RNA Methylation in Gene Expression Regulation
NCI's Center for Cancer Research (CCR) Grand Rounds
Chuan He, Ph.D., is the John T. Wilson Distinguished Service Professor in the Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics at the University of Chicago. He was born in P. R. China in 1972 and received his B.S. (1994) from the University of Science and Technology of China. He received his Ph.D. degree from Massachusetts Institute of Technology in chemistry in 2000 with Professor Stephen J. Lippard. After being trained as a Damon-Runyon postdoctoral fellow with Professor Gregory L. Verdine at Harvard Unive...
Source: Videocast - All Events - February 20, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Sensing from within: how the immune system discriminates friend from foe
NIH Director's Wednesday Afternoon Lecture Series
The Fitzgerald lab is focused on understanding the molecular mechanisms controlling the inflammatory response. We are interested in determining how the immune system discriminates between pathogens, resident microflora and host molecules to both protect the host from infection and avoid damaging inflammatory diseases. We employ multifaceted approaches including immunology, biochemistry, molecular biology and genetics to understand these mechanisms.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 4/25/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Towards Minimally-invasive or Non-invasive Approaches to Assess Tissue Oxygenation Pre- and Post-Transfusion Workshop (Day 2)
The goal of this workshop is to discuss potential next steps to facilitate the development of new technologies and/or biomarker panels to assess tissue oxygenation in a minimally to non-invasive fashion pre- and post-transfusion of Red Blood Cells (RBCs). The 2015 Transfusion Symposium identified tissue oxygenation assessment as a priority area. The development of minimally to non-invasive procedures to accurately measure tissue oxygenation are needed 1) pre-transfusion to predict who would benefit from RBC transfusions, and (2) post-transfusion to determine if the patient did benefit (and to be able to test the differenti...
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Towards Minimally-invasive or Non-invasive Approaches to Assess Tissue Oxygenation Pre- and Post-Transfusion Workshop (Day 1)
The goal of this workshop is to discuss potential next steps to facilitate the development of new technologies and/or biomarker panels to assess tissue oxygenation in a minimally to non-invasive fashion pre- and post-transfusion of Red Blood Cells (RBCs). The 2015 Transfusion Symposium identified tissue oxygenation assessment as a priority area. The development of minimally to non-invasive procedures to accurately measure tissue oxygenation are needed 1) pre-transfusion to predict who would benefit from RBC transfusions, and (2) post-transfusion to determine if the patient did benefit (and to be able to test the differenti...
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Joseph J. Kinyoun Memorial Lecture - Antibodies Against Ebola and Lassa: A Global Collaboration
Joseph J. Kinyoun Memorial Lecture 2017
Dr. Erica Ollmann Saphire, director of the Viral Hemorrhagic Fever Immunotherapeutic Consortium (VIC), will deliver the 2017 Joseph J. Kinyoun Memorial Lecture.
Her talk, “ Antibodies Against Ebola and Lassa: A Global Collaboration, ” will explore the features of antibodies that protect against these deadly viruses and the ongoing need for scientists to collaborate in this research to establish a complete knowledge base. During the past three years, VIC researchers from dozens of labs on five continents have studied these protective antibodies. The VIC aims to fill critical knowl...
Source: Videocast - All Events - November 27, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Towards the assembly of a synthetic bacterial cell
NIH Director's Seminar Series
Bacterial spores, amongst the hardiest organisms on earth, are dormant cell types produced by certain species to protect the cell ’ s genetic material from harsh environmental conditions. Spores of Bacillus subtilis are encased in a thick protein shell, the “ coat ” , which participates in conferring the amazing resistance properties of spores. Using a combination of classical genetics and biochemistry, buttressed by cytological, biophysical, and computational techniques, we are studying spore coat assembly to understand how cells build and localize large static biological structures. We...
Source: Videocast - All Events - November 9, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Principles of Epigenetics and Chromatin in Development and Human Disease
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Ali Shilatifard, Professor and Chairman of the Department of Biochemistry and Molecular Genetics of the Northwestern University Feinberg School of Medicine, is a world renown biochemist and molecular biologist. He is a respected expert in the field of transcription and epigenetics, specifically as it relates to cancer biology. He has an immense interest in understanding the intricate molecular mechanisms of the regulation of gene expression, the mechanisms that activate or suppress a particular gene ’ s traits. As a Jane Coffin Childs postdoctoral fellow, Dr. Sh...
Source: Videocast - All Events - October 23, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The plasticity and migratory responses of innate lymphoid cells: more similarity to T cells than you thought
Immunology Interest Group Seminar Series
The identification of innate lymphoid cells (ILCs) was a major step forward in developing a better understanding of host defense. Although ILC lack the capacity for antigen recognition, they show striking similarities with T cell subsets in both the transcription factors that govern their differentiation and the effector cytokines they produce. One major difference in the existing concepts of ILC and adaptive T cell responses is that the former are considered to act largely as tissue resident effectors whereas T cells migrate from secondary lymphoid tissues of activation to peripher...
Source: Videocast - All Events - May 30, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Brave new world: recent evolution of an insect-transmitted pathogen
NIH Director's Wednesday Afternoon Lecture Series
In their natural settings microbes seldom encounter conditions that are propitious for unrestricted growth. Rather, they must survive in environments where most of the time they are faced with limiting amounts of essential nutrients, stressful stimuli and the presence of other living organisms. Since the early 1980s, Dr. Kolter ’ s laboratroy has investigated many of these survival strategies using approaches from genetics, biochemistry and ecology.For more information go tohttps://oir.nih.gov/wals/2016-2017Air date: 5/17/2017 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 11, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Epithelial molecules shaping immunosurveillance by local T cells
Immunology Interest Group Seminar Series
The thesis of conventional immunology is centralized control whereby responses to infection within tissues are decided within lymph nodes, from which effector T lymphocytes are dispatched to quell regional disturbances. But this cannot explain the observation that many tissues at steady state are T cell-rich. Do such cells simply provide responses to infection or do they provide more generalized means to sustain tissue integrity and organ function? Likewise, how are such cells able to respond to acute stress but not drive constitutive tissue inflammation? And, how do immune cell –...
Source: Videocast - All Events - May 8, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
An Integrative Approach to Understanding Lung Cancer Health Disparities
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Brid Ryan is currently an Investigator at the National Cancer Institute. She is head of the Integrative and Translational Molecular Epidemiology Group in the Laboratory of Human Carcinogenesis. She earned a B.Sc. degree in Biochemistry from University College Cork, Ireland and a Ph.D. in Cancer Biology from University College Dublin, Ireland. Dr. Ryan joined the NCI Cancer Prevention Fellowship Program in 2006, a component of which provided credit towards a M.P.H. degree, which she completed in 2007 at University College Dublin.
As part of the NCI Fellowship progr...
Source: Videocast - All Events - January 30, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Evolution of Adaptive Immunity: ‘Double-duty’ Dendritic Cells in Cold-blooded Vertebrates
Immunology Interest Group
Martin Flajnik earned his Ph.D. at the University of Rochester (NY) under Nicholas Cohen (of comparative- and psychoneuro-immunology fame) and then did his postdoc at the Basel Institute for Immunology under the noted amphibian immunologist Louis Du Pasquier. Flajnik’s first faculty position was at the University of Miami (1988-’98) and he has toiled at The University of Maryland Baltimore ever since. His research has always centered on the evolution of adaptive immunity in the vertebrates and have included studies of: thymic education; MHC biochemistry and genetics; emergence and function of...
Source: Videocast - All Events - June 24, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Causality and Chance in Cancer and in Other Clonal Diseases
NCI’s Center for Cancer Research (CCR) Grand Rounds
Dr. Lucio Luzzatto received his M.D. from the University of Genova and then went on to do a fellowship in hematology at the University of Pavia and receive his Ph.D. in biochemistry from the Ministry of Education in Rome. The leitmotiv of his research has been to understand, in depth, blood diseases with the ultimate purpose to improve their management. In the area of G6PD he did extensive studies in population and biochemical genetics, and in the early eighties cloned the G6PD gene. He took part in solving the 3D structure of human G6PD, and thus eventually he and hi...
Source: Videocast - All Events - March 14, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
RNA-dependent Chromatin Insulator Function
NIH Director's Seminar Series
A central question in cell biology is how a single genome can give rise to many different cell types with specialized functions and properties. It has become increasingly apparent that proper control of gene expression requires complex organization of DNA at the level of chromatin. Chromatin insulators are DNA-protein complexes that influence gene expression by establishing chromatin domains subject to distinct transcriptional controls, likely through alteration of their spatial arrangement within the nucleus. Our work has focused on elucidating mechanisms of chromatin insulator function and ...
Source: Videocast - All Events - February 22, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
When Watson and Crick Get Linked: DNA Interstrand Crosslink Repair and Human Disease
NCI’s Center for Cancer Research (CCR) Grand Rounds
Dr. Smogorzewska received her B.S. in molecular biology and biochemistry from the University of Southern California in 1995, her Ph.D. from The Rockefeller University in 2002 where she was mentored by Dr. Titia de Lange and her M.D. from Weill Cornell Medical College in 2003. Following a residency in clinical pathology at Massachusetts General Hospital, she joined Harvard Medical School as a postdoctoral fellow in Stephen Elledge's lab in 2005. She joined The Rockefeller University as an assistant professor in 2009 and was promoted to associate professor in 2015.
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Source: Videocast - All Events - February 1, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
