Long-gap esophageal atresia: gastric transposition or esophageal lengthening with delayed primary anastomosis? A systematic review
ConclusionsThis systematic review highlights the morbidity associated with both surgical procedures and the variety in reporting outcomes. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - April 24, 2024 Category: Surgery Source Type: research
Laparoscopic repair of duodenal atresia: systematic review and meta-analysis after consistent implementation of the technique in the past decade
ConclusionsLRDA showed equivalent complication rates compared to OR with an additional benefit of quicker establishment of feeds. There was no significant difference in complication and conversion rates between laparoscopic techniques. Despite a longer operative time, LRDA provides a safe minimal access approach for neonates after this consistent implementation of the technique in the past decade. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 24, 2024 Category: Surgery Source Type: research
Molecules, Vol. 29, Pages 1944: A Rapid Self-Assembling Peptide Hydrogel for Delivery of TFF3 to Promote Gastric Mucosal Injury Repair
Zhao
Luo
Self-assembled peptide-based nanobiomaterials exhibit promising prospects for drug delivery applications owing to their commendable biocompatibility and biodegradability, facile tissue uptake and utilization, and minimal or negligible unexpected toxicity. TFF3 is an active peptide autonomously secreted by gastric mucosal cells, possessing multiple biological functions. It acts on the surface of the gastric mucosa, facilitating the repair process of gastric mucosal damage. However, when used as a drug, TFF3 faces significant challenges, including short retention time in the gastric mucosal cavity and deacti...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Chen Luo Su Lu Zhao Luo Tags: Article Source Type: research
Economic analysis of surgical outcome monitoring using control charts: the SHEWHART cluster randomised trial
Conclusions
Using control charts paired with indicator feedback to surgical teams was associated with significant reductions in hospital bed-days within 30 days following surgery, and hospital costs reimbursed for this care by the insurer.
Trial registration number
NCT02569450. (Source: BMJ Quality and Safety)
Source: BMJ Quality and Safety - April 24, 2024 Category: General Medicine Authors: Skinner, S., Pascal, L., Polazzi, S., Chollet, F., Lifante, J.-C., Duclos, A., On behalf of the SHEWHART Trial Group Tags: Open access, Editor's choice Original research Source Type: research
Characterization of structural, genotoxic, and immunological effects of methyl methanesulfonate (MMS) induced DNA modifications: Implications for inflammation-driven carcinogenesis
This study focuses on an in-depth understanding of the structural instability, induced antigenicity on the DNA molecule, cross-reactive anti-DNA antibodies, and cytotoxic potential of MMS in peripheral lymphocytes and cancer cell lines. The findings are decisive in identifying the hazardous nature of MMS to alter the intricacies of DNA and morphology of the cell. Structural alterations were assessed through UV-Vis, fluorescence, liquid chromatography, and mass spectroscopy (LCMS). The thermal instability of DNA was analyzed using duplex melting temperature profiles. Scanning and transmission electron microscopy revealed gr...
Source: International Journal of Biological Macromolecules - April 23, 2024 Category: Biochemistry Authors: Mohd Mustafa Safia Habib Khalid Imtiyaz Neda Tufail Rizwan Ahmad Bazigha Hamim Kashif Abbas Waleem Ahmad Shifa Khan None Moinuddin M Moshahid A Rizvi Md Imtaiyaz Hassan Shahid Ali Siddiqui Source Type: research
Calcium signaling induces partial EMT and renal fibrosis in a Wnt4 < sup > mCherry < /sup > knock-in mouse model
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167180. doi: 10.1016/j.bbadis.2024.167180. Online ahead of print.ABSTRACTThe renal tubular epithelial cells (TEC) have a strong capacity for repair after acute injury, but when this mechanism becomes uncontrollable, it leads to chronic kidney diseases (CKD). Indeed, in progress toward CKDs, the TECs may dedifferentiate, undergo epithelial-to-mesenchyme transition (EMT), and promote inflammation and fibrosis. Given the critical role of Wnt4 signaling in kidney ontogenesis, we addressed whether changes in this signaling are connected to renal inflammation and fibrosis by taking...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Florence Naillat Ganga Deshar Anni Hankkila Aleksandra Rak-Raszewska Abhishek Sharma Renata Prunskaite-Hyyrylainen Antti Railo Jingdong Shan Seppo J Vainio Source Type: research
Silicone Oil Tamponade for Therapy of Primary Retinal Detachment in Patients Who Live at High Altitudes
CONCLUSION: PPV with SO injection seems to be a safe and efficient surgical approach in the treatment of primary uncomplicated RRD in patients living at high altitudes and was associated with good anatomical and functional outcome in our series. However, the need for a follow-up surgery to remove SO should be weighed in these cases.PMID:38653297 | DOI:10.1055/a-2233-0971 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 23, 2024 Category: Opthalmology Authors: Tim Beltraminelli Quentin Hessler Theodor Stappler Jelena Potic Thomas J Wolfensberger Lazaros Konstantinidis Source Type: research
Correction of Congenital Syndactyly of the Hand with Minimal Full-Thickness Skin Graft from the Weight-Bearing Midline Plantar Area
CONCLUSION: Correction of congenital hand syndactyly using midline plantar FTSG from the weight-bearing area can reduce scarring on the hand dorsum, ensure superior color similarity with surrounding skin, and offer inconspicuous donor sites compared to no-skin-graft or groin FTSG techniques.PMID:38652871 | DOI:10.1097/PRS.0000000000011484 (Source: Hand Surgery)
Source: Hand Surgery - April 23, 2024 Category: Surgery Authors: Soo Jin Woo Kwang Hyun Park Sang Hyun Woo Hyun Jae Nam Source Type: research
Microsurgery in carotid body paraganglioma
CONCLUSIONS: The small study size and its retrospective nature suggests caution; however, our results show that microsurgery can allow a safe and precise dissection of the carotids and nerves.PMID:38651551 | DOI:10.14639/0392-100X-N2761 (Source: Acta Otorhinolaryngologica Italica)
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Antonio Mazzoni Leonardo Franz Elisabetta Zanoletti Source Type: research
Molecular mechanism of high glucose-induced mitochondrial DNA damage in retinal ganglion cells
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):219-224. doi: 10.14715/cmb/2024.70.3.33.ABSTRACTMitochondrial DNA damage in retinal ganglion cells (RGCs) may be closely related to lesions of glaucoma. RGCs were cultured with different concentrations of glucose and grouped into 3 groups, namely normal control (NC) group, Low-Glu group, and High-Glu group. Cell viability was measured with cell counting kit-8, and cell apoptosis was measured using flow cytometry. The DNA damage was measured with comet assay, and the morphological changes of damaged mitochondria in RGCs were observed using TEM. Western blot analyzed the expr...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jinzi Zhou Fenghua Chen Aimin Yan Xiaobo Xia Source Type: research
Outcomes of Concomitant Maze Procedure in Tricuspid Repair for Severe Tricuspid Regurgitation
CONCLUSION: The Maze procedure during TV repair in patients with severe TR and persistent AF showed acceptable SR rates and lower MACCE rates compared to those without the procedure, while also promoting LA reverse remodeling.PMID:38651225 | DOI:10.3346/jkms.2024.39.e143 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Ilkun Park Suryeun Chung Yang Hyun Cho Kiick Sung Wook Sung Kim Kyungsub Song Joong Hyun Ahn Chang Seok Jeon Pyo Won Park Dong Seop Jeong Source Type: research
Pneumothorax during shoulder surgery
Tidsskr Nor Laegeforen. 2024 Apr 4;144(5). doi: 10.4045/tidsskr.23.0542. Print 2024 Apr 23.ABSTRACTBACKGROUND: Pneumothorax following shoulder arthroscopy, although rare, is documented in over 30 PubMed case reports as occurring during or within 10 hours post-procedure.CASE PRESENTATION: A fit septuagenarian underwent a two-hour arthroscopic rotator cuff repair with IV anaesthesia and laryngeal mask airway, without a nerve block. With one hour remaining of the operation, the patient had desaturation and hypotension. Lung sliding was absent on ultrasound and x-ray confirmed left-sided tension pneumothorax. Successful thorac...
Source: Tidsskrift for den Norske Laegeforening - April 23, 2024 Category: General Medicine Authors: Ellisiv Seines Mariann Harneshaug Trine Skjeflo Fredrik Isachsen Erik Waage Nielsen Source Type: research
DNA damage, obesity and obesity-related health complications: what are new data telling us?
This article surveys new data that support these contentions.RECENT FINDINGS: Whole exome sequencing analyses have identified rare variants linked to high BMI and adiposity. Two of the identified genes are linked to DNA damage and DNA repair, suggesting that DNA damage itself may play a role in the cause of obesity. It has also been recognized that obesity increases DNA damage in breast tissue of carriers of BRCA mutations and rates of tumour formation in BRCA1+ mice, indicating effect of obesity on cancer development in high-risk populations. In addition, obesity promotes cancer cell chemoresistance by decreasing fatty ac...
Source: Clinical Genitourinary Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Marta W łodarczyk Gra żyna Nowicka Source Type: research
DNA damage, obesity and obesity-related health complications: what are new data telling us?
This article surveys new data that support these contentions.RECENT FINDINGS: Whole exome sequencing analyses have identified rare variants linked to high BMI and adiposity. Two of the identified genes are linked to DNA damage and DNA repair, suggesting that DNA damage itself may play a role in the cause of obesity. It has also been recognized that obesity increases DNA damage in breast tissue of carriers of BRCA mutations and rates of tumour formation in BRCA1+ mice, indicating effect of obesity on cancer development in high-risk populations. In addition, obesity promotes cancer cell chemoresistance by decreasing fatty ac...
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Marta W łodarczyk Gra żyna Nowicka Source Type: research
Aftershocks; about the psychological consequences of gas extraction in Groningen
CONCLUSION: The knowledge available within psychiatry and psychology about the development and treatment of psychological complaints should play a role in researching and improving the well-being and the mental health of those affected by the gas extraction problem, now and in the future.PMID:38650513 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - April 23, 2024 Category: Psychiatry Authors: Y Meesters R A Schoevers Source Type: research
