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A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment
The limited ability of cytotoxic T cells to infiltrate solid tumors hampers immune surveillance and the efficacy of immunotherapies in cancer. Adenosine accumulates in solid tumors and inhibits tumor-specific T cells. Adenosine inhibits T cell motility through the A2A receptor (A2AR) and suppression of KCa3.1 channels. We conducted three-dimensional chemotaxis experiments to elucidate the effect of adenosine on the migration of peripheral blood CD8+ T cells from head and neck squamous cell carcinoma (HNSCC) patients. The chemotaxis of HNSCC CD8+ T cells was reduced in the presence of adenosine, and the effect was greater o...
Source: Signal Transduction Knowledge Environment - April 24, 2018 Category: Science Authors: Chimote, A. A., Balajthy, A., Arnold, M. J., Newton, H. S., Hajdu, P., Qualtieri, J., Wise-Draper, T., Conforti, L. Tags: STKE Research Articles Source Type: news

Skin cancer: Four ways to prevent the UK’s most common cancer
SKIN cancer kills seven people in the UK everyday, but it is largely preventable. Here are the best ways to prevent sun damage from UV exposure, in order to minimise your risk of developing the cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - April 23, 2018 Category: Consumer Health News Source Type: news

TLR9 Agonist May Reverse Resistance to Immune Checkpoint Inhibition in Melanoma
Treatment with the TLR9 agonist CMP-001 appeared to potentially reverse resistance to immune checkpoint inhibition in patients with metastatic melanoma. (Source: CancerNetwork)
Source: CancerNetwork - April 20, 2018 Category: Cancer & Oncology Authors: Dave Levitan Tags: Melanoma SiteTerms/www.cannabissciencetech.com/News Source Type: news

PAs May Have Lower Diagnostic Accuracy for Melanoma
FRIDAY, April 20, 2018 -- Physician assistants (PAs) perform more skin biopsies per case of skin cancer diagnosed and diagnose fewer melanomas in situ than dermatologists, according to a study published online April 18 in JAMA Dermatology. Alyce M.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 20, 2018 Category: Pharmaceuticals Source Type: news

Most Smokers With Head and Neck Cancer Have Tried to Quit
THURSDAY, April 19, 2018 -- Most active smokers with head and neck squamous cell carcinoma (HNSCC) have made one or more quit attempts, according to a study published online April 12 in JAMA Otolaryngology-Head& Neck Surgery. Samir S.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 19, 2018 Category: Pharmaceuticals Source Type: news

Sensus Healthcare inks multiple distro deals, launches global expansion project
Superficial radiation therapy device developer Sensus Healthcare (NSDQ:SRTSU) today released plans for a global expansion, including new distribution agreements in China, Germany, Mexico, Cuba and Costa Rica. Sensus makes low-energy photon X-ray systems for treating non-melanoma skin cancers, including basal cell and squamous cell carcinomas, and keloids. The Boca Raton, Fla.-based company refers to the technology as superficial radiation therapy, and claims that the tech has been sued to “effectively and safely treat oncological and non-oncological skin conditions.” “Following our new partnersh...
Source: Mass Device - April 19, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Distribution Oncology Sensus Healthcare LLC Source Type: news

OncoBreak: Clinical Trial Barriers; Healthy Cancer Patients; Marriage and Melanoma
(MedPage Today) -- News, features, and commentary about cancer-related issues (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - April 19, 2018 Category: American Health Source Type: news

Drug May Reverse Anti-PD-1 Resistance in Melanoma (CME/CE)
(MedPage Today) -- Responses in 22% of resistant patients with TLR9 agonist (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - April 19, 2018 Category: Dermatology Source Type: news

Skin cancer symptoms: Four skin conditions that raise your risk of developing the disease
SKIN cancer symptoms can include a new mole or a change in an existing mole. UV exposure is the main preventable cause of the disease, and wearing sunscreen can help keep you safe in the sun. But there are four skin conditions that can put you more at risk of developing the disease. (Source: Daily Express - Health)
Source: Daily Express - Health - April 19, 2018 Category: Consumer Health News Source Type: news

Marriage Means 'I Do' for Skin Cancer Detection
Title: Marriage Means 'I Do' for Skin Cancer DetectionCategory: Health NewsCreated: 4/18/2018 12:00:00 AMLast Editorial Review: 4/19/2018 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - April 19, 2018 Category: Cancer & Oncology Source Type: news

Skin cancers linked with reduced risk of Alzheimer's disease
(Wiley) Previous studies have demonstrated a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including non-melanoma skin cancers (including squamous cell cancers and basal cell cancers). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 19, 2018 Category: International Medicine & Public Health Source Type: news

Drug combination targeting HSP90 and BRAF is safe and effective in advanced melanoma
(H. Lee Moffitt Cancer Center& Research Institute) A team of researchers at Moffitt Cancer Center have been working to learn more about how melanoma becomes resistant to BRAF inhibitors in order to develop new treatment strategies. They tested whether a drug targeting heat shock protein 90 (HSP90) combined with the BRAF inhibitor vemurafenib could be a safe and potentially effective strategy to treat patients with melanoma. Their study was published online ahead of print in Clinical Cancer Research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 19, 2018 Category: Cancer & Oncology Source Type: news

PAs Fare Worse Than Derms for Skin Cancer Diagnosis
(MedPage Today) -- AAPA/SDPA call study'fundamentally flawed'(Source: MedPage Today Public Health)
Source: MedPage Today Public Health - April 18, 2018 Category: American Health Source Type: news

Marital Status Tied to Earlier Presentation of Melanoma
WEDNESDAY, April 18, 2018 -- For patients with localized melanoma, marital status is associated with earlier presentation, according to a study published online April 18 in JAMA Dermatology. Cimarron E. Sharon, from the Hospital of the University of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 18, 2018 Category: Pharmaceuticals Source Type: news

New Approach to Melanoma Treatment Identified New Approach to Melanoma Treatment Identified
Drugs that induce a self-inflicted cell-death process called ferroptosis could be used to target de-differentiated melanoma cells, thereby increasing the efficacy of both targeted and immune therapies, researchers suggest.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - April 18, 2018 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news

Married People Less Likely to Die From Melanoma
People who were married were more likely than single people to have melanoma detected in the earlier, more treatable, stages. (Source: NYT Health)
Source: NYT Health - April 18, 2018 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Skin Cancer Marriages Melanomas Single Persons Deaths (Fatalities) Source Type: news

Neoadjuvant Anti-PD-1 Active in Multiple Tumors (CME/CE)
(MedPage Today) -- Major responses in pilot study for NSCLC, melanoma, bladder cancers (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - April 18, 2018 Category: Dermatology Source Type: news

Spouses can boost early detection for melanoma patients
Married patients with melanoma are slightly more likely to be diagnosed in earlier more treatable stages than unmarried patients (Source: ABC News: Health)
Source: ABC News: Health - April 18, 2018 Category: Consumer Health News Tags: Health Source Type: news

Spouses Can Boost Early Detection For Melanoma Patients, Study Says
CHICAGO (AP) — There’s an extra bonus to marriage for melanoma patients: They tend to be diagnosed in earlier more treatable stages than patients who are unmarried, widowed or divorced, a new study says. Spouses may be apt to notice suspicious moles on their partners that could signal melanoma, the most dangerous type skin cancer. More importantly, they may also be more inclined to nag their partners to get those moles checked out, the researchers said. The findings suggest that unmarried people should ask relatives or friends to do skin checks or seek frequent skin exams with dermatologists. Why marriage might...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 18, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Local TV Melanoma Skin Cancer Source Type: news

Being married cuts your risk of skin cancer death
A study of 50,000 American skin cancer patients found that, of those who were married, 45.7 percent had a stage 1, which has a 98 percent survival rate. (Source: the Mail online | Health)
Source: the Mail online | Health - April 18, 2018 Category: Consumer Health News Source Type: news

Marriage Means'I Do' for Skin Cancer Detection
WEDNESDAY, April 18, 2018 -- A walk down the aisle may be a healthy step to better skin cancer detection. New research shows that simply by being married, people increase their odds that a melanoma -- the most deadly form of skin cancer -- will be... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 18, 2018 Category: General Medicine Source Type: news

Resistance to PD-1 Inhibition Overcome With a Combination Resistance to PD-1 Inhibition Overcome With a Combination
For metastatic melanoma that acquires resistance to PD-1 inhibition, that resistance may be overcome with a combination of the same PD-1 inhibitor and a toll-like receptor agonist, CMP-001.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 18, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Skin cancer symptoms: Put on sunscreen this many minutes before exposure to the sun
SKIN cancer symptoms usually come in the form of a new mole or a change in an existing mole. UV exposure is the main preventable cause of the disease, and wearing sunscreen can help keep you safe in the sun. But how long before leaving your home should you put on suncream? (Source: Daily Express - Health)
Source: Daily Express - Health - April 18, 2018 Category: Consumer Health News Source Type: news

Skin cancer symptoms: Put on sunscreen this many minutes before going out to avoid disease
SKIN cancer symptoms usually come in the form of a new mole or a change in an existing mole. UV exposure is the main preventable cause of the disease, and wearing sunscreen can help keep you safe in the sun. But how long before leaving your home should you put on suncream? (Source: Daily Express - Health)
Source: Daily Express - Health - April 18, 2018 Category: Consumer Health News Source Type: news

Is marital status associated with early detection of localized melanoma?
(JAMA Network) Marital status was associated with earlier detection of localized melanoma, with married patients more likely to present with early stage tumors than patients who were never married, divorced or widowed. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 18, 2018 Category: International Medicine & Public Health Source Type: news

Early skin cancer more accurately diagnosed by dermatologist than other providers
(University of Pittsburgh Schools of the Health Sciences) PAs increasingly used in dermatology to cut costs and improve access, but are less likely than dermatologists to accurately diagnose early stage skin cancers, according to new research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 18, 2018 Category: Cancer & Oncology Source Type: news

Marriage Means 'I Do' for Skin Cancer Detection
(Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - April 18, 2018 Category: Cancer & Oncology Source Type: news

Epacadostat/Durvalumab Combo Well Tolerated in Solid Tumor Trial
At AACR 2018 AACR, Dr. Aung Naing of MD Anderson presented ECHO-203, the first data on epacadostat in combination with an anti –PD-L1 inhibitor. (Source: CancerNetwork)
Source: CancerNetwork - April 17, 2018 Category: Cancer & Oncology Authors: Dave Levitan Tags: Conferences/AACR Street Team Lung Cancer Melanoma News Source Type: news

Males With BRCA Mutations Have Increased Risk of Certain Cancers
Increased incidence of malignant disease, specifically prostate, melanoma, pancreas, breast cancers (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 17, 2018 Category: Cancer & Oncology Tags: Dermatology, Gastroenterology, Oncology, Pathology, Urology, Journal, Source Type: news

Males With BRCA Mutations Have Increased Risk of Certain Cancers
TUESDAY, April 17, 2018 -- Males with BRCA mutations have increased incidence of malignant disease, specifically prostate, melanoma, pancreas, and breast cancers, according to a research letter published online April 12 in JAMA Oncology. Roy Mano,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 17, 2018 Category: Pharmaceuticals Source Type: news

Combination therapy strengthens T cells in melanoma pre-clinical study
(University of Texas M. D. Anderson Cancer Center) A pre-clinical study of two drugs designed to boost T cell performance, has revealed the agents, when give in combination, may enhance the immune system's ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN. The study was led by investigators at The University of Texas MD Anderson Cancer Center. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 17, 2018 Category: Cancer & Oncology Source Type: news

Adjuvant Pembrolizumab Reduces Recurrence Risk in High-Risk Resected Stage III Melanoma
Dr. Alexander Eggermont presented results of KEYNOTE-045/EORTC 1325-MG, in which melanoma patients with recurrence on placebo can receive pembrolizumab. (Source: CancerNetwork)
Source: CancerNetwork - April 16, 2018 Category: Cancer & Oncology Authors: Dave Levitan Tags: Conferences/AACR Street Team Melanoma News Source Type: news

Drug Keytruda May Help Block Melanoma's Return
The drug also gained attention after former President Jimmy Carter announced in 2015 that Keytruda had beaten back his brain cancer. (Source: WebMD Health)
Source: WebMD Health - April 16, 2018 Category: Consumer Health News Source Type: news

New Studies Show Immune Treatments Could Be Key in the Fight Against Lung Cancer
Researchers report some of the most encouraging results yet for treating lung cancer with the latest immune-based treatments, most of which have been approved to treat other types of tumors. In three papers presented at the American Association for Cancer Research annual meeting, and published simultaneously in the New England Journal of Medicine, lung cancer experts found innovative ways to weaken lung tumors to improve people’s chances of surviving the disease. “There is definitely a high unmet need,” says Patrick Forde, assistant professor of oncology and associate member of the Bloomberg-Kimmel Instit...
Source: TIME: Health - April 16, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Cancer cancer immunotherapy Source Type: news

Adjuvant Pembrolizumab Beneficial in Stage III Melanoma
MONDAY, April 16, 2018 -- Pembrolizumab is associated with significantly longer recurrence-free survival than placebo as adjuvant therapy for high-risk stage III melanoma, according to a study published online April 15 in the New England Journal of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 16, 2018 Category: Pharmaceuticals Source Type: news

Adjuvant Pembrolizumab for Melanoma -- Approval Imminent? Adjuvant Pembrolizumab for Melanoma -- Approval Imminent?
Pembrolizumab is poised to join the ranks of ipilimumab and nivolumab as adjuvant therapy for patients with stage III melanoma, after showing a 43% reduction in risk for recurrence.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 16, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Drug Keytruda May Help Block Melanoma's Return
MONDAY, April 16, 2018 -- Taking the drug Keytruda after surgery for advanced melanoma significantly reduced patients'risk of their cancer returning, a new study found. Last May, Keytruda (pembrolizumab) became the first ever drug approved by the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 16, 2018 Category: General Medicine Source Type: news

Drug Keytruda May Help Block Melanoma's Return
Title: Drug Keytruda May Help Block Melanoma's ReturnCategory: Health NewsCreated: 4/16/2018 12:00:00 AMLast Editorial Review: 4/16/2018 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - April 16, 2018 Category: Cancer & Oncology Source Type: news

AACR: How do melanoma cells survive drug treatment long enough to acquire drug resistance?
(University of Colorado Anschutz Medical Campus) 'What we find is that dabrafenib, even at high doses, does not fully turn off the MAPK pathway, thereby enabling eventual escape from drug,' says Sabrina Spencer, Ph.D. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 16, 2018 Category: Cancer & Oncology Source Type: news

Drug Keytruda May Help Block Melanoma's Return
(Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - April 16, 2018 Category: Cancer & Oncology Source Type: news

Secondary Prevention Strategies for Nonmelanoma Skin Cancer
In this article, we review the published literature and evaluate secondary prevention strategies for nonmelanoma skin cancer. We also explore investigational therapies proposed for chemoprevention of nonmelanoma skin cancers. (Source: CancerNetwork)
Source: CancerNetwork - April 15, 2018 Category: Cancer & Oncology Authors: Adriana T. Lopez, BA Larisa Geskin, MD Richard D. Carvajal, MD Tags: Oncology Journal Review Article Skin Cancer (Nonmelanoma) Source Type: news

Adjuvant Anti-PD-1 Scores Again in Melanoma
(MedPage Today) -- Recurrence risk falls by more than 40% with pembrolizumab (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - April 15, 2018 Category: Primary Care Source Type: news

Using anti-PD-1 therapy pre-surgery in melanoma patients can identify those most likely to benefit
(University of Pennsylvania School of Medicine) Checkpoint inhibitors that block the protein PD-1 are used in melanoma patients after they've had surgery to remove their cancer, but not all patients benefit from the immunotherapy. Now a new study from the Abramson Cancer Center of the University of Pennsylvania found that shifting use of anti-PD-1 drugs to before surgery may provide clues about which patients will benefit and which may be at increased risk for recurrence. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 15, 2018 Category: Cancer & Oncology Source Type: news

Inhibiting metabolism found to be effective in treating aggressive form of lung cancer
FINDINGSResearchers from UCLA and Long Beach Memorial Medical Center have found that two targeted therapies could be more effective if used in combination to treat squamous cell carcinomas of the lung. The two drugs, MLN128 and CB-839, individually target the metabolism of key nutrients glucose and glutamine, respectively, prohibiting the cancer from switching metabolic gears between glucose (a simple sugar) and glutamine (an amino acid) to tap vital sources of energy. This switch enables the cancer cells to adapt their metabolism and evade treatments.BACKGROUNDNon-small cell lung cancer makes up about 85 percent of all lu...
Source: UCLA Newsroom: Health Sciences - April 13, 2018 Category: Universities & Medical Training Source Type: news

Discovery of 4 subtypes of melanoma points to new treatment approaches
FINDINGSMelanoma, a relatively rare but deadly skin cancer, has been shown to switch differentiation states — that is, to regress to an earlier stage of development — which can lead it to become resistant to treatment. Now, UCLA researchers have found that melanomas can be divided into four distinct subtypes according to their stages of differentiation. Cell subtypes that de-differentiated — meaning that they reverted back to a less-mature cell — showed sensitivity to a type of self-inflicted cell death called ferroptosis.The research also showed that certain subtypes of melanoma cells could be succ...
Source: UCLA Newsroom: Health Sciences - April 12, 2018 Category: Universities & Medical Training Source Type: news

Medical News Today: Blocking melanoma's 'escape route'
A new study finds that, as melanoma tries to evade treatment, it differentiates into four subtypes. Some of these are vulnerable to treatment. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 12, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Novel combination therapy effective for NRAS mutant and therapy resistant melanoma
(The Wistar Institute) Wistar researchers have identified a novel therapeutic vulnerability in NRAS mutant melanoma and an effective strategy to address it, using a combination of two clinically relevant inhibitors, according to study results published online in EMBO Molecular Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2018 Category: Cancer & Oncology Source Type: news

Discovery of 4 subtypes of melanoma points to new treatment approaches
(University of California - Los Angeles Health Sciences) UCLA researchers have found that melanomas can be divided into four distinct subtypes according to their stages of differentiation. Cell subtypes that de-differentiated -- meaning that they reverted back to a less-mature cell -- showed sensitivity to a type of self-inflicted cell death called ferroptosis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2018 Category: Cancer & Oncology Source Type: news

New FDA guidelines on sunscreen can help protect your skin from the sun
We have all heard that we need to protect our skin from the damaging rays of the sun. In fact, each year there are more new cases of skin cancer than the combined incidence of cancers of the breast, prostate, lung and colon. But a trip to the sunscreen section of your local drugstore can leave you reeling from abbreviation overload. UVA? UVB? What happened to plain old SPF? The n ew ratings and terminology can be a little confusing, but it means you get more information about effective skin protection. The… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - April 11, 2018 Category: Pharmaceuticals Authors: Dr. Jonathan Lee Source Type: news

Outcomes in Melanoma After Stopping Nivolumab and Ipilimumab Outcomes in Melanoma After Stopping Nivolumab and Ipilimumab
Many patients continue to derive benefit from combined nivolumab and ipilimumab after discontinuation.Journal of Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 11, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news