Cross-talk between histone modifications
(Source: ScienceNOW)
Source: ScienceNOW - January 21, 2021 Category: Science Authors: Purnell, B. A. Tags: Biochemistry twis Source Type: news
Separation anxiety
(Source: ScienceNOW)
Source: ScienceNOW - January 21, 2021 Category: Science Authors: Leslie, M. Tags: Biochemistry, Cell Biology Feature Source Type: news
Model for rare cancer results instead in obesity
While a typo in a letter or email is a problem it's not a big one, usually. But when that typo is in genetic code, it's a very different matter. Mayo researchers in the lab of L. James Maher, III, Ph.D., a Mayo Clinic biochemist, and their collaborators, are examining a genetic typo that can lead [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - January 19, 2021 Category: Databases & Libraries Source Type: news
Royal Society award enables University researcher to study neurodegenerative disease
Professor Peter Cullen, a Wellcome Trust Investigator from the School of Biochemistry at the University of Bristol, has been awarded the Royal Society Noreen Murray Professorship to expand his research into neurological sciences. (Source: University of Bristol news)
Source: University of Bristol news - January 15, 2021 Category: Universities & Medical Training Tags: Announcements, Staff notices; Faculty of Biomedical Sciences, School of Biochemistry, Faculty of Biomedical Sciences Source Type: news
LSU Health awarded $2.5m grant to reduce stroke risk for obese women on contraceptives
(Louisiana State University Health Sciences Center) The National Heart, Lung, and Blood Institute of the National Institutes of Health has awarded Rinku Majumder, PhD, Associate Professor of Biochemistry& Molecular Biology at LSU Health New Orleans School of Medicine, a $2.5 million grant over four years to help reduce the high stroke risk to women with obesity who take estrogen-containing birth control pills. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 14, 2021 Category: International Medicine & Public Health Source Type: news
Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81
Signaling through the CD19-CD81 co-receptor complex, in combination with the B cell receptor, is a critical determinant of B cell development and activation. It is unknown how CD81 engages CD19 to enable co-receptor function. Here, we report a 3.8-angstrom structure of the CD19-CD81 complex bound to a therapeutic antigen-binding fragment, determined by cryo–electron microscopy (cryo-EM). The structure includes both the extracellular domains and the transmembrane helices of the complex, revealing a contact interface between the ectodomains that drives complex formation. Upon binding to CD19, CD81 opens its ectodomain ...
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Susa, K. J., Rawson, S., Kruse, A. C., Blacklow, S. C. Tags: Biochemistry, Cell Biology reports Source Type: news
Structure of a transcribing RNA polymerase II-U1 snRNP complex
To initiate cotranscriptional splicing, RNA polymerase II (Pol II) recruits the U1 small nuclear ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA). Here, we report the cryo–electron microscopy structure of a mammalian transcribing Pol II–U1 snRNP complex. The structure reveals that Pol II and U1 snRNP interact directly. This interaction positions the pre-mRNA 5' splice site near the RNA exit site of Pol II. Extension of pre-mRNA retains the 5' splice site, leading to the formation of a "growing intron loop." Loop formation may facilitate scanning of nascent pre-mRNA for the 3' ...
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Zhang, S., Aibara, S., Vos, S. M., Agafonov, D. E., Lührmann, R., Cramer, P. Tags: Biochemistry, Molecular Biology reports Source Type: news
A tight couple makes messenger RNAs
(Source: ScienceNOW)
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Jiang, D. Tags: Biochemistry, Molecular Biology twis Source Type: news
A key complex in B cell activation
(Source: ScienceNOW)
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Vinson, V. Tags: Biochemistry, Cell Biology twis Source Type: news
UT Southwestern biochemist recognized for pioneering metabolic research
(TAMEST) DALLAS - UT Southwestern Biochemist Benjamin Tu, Ph.D., is the recipient of the 2021 Edith and Peter O'Donnell Award in Science from TAMEST (The Academy of Medicine, Engineering and Science of Texas). He was chosen for his pioneering research on cellular roles of small molecule metabolites that may have relevance for cancer treatments and other diseases. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 13, 2021 Category: Cancer & Oncology Source Type: news
mRNA Technology Gave Us the First COVID-19 Vaccines. It Could Also Upend the Drug Industry
“No!” The doctor snapped. “Look at me!”
I had been staring her in the eyes, as she had ordered, but when a doctor on my other side began jabbing me with a needle, I started to turn my head. “Don’t look at it,” the first doctor said. I obeyed.
This was in early August in New Orleans, where I had signed up to be a participant in the clinical trial for the Pfizer-BioNTech COVID-19 vaccine. It was a blind study, which meant I was not supposed to know whether I had gotten the placebo or the real vaccine. I asked the doctor if I would really been able to tell by looking at the syringe. &...
Source: TIME: Health - January 11, 2021 Category: Consumer Health News Authors: Walter Isaacson Tags: Uncategorized COVID-19 feature Magazine Source Type: news
mRNA Technology Gave Us the First COVID-19 Vaccines. It Could Also Upend the Drug Industry
“No!” The doctor snapped. “Look at me!”
I had been staring her in the eyes, as she had ordered, but when a doctor on my other side began jabbing me with a needle, I started to turn my head. “Don’t look at it,” the first doctor said. I obeyed.
This was in early August in New Orleans, where I had signed up to be a participant in the clinical trial for the Pfizer-BioNTech COVID-19 vaccine. It was a blind study, which meant I was not supposed to know whether I had gotten the placebo or the real vaccine. I asked the doctor if I would really been able to tell by looking at the syringe. &...
Source: TIME: Science - January 11, 2021 Category: Science Authors: Walter Isaacson Tags: Uncategorized COVID-19 feature Magazine Source Type: news
Two antibodies against flaviviruses
(Source: ScienceNOW)
Source: ScienceNOW - January 7, 2021 Category: Science Authors: Vinson, V. Tags: Biochemistry, Microbiology twis Source Type: news
Remodeling an RNA processing machine
(Source: ScienceNOW)
Source: ScienceNOW - January 7, 2021 Category: Science Authors: Jiang, D. Tags: Biochemistry twis Source Type: news
Glycylation regulates axonemal dyneins
(Source: ScienceNOW)
Source: ScienceNOW - January 7, 2021 Category: Science Authors: Hurtley, S. M. Tags: Biochemistry, Cell Biology twis Source Type: news
