of the Stanford Center on Longevity. In addition, he is chief of neurology at the  Veterans Affairs Palo Alto Health Care System.His appointment is effective Oct. 1.&ldquo...
Source: UCLA Newsroom: Health Sciences - July 7, 2021 Category: Universities & Medical Training Source Type: news

Gambia: Upstate Faculty Member Named As a Pew Scholar in Biomedical Sciences
[The Point] Alaji Bah, PhD, assistant professor in the Department of Biochemistry and Molecular Biology at Upstate Medical University has been named as a 2021 Pew Scholar in the Biomedical Sciences, the Pew Charitable Trusts announced. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - July 7, 2021 Category: African Health Source Type: news

NIDCR's Summer 2021 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Summer 2021 E-Newsletter In this issue: NIDCR News Funding Opportunities & Related Notices NIH/HHS News Subscribe to NICDR News Science Advances   Grantee News   NIDCR News NIDCR to Release Report on Oral Health in America As a 20-year follow-up to the seminal Oral Health in America: A Report of the Surgeon General, NIDCR will release Oral Health in America: Advances and Challenges in the fall of 2021. The report will illuminate new directions...
Source: NIDCR Science News - July 1, 2021 Category: Dentistry Source Type: news

UofL researchers lead call to increase genetic diversity in immunogenomics
(University of Louisville) Historically, most large-scale immunogenomic studies - those exploring the association between genes and disease - were conducted with a bias toward individuals of European ancestry. Corey T. Watson, Ph.D., assistant professor in the University of Louisville Department of Biochemistry and Molecular Genetics, is leading a call to actively diversify the genetic resources he and fellow immunogenomics researchers use in their work to advance genomic medicine more equitably. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 29, 2021 Category: Infectious Diseases Source Type: news

UConn researchers find health benefits of connecticut-grown sugar kelp
(University of Connecticut) In a paper published in the Journal of Nutritional Biochemistry, the researchers reported significant findings supporting the nutritional benefits of Connecticut-grown sugar kelp. They found brown sugar kelp (Saccharina latissima) inhibits hepatic inflammation and fibrosis in a mouse model of diet-induced non-alcoholic steatohepatitis, a fatty liver disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 24, 2021 Category: International Medicine & Public Health Source Type: news

No lab required: New technology can diagnose infections in minutes
(McMaster University) Engineering, biochemistry and medical researchers at McMaster University have combined their skills to create a hand-held rapid test for bacterial infections that can produce accurate, reliable results in less than an hour, eliminating the need to send samples to a lab. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 24, 2021 Category: Infectious Diseases Source Type: news

Upstate faculty member named as a Pew Scholar in Biomedical Sciences
Alaji Bah, PhD, assistant professor in the Department of Biochemistry and Molecular Biology at Upstate Medical University was one of only 22 individuals out of 198 nominations to be named a Pew Scholar. (Source: SUNY Upstate Medical)
Source: SUNY Upstate Medical - June 15, 2021 Category: Universities & Medical Training Tags: News Source Type: news

Bacteria hijack latent phage of competitor
(University of Vienna) Bacteriophages are still a relatively unknown component of the human microbiome. However, they can play a powerful role in the life cycles of bacteria. Biochemist Thomas B ö ttcher from the University of Vienna and Ph.D. student Magdalena Jancheva were able to show for the first time how Pseudomonas bacteria use a self-produced signal molecule to selectively manipulate phages in a competing bacterial strain to defeat their enemy. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 10, 2021 Category: Biology Source Type: news

Researchers find toxin from maple tree in cow's milk
(Martin-Luther-Universit ä t Halle-Wittenberg) Cows can pass on the hypoglycin A toxin through their milk, a study by the Martin Luther University Halle-Wittenberg (MLU) and the Leibniz Institute of Plant Biochemistry (IPB) in Toxins shows. The substance can cause severe symptoms in humans and animals. Small amounts of the toxin were detected in the raw milk of cows that grazed in a pasture exposed to sycamore maple. The team calls for further investigations to realistically assess the potential dangers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 7, 2021 Category: International Medicine & Public Health Source Type: news

Baylor study uses candy-like models to make STEM accessible to visually impaired students
(Baylor University) A breakthrough study by Bryan Shaw, Ph.D., professor of chemistry and biochemistry at Baylor University, aims to make science more accessible to people who are blind or visually impaired through small, candy-like models. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 28, 2021 Category: International Medicine & Public Health Source Type: news

Jerome Kagan, Who Tied Temperament to Biology, Dies at 92
A Harvard psychologist, he originally attributed personality traits to nurturing only. Then he concluded, We ’re largely born this way. (Source: NYT Health)
Source: NYT Health - May 21, 2021 Category: Consumer Health News Authors: Sam Roberts Tags: Psychology and Psychologists Deaths (Obituaries) Harvard University Kagan, Jerome Children and Childhood Parenting Biology and Biochemistry Source Type: news

Novel method of labeling DNA bases for sequencing
(Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague)) A research team headed by Michal Hocek of IOCB Prague (Czech Republic) and Ciara K. O'Sullivan of Universitat Rovira i Virgili (Spain) have developed a novel method for labeling DNA, which in the future can be used for sequencing DNA by means of electrochemical detection. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 18, 2021 Category: Biology Source Type: news

How the United States Beat the Coronavirus Variants, for Now
The country has managed to avoid a variant-fueled spike in coronavirus cases. Scientists say we were lucky. (Source: NYT Health)
Source: NYT Health - May 14, 2021 Category: Consumer Health News Authors: Carl Zimmer and Apoorva Mandavilli Tags: Coronavirus (2019-nCoV) Research Disease Rates Biology and Biochemistry Vaccination and Immunization your-feed-healthcare Source Type: news

Research team investigates causes of tuberous sclerosis
(University of M ü nster) A team of biochemists from the Faculties of Chemistry/Pharmacy and Medicine at the University of M ü nster has discovered a mechanism which regulates cell division and cell growth. The results can help to understand how Tuberous Sclerosis, a genetic disease, arises. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 12, 2021 Category: Biology Source Type: news

Archaeal enzyme that produces membrane lipids is spectacularly promiscuous
(University of Groningen) Cells of all life forms are surrounded by a membrane that is made of phospholipids. One of these are the cardiolipins. When studying the enzyme that is responsible for producing cardiolipins in archaea (single-cell organisms that constitute a separate domain of life), biochemists at the University of Groningen made a surprising discovery. A single archaeal enzyme can produce a spectacular range of natural and non-natural cardiolipins, as well as other phospholipids. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 6, 2021 Category: Biology Source Type: news

What Are Some Etiologies for Intellectual Disability?
Discussion “Intellectual disability (ID) is a neurodevelopmental disorder that is characterized by deficits in both intellectual functioning and adaptive function whose onset is in the development period.” Global developmental delay (GDD) is used to describe children from 0-5 years old with significant delays in 2 or more developmental areas. These delays may be transient but up to 2/3 of children with GDD will have ID. Overall 1-3% of the general population has ID which makes it very common. Most children with GDD/ID are identified because of delays in meeting milestones or general academic achievement. ID pat...
Source: PediatricEducation.org - May 3, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Geisel Professor Elected to the National Academy of Sciences
Ta-Yuan (T.Y.) Chang, PhD, a professor of biochemistry and cell biology at Dartmouth’s Geisel School of Medicine, has been elected to the National Academy of Sciences (NAS), considered to be one of the country’s premier scientific societies. (Source: News at Dartmouth Medical School)
Source: News at Dartmouth Medical School - April 29, 2021 Category: Hospital Management Authors: Timothy Dean Tags: News Press Release Chang Laboratory National Academy of Sciences Source Type: news

Proposal of new universal nomenclature for oxytocin and vasotocin genes
(University of Barcelona) Oxytocin and arginine vasopressin are two hormones in the endocrine system that can act as neurotransmitters and regulate -in vertebrates and invertebrates- a wide range of biological functions, such as bonding formation, breastfeeding, birth or arterial pressure. Biochemists in the pregenomic era, named these genes differently in different species, due to small protein coding differences. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 28, 2021 Category: International Medicine & Public Health Source Type: news

Bristol documentary photographer captures some of the faces behind COVID-19 research
The human stories behind Bristol scientists who are playing an important role in global efforts to overcome COVID-19 have been captured in a billboard campaign by a Bristol-based photographer. (Source: University of Bristol news)
Source: University of Bristol news - April 26, 2021 Category: Universities & Medical Training Tags: Health, International, Research; Faculty of Life Sciences, Faculty of Life Sciences, School of Cellular and Molecular Medicine, Faculty of Life Sciences, School of Biochemistry, Faculty of Science, Faculty of Science, School of Chemistry, Faculty of Healt Source Type: news

Real Life TS Book Club Discussion
Join The Scientist on May 21 to discuss Brandon Taylor ’s novel about a biochemistry graduate student navigating relationships inside and outside the lab. (Source: The Scientist)
Source: The Scientist - April 23, 2021 Category: Science Tags: Sponsored Webinars Source Type: news

Fifty years of collaborative science
(American Society for Biochemistry and Molecular Biology) Scientists from around the world will come together virtually to celebrate the 50th anniversary of a key piece of the infrastructure for sharing scientific knowledge: the Protein Data Bank. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 22, 2021 Category: Biology Source Type: news

A new study identifies interleukin 11 as a marker of cancer-associated fibroblasts
(Toho University) A research group led by Prof. Hiroyasu Nakano of Department of Biochemistry, Toho University Faculty of Medicine, found that interleukin 11 (IL-11)-positive cells rapidly appear in the colons of mice with colitis and colitis-associated colorectal cancers. In RNA-seq analysis of the gene expression profiles, they found that high expression of enriched genes in IL-11-positive fibroblasts correlated with short duration of disease-free survival in human colorectal cancer patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 22, 2021 Category: Cancer & Oncology Source Type: news

Exclusive: Inside the Facilities Making the World ’s Most Prevalent COVID-19 Vaccine
If you’ve been vaccinated for COVID-19, chances are pretty high that you’re benefiting from a product made by BioNTech. The German biotech company, co-founded by a husband-and-wife team of scientists, developed the vaccine that became not only the first to earn authorization in the U.S. for COVID-19 in December but also the first ever based on a new technology involving the genetic material mRNA. In interviews in December and March, co-founders Ugur Sahin and Ozlem Tureci spoke about their whirlwind year and their partnership with U.S. pharmaceutical company Pfizer to test and manufacture the vaccine. Over thre...
Source: TIME: Health - April 19, 2021 Category: Consumer Health News Authors: Alice Park and Aryn Baker/Marburg, Germany Tags: Uncategorized COVID-19 Exclusive feature longform Magazine photography Source Type: news

Lab-grown embryos mix human and monkey cells
(Source: ScienceNOW)
Source: ScienceNOW - April 15, 2021 Category: Science Authors: Leslie, M. Tags: Biochemistry, Medicine, Diseases In Depth Source Type: news

Professor Herbert Gutfreund FRS, 1921 – 2021
Professor Herbert “ Freddie ” Gutfreund, Emeritus Professor of Biochemistry, died in March 2021. Professor Stephen Halford FRS offers this appreciation. (Source: University of Bristol news)
Source: University of Bristol news - April 14, 2021 Category: Universities & Medical Training Tags: Obituaries; Faculty of Life Sciences, School of Biochemistry, Faculty of Life Sciences Source Type: news

Newly launched British biotech company pioneers ground-breaking potential treatments for COVID-19
A team of top scientists from the University of Bristol have announced the formation of a new biotech company that is developing ground-breaking and newly patented potential treatments for coronavirus. (Source: University of Bristol news)
Source: University of Bristol news - April 13, 2021 Category: Universities & Medical Training Tags: Business and Enterprise, Health, Research, International; Faculty of Life Sciences, Faculty of Life Sciences, School of Biochemistry, Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School, Institutes, Institutes, Bristol BioDesign Source Type: news

A multidimensional view of the coronavirus
(Technical University of Munich (TUM)) What exactly happens when the corona virus SARS-CoV-2 infects a cell? In Nature, a team from the Technical University of Munich (TUM) and the Max Planck Institute of Biochemistry paints a comprehensive picture of the viral infection process. For the first time, the interaction between the coronavirus and a cell is documented at five distinct proteomics levels. This knowledge will help to gain a better understanding of the virus and find starting points for therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 12, 2021 Category: International Medicine & Public Health Source Type: news

Structure and dynamics of the CGRP receptor in apo and peptide-bound forms
G protein–coupled receptors (GPCRs) are key regulators of information transmission between cells and organs. Despite this, we have only a limited understanding of the behavior of GPCRs in the apo state and the conformational changes upon agonist binding that lead to G protein recruitment and activation. We expressed and purified unmodified apo and peptide-bound calcitonin gene–related peptide (CGRP) receptors from insect cells to determine their cryo–electron microscopy (cryo-EM) structures, and we complemented these with analysis of protein conformational dynamics using hydrogen-deuterium exchange mass s...
Source: ScienceNOW - April 8, 2021 Category: Science Authors: Josephs, T. M., Belousoff, M. J., Liang, Y.-L., Piper, S. J., Cao, J., Garama, D. J., Leach, K., Gregory, K. J., Christopoulos, A., Hay, D. L., Danev, R., Wootten, D., Sexton, P. M. Tags: Biochemistry, Cell Biology, Online Only r-articles Source Type: news

Mechanism and dynamics of fatty acid photodecarboxylase
Fatty acid photodecarboxylase (FAP) is a photoenzyme with potential green chemistry applications. By combining static, time-resolved, and cryotrapping spectroscopy and crystallography as well as computation, we characterized Chlorella variabilis FAP reaction intermediates on time scales from subpicoseconds to milliseconds. High-resolution crystal structures from synchrotron and free electron laser x-ray sources highlighted an unusual bent shape of the oxidized flavin chromophore. We demonstrate that decarboxylation occurs directly upon reduction of the excited flavin by the fatty acid substrate. Along with flavin reoxidati...
Source: ScienceNOW - April 8, 2021 Category: Science Authors: Sorigue, D., Hadjidemetriou, K., Blangy, S., Gotthard, G., Bonvalet, A., Coquelle, N., Samire, P., Aleksandrov, A., Antonucci, L., Benachir, A., Boutet, S., Byrdin, M., Cammarata, M., Carbajo, S., Cuine, S., Doak, R. B., Foucar, L., Gorel, A., Grü Tags: Biochemistry, Online Only r-articles Source Type: news

Heavy water tastes sweet
(Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague)) Ordinary pure water has no distinct taste, but how about heavy water? Does it taste sweet, as anecdotal evidence going back to 1930s may have indicated? And if yes - why, when D2O is chemically practically identical to H2O? Researchers led by Pavel Jungwirth from IOCB Prague and Masha Niv from the Hebrew University show that, unlike ordinary water, heavy water tastes sweet to humans with this effect being mediated by the sweet taste receptor. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 7, 2021 Category: Biology Source Type: news

LSU Health New Orleans study discovers source of Zika neurodevelopmental defects
(Louisiana State University Health Sciences Center) A study led by Edward Wojcik, PhD, Associate Professor of Biochemistry& Molecular Biology at LSU Health New Orleans School of Medicine, identified how microcephaly (abnormally small heads) and blindness may develop in Zika-infected fetuses, as well as a new way to potentially prevent these neurodevelopmental defects. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 6, 2021 Category: Infectious Diseases Source Type: news

Committee with no domain expertise approved indigenously manufactured Covaxin, say health experts
“The committee is Delhi centric and dominated by disciplines not connected to vaccines and clinical research. Like in the US such important committees should be multidisciplinary with virologist, persons having a background in cellular and molecular biology, biochemistry, public health and experie nce of conducting clinical research,” former health secretary Sujatha Rao said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 6, 2021 Category: Pharmaceuticals Source Type: news

Committee with no domain expertise approved indigenously manufactured Covaxin: Health experts
“The committee is Delhi centric and dominated by disciplines not connected to vaccines and clinical research. Like in the US such important committees should be multidisciplinary with virologist, persons having a background in cellular and molecular biology, biochemistry, public health and experie nce of conducting clinical research,” former health secretary Sujatha Rao said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 6, 2021 Category: Pharmaceuticals Source Type: news

Researchers Are Hatching a Low-Cost Covid-19 Vaccine
A new formulation entering clinical trials in Brazil, Mexico, Thailand and Vietnam could change how the world fights the pandemic. (Source: NYT Health)
Source: NYT Health - April 5, 2021 Category: Consumer Health News Authors: Carl Zimmer Tags: your-feed-science Clinical Trials Coronavirus (2019-nCoV) MERS (Middle East Respiratory Syndrome) Eggs Immune System Influenza Factories and Manufacturing Antibodies Drugs (Pharmaceuticals) Biology and Biochemistry Gates, Bill and Me Source Type: news

Disrupted biochemical pathway in the brain linked to bipolar disorder
(University of Wisconsin-Madison) In new research, scientists at the University of Wisconsin-Madison have found for the first time that disruptions to a particular protein called Akt can lead to the brain changes characteristic of bipolar disorder. The results offer a foundation for research into treating the often-overlooked cognitive impairments of bipolar disorder, such as memory loss, and add to a growing understanding of how the biochemistry of the brain affects health and disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 1, 2021 Category: International Medicine & Public Health Source Type: news

Structure of the human Mediator-bound transcription preinitiation complex
Eukaryotic transcription requires the assembly of a multisubunit preinitiation complex (PIC) composed of RNA polymerase II (Pol II) and the general transcription factors. The coactivator Mediator is recruited by transcription factors, facilitates the assembly of the PIC, and stimulates phosphorylation of the Pol II C-terminal domain (CTD) by the TFIIH subunit CDK7. Here, we present the cryo–electron microscopy structure of the human Mediator-bound PIC at a resolution below 4 angstroms. Transcription factor binding sites within Mediator are primarily flexibly tethered to the tail module. CDK7 is stabilized by multiple...
Source: ScienceNOW - April 1, 2021 Category: Science Authors: Abdella, R., Talyzina, A., Chen, S., Inouye, C. J., Tjian, R., He, Y. Tags: Biochemistry r-articles Source Type: news