TNM Staging 8th Edition and Its Implications for Skin Cancer TNM Staging 8th Edition and Its Implications for Skin Cancer
This article summarizes important changes in the 8th edition of TNM that impact the staging, risk stratification, and management of melanoma and nonmelanoma skin cancer.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 19, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

MHRA Drug Safety Update: Hydrochlorothiazide: risk of non-melanoma skin cancer particularly in long-term use
The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a drug safety update: Hydrochlorothiazide: risk of non-melanoma skin cancer, particularly in long-term use... (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - November 15, 2018 Category: Drugs & Pharmacology Source Type: news

When Melanoma spreads to the brain, patients with BRAF or MEK mutations can find novel treatment
(University of Arizona Health Sciences) Its ample sun puts residents at risk for melanoma, but Arizona is also home to experimental treatments through early-phase clinical trials at the University of Arizona Cancer Center. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 15, 2018 Category: Cancer & Oncology Source Type: news

New Melanoma Treatments Do Not Supplant Surgery as First-Line Therapy New Melanoma Treatments Do Not Supplant Surgery as First-Line Therapy
Although several new melanoma treatments have shown promise, none replaces surgery as the primary therapy yet, according to updated guidelines from the American Academy of Dermatology (AAD).Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 13, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Clinical study finds Chinese medicine improves survival rates in colorectal cancer patients
(Natural News) Colorectal cancer is one of the most diagnosed cancers in the U.S., excluding skin cancer. It’s estimated that at least 140,000 American adults will be diagnosed with the condition each year, with 50,000 cases leading to death. In a study, researchers from the Central South University in China have suggested using Traditional Chinese Medicine to... (Source: NaturalNews.com)
Source: NaturalNews.com - November 11, 2018 Category: Consumer Health News Source Type: news

Suicide risk in melanoma: what do we know? - Komic A, Taludker A, Walsh N, Jones A, Lawson A, Bateson B, Kruse EJ.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - November 9, 2018 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

New Guidelines for Early-Stage Melanoma Treatment
The American Academy of Dermatology published new clinical practice guidelines with recommendations for the treatment of primary cutaneous melanoma. (Source: CancerNetwork)
Source: CancerNetwork - November 9, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Yale study shows immunotherapy drug helps patients with metastatic melanoma
New research suggests that melanoma patients with brain metastases should be given a combination of two types of checkpoint inhibitors. (Source: Yale Science and Health News)
Source: Yale Science and Health News - November 8, 2018 Category: Universities & Medical Training Source Type: news

Quiz: How COLUMBUS Study Results Impact Skin Cancer Treatment
How much do you know about the COLUMBUS study? Test your knowledge of the phase III trial with our latest quiz. (Source: CancerNetwork)
Source: CancerNetwork - November 7, 2018 Category: Cancer & Oncology Source Type: news

Medical News Today: What to know about nodular melanoma
Nodular melanoma is the most aggressive form of skin cancer. In this article, we look at the symptoms, causes, risk factors, and treatments for nodular melanoma. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 6, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

OncoSec shares fall on preliminary data from skin cancer trial
Shares in OncoSec Medical (NSDQ:ONCS) fell nearly -60% this morning after the company revealed preliminary data from its Phase IIb trial of intratumoral delivery of Tavo in people with unresectable, advanced melanoma. OncoSec’s lead product, Tavo, uses electroporation to deliver IL-12 directly into a patient’s tumor, triggering an immune response. Get the full story at our sister site, Drug Delivery Business News. The post OncoSec shares fall on preliminary data from skin cancer trial appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - November 6, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Drug-Device Combinations Oncology Pharmaceuticals Wall Street Beat OncoSec Medical Source Type: news

How melanoma evades targeted therapies
(Thomas Jefferson University) New research shows how metastatic melanoma becomes resistant to a common class of targeted therapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 6, 2018 Category: Cancer & Oncology Source Type: news

NCRI: Highlights from the Annual Conference
(MedPage Today) -- Prostate cancer tradeoffs, rising melanoma mortality, safer regimen for thyroid cancer (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - November 6, 2018 Category: Dermatology Source Type: news

Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH
The production of melanin increases skin pigmentation and reduces the risk of skin cancer. Melanin production depends on the pH of melanosomes, which are more acidic in lighter-skinned than in darker-skinned people. We showed that inhibition of soluble adenylyl cyclase (sAC) controlled pigmentation by increasing the pH of melanosomes both in cells and in vivo. Distinct from the canonical melanocortin 1 receptor (MC1R)–dependent cAMP pathway that controls pigmentation by altering gene expression, we found that inhibition of sAC increased pigmentation by increasing the activity of tyrosinase, the rate-limiting enzyme i...
Source: Signal Transduction Knowledge Environment - November 6, 2018 Category: Science Authors: Zhou, D., Ota, K., Nardin, C., Feldman, M., Widman, A., Wind, O., Simon, A., Reilly, M., Levin, L. R., Buck, J., Wakamatsu, K., Ito, S., Zippin, J. H. Tags: STKE Research Articles Source Type: news

Medical News Today: Melanoma: More evidence that antioxidants speed up tumor spread
New research reveals that antioxidants that bind to mitochondria — the main source of free radicals — either have no effect or cause tumors to grow faster. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 5, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Global skin cancer deaths rising for men but not women, study says
Men are dying at a higher rate than women from melanoma, an aggressive form of skin cancer, a new global analysis said. (Source: CNN.com - Health)
Source: CNN.com - Health - November 5, 2018 Category: Consumer Health News Source Type: news

Global skin cancer deaths rising for men but not women
Men are dying at a higher rate than women from melanoma, an aggressive form of skin cancer, a new global analysis said. (Source: CNN.com - Health)
Source: CNN.com - Health - November 5, 2018 Category: Consumer Health News Source Type: news

Global Melanoma Deaths Up Among Men, But Not Women
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 5, 2018 Category: Cancer & Oncology Tags: Dermatology, Family Medicine, Gynecology, Oncology, Reproductive Medicine, Preventive Medicine, News, Source Type: news

Global skin cancer deaths rising for men, but not women, study says
Men are dying at a higher rate than women from melanoma, an aggressive form of skin cancer, a new global analysis said. (Source: CNN.com - Health)
Source: CNN.com - Health - November 5, 2018 Category: Consumer Health News Source Type: news

World Melanoma Deaths Up Among Men, But Not Women
Melanoma death rates were higher for men than for women, according to an analysis of World Health Organization data from 33 countries between 1985 and 2015. (Source: WebMD Health)
Source: WebMD Health - November 5, 2018 Category: Consumer Health News Source Type: news

Skin cancer deaths have soared around the world since the 1980s
Australia has the worst relationship with melanoma - it kills 8.3 people per every 100,000. The UK ranks 15th out of 33 with 4.2 deaths for the same amount of population. (Source: the Mail online | Health)
Source: the Mail online | Health - November 5, 2018 Category: Consumer Health News Source Type: news

Global Melanoma Deaths Up Among Men, But Not Women
MONDAY, Nov. 5, 2018 -- Melanoma skin cancer death rates in men are on the rise in most countries, but are stable or declining for women in some, according to a new study. Researchers analyzed World Health Organization data from 33 countries... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 5, 2018 Category: General Medicine Source Type: news

Global Melanoma Deaths Up Among Men, But Not Women
Title: Global Melanoma Deaths Up Among Men, But Not WomenCategory: Health NewsCreated: 11/5/2018 12:00:00 AMLast Editorial Review: 11/5/2018 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - November 5, 2018 Category: Cancer & Oncology Source Type: news

Team studying rare disorder discovers novel way to target melanoma
(University of North Texas Health Science Center) While studying a rare genetic disorder called NGLY1 deficiency, UNT Health Science Center researchers discovered a new targeted treatment for combating melanoma, a skin cancer that kills about 9,000 people in the United States each year. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 5, 2018 Category: International Medicine & Public Health Source Type: news

Global Melanoma Deaths Up Among Men, But Not Women
(Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 5, 2018 Category: Cancer & Oncology Source Type: news

Melanoma death rates are rising in men but static or falling in women
(National Cancer Research Institute) The rate of men dying from malignant melanoma has risen in populations around the world, while in some countries the rates are steady or falling for women, according to research presented at the 2018 NCRI Cancer Conference. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 4, 2018 Category: Cancer & Oncology Source Type: news

AAD Releases New Guidelines for the Tx of Cutaneous Melanoma
Guidelines recommend surgical excision as primary treatment modality, emphasize individualized care (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 1, 2018 Category: Cancer & Oncology Tags: Dermatology, Oncology, Pathology, Pharmacy, Radiology, Surgery, Journal, Source Type: news

Senhwa Biosciences Silmitasertib filed IND of Basal Cell Carcinoma approved by FDA
TAIPEI, Taiwan and SAN DIEGO, Nov. 1, 2018 -- (Healthcare Sales & Marketing Network) -- Senhwa Biosciences Inc. (TPEx: 6492) announced today that FDA has approved its IND application for basal cell carcinoma (BCC). To accelerate the development of this ne... Biopharmaceuticals, Oncology, FDA Senhwa Biosciences, Silmitasertib, basal cell carcinoma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 1, 2018 Category: Pharmaceuticals Source Type: news

AAD Releases New Guidelines for the Tx of Cutaneous Melanoma
THURSDAY, Nov. 1, 2018 -- New guidelines have been released for the treatment of primary cutaneous melanoma, according to a report from the American Academy of Dermatology published online Nov. 1 in the Journal of the American Academy of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 1, 2018 Category: Pharmaceuticals Source Type: news

Fishing for new leads in a rare melanoma
(Boston Children's Hospital) Many cancers arise from a double hit: activation of a tumor-promoting gene plus loss of a tumor suppressor gene. A new study shows that zebrafish, a versatile model for disease research and drug discovery, can help tease out the interplay of genetic alterations in cancer, and could help guide treatment strategies. The study involved mucosal melanomas, a rare, poorly understood and often deadly type of melanoma that affects internal surfaces of the body. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 1, 2018 Category: Cancer & Oncology Source Type: news

Specific CD8 T cell states may indicate response to immune checkpoint therapy for melanoma
(Massachusetts General Hospital) A multi-institutional research team, led by investigators at Massachusetts General Hospital and the Broad Institute of MIT and Harvard, has identified specific states of cytotoxic CD8 T cells associated with patient response to checkpoint immunotherapy for melanoma. Their study providing data that could help better understand why checkpoint therapy doesn't work for all patients and may enable development of tests to predict which patients may be helped by the approach. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 1, 2018 Category: Cancer & Oncology Source Type: news

Is Controversy Over NCRT Plus Surgery Warranted in Esophageal Squamous Cell Carcinoma?
A new study adds to evidence examining whether neoadjuvant chemoradiotherapy plus surgery improves survival vs surgery alone in locally advanced ESCC. (Source: CancerNetwork)
Source: CancerNetwork - October 31, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Medical News Today: What are the symptoms of skin cancer?
Skin cancer is the most common cancer in the United States. People should check every month for signs of melanoma and other skin cancers. In this article, we take a close look at the types of skin cancer and the symptoms to look for. We also discuss risk factors and prevention. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

RNA-protein network may explain why melanoma grows more
(Tokyo University of Agriculture and Technology) A collaboration led by scientists from KU Leuven, Belgium, with Tokyo University of Agriculture and Technology (TUAT), Japan, revealed a new way to fight melanoma. They realize that a melanoma-specific long non-coding RNA, named SAMMSON, interacts with the protein CARF, to properly coordinate protein synthesis in both the cytosol and mitochondria of melanoma cells. This mechanism ensures the maintenance of proteostasis during cell growth, thus avoiding the induction of cell death. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 29, 2018 Category: Cancer & Oncology Source Type: news

What your FEET say about your health - and what will happen if you ignore it, a doctor reveals
EXCLUSIVE: Dr Dawn Harper, an NHS doctor from Gloucestershire, reveals warning signs in the look and smell of feet. Common symptoms can get as serious as skin cancer, she says. (Source: the Mail online | Health)
Source: the Mail online | Health - October 26, 2018 Category: Consumer Health News Source Type: news

New data provides guidance for management of moderately dysplastic moles
(Beth Israel Deaconess Medical Center) Study suggests close observation is a reasonable management strategy for moderately dysplastic moles, but certain patients require continued screening for risk for melanoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 26, 2018 Category: International Medicine & Public Health Source Type: news

Dysplastic Nevi: Monitoring and Management Dysplastic Nevi: Monitoring and Management
Is it safe to observe moderately dysplastic nevi with positive histologic margins, or is the risk for cutaneous melanoma too high?Medscape Dermatology (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - October 25, 2018 Category: Pathology Tags: Dermatology Viewpoint Source Type: news

Mother, 34, is left with a HOLE in her face after using sunbeds for almost a DECADE
Carrie Doles, 34, from Chicago, Illinois, has been left with face paralysis and crippling headaches after having surgery for skin cancer she was diagnosed with at 26, caused by years of using sunbeds. (Source: the Mail online | Health)
Source: the Mail online | Health - October 25, 2018 Category: Consumer Health News Source Type: news

A team of scholars tested a new way of skin cancer early diagnostics
(Samara University) A team of scholars of Samara National Research University and Samara State Medical University as well as clinic specialists of Samara Regional Oncology Centre (SROC) tested a new way of skin cancer early diagnostics with the help of original complex of three devices. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 25, 2018 Category: Cancer & Oncology Source Type: news

New role for protein could lead to novel treatments for cancer and vascular disease
(York University) Researchers at York University have found a new role for a well-known protein in the body that may explain, in part, what goes wrong in certain cancers, as well as vascular and neurological disorders.Beta-catenin, a wide-ranging and important protein for the regulation of cell function from the embryonic stage to adulthood, has already been implicated in the development of certain cancers, including colon, breast, leukemia and melanoma. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 25, 2018 Category: Biology Source Type: news

New combination treatment flips the switch on melanoma cells
(University of Colorado Anschutz Medical Campus) Navitoclax plus A-1210477 not only killed melanoma cells, but also killed the melanoma initiating cells (aka cancer stem cells) that often resist therapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 23, 2018 Category: Cancer & Oncology Source Type: news

Biomarker blood test confirms remission in patients with HPV+ oral cancer
(American Society for Radiation Oncology) A highly sensitive blood test that detects minute traces of cancer-specific DNA has been shown to accurately determine whether patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC) are free from cancer following radiation therapy. Findings will be presented today at the 60th Annual Meeting of the American Society for Radiation Oncology (ASTRO). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 23, 2018 Category: Cancer & Oncology Source Type: news

HPV blood test shows promise for tracking head and neck cancer after treatment
(UNC Lineberger Comprehensive Cancer Center) Researchers will present preliminary findings at the 60th Annual Meeting of the American Society for Radiation Oncology in San Antonio on Tuesday, Oct. 23, from a study that evaluated a blood test for HPV-linked oropharyngeal squamous cell carcinoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 23, 2018 Category: Cancer & Oncology Source Type: news

Observation May Be Acceptable for Moderately Dysplastic Nevi With Positive Margins Observation May Be Acceptable for Moderately Dysplastic Nevi With Positive Margins
Routine skin surveillance is a"reasonable" approach to managing moderately dysplastic nevi with positive histologic margins, although patients with two or more such nevi are at increased risk of developing cutaneous melanoma at a different site, researchers say.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - October 22, 2018 Category: Pathology Tags: Hematology-Oncology News Source Type: news

You Can Cut Your Cancer Risk By Eating Organic, New Study Says
(CNN) — You can protect yourself from cancer by eating organic, a new study suggests. Those who frequently eat organic foods lowered their overall risk of developing cancer, a study published Monday in JAMA Internal Medicine finds. Specifically, those who primarily eat organic foods were more likely to ward off non-Hodgkin lymphoma and postmenopausal breast cancer compared to those who rarely or never ate organic foods. Led by Julia Baudry, an epidemiologist at Institut National de la Sante et de la Recherche Medicale in France, a team of researchers looked at the diets of 68,946 French adults. More than three-quarte...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 22, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Cancer Local TV Organic Source Type: news

Non-Invasive Gene Expression Testing to Rule Out Melanoma Non-Invasive Gene Expression Testing to Rule Out Melanoma
A new gene expression test, the Pigmented Lesion Assay, can help clinicians rule out melanoma and avoid a surgical biopsy of concerning pigmented lesions.Skin Therapy Letter (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 22, 2018 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Study: Best Treatments for Basal Cell Carcinoma
When treating low-risk primary basal cell carcinoma (BCC), surgery and external beam radiation yield a better chance of a cure and a lower recurrence rate compared with other treatment modalities. This is the finding of a recent meta-analysispublished in theAnnals of Internal Medicine. (Source: CancerNetwork)
Source: CancerNetwork - October 17, 2018 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Combining genetic and sun exposure data improves skin cancer risk estimates
(American Society of Human Genetics) By combining data on individuals' lifetime sun exposure and their genetics, researchers can generate improved predictions of their risk of skin cancer, according to findings presented at the American Society of Human Genetics (ASHG) 2018 Annual Meeting in San Diego, Calif. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 17, 2018 Category: Cancer & Oncology Source Type: news

New sensor helps prevent skin cancer by changing color when you’ve had too much sun, fits on a thumbnail
(Natural News) Heliophiles are in for a treat. UV Sense, a recently launched sensor, can alert users when they’ve had too much exposure. UV Sense is a battery-free device that can fit on a thumbnail, and it was designed to detect radiation from the sun. The sensor can change color to indicate the radiation levels of... (Source: NaturalNews.com)
Source: NaturalNews.com - October 16, 2018 Category: Consumer Health News Source Type: news

Machine-learning driven findings uncover new cellular players in tumor microenvironment
(CytoReason) New findings presented today by CytoReason reveals possible new cellular players in the tumor microenvironment that could impact the treatment process for the most in-need patients -- those who have already failed to respond to ipilimumab (anti-CTLA4) immunotherapy. Once validated, the findings could point the way to improved strategies for the staging and ordering of key immunotherapies in refractory melanoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2018 Category: International Medicine & Public Health Source Type: news