Chronic Adverse Effects From Anti - PD - 1 Immunotherapies Common
About 43 percent of patients who receive anti - PD1 therapy for advanced melanoma have chronic immune - related adverse effects (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 16, 2021 Category: Cancer & Oncology Tags: Dermatology, Oncology, Pharmacy, Journal, Source Type: news

Chronic Adverse Effects From Anti-PD-1 Immunotherapies Common
FRIDAY, April 16, 2021 -- Chronic immune-related adverse effects after adjuvant treatment with anti-programmed cell death 1 (anti-PD-1) immunotherapies for melanoma are more common than previously thought, according to a study published online March... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 16, 2021 Category: Pharmaceuticals Source Type: news

Tebentafusp improves OS: A First in Metastatic Uveal Melanoma Tebentafusp improves OS: A First in Metastatic Uveal Melanoma
First-line tebentafusp significantly improved overall survival (OS) when compared with immunotherapy or chemotherapy in patients with metastatic uveal melanoma in a phase 3 trial.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - April 16, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Made-to-Order TILs Effective Against Metastatic Melanoma Made-to-Order TILs Effective Against Metastatic Melanoma
Cell therapy with tumor-infiltrating lymphocytes (TILs) extracted from tumor tissue yielded responses in patients with heavily pretreated malignant melanoma.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - April 15, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Teen Tanning Bed Ban Would Prevent Thousands of U.S. Melanoma Cases
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 14, 2021 Category: Cancer & Oncology Tags: Dermatology, Oncology, Pediatrics, Preventive Medicine, News, Source Type: news

Teen Tanning Bed Ban Would Prevent Thousands of U.S. Melanoma Cases
WEDNESDAY, April 14, 2021 -- A U.S.-wide ban on teen use of tanning beds would prevent thousands of cases of skin cancer and save millions in health care costs, researchers say. Indoor tanning has been linked to an increased risk of melanoma -- the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 14, 2021 Category: General Medicine Source Type: news

Teen Tanning Bed Ban Would Prevent Thousands of U.S. Melanoma Cases
Title: Teen Tanning Bed Ban Would Prevent Thousands of U.S. Melanoma CasesCategory: Health NewsCreated: 4/14/2021 12:00:00 AMLast Editorial Review: 4/14/2021 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - April 14, 2021 Category: Cancer & Oncology Source Type: news

Don ’t Be Afraid To Seek Cancer Help During The Pandemic, Dermatologist Warns
Early diagnosis is particularly important for malignant melanoma: the deadliest form of skin cancer. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - April 13, 2021 Category: Pharmaceuticals Authors: Katherine Hignett, Contributor Tags: Healthcare /healthcare Innovation /innovation Source Type: news

Could Widely Used Blood Pressure Meds Raise Skin Cancer Risk?
Title: Could Widely Used Blood Pressure Meds Raise Skin Cancer Risk?Category: Health NewsCreated: 4/12/2021 12:00:00 AMLast Editorial Review: 4/13/2021 12:00:00 AM (Source: MedicineNet High Blood Pressure General)
Source: MedicineNet High Blood Pressure General - April 13, 2021 Category: Cardiology Source Type: news

Study suggests common drug could be used to prevent certain skin cancers
(Ohio State University Wexner Medical Center) New data published by researchers at The OSUCCC - James suggests that an oral drug currently used in the clinical setting to treat neuromuscular diseases could also help prevent a common form of skin cancer caused by damage from ultraviolet-B radiation from the sun. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

Banning Youth Use of Tanning Bed Would Be Cost - Effective
Ban could reduce the number of melanoma cases and decrease lifetime health care costs, despite compliance costs (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 12, 2021 Category: Cancer & Oncology Tags: Dermatology, Family Medicine, Gynecology, Internal Medicine, Oncology, Pediatrics, Journal, Source Type: news

Thiazides May Up Risk for Skin Cancer in Older Adults
Increased exposure linked to significantly increased rates of incident keratinocyte carcinoma, melanoma in adults ≥66 years (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 12, 2021 Category: Cancer & Oncology Tags: Cardiology, Dermatology, Family Medicine, Internal Medicine, Oncology, Pharmacy, Journal, Source Type: news

Widely Used BP Meds May Raise Skin Cancer Risk
Certain blood pressure drugs can increase sensitivity to the sun's harmful ultraviolet (UV) rays. (Source: WebMD Health)
Source: WebMD Health - April 12, 2021 Category: Consumer Health News Source Type: news

Could Widely Used Blood Pressure Meds Raise Skin Cancer Risk?
MONDAY, April 12, 2021 -- Most people are familiar with common sun-protection advice, from wearing and reapplying sunscreen to putting on a hat. But a new Canadian study finds that for people who take certain blood pressure medications, that advice... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 12, 2021 Category: General Medicine Source Type: news

Thiazides May Up Risk for Skin Cancer in Older Adults
MONDAY, April 12, 2021 -- Higher exposure to thiazides is associated with increased rates of incident keratinocyte carcinoma and melanoma among older adults, according to a study published online April 12 in CMAJ, the journal of the Canadian Medical... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 12, 2021 Category: Pharmaceuticals Source Type: news

Study shows tanning bed ban would reduce skin cancer rates in minors and cut healthcare costs
(Wiley) A recent study indicates that a US ban on the use of tanning beds among minors would prevent thousands of cases of melanoma in adolescents and would save millions of dollars in healthcare costs. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Cancer symptoms: Three key indications you might have skin cancer
CANCER on the skin is visible, but you need to know what you're looking for. There are three key indicators that you require dermatological assistance. Getting help early is vital if you want to cure skin cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - April 11, 2021 Category: Consumer Health News Source Type: news

Yale Cancer Center study shows novel immunotherapy approach to fight melanoma
(Yale University) In a new study led by Yale Cancer Center, researchers have advanced a tumor-targeting and cell penetrating antibody that can deliver payloads to stimulate an immune response to help treat melanoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 11, 2021 Category: Cancer & Oncology Source Type: news

Cancer-killing virus therapy shows promise against inoperable skin cancers
(NYU Langone Health / NYU School of Medicine) Early results show that a new combination drug therapy is safe and effective against advanced skin cancer in patients who were not able to have their tumors surgically removed. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 9, 2021 Category: International Medicine & Public Health Source Type: news

Changes in Cancer Incidence, Deaths Expected by 2040
THURSDAY, April 8, 2021 -- Cancer incidence and death are expected to change by 2040, with breast cancer remaining the most common cancer followed by melanoma, then lung cancer, according to a study published online April 7 in JAMA Network... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 8, 2021 Category: Pharmaceuticals Source Type: news

The Future of Cancer for Americans
THURSDAY, April 8, 2021 -- At first glance, it appears that little will change between now and 2040 when it comes to the types of cancers that people develop and that kill them, a new forecast shows. Breast, melanoma, lung and colon cancers are... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 8, 2021 Category: General Medicine Source Type: news

Huntsman Cancer Institute research shows melanoma rates in Utah compared to
(Huntsman Cancer Institute) Utah had more melanoma deaths than any other state from 1975 to 2013, says a letter published today by HCI researchers in the New England Journal of Medicine. In contrast to the rest of the United States, melanoma mortality in Utah increased by 0.8% per year over that period. The researchers say this data emphasizes the need to stay vigilant about preventing melanoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 8, 2021 Category: Cancer & Oncology Source Type: news

Moffitt investigators identify STING gene methylation allows melanoma to evade the immune system
(H. Lee Moffitt Cancer Center& Research Institute) In a new article published in Proceedings of the National Academy of Sciences of the United States of America, Moffitt Cancer Center researchers demonstrate how an important defect in STING gene expression in melanoma cells contributes to their evasion from immune cell detection and destruction. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 8, 2021 Category: Cancer & Oncology Source Type: news

MPO in myeloid cells mitigates melanoma
(Source: ScienceNOW)
Source: ScienceNOW - April 8, 2021 Category: Science Authors: Wong, W. Tags: twis Source Type: news

An amyloid link between Parkinson's disease and melanoma
(American Chemical Society) On the surface, Parkinson's disease and melanoma do not appear to have much in common. However, for nearly 50 years, doctors have recognized that Parkinson's disease patients are more likely to develop melanoma than the general population. Now, scientists report a molecular link between the two diseases in the form of protein aggregates known as amyloids. The researchers will present their results today at ACS Spring 2021. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 7, 2021 Category: Cancer & Oncology Source Type: news

A drug that can stop tumors from growing
(University of Colorado Anschutz Medical Campus) In a paper published in the journal PNAS last month, CU Cancer Center members detail their work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. By inhibiting NLRP3, the researchers found, they can reduce inflammation and the resultant tumor expansion. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 7, 2021 Category: International Medicine & Public Health Source Type: news

Myeloid cell-derived HOCl is a paracrine effector that trans-inhibits IKK/NF-{kappa}B in melanoma cells and limits early tumor progression
The myeloperoxidase (MPO) system of myeloid-derived cells (MDCs) is central to cellular innate immunity. Upon MDC activation, MPO is secreted into phagosomes where it catalyzes the production of hypochlorous acid (HOCl), a potent chlorinating oxidant. Here, we demonstrated that the myeloid lineage–restricted MPO-HOCl system had antitumor effects in early melanoma growth in aged mice. Orthotopic melanomas grew more slowly in immunocompetent MPO+/+ host mice compared to age-matched syngeneic MPO–/– mice. Real-time intravital tumor imaging in vivo and in cell cocultures revealed a cell-cell proximity-depende...
Source: Signal Transduction Knowledge Environment - April 6, 2021 Category: Science Authors: Liu, T. W., Gammon, S. T., Yang, P., Fuentes, D., Piwnica-Worms, D. Tags: STKE Research Articles Source Type: news

I got deadly skin cancer in my garden... in Surrey
Despite holidaying in the UK, Jackie Palmer, 70, from Surrey has had malignant melanoma, the most deadly form of skin cancer, twice. The first time, she was only 35. (Source: the Mail online | Health)
Source: the Mail online | Health - April 5, 2021 Category: Consumer Health News Source Type: news

Screening May Improve Early Detection for Melanoma - Prone
Reduced thickness of melanoma lesions seen for patients receiving routine skin cancer screening, education about self - exam (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 2, 2021 Category: Cancer & Oncology Tags: Dermatology, Oncology, Pathology, Journal, Source Type: news

Chronic Immune-Related Adverse Events Likely Common After Anti-PD-1 Therapy for Melanoma Chronic Immune-Related Adverse Events Likely Common After Anti-PD-1 Therapy for Melanoma
Chronic immune-related adverse events associated with Anti-PD-1 therapy for melanoma were more common than previously thought in a retrospective multicenter study.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 2, 2021 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Screening May Improve Early Detection for Melanoma-Prone
FRIDAY, April 2, 2021 -- For melanoma-prone families, reduced melanoma thickness is observed for those who receive screening for skin cancer and education about skin self-exams, according to a study published in the April issue of Cancer... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 2, 2021 Category: Pharmaceuticals Source Type: news

Whole-body screening and ed. in melanoma-prone families may improve early detection rates
(American Association for Cancer Research) Among patients at high risk of melanoma, those who received routine skin cancer screening and education about skin self-exams were significantly more likely to be diagnosed with thinner and earlier stage melanomas. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 2, 2021 Category: Cancer & Oncology Source Type: news

Novel cancer vaccine targets oncogenes known to evade immunity in melanoma and neuroblastoma models
(Children's National Hospital) A personalized tumor cell vaccine strategy targeting Myc oncogenes combined with checkpoint therapy creates an effective immune response that bypasses antigen selection and immune privilege, according to a pre-clinical study for neuroblastoma and melanoma. The neuroblastoma model showed a 75% cure with long-term survival, researchers at Children's National Hospital found. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 2, 2021 Category: International Medicine & Public Health Source Type: news

Skin cancer warning - high orange consumption linked to raised risk of melanoma in study
SKIN cancer is one of the most common cancers in the world - UV radiation from the sun is the number one cause. But what are the other causes? A new study has linked high orange consumption to increased risk of melanoma. (Source: Daily Express - Health)
Source: Daily Express - Health - March 31, 2021 Category: Consumer Health News Source Type: news

Wrong Daughter Told She Lacks Melanoma Mutation, Then Gets It Wrong Daughter Told She Lacks Melanoma Mutation, Then Gets It
Switched genetic tests lead to lawsuit; medical center is blamed for triple amputee's injuries; protecting healthcare workers from COVID-related lawsuits.Medscape Business of Medicine (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 31, 2021 Category: Consumer Health News Tags: Family Medicine/Primary Care News Source Type: news

Higher testosterone levels in men linked to greater melanoma risk
Study finds testosterone associated with risk of developing potentially deadly skin cancer, but causation not provedMen with high levels of testosterone have an increased risk of developing a potentially deadly skin cancer, researchers have found.According toCancer Research UK, which funded the study, one in 36 UK males and one in 47 UK females will be diagnosed with melanoma skin cancer in their lifetime. It said 86% of melanoma cases were preventable, typically caused by use of sunbeds or staying out in the sun, but other factors played a role in who is most at risk, including age and genetics.Continue reading... (Source...
Source: Guardian Unlimited Science - March 31, 2021 Category: Science Authors: Nicola Davis Tags: Medical research Skin cancer Health Science Society Source Type: news

Obesity Tied to Increased Mortality Overall in Patients With Cancer
Risk for death lower for patients with lung cancer, renal cell carcinoma, melanoma with versus without obesity (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 30, 2021 Category: Cancer & Oncology Tags: Dermatology, Gastroenterology, Gynecology, Internal Medicine, Nephrology, Oncology, Pathology, Pulmonology, Radiology, Journal, Source Type: news

Quibim works with Highlight Therapeutics to improve immunotherapy in melanoma with AI
Companies will shed light on immunotherapy, an emerging therapeutic approach that  helps the immune system fight cancer, in a brand-new study on one of the most impacting cancers worldwide.  (Source: mobihealthnews)
Source: mobihealthnews - March 30, 2021 Category: Information Technology Tags: Operations, Analytics, Workflow, Emerging Technologies, Business, Data and Information, Process, Technology Source Type: news

Actinic Keratosis Diagnosis Ups Cumulative Risk for Skin Cancer
MONDAY, March 29, 2021 -- The annual increase in risk for cutaneous squamous cell carcinoma (cSCC) is higher for patients who have received a diagnosis of one or more actinic keratoses (AKs), according to a study published online March 24 in JAMA... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 29, 2021 Category: Pharmaceuticals Source Type: news

What Are Indications for a Ileostomy?
Discussion There are three types of inflammatory bowel disease (IBD): Crohn’s disease (CD) – can affect entire gastrointestinal tract but often is discontinuous (i.e., has skipped areas), has transmural inflammation and disease, has granulomas Ulcerative colitis (UC) – affects the colon, is continuous (i.e., has no skipped areas) and has superficial mucosal ulcerations Unclassified IBD – has chronic colitis but not specific features of CD or UC The specific pathogenesis appears to be multifactorial with having a genetic predisposition (1.6 – 30% risk of developing UC if patient has first deg...
Source: PediatricEducation.org - March 29, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Improved awareness of dermatology in skin of colour can prevent missed cancer diagnoses
Skin cancer prognosis is poorer in people of colour, partly because doctors are not taught about presentations in darker skin, according to consultant dermatologist Dr Sharon Belmo. (Source: GP Online News)
Source: GP Online News - March 26, 2021 Category: Primary Care Tags: Clinical News Source Type: news

UCLA researchers receive $6 million from NIH to explore new pancreatic cancer therapies
A team of researchers from theUCLA Jonsson Comprehensive Cancer Center has been awarded two research grants totaling $6 million from the National Institutes of Health to identify new ways to treat pancreatic cancer.Pancreatic cancer is the third leading cause of cancer-related mortality in the United States, accounting for more than 47,000 deaths annually. Only 1 in 10 people diagnosed with this particularly aggressive disease live beyond five years, and most therapies — including conventional chemotherapies, targeted therapies and immunotherapies — are unsuccessful in treating it.“Pancreatic cancer is on...
Source: UCLA Newsroom: Health Sciences - March 25, 2021 Category: Universities & Medical Training Source Type: news

New biomarkers of malignant melanoma identified
(University of Granada) A team of researchers has studied the molecular profile of small " messenger " vesicles called exosomes, produced by cancer stem cells (CSCs), which play a key role in the process of carcinogenesis and metastasis in the blood of patients with malignant melanoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 25, 2021 Category: Cancer & Oncology Source Type: news

Forty-three percent of melanoma patients have chronic complications from immunotherapies
(Vanderbilt University Medical Center) Chronic side effects among melanoma survivors after treatment with anti-PD-1 immunotherapies are more common than previously recognized, according to a study published March 25 in JAMA Oncology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 25, 2021 Category: Cancer & Oncology Source Type: news

Study of NCOA3 yields novel findings of melanoma progression
(Sutter Health) For the first time, activation of nuclear receptor coactivator 3 (NCOA3) has been shown to promote the development of melanoma through regulation of ultraviolet radiation (UVR) sensitivity, cell cycle progression and circumvention of the DNA damage response. Results of a pre-clinical study led by Mohammed Kashani-Sabet, M.D., Medical Director of the Cancer Center at Sutter's California Pacific Medical Center (CPMC) in San Francisco, CA were published online today in Cancer Research, a journal of the American Association for Cancer Research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 25, 2021 Category: Cancer & Oncology Source Type: news

Salk scientists receive $1.5 million from The Conrad Prebys Foundation's inaugural grant cycle
(Salk Institute) Salk Professor Thomas Albright has been awarded $1 million and Assistant Professor Edward Stites awarded $500,000 by The Conrad Prebys Foundation as part of its inaugural round of grants. The funding will support Albright's project looking at how our visual sense changes as we age or gain experience at new visual tasks, and Stites' project investigating how specific FDA-approved drugs function against three types of melanoma mutations, which drive approximately 80 percent of melanomas. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 25, 2021 Category: International Medicine & Public Health Source Type: news

Studies Back Neoadjuvant Strategies for Melanoma Studies Back Neoadjuvant Strategies for Melanoma
Two analyses of neoadjuvant immunotherapy support more rigorous study with RCTs of neoadjuvant vs adjuvant strategies for melanoma, says Dr Weber.Medscape Oncology (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - March 24, 2021 Category: Surgery Tags: Hematology-Oncology Commentary Source Type: news

Prognostic Impact of Ulceration in Patients With Melanoma Prognostic Impact of Ulceration in Patients With Melanoma
Does the extent of ulceration predict relapse-free or overall survival in patients with primary cutaneous melanoma?The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 24, 2021 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Researchers find cellular evidence behind lasting immune response in some cancer survivors
(Dartmouth-Hitchcock Medical Center) A durable response to immunotherapy involves functional immune system cells called T cells entering a tumor. Researchers at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center have discovered that a subset of T cells, called resident memory T cells, in patients with melanoma also enters skin and blood, working there for years after the tumor is gone. No prior study has demonstrated cellular evidence of such long-lived immunity to cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 24, 2021 Category: Cancer & Oncology Source Type: news

High - Risk Clinic for Melanoma Surveillance Is Scalable
Even expansion to a primary care skin cancer clinic tied to consistent and sustainable benefits (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 23, 2021 Category: Cancer & Oncology Tags: Dermatology, Family Medicine, Internal Medicine, Oncology, Surgery, Journal, Source Type: news