Co-Diagnostics, Inc. Announces New Chief Financial Officer
Company also elevates in-house Senior VP of Biochemistry to Chief Scientific Officer SALT LAKE CITY, Feb. 23, 2021 -- (Healthcare Sales & Marketing Network) -- Co-Diagnostics, Inc. (Nasdaq: CODX), a molecular diagnostics company with a unique, patented... Diagnostics, Personnel Co-Diagnostics, molecular diagnostics (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 23, 2021 Category: Pharmaceuticals Source Type: news

Bristol Science Film Festival 2021 - calling all creatives to submit short films!
Bristol ’ s Science Film Festival is set to take place this summer and the organisers of the annual event are calling for submissions from amateur and professional movie makers ahead of the festival ’ s September showcase. Film-makers behind shortlisted films will have their films screened and a chance to win cash prizes. (Source: University of Bristol news)
Source: University of Bristol news - February 18, 2021 Category: Universities & Medical Training Tags: Research, Health, Current students, Alumni; Faculty of Life Sciences, Faculty of Life Sciences, School of Biochemistry, Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School, Institutes, Elizabeth Blackwell; Press Release Source Type: news

Bristol Science Film Festival 2021 - calling all creatives to submit short films!
Bristol ’ s Science Film Festival is set to take place this summer and the organisers of the annual event are calling for submissions from amateur and professional movie makers ahead of the festival ’ s July showcase. Film-makers behind shortlisted films will have their films screened and a chance to win cash prizes. (Source: University of Bristol news)
Source: University of Bristol news - February 18, 2021 Category: Universities & Medical Training Tags: Research, Health, Current students, Alumni; Faculty of Life Sciences, Faculty of Life Sciences, School of Biochemistry, Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School, Institutes, Elizabeth Blackwell; Press Release Source Type: news

De novo design of transmembrane {beta} barrels
Transmembrane β-barrel proteins (TMBs) are of great interest for single-molecule analytical technologies because they can spontaneously fold and insert into membranes and form stable pores, but the range of pore properties that can be achieved by repurposing natural TMBs is limited. We leverage the power of de novo computational design coupled with a "hypothesis, design, and test" approach to determine TMB design principles, notably, the importance of negative design to slow β-sheet assembly. We design new eight-stranded TMBs, with no homology to known TMBs, that insert and fold reversibly into synthetic lipid me...
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Vorobieva, A. A., White, P., Liang, B., Horne, J. E., Bera, A. K., Chow, C. M., Gerben, S., Marx, S., Kang, A., Stiving, A. Q., Harvey, S. R., Marx, D. C., Khan, G. N., Fleming, K. G., Wysocki, V. H., Brockwell, D. J., Tamm, L. K., Radford, S. E., Baker, Tags: Biochemistry, Online Only r-articles Source Type: news

Mechanism of membrane-tethered mitochondrial protein synthesis
We report cryo–electron microscopy structures of human mitoribosomes with nascent polypeptide, bound to the insertase oxidase assembly 1–like (OXA1L) through three distinct contact sites. OXA1L binding is correlated with a series of conformational changes in the mitoribosomal large subunit that catalyze the delivery of newly synthesized polypeptides. The mechanism relies on the folding of mL45 inside the exit tunnel, forming two specific constriction sites that would limit helix formation of the nascent chain. A gap is formed between the exit and the membrane, making the newly synthesized proteins accessible. O...
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Itoh, Y., Andrell, J., Choi, A., Richter, U., Maiti, P., Best, R. B., Barrientos, A., Battersby, B. J., Amunts, A. Tags: Biochemistry, Molecular Biology reports Source Type: news

Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity
Although bespoke, sequence-specific proteases have the potential to advance biotechnology and medicine, generation of proteases with tailor-made cleavage specificities remains a major challenge. We developed a phage-assisted protease evolution system with simultaneous positive and negative selection and applied it to three botulinum neurotoxin (BoNT) light-chain proteases. We evolved BoNT/X protease into separate variants that preferentially cleave vesicle-associated membrane protein 4 (VAMP4) and Ykt6, evolved BoNT/F protease to selectively cleave the non-native substrate VAMP7, and evolved BoNT/E protease to cleave phosp...
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Blum, T. R., Liu, H., Packer, M. S., Xiong, X., Lee, P.-G., Zhang, S., Richter, M., Minasov, G., Satchell, K. J. F., Dong, M., Liu, D. R. Tags: Biochemistry, Molecular Biology r-articles Source Type: news

Moving targets of neurotoxins
(Source: ScienceNOW)
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Jiang, D. Tags: Biochemistry, Molecular Biology twis Source Type: news

Building a barrel
(Source: ScienceNOW)
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Vinson, V. Tags: Biochemistry twis Source Type: news

Making the energy makers
(Source: ScienceNOW)
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Jiang, D. Tags: Biochemistry, Molecular Biology twis Source Type: news

Bristol Science Film Festival 2021 calling all creatives to submit short films!
Bristol ’ s Science Film Festival is set to take place this summer and the organisers of the annual event are calling for submissions from amateur and professional movie makers ahead of the festival ’ s September showcase. Film-makers behind shortlisted films will have their films screened and a chance to win cash prizes. (Source: University of Bristol news)
Source: University of Bristol news - February 15, 2021 Category: Universities & Medical Training Tags: Research, Health, Current students; Faculty of Life Sciences, Faculty of Life Sciences, School of Biochemistry, Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School, Institutes, Elizabeth Blackwell; Press Release Source Type: news

John Bishop obituary
My friend and colleague John Bishop, who has died aged 85, was a pioneer of molecular cell biology whose career bridged a remarkable era in life sciences – from genes to genetic engineering.Born in Edinburgh, to Mary (nee Oliver) and Robert Bishop, John was raised in the nearby town of Bo ’ness, where his father was a shopkeeper. He won a scholarship to attend George Heriot’s school in Edinburgh, and then studied genetics at Edinburgh University (BSc with first-class honours, 1957), and took a PhD in the same department. In 1959 he married Jill Spowart, a fellow student.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - February 12, 2021 Category: Science Authors: Richard Lathe Tags: Biochemistry and molecular biology Genetics Science Source Type: news

A double punch against SARS-CoV-2
(Source: ScienceNOW)
Source: ScienceNOW - February 11, 2021 Category: Science Authors: Vinson, V. Tags: Biochemistry, Microbiology twis Source Type: news

Kinesin takes substeps
(Source: ScienceNOW)
Source: ScienceNOW - February 11, 2021 Category: Science Authors: Jiang, D. Tags: Biochemistry, Materials Science twis Source Type: news

Comment on "Structural evidence for a dynamic metallocofactor during N2 reduction by Mo-nitrogenase"
Kang et al. (Reports, 19 June 2020, p. 1381) report a structure of the nitrogenase MoFe protein that is interpreted to indicate binding of N2 or an N2-derived species to the active-site FeMo cofactor. Independent refinement of the structure and consideration of biochemical evidence do not support this claim. (Source: ScienceNOW)
Source: ScienceNOW - February 11, 2021 Category: Science Authors: Peters, J. W., Einsle, O., Dean, D. R., DeBeer, S., Hoffman, B. M., Holland, P. L., Seefeldt, L. C. Tags: Biochemistry t-comment Source Type: news

Response to Comment on "Structural evidence for a dynamic metallocofactor during N2 reduction by Mo-nitrogenase"
Peters et al. comment on our report of the dynamic structure of the nitrogenase metallocofactor during N2 reduction. Their claim that their independent structural refinement and consideration of biochemical data contradict our finding is incorrect and is strongly refuted by our biochemical and structural data that collectively and conclusively point to the binding of dinitrogen species to the nitrogenase cofactor. (Source: ScienceNOW)
Source: ScienceNOW - February 11, 2021 Category: Science Authors: Kang, W., Lee, C. C., Jasniewski, A. J., Ribbe, M. W., Hu, Y. Tags: Biochemistry t-comment Source Type: news