Does Screening for Skin Cancer Result in Melanoma Overdiagnosis? Does Screening for Skin Cancer Result in Melanoma Overdiagnosis?
Screening for skin cancer should stop, as it is contributing to an overdiagnosis of melanoma, say NEJM authors, but the issue is nuanced, retort melanoma experts.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 14, 2021 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Conjunctival Melanoma May Be Attributed to UV  Radiation Conjunctival Melanoma May Be Attributed to UV  Radiation
According to a new study published in Nature Communications, exposure to ultraviolet radiation can lead to a rare type of eye cancer called conjunctival melanoma.Medscape News UK (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 13, 2021 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Janssen to Highlight Commitment to Lung Cancer Science and Innovation with Eight Data Presentations at the International Association for the Study of Lung Cancer ’s 2020 World Conference on Lung Cancer
January 12, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that eight company-sponsored presentations, including two oral presentations, will be featured at the International Association for the Study of Lung Cancer’s (IASLC) 2020 World Conference on Lung Cancer (WCLC) Singapore taking place virtually January 28-31, 2021. The presentations include updated data from the Phase 1 CHRYSALIS study (NCT02609776) evaluating amivantamab in patients with NSCLC and EGFR exon 20 insertion mutations and two studies that characterize the high unmet need and lack of stand...
Source: Johnson and Johnson - January 13, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Skin cancer: Main symptoms to look out for warning of basal cell carcinoma
SKIN cancer is not only a condition one needs to worry about in the summertime. What are the main symptoms to look out for in basal cell carcinoma? (Source: Daily Express - Health)
Source: Daily Express - Health - January 12, 2021 Category: Consumer Health News Source Type: news

New humanized mouse model provides insight into immunotherapy resistance
(The Wistar Institute) Wistar scientists have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 12, 2021 Category: International Medicine & Public Health Source Type: news

Texas A & M research explores how melanoma grows and spreads
(Texas A&M University) The first step in treating cancer is understanding how it starts, grows and spreads throughout the body. A relatively new cancer research approach is the study of metabolites, the products of different steps in cancer cell metabolism, and how those substances interact. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 12, 2021 Category: Cancer & Oncology Source Type: news

Proteogenomics offers insight to treating head and neck squamous cell carcinoma
(Baylor College of Medicine) A new study identifies three molecular subtypes in head and neck squamous cell carcinoma (HNSCC) that could be used to better determine appropriate treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 7, 2021 Category: International Medicine & Public Health Source Type: news

An epidemic of overdiagnosis: Melanoma diagnoses sky rocket
(Brigham and Women's Hospital) In a Sounding Board article, Welch and colleagues present evidence for why they believe that increased diagnostic scrutiny is the primary driver of the rapid rise in melanoma diagnoses. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 6, 2021 Category: Cancer & Oncology Source Type: news

Skin cancer risk depends on trigger for DNA repair
Zalfa Abdel-Malek, Ph.D., discussed how a trigger for DNA repair impacts skin cancer risk, and development of a treatment that tans and protects. (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - January 6, 2021 Category: Environmental Health Source Type: news

Skin cancer symptoms: Five warning signs of a basal cell carcinoma
SKIN CANCER can successfully be removed, without complications, with early detection and treatment. There are five warning signs of basal cell carcinoma. What are they? (Source: Daily Express - Health)
Source: Daily Express - Health - December 30, 2020 Category: Consumer Health News Source Type: news

Even Winter Carries Skin Cancer Risks for College Students
THURSDAY, Dec. 24, 2020 – Researchers from two universities in Utah have a warning for students planning to hit the slopes or play in the snow without sunscreen: You could greatly increase your risk of skin cancer. A survey of students by Brigham... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 24, 2020 Category: General Medicine Source Type: news

Even Winter Carries Skin Cancer Risks for College Students
Title: Even Winter Carries Skin Cancer Risks for College StudentsCategory: Health NewsCreated: 12/24/2020 12:00:00 AMLast Editorial Review: 12/24/2020 12:00:00 AM (Source: MedicineNet Skin General)
Source: MedicineNet Skin General - December 24, 2020 Category: Dermatology Source Type: news

UV Exposure Likely Not a Melanoma Risk for People of Color UV Exposure Likely Not a Melanoma Risk for People of Color
The association between ultraviolet (UV) exposure and melanoma is"weak" for skin of color, according to a new systematic review.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - December 23, 2020 Category: Surgery Tags: Hematology-Oncology News Source Type: news

Rakuten Medical Enrolls First Patient in the U.S. Clinical Trial for its Lead Product, ASP-1929 in Combination with Anti-PD1 Therapy, for Head and Neck Cancer or Cutaneous Squamous Cell Carcinoma
SAN MATEO, Calif., Dec. 23, 2020 -- (Healthcare Sales & Marketing Network) -- Rakuten Medical, Inc. (Rakuten Medical) today announced that their Phase 1b/2 clinical trial, an Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 ... Biopharmaceuticals, Oncology Rakuten Medical, photoimmunotherapy, Illuminox (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 23, 2020 Category: Pharmaceuticals Source Type: news

ICI for Cancer Ups Cardiac Event Risk: Danish Data ICI for Cancer Ups Cardiac Event Risk: Danish Data
Within 6 months of treatment initiation, patients with lung cancer or malignant melanoma who received PD-1 inhibitors had increased rates of cardiac eventsMedscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 22, 2020 Category: Cancer & Oncology Tags: Cardiology News Source Type: news

How cancers hurt themselves to hurt immune cells more
(Weizmann Institute of Science) A study of melanoma cells explains a puzzling response they exhibit to ward off T cell attacks. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: news

Immune Checkpoint Inhibitor Therapy Tied to Cardiac Event Risk
Increased risks persist beyond six months for patients with lung cancer receiving PD1i and with malignant melanoma receiving CTLA - 4i (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - December 18, 2020 Category: Cancer & Oncology Tags: Cardiology, Dermatology, Oncology, Pharmacy, Pulmonology, Journal, Source Type: news

Immune Checkpoint Inhibitor Therapy Tied to Cardiac Event Risk
FRIDAY, Dec. 18, 2020 -- Immune checkpoint inhibitor (ICI) treatment is associated with increased cardiac events among patients with lung cancer and malignant melanoma, according to a study published online Dec. 9 in the European Heart... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 18, 2020 Category: Pharmaceuticals Source Type: news

UV Exposure Not Linked to Risk for Melanoma in Skin of Color
In 11 of 13 studies reviewed, no association observed between UV exposure, melanoma in skin of color (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - December 17, 2020 Category: Cancer & Oncology Tags: Dermatology, Family Medicine, Internal Medicine, Oncology, Journal, Source Type: news

Fecal Transplant Overcomes Nivolumab Resistance in Melanoma Fecal Transplant Overcomes Nivolumab Resistance in Melanoma
"We were surprised by the clinical results," say researchers reporting a small trial involving 10 patients with refractory metastatic melanoma, three of whom again experienced treatment response.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 17, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

UV Exposure Not Linked to Risk for Melanoma in Skin of Color
THURSDAY, Dec. 17, 2020 -- Among people with skin of color, ultraviolet (UV) exposure may not be an important risk factor for melanoma, according to a review published online Dec. 16 in JAMA Dermatology. Fabiana C.P.S. Lopes, M.D., from the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 17, 2020 Category: Pharmaceuticals Source Type: news

For college students, skin cancer risk remains high in winter months
(Brigham Young University) New research finds college students could be just as at risk for developing skin cancer in the dead of winter as they are in the middle of summer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 17, 2020 Category: International Medicine & Public Health Source Type: news

UV exposure, risk of melanoma in skin of color
(JAMA Network) The association between ultraviolet (UV) light exposure and the risk of melanoma in individuals with skin of color was examined with a review of the results of 13 studies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 16, 2020 Category: Cancer & Oncology Source Type: news

Everything you want to know about sunscreen
(Canadian Medical Association Journal) From safety and effectiveness to who should use sunscreen and how to apply it, Canadian dermatologists review the latest evidence and guidelines on use of sunscreen. The review, published inCMAJ (Canadian Medical Association Journal), recommends that everyone older than six months of age should use sunscreen to protect against skin cancer (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 14, 2020 Category: Cancer & Oncology Source Type: news

New combination therapy could help fight difficult-to-treat cancers with common mutations
(University of California - Los Angeles Health Sciences) UCLA scientists describe a new combination therapy that suppresses the MAPK pathway by holding cancer-driving proteins in a death grip. This combination of two small molecules has the potential to treat not only BRAF mutated melanoma but also additional aggressive subtypes of cancers, including melanoma, lung, pancreatic and colon cancers that harbor common mutations in cancer genes called RAS or NF1. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 14, 2020 Category: International Medicine & Public Health Source Type: news

Phil Tufnell health: Ex-cricketer opens up about his former cancer diagnosis
PHIL TUFNELL, 54, was afforded the opportunity to see the world as an international cricketer. The ex-cricketer may have lapped up his time spent outside but it resulted in a skin cancer diagnosis. (Source: Daily Express - Health)
Source: Daily Express - Health - December 11, 2020 Category: Consumer Health News Source Type: news

Beta-Blocker May Improve Melanoma Treatment Response Beta-Blocker May Improve Melanoma Treatment Response
Response rates were high without dose-limiting toxicities in a small phase 1 study that evaluated the addition of propranolol to pembrolizumab in treatment-naive patients with metastatic melanoma.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 10, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Phase 1 trial assesses whether fecal microbiota transplant impacts cancer patients resistant to immu
(American Association for the Advancement of Science) In one of the first in-human studies to investigate whether modifying the gut microbiome by a fecal microbiota transplant could make cancer immunotherapy more effective, researchers analyzing this in ten cancer patients with refractory melanoma suggest the treatment can improve patient outcomes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 10, 2020 Category: Cancer & Oncology Source Type: news

New findings shed light on the repair of UV-induced DNA damage
(Kobe University) A repair system in our cells fixes DNA damage caused by exposure to ultraviolet (UV) light from the sun, however the detailed process behind this is not fully understood. An international research team led by Professor Sugasawa at Kobe University's Biosignal Research Center has clarified the regulatory mechanism of the ubiquitin-proteasome system in recognizing and repairing UV-damaged DNA. This new discovery will contribute towards illuminating the onset mechanisms of diseases such as skin cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 8, 2020 Category: Cancer & Oncology Source Type: news

New Data Demonstrate Long-Term Benefit of IMBRUVICA ® (ibrutinib) as First-Line Treatment for High-Risk Chronic Lymphocytic Leukemia
This study highlighted the need for cytogenetic/molecular testing before CIT treatment, consistent with clinical treatment guidelines.[8],[9]Real-World Prognostic Biomarker Testing, Treatment Patterns, And Dosing Among Patients With CLL/SLL From the informCLL™ Prospective Observational Registry (Abstract #547)An oral presentation on Monday, December 7, will feature results from the informCLL™ real-world prospective observational registry assessing treatment patterns in the era of novel agents.4 Key Study Findings:· The most common index treatment was IMBRUVICA®; the majority of patients treated with ...
Source: Johnson and Johnson - December 6, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Disease-Free Survival Data from CAPTIVATE Study Demonstrate Benefit of IMBRUVICA ® (ibrutinib)-Based Regimen as Fixed Duration, First-Line Treatment for Patients with Chronic Lymphocytic Leukemia
December 5, 2020 (RARITAN, N.J.) – New data from the Phase 2 CAPTIVATE study were presented today during an oral session at the 2020 American Society of Hematology (ASH) Annual Meeting (Abstract #123). The study evaluated the efficacy and safety of IMBRUVICA® (ibrutinib) plus venetoclax in the treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) and showed that, after achieving undetectable minimal residual disease (uMRD) in both the blood and bone marrow with the IMBRUVICA® combination regimen, the one-year disease-free survival (DFS) of patients randomized ...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Submits Application to U.S. FDA Seeking Approval of Amivantamab for the Treatment of Patients with Metastatic Non-Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations
RARITAN, N.J., December 3, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) seeking approval of amivantamab for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy. The application marks the first-ever regulatory submission for the treatment of patients with NSCLC with EGFR exon 20 insertion mutations.[1] The Company...
Source: Johnson and Johnson - December 3, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Daily Sunscreen Prevents More Melanoma Deaths vs Early Detection Daily Sunscreen Prevents More Melanoma Deaths vs Early Detection
A recent Australian study has concluded the most cost-effective way to lower both the incidence of melanoma and deaths over the long haul is through primary prevention in the form of daily sunscreen use.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 3, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Non-melanoma skin cancer management and COVID-19 - update, Royal College of Radiologists
This update looks at the potential risks of complication and death in cancer patients over the winter period, and suggests that it is desirable that oncologists should avoid delaying curative interventions (systemic treatments, radiation and surgery). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 3, 2020 Category: Consumer Health News Source Type: news

Malignant melanoma management and COVID-19 pandemic - update, Royal College of Radiologists
This update looks at the potential risks of complication and death in cancer patients over the winter period, and suggests that it is desirable that oncologists should avoid delaying curative interventions (systemic treatments, radiation and surgery). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 3, 2020 Category: Consumer Health News Source Type: news

Study: Immunotherapy Vaccine for Mesothelioma Still Promising
The ONCOS-102 immunotherapy vaccine continues its move toward future, first-line standard of care treatment for malignant pleural mesothelioma, based upon the latest study follow-up data. When combined with standard chemotherapy, the genetically modified adenovirus has produced a median overall survival of at least 18.2 months, according to results released in late November from the ongoing clinical trial. Median overall survival was more than four months better than the control group receiving chemotherapy alone in the randomized trial. ONCOS-102 is manufactured by Targovax, a small Scandinavian biotech company focused on...
Source: Asbestos and Mesothelioma News - December 3, 2020 Category: Environmental Health Authors: Fran Mannino Source Type: news

Huntsman Cancer Institute researchers identify promising drug combination for melanoma
This study was published in the journalClinical Cancer Research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 3, 2020 Category: Cancer & Oncology Source Type: news

Mayo Clinic Q & amp;A podcast: Regenerative medicine helps with facial reconstruction after skin cancer
For generations, people have intentionally and unintentionally exposed their skin to the sun. As a result, skin cancer has become the most common form of cancer in the U.S., according to the Centers for Disease Control and Prevention. Treatment options are limited for people with skin cancer, especially on the face and more specifically the [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - December 3, 2020 Category: Databases & Libraries Source Type: news

Skin cancer: Is your mole cancerous? An expert shares what to look out for
SKIN cancer can be notoriously hard to detect as it's "frequently not itchy nor painful", shares Dr Hiba Injibar. Speaking to the Express, the dermatologist reveals how to check your own skin and moles at home. (Source: Daily Express - Health)
Source: Daily Express - Health - November 28, 2020 Category: Consumer Health News Source Type: news

T-ray technology reveals what's getting under your skin
(University of Warwick) A new method for analysing the structure of skin using a type of radiation known as T-rays could help improve the diagnosis and treatment of skin conditions such as eczema, psoriasis and skin cancer. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 26, 2020 Category: Biology Source Type: news

Most Cost-effective to Use Immunotherapy First in Melanoma Most Cost-effective to Use Immunotherapy First in Melanoma
Up-front immunotherapy is the most cost-effective option for treating newly diagnosed unresectable stage III or IV melanoma with unknown BRAF mutation status, concludes a modeling analysis.Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - November 24, 2020 Category: Dermatology Tags: Hematology-Oncology News Source Type: news

Scientists regenerate skin with stem cells to see how DNA defects in kids cause cancer
(Cincinnati Children's Hospital Medical Center) Physicians and scientists at Cincinnati Children's Hospital Medical Center used new stem cell technology to regenerate and study living patient-specific skin in the lab, giving them a precise close up view of how inherited DNA defects cause skin damage and deadly squamous cell carcinoma in children and young adults with Fanconi anemia (FA). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 23, 2020 Category: Cancer & Oncology Source Type: news

Skin cancer signs: The five signs you may have melanoma
MELANOMA skin cancer is the fifth most common type of cancer for men and women in the UK in 2020. Here are the five signs you may have melanoma. (Source: Daily Express - Health)
Source: Daily Express - Health - November 22, 2020 Category: Consumer Health News Source Type: news

Mitotic Rate Makes Comeback as Melanoma Prognosticator Mitotic Rate Makes Comeback as Melanoma Prognosticator
However, mitotic rate, like tumor thickness, is a continuous variable. And like tumor thickness, mitotic rate has a nonlinear relationship with survival.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - November 20, 2020 Category: Cancer & Oncology Tags: Dermatology News Source Type: news

AI Model May Predict Immunotherapy Response in Melanoma
Histology slides, clinical data used to predict immune checkpoint inhibitor response in advanced melanoma (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 19, 2020 Category: Cancer & Oncology Tags: Dermatology, Oncology, Pathology, Pharmacy, Journal, Source Type: news

AI Model May Predict Immunotherapy Response in Melanoma
THURSDAY, Nov. 19, 2020 -- An algorithm that combines deep learning on histology slides and patient clinical data may predict immune checkpoint inhibitor (ICI) response in patients with advanced melanoma, according to a study published online Nov.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 19, 2020 Category: Pharmaceuticals Source Type: news

AI Model May Predict Immunotherapy Response in Melanoma
WEDNESDAY, Nov. 18, 2020 -- An algorithm that combines deep learning on histology slides and patient clinical data may predict immune checkpoint inhibitor (ICI) response in patients with advanced melanoma, according to a study published online Nov.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 19, 2020 Category: Pharmaceuticals Source Type: news

Interventions for basal cell carcinoma of the skin
Why is this question important?Basal cell carcinoma (BCC) is the most common form of skin cancer among people with white skin.BCC is not usually life ‐threatening but if left untreated, it can cause important disfigurement, especially on the face.Surgical removal of the affected area and surrounding skin is usually the first option for treating BCC. Several different surgical approaches exist as well as non ‐surgical treatments, such as radiotherapy (high doses of radiation that kill cancer cells), and anti‐cancer creams, gels and ointments.We reviewed the evidence from research studies, to find out which treatments ...
Source: Cochrane News and Events - November 18, 2020 Category: Information Technology Authors: Lydia Parsonson Source Type: news

AI may predict response to immune checkpoint blockade in patients with metastatic melanoma
(American Association for Cancer Research) A computational method that combines clinicodemographic variables with deep learning of pre-treatment histology images could predict response to immune checkpoint blockade among patients with advanced melanoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: news

Artificial intelligence program can pick best candidates for skin cancer treatment
(NYU Langone Health / NYU School of Medicine) Experts trained a computer to tell which skin cancer patients may benefit from drugs that keep tumors from shutting down the immune system's attack on them, a new study finds. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: news