Percutaneous edge-to-edge repair in patients with heart failure and secondary mitral regurgitation
(PCR) Heart failure is a common cardiovascular disorder with ominous prognosis despite significant therapeutic advances. Mitral regurgitation (MR, leaking of the mitral valve within the heart) affects at least 50% of patients with heart failure and is independently associated with worse prognosis. Timely diagnosis is essential, and management is complex, requiring an expert approach. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 17, 2019 Category: International Medicine & Public Health Source Type: news

Former President Jimmy Carter Out of Hospital
Former President Jimmy Carter, 94, was released from the hospital Thursday, after surgery to repair a broken hip. Former first lady Rosalynn Carter also was released, after feeling faint Wednesday and being admitted for observation and testing. (Source: WebMD Health)
Source: WebMD Health - May 16, 2019 Category: Consumer Health News Source Type: news

Yale study identifies how cancer drug inhibits DNA repair in cancer cells
According to Yale research, a cancer drug thought to be of limited use may be able to stop certain cancer cells from repairing their DNA in order to survive. (Source: Yale Science and Health News)
Source: Yale Science and Health News - May 15, 2019 Category: Universities & Medical Training Source Type: news

Do Some Animals Have The DNA To Prevent Cancer?
BOSTON (CBS) – Being overweight increases your risk of cancer, but it turns out this is not always the case in the rest of the animal kingdom. Whales, for example, rarely get cancer, and researchers from Northern Arizona University wanted to know why. Despite being big and blubbery, whales rarely develop or die from cancer, unlike humans and other mammals like cats and dogs. The same is true for elephants. To find out why, researchers studied the DNA of skin samples taken from a female humpback whale off the coast of Massachusetts. Her name is Salt, and scientists have been studying her for decades. They found that w...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - May 15, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Healthwatch Syndicated Local Cancer DNA Research Northern Arizona University Source Type: news

Light-activated bio-glue that moves with a beating heart can repair life-threatening wounds in pigs
Uncontrolled bleeding during surgery can cause death. What if, instead of slow surgical stitching, you could rapidly glue a wound together? (Source: CNN.com - Health)
Source: CNN.com - Health - May 15, 2019 Category: Consumer Health News Source Type: news

Society for Participatory Medicine Welcomes Burt Rosen as President & Expands Board of Directors
Addition of Helene D. Clayton-Jeter, OD, and Amber Soucy, MSN, RN, Invigorates Momentum to Advance Dialogue Between Patients, Providers and Caregivers   BOSTON—May 15, 2019—The Society for Participatory Medicine, the preeminent organization in promoting true partnerships between patients, caregivers and healthcare professionals, is pleased to welcome Burt Rosen as president along with the addition of Helene D. Clayton-Jeter, OD, and Amber Soucy, MSN, RN, to its board of directors. Their involvement with the society will help advance the movement of participatory medicine, in which patients, caregivers and...
Source: Society for Participatory Medicine - May 15, 2019 Category: General Medicine Authors: Society for Participatory Medicine Staff Tags: News News Releases Source Type: news

Tool Predicts Quality Measures After Ventral Hernia Repair
WEDNESDAY, May 15, 2019 -- The Outcomes Reporting App for Clinical and Patient Engagement (ORACLE) tool can predict quality measures following ventral hernia repair (VHR) and facilitate preoperative surgeon-patient discussions, according to a study... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 15, 2019 Category: Pharmaceuticals Source Type: news

Cardiac Stem Cells in the Post-Anversa Era Cardiac Stem Cells in the Post-Anversa Era
Recent investigations have discredited much of the literature supporting c-Kit+ cardiac stem cells having any role in cardiac repair. Where do we go from here?European Heart Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 15, 2019 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Yale study identifies how cancer drug inhibits DNA repair in cancer cells
(Yale University) According to researchers at Yale Cancer Center, a cancer drug thought to be of limited use possesses a superpower of sorts: It is able to stop certain cancer cells from repairing their DNA in order to survive. The study, published today in the journal Science Translational Medicine, suggests that combining this drug, cediranib, with other agents could potentially deliver a lethal blow in cancer that uses a specific pathway -- or process -- to create DNA repair cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: news

Glucosamine supplements may reduce stroke risk
Study finds lower risk of CVD events in users Related items fromOnMedica The new GP contract: transforming primary care, transforming CVD prevention New ‘treadmill test’ can predict mortality Heart disease and stroke deaths plummet in Scotland Public urged to check their ‘heart age’ to prevent premature death Mexican fish offer clues on heart repair (Source: OnMedica Latest News)
Source: OnMedica Latest News - May 15, 2019 Category: UK Health Source Type: news

Smith and Nephew launches new FLOW 90(TM) Wand at ISAKOS joining its innovative collection of COBLATION(TM) technology and shoulder repair portfolios
LONDON, May 13, 2019 -- (Healthcare Sales & Marketing Network) -- Smith & Nephew (LSE: SN,NYSE: SNN), the global medical technology business, today announces the U.S. launch of the WEREWOLF™ FLOW 90 Wand with FLOW~IQ™ Technology. Designed for use in the s... Devices, Orthopaedic, Product Launch Smith & Nephew, WEREWOLF, FLOW 90 Wand, COBLATION System (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 13, 2019 Category: Pharmaceuticals Source Type: news

Book Review: Healing Relational Trauma  with Attachment-Focused Interventions
For a young child, traumatic experiences can lead to a pattern of mistrust, anticipation of further trauma, avoidance, and difficulty relating to others. Their development can be compromised. Their sense of self can become fractured, and their lives become merely an expression of their trauma. Helping children like this requires a deeply sensitive clinical approach that begins with the children’s relationships. “When children develop patterns of survival that involve them relying on themselves, not others, they do so out of a profound mistrust that others will meet their needs and will do what is best for them,...
Source: Psych Central - May 11, 2019 Category: Psychiatry Authors: Claire Nana Tags: Abuse Book Reviews Caregivers Children and Teens Communication Disorders Domestic Violence Family General Memory and Perception Parenting Psychology Psychotherapy Relationships & Love Self-Esteem Trauma Treatment books ab Source Type: news

Pioneering gene therapy could repair deadly heart attack damage
Researchers at King's College London injected pigs with a gene which restarted the growth of specialised heart cells called cardiomyocytes, the majority of which are developed before birth. (Source: the Mail online | Health)
Source: the Mail online | Health - May 10, 2019 Category: Consumer Health News Source Type: news

Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications - Venkatesh K, Ghosh SK, Mullick M, Manivasagam G, Sen D.
Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites of damage which can generate both neuronal and glial population ha... (Source: SafetyLit)
Source: SafetyLit - May 10, 2019 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Studying DNA breaks to protect future space travelers
(NASA/Johnson Space Center) Earth's atmosphere shields life on the ground from cosmic radiation that can damage DNA. Astronauts in space have no such protection, and that puts them at risk. An investigation on the International Space Station examines DNA damage and repair in space in order to help protect the long-term health of space travelers. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 9, 2019 Category: Biology Source Type: news

Will MSC micropellets outperform single cells for cartilage regeneration?
(Mary Ann Liebert, Inc./Genetic Engineering News) Repair of cartilage injuries or defects is aided by the introduction of mesenchymal stem cells (MSCs), which can be incorporated into hydrogels to amplify their effects. In a new report, researchers directly compared chondrogenic induction by hydrogels that were prepared using MSCs either as single cell suspensions or as 100-500-cell micropellets. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 9, 2019 Category: Biology Source Type: news

Vericel looks to market a gel for burns with new $142M licensing deal
Cambridge-based cell therapy firm Vericel Corp. has forged a $142 million deal to license a gel used to help heal burns that made just over $3 million in sales last year at an Israeli company. Vericel (Nasdaq: VCEL) will pay $17.5 million upfront and up to $125 million in milestones to license and sell the burn repair product NexoBrid from Israeli company MediWound Ltd., it announced Tuesday. The gel uses enzymes to remove burned tissue, with around 93 percent of subjects experiencing c omplete removal… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - May 8, 2019 Category: Pharmaceuticals Authors: Allison DeAngelis Source Type: news

Vericel looks to market a gel for burns with new $142M licensing deal
Cambridge-based cell therapy firm Vericel Corp. has forged a $142 million deal to license a gel used to help heal burns that made just over $3 million in sales last year at an Israeli company. Vericel (Nasdaq: VCEL) will pay $17.5 million upfront and up to $125 million in milestones to license and sell the burn repair product NexoBrid from Israeli company MediWound Ltd., it announced Tuesday. The gel uses enzymes to remove burned tissue, with around 93 percent of subjects experiencing c omplete removal… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 8, 2019 Category: Biotechnology Authors: Allison DeAngelis Source Type: news

A Boat Crushed His Face. Then Plastic Surgeons Hit Him With $167,000 in Medical Costs
Bob Ensor didn’t see the boom swinging violently toward him as he cleaned a sailboat in dry dock on a spring day two years ago. But he heard the crack as it hit him in the face. He was transported by ambulance to an in-network hospital near his home in Middletown, N.J., where initial X-rays showed his nose was broken as were several bones of his left eye socket. The emergency physician summoned the on-call plastic surgeon, who admitted him to the hospital and scheduled him for surgery the next day. Shortly before surgery, the doctor introduced Ensor to a second plastic surgeon who would assist in the 90-minute proced...
Source: TIME: Health - May 6, 2019 Category: Consumer Health News Authors: Michelle Andrews / Kaiser Health News Tags: Uncategorized Healthcare Source Type: news

Researchers find protein that suppresses muscle repair in mice
(University of Illinois at Urbana-Champaign, News Bureau) Researchers report that a protein known to be important to protein synthesis also influences muscle regeneration and regrowth in an unexpected manner. The discovery, along with the identification of an inhibitor that blocks its effects, could one day lead to new methods for treating disorders that result in muscle weakness and loss of muscle mass, the researchers said. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 6, 2019 Category: International Medicine & Public Health Source Type: news

Barton on DNA electrochemistry at NIEHS Distinguished Lecture
Jacqueline Barton shared insights into the role of electron transfer in DNA repair. (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - May 2, 2019 Category: Environmental Health Source Type: news

Mutational intensity influences a tumor's response to PD-1 immunotherapy
(American Association for the Advancement of Science) Following FDA approval last year of PD-1 immune checkpoint inhibitors for tumors with mismatch repair deficiency, a new study reveals more about why responses of these tumors to this immunotherapy vary, specifically implicating mutation intensity. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 2, 2019 Category: Cancer & Oncology Source Type: news

Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response
This study provides a rationale for the genome-wide characterization of MSI intensity and mutational load to better profile responses to anti–PD-1 immunotherapy across MMR-deficient human cancers. (Source: ScienceNOW)
Source: ScienceNOW - May 2, 2019 Category: Science Authors: Mandal, R., Samstein, R. M., Lee, K.-W., Havel, J. J., Wang, H., Krishna, C., Sabio, E. Y., Makarov, V., Kuo, F., Blecua, P., Ramaswamy, A. T., Durham, J. N., Bartlett, B., Ma, X., Srivastava, R., Middha, S., Zehir, A., Hechtman, J. F., Morris, L. G., Wei Tags: Genetics, Medicine, Diseases reports Source Type: news

Hormones that mimic the womb might help brain heal from multiple sclerosis
FINDINGSUCLA researchers stimulated brain repair in mice with two of the most widely used analogues for multiple sclerosis by treating them with estrogen. The hormone induced the expression of cholesterol synthesis genes in cells that make myelin, the protective coating around nerves. The researchers found that mechanisms underlying this process, called remyelination, appeared to mimic known processes of myelination when the fetal brain is developing and is exposed naturally to a related estrogen in the mother ’s blood.BACKGROUNDIn MS, the body ’s immune system attacks the protective myelin coating around nerve...
Source: UCLA Newsroom: Health Sciences - April 29, 2019 Category: Universities & Medical Training Source Type: news

The benefits of forgiving: young children respond positively to those who forgive - Oostenbroek J, Vaish A.
Forgiveness helps to repair relationships and thus helps maintain cooperation. Might forgiveness also convey to others that the forgiver is a valuable cooperation partner? We propose that if victims' forgiveness displays have evolved as important social cu... (Source: SafetyLit)
Source: SafetyLit - April 29, 2019 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Vascular repair after firearm injury is associated with increased morbidity and mortality - Siracuse JJ, Cheng TW, Farber A, James T, Zuo Y, Kalish JA, Jones DW, Kalesan B.
OBJECTIVE: Firearm injuries have high morbidity and mortality. Presentation of injuries requiring concurrent vascular repair and its outcomes are unclear. Our study's objective was to characterize the injury details and to assess the associated mortality a... (Source: SafetyLit)
Source: SafetyLit - April 29, 2019 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

First Patient in New England Treated With the Agili-C(TM) Implant at CartiHeal's Pivotal Study
KFAR SABA, Israel, April 29, 2019 -- (Healthcare Sales & Marketing Network) -- Christian Lattermann, M.D., Chief of the Sports Medicine Service and Director of the Center for Cartilage Repair at Brigham and Women's Hospital in Boston, recently became the ... Devices, Orthopaedic CartiHeal, Agili-C , osteochondral defects, osteoarthritic joints (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 29, 2019 Category: Pharmaceuticals Source Type: news

Cardiac Dimensions Spot on with FMR Treatment
This study adds to the growing body of evidence demonstrating the effectiveness and safety of the Carillon System in two key measurements of FMR - a significant MR reduction and favorable left ventricular remodeling, observed most recently in the REDUCE FMR trial, the first and only randomized, blinded, sham-controlled trial conducted in structural heart,” Casciaro said in a release. Cardiac Dimensions has been building itself up as a powerful competitor in the FMR market. A year ago, the company raised $39 million to build strong clinical evidence for its Carillon Mitral Contour System. And in September ...
Source: MDDI - April 26, 2019 Category: Medical Devices Authors: Omar Ford Tags: Cardiovascular Source Type: news

Brake response time recovery after achilles tendon repair - Reb CW, McDonald E, Shakked RJ, Winters BS, Pedowitz DI, Raikin SM, Daniel JN.
This study evaluated when patients' brake response time (BRT) recovers after right Achilles repair. METHODS: Institutional review board-approved prospective study of 60 patients. Assessments included visual analogue scale pain (VAS) sco... (Source: SafetyLit)
Source: SafetyLit - April 26, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Mozambique: healthcare after Cyclone Idai
Update 26th April – Doctors of the World teams are currently monitoring the impact of Cyclone Kenneth and will provide support if needed. John Segredo Accommodation Centre is a makeshift camp set up for those displaced by Cyclone Idai.   100 km from the port city of Beira, the camp is currently housing thousands of people. There are serious concerns about the source of drinking water,which is located many miles away and was significantly damaged by the passing storm, and food is currently rationed. “We help repair and equip local health centers so that they can resume operations. At the same time, we are ...
Source: Doctors of the World News - April 26, 2019 Category: International Medicine & Public Health Authors: Martina Villa Tags: Uncategorised Source Type: news

Gene repair improves memory and seizures in adult autism model
(Scripps Research Institute) There may be reason to treat severe neurodevelopmental disorders at any stage of life, a new study of SYNGAP1 related autism suggests. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 26, 2019 Category: International Medicine & Public Health Source Type: news

Vascular surgery after firearm injury associated with increased morbidity and mortality
(Boston University School of Medicine) Researchers from Boston University School of Medicine (BUSM) found that among all hospitalizations that were due to firearm injury, patients who underwent surgical repair of their major blood vessels had the highest injury severity score (predictor of in-hospital death). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 25, 2019 Category: International Medicine & Public Health Source Type: news

Songbird-body changes that allow migration may have human health implications
(Penn State) Songbirds that pack on as much as 50 percent of their body weight before migrating and that sleep very little, exhibit altered immune system and tissue-repair function during the journey, which may hold implications for human health, according to Penn State researchers. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 25, 2019 Category: Biology Source Type: news

Medical News Today: Hair breakage: 10 causes and ways to repair
This article looks at common causes and how to treat dry, brittle, or broken hair. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 25, 2019 Category: Consumer Health News Tags: Dermatology Source Type: news

Boston Children ’ s Researchers Find Possible Way To Repair Damaged Hearts
BOSTON (CBS) – Researchers at Boston Children’s Hospital may have found a way to repair damaged heart tissue after a heart attack. When someone has a heart attack, muscle cells in the heart die off and generally don’t get replaced. Instead scar tissue forms and that can eventually lead to heart failure. But researchers may have found a way to get heart cells to regrow using microRNAs, small molecules that regulate gene function in developing hearts. When injected into mice after a heart attack, within 10 days these molecules helped minimize cell death and reduced inflammation. With time, the treated heart...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 24, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Syndicated Local Boston Children's Hospital Dr. Mallika Marshall HealthWatch Source Type: news

Is Boston Scientific Worried About Paclitaxel and Vaginal Mesh Headwinds?
Boston Scientific had a lot to celebrate this week after FDA approved the company's much-anticipated Lotus Edge Valve for transcatheter aortic valve replacement. But enthusiasm for the approval was dampened during the company's first-quarter earnings call Wednesday by recent regulatory setbacks. The company is feeling the impact of ongoing Paclitaxel concerns, FDA's recent decision on vaginal mesh products, and the shutdown of an Illinois sterilization plant that previously sterilized products in Boston Scientific's men's health business. Here's a look at how each of these issues has impacted Boston...
Source: MDDI - April 24, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Business Cardiovascular Source Type: news

Eczema: The oil-based treatment proven to reduce inflammation and repair skin
ECZEMA is a condition that causes a person ’s skin to become sore, itchy, dry and cracked. While experts recommend emollients and steroid creams, these don’t always work for everyone. An alternative, natural remedy, which cold prove effective, contains the ingredient oats. (Source: Daily Express - Health)
Source: Daily Express - Health - April 24, 2019 Category: Consumer Health News Source Type: news

Medical News Today: Using small molecules to regenerate heart tissue
New research in mice uses gene-regulating molecules called microRNAs to repair heart tissue after an adverse cardiovascular event such as a heart attack. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 24, 2019 Category: Consumer Health News Tags: Heart Disease Source Type: news

Fascinating video shows surgeons doing a pioneering spine operation on a baby inside the WOMB
WARNING: GRAPHIC CONTENT. Dr Wael El Banna, a surgeon in Cairo, Egypt, filmed a spinal repair operation done on a baby with spina bifida in which he removes the pregnant mother's womb. (Source: the Mail online | Health)
Source: the Mail online | Health - April 23, 2019 Category: Consumer Health News Source Type: news

New biomaterials could promote natural wound healing
While doctors have various materials on hand to dress wounds, researchers continue to look for ways to improve those supplies. A recent development from a team at Imperial College London involves a new molecule that can change how traditional wound care materials react with the body. By interacting with tissues as healing takes place, the molecule can promote accelerated yet natural wound healing. Here are the details on this innovative wound care development: What is this new molecule? The researchers named the new molecules traction force-activated payloads, or TrAPs for short. They're designed to connect wound care ...
Source: Advanced Tissue - April 23, 2019 Category: Dermatology Authors: AdvancedTissue Tags: Wound healing Source Type: news

Proofreading the book of life: Gene editing made safer
(Arizona State University) In research appearing in the advanced online edition of the journal Nature Communications, Karen Andersen, Samira Kiani and their colleagues at Arizona State University describe a method of rendering the gene editing tool CRISPR-Cas9 'immunosilent,' potentially allowing the editing and repair of genes to be accomplished reliably and stealthily. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 23, 2019 Category: Cancer & Oncology Source Type: news

New approach to repair fetal membranes may prevent birth complications
(Queen Mary University of London) Researchers from Queen Mary University of London and University College London have developed a new approach to repair defects in fetal membranes which could prevent life-long medical conditions and disabilities associated with preterm birth. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 23, 2019 Category: International Medicine & Public Health Source Type: news

'Longevity gene' responsible for more efficient DNA repair
(University of Rochester) University of Rochester researchers found that the gene sirtuin 6 (SIRT6) is responsible for more efficient DNA repair in species with longer lifespans. The research illuminates new targets for anti-aging interventions and could help prevent age-related diseases. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 23, 2019 Category: Biology Source Type: news

Injection Timing Tied to Risk for Infection in Rotator Cuff Repair
MONDAY, April 22, 2019 -- For patients undergoing arthroscopic rotator cuff repair, corticosteroid injections within the previous month are associated with an increased risk for surgical site infection, according to a study published in the April 17... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 22, 2019 Category: Pharmaceuticals Source Type: news

OHSU study offers hope for people with multiple sclerosis
In multiple sclerosis, the immune system eats away at the sheath that protects the nerves, disrupting signals between the brain and the body and causing problems in walking and eyesight. No drugs have ever been developed to restore that protective layer, called myelin. But a study out Thursday from Oregon Health& Science University offers some hope. Researchers found myelin repair is possible, though their method has not yet been tested in humans. The potential game changer is a compound called… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - April 18, 2019 Category: American Health Authors: Elizabeth Hayes Source Type: news

Best supplements for eczema: The plant-based oil that could repair sore and cracked skin
BEST supplements for eczema: When it comes to eczema, experts often recommend special moisturisers, creams and ointments to relieve symptoms. But these don ’t work for everybody. An alternative treatment could be found in a plant-based oil, native to the desert regions of northern America. (Source: Daily Express - Health)
Source: Daily Express - Health - April 18, 2019 Category: Consumer Health News Source Type: news

Vaginal Mesh Is Just One of Boston Scientific & #039;s Headaches This Year
Boston Scientific expects to take a $25 million revenue hit after FDA ordered two of its surgical mesh products off the market this week, the company disclosed in an SEC filing. Unfortunately, that's not the only revenue headwind the company has to worry about this year. Boston Scientific is one of about a handful of companies that develop paclitaxel drug-coated balloons and drug-coated stents. Paclitaxel devices received some bad press in January after a meta-analysis showed an increased risk of death for patients treated with these devices in the femoral and/or popliteal arteries of the lower limbs. Two drug-...
Source: MDDI - April 18, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Business Regulatory and Compliance Source Type: news

Timing of steroid shots before rotator cuff surgery affects infection risk
(Wolters Kluwer Health) For patients undergoing arthroscopic surgery to repair a torn rotator cuff, previous steroid injections into the shoulder don't increase the risk of surgical-site infection - unless the injection is administered within one month before surgery, reports a study in the April 17, 2019, issue of the Journal of Bone& Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 18, 2019 Category: International Medicine & Public Health Source Type: news

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq
CRISPR-Cas genome editing induces targeted DNA damage but can also affect off-target sites. Current off-target discovery methods work using purified DNA or specific cellular models but are incapable of direct detection in vivo. We developed DISCOVER-Seq (discovery of in situ Cas off-targets and verification by sequencing), a universally applicable approach for unbiased off-target identification that leverages the recruitment of DNA repair factors in cells and organisms. Tracking the precise recruitment of MRE11 uncovers the molecular nature of Cas activity in cells with single-base resolution. DISCOVER-Seq works with multi...
Source: ScienceNOW - April 18, 2019 Category: Science Authors: Wienert, B., Wyman, S. K., Richardson, C. D., Yeh, C. D., Akcakaya, P., Porritt, M. J., Morlock, M., Vu, J. T., Kazane, K. R., Watry, H. L., Judge, L. M., Conklin, B. R., Maresca, M., Corn, J. E. Tags: Molecular Biology, Techniques reports Source Type: news

Achilles Tendon Repair After Rupture: To Operate or Not
No abstract available (Source: Lippincott's Bone and Joint Newsletter)
Source: Lippincott's Bone and Joint Newsletter - April 17, 2019 Category: Orthopaedics Tags: CME Article Source Type: news