WALS NIH Director's Lecture: The Future of CRISPR: What ’ s Ahead for Genome Editing
Jennifer Doudna is a Nobel Laureate in Chemistry, and a Professor of Biochemistry, Biophysics and Structural Biology. Her research focuses on RNA as it forms a variety of complex globular structures, some of which function like enzymes or form functional complexes with proteins. Her lab's research into RNA biology led to the discovery of CRISPR-Cas9 as a tool for making targeted changes to the genome. In bacteria, CRISPR systems preserve invading genetic material and incorporate it into surveillance complexes to achieve adaptive immunity. Crystal structures of diverse Cas9 proteins reveal RNA-mediated conformational activa...
Source: Videocast - All Events - February 12, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: A small RNA perspective on genome integrity
Small non-coding RNAs play crucial roles in development and disease by regulating gene expression, defending against viruses, and controlling mobile genetic elements (transposons). Our research focuses on PIWI-interacting RNAs (piRNAs) that silence transposons to safeguard the integrity of germline genomes. PIWI-piRNA complexes act as RNA-guided defense and are essential for germ cell health and fertility. To better understand the molecular mechanisms of this RNA-based immune system, we employ an integrated approach that combines genetics, biochemistry, and next-generation sequencing. Results from our studies elucidate fun...
Source: Videocast - All Events - November 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: A Garden of Forking Paths: Branching, Switching, and Reversing in Homologous Recombination
CCR Grand Rounds “ A Garden of Forking Paths: Branching, Switching, and Reversing in Homologous Recombination ” Michael Lichten, Ph.D.NIH Scientist EmeritusLaboratory of Biochemistry and Molecular BiologyCenter for Cancer Research, NCI Friday, October 20, 202312:00 – 1:00 p.m.Lipsett AmphitheaterAir date: 10/20/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 11, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS Lecture: Laura Niedernhofer Ph.D.
Laura Niedernhofer joined the University of Minnesota in July 2018 to direct the new Institute on the Biology of Aging& Metabolism ;(external link)(iBAM) and Medical Discovery Team on the Biology of Aging. She is also a Professor in the Department of Biochemistry, Molecular Biology and Biophysics at UMN. Dr. Niedernhofer ’ s expertise is in DNA damage and repair, genome instability disorders, cellular senescence and aging. Her research program is centered on studying fundamental mechanisms of aging and developing therapeutics to target them. Her research program implements a murine model of a human progeroid syndrome...
Source: Videocast - All Events - October 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The Future of CRISPR: What ’ s Ahead for Genome Editing
Jennifer Doudna is a Nobel Laureate in Chemistry, and a Professor of Biochemistry, Biophysics and Structural Biology. Her research focuses on RNA as it forms a variety of complex globular structures, some of which function like enzymes or form functional complexes with proteins. Her lab's research into RNA biology led to the discovery of CRISPR-Cas9 as a tool for making targeted changes to the genome. In bacteria, CRISPR systems preserve invading genetic material and incorporate it into surveillance complexes to achieve adaptive immunity. Crystal structures of diverse Cas9 proteins reveal RNA-mediated conformational activa...
Source: Videocast - All Events - August 30, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The dark side of DNA - how the immune system senses DNA as a danger signal
Zhijian “ James ” Chen ’ s research into complex cellular biochemistry has led to the discovery of pathways and proteins that trigger immune and stress responses. Chen has identified proteins, such as the mitochondrial protein MAVS, that are crucial to the body ’ s defense against RNA viruses such as influenza and Ebola. Now, Chen and his team are dissecting a signaling pathway involving a novel DNA sensor – cyclic GMP-AMP (cGAMP) synthase, or cGAS – which activates an interferon response that may play a role in immune defense against pathogens and malignant cells, as well as in autoimmune diseases such as lupu...
Source: Videocast - All Events - July 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Quantitative proteomics for understanding mechanisms in human disease
Dr. Benjamin Garcia is the Raymond H. Wittcoff Distinguished Professor, head of the Department of Biochemistry and Molecular Biophysics, and a preeminent authority on the proteomics of epigenetic regulation. A recognized leader in mass spectrometry, he has made seminal contributions to understanding histone biology and its role in physiologic and pathophysiologic processes. Recognized with many awards including the American Society for Mass Spectrometry Biemann Medal, Dr. Garcia is at the forefront of academic and industry approaches to quantitative proteomics. Diabetes and its metabolic consequences are known to have robu...
Source: Videocast - All Events - July 19, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The Great Escape: Phage Lysis and Its Control
The National Institute of General Medical Sciences (NIGMS) established the DeWitt Stetten Jr. Lecture in 1982 on the occasion of the institute ’ s 20th anniversary in honor of its third director, DeWitt “ Hans ” Stetten, Jr., M.D., Ph.D. Stetten was an esteemed biomedical research and administrator who had a varied biomedical career at and beyond the NIH. He first came to NIH in 1954 as associate director of intramural research at what was then called the National Institute of Arthritis and Metabolic Diseases. Having made his imprint there, he left the NIH to serve as dean of the Rutgers University Medical School fro...
Source: Videocast - All Events - July 19, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The Phase of Fat: Mechanisms and Physiology of Lipid Storage
Speaker Tobias Walther, Ph.D., is an HHMI Investigator and a Program Chair at Sloan Kettering Institute. Walther is interested in the mechanisms that underlie lipid storage in cell membranes and energy metabolism. Walther and his team study how lipids are formed and stored and how these processes contribute to obesity and metabolic disease. They apply a wide range of interdisciplinary approaches, from biophysics and biochemistry to proteomics and lipidomics, to discover global insights into the regulation of lipid metabolism. Once they have identified important regulatory circuits, they use methodologies such as live cell ...
Source: Videocast - All Events - June 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Author Lecture and Meet-and-Greet with Nick Lane - Transformer: The Deep Chemistry of Life and Death
Please join us for a special lecture and reception with scientist and author Nick Lane, Ph.D., a British biochemist and writer. He is a professor in evolutionary biochemistry at University College London. He has published five books to date which have won several awards. His latest book, and the subject of this lecture, is Transformer: The Deep Chemistry of Life and Death. This lecture is sponsored mutually by FAES, the OIR, and Demystifying Medicine.Air date: 6/26/2023 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 19, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
New insights into fungal enzymes may reduce crop losses.
Biochemists from the University of California, Berkeley, have learned about the fungal enzyme that causes blast disease. New fungicides would reduce the substantial annual losses of rice and other susceptible crops.This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - March 1, 2023 Category: Science Source Type: video
The Coming of Age of De Novo Protein Design
David Baker is an HHMI Investigator, head of the Institute for Protein Design and the Henrietta and Aubrey Davis Endowed Professor in Biochemistry at University of Washington, Seattle. This lecture was originally titled " Protein Design Using Deep Learning. "For more information go tohttps://oir.nih.gov/walsAir date: 12/14/2022 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 12, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunology Interest Group: Chemokines and anionic phospholipids: new binding partners for microbial killing and apoptotic cell clearance
Virologist and biochemist studying the immune evasion strategies deployed by viruses to gain new insights into the mechanisms of the immune system and identify new targets for anti-microbial, anti-viral and anti-inflammatory therapies.For more information go tohttps://www.niaid.nih.gov/research/immunology-seminarsAir date: 12/21/2022 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 28, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Sergio Pontejo - Chemokines and anionic phospholipids: new binding partners for microbial killing and apoptotic cell clearance.
Virologist and biochemist studying the immune evasion strategies deployed by viruses to gain new insights into the mechanisms of the immune system and identify new targets for anti-microbial, anti-viral and anti-inflammatory therapies.For more information go tohttps://www.niaid.nih.gov/research/immunology-seminarsAir date: 12/21/2022 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 23, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
The Secret Life of Introns
NIH Director ’ s Wednesday Afternoon Lecture Series
Tracy Johnson is the Maria Rowena Ross Chair of Cell Biology and Biochemistry. Dr. Johnson moved from UC San Diego to UCLA in 2013 to join the faculty in Molecular, Cell, and Developmental Biology. She earned her B.A. in Biochemistry and Cell Biology from UCSD, her Ph.D. in Biochemistry and Molecular Biology from UC Berkeley, and was a Jane Coffin Childs postdoctoral fellow at the California Institute of Technology (Caltech) where she studied the mechanisms of RNA splicing with John Abelson. Dr. Johnson s research is focused on the mechanisms of eukaryotic RNA proces...
Source: Videocast - All Events - August 29, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
