2021 Fast 55 honoree: CardioSolution
CardioSolution, a physician-led health care staffing firm, helps build, augment and operate cardiovascular programs across the country. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - June 17, 2021 Category: American Health Source Type: news

Combining Low-Salt, DASH Diets May Reduce Cardiac Damage
THURSDAY, June 17, 2021 -- Dietary interventions, like the Dietary Approaches to Stop Hypertension (DASH) diet and low sodium consumption, can improve cardiovascular risk factors in a relatively short time period, according to a study published in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 17, 2021 Category: Pharmaceuticals Source Type: news

Treating Sleep Apnea Lowers MI, Stroke Risk Treating Sleep Apnea Lowers MI, Stroke Risk
Treating sleep apnea reduces the risk for stroke, myocardial infarction, and other cardiovascular events, new research shows.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - June 17, 2021 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Driver state detection based on cardiovascular system and driver reaction information using a graphical model - Nguyen TT, Aoki H, Le AS, Akio H, Aoki K, Inagami M, Suzuki T.
Traffic accidents are mainly caused by human error. In an aging society, the number of accidents attributed to elderly drivers is increasing. One noteworthy reason for this is operation misapplication. Studies have been conducted on the use of human-machin... (Source: SafetyLit)
Source: SafetyLit - June 17, 2021 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Modifiable Cardiovascular Risk Factors Linked to Severity of COVID-19
WEDNESDAY, June 16, 2021 -- Many modifiable cardiovascular risk factors are associated with more severe consequences from COVID-19, according to a review published online June 9 in the European Heart Journal: Quality of Care& Clinical... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 16, 2021 Category: Pharmaceuticals Source Type: news

Coronary angiography video interpolation methods to reduce x-ray exposure frequency
(Compuscript Ltd) In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2021.0011, Xiao-lei Yin, Dong-xue Liang, Lu Wang, Jing Qiu, Zhi-yun Yang, Jian-zeng Dong and Zhao-yuan Ma from Tsinghua University, Beijing, China; Capital Medical University, Beijing, China and The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China analyse coronary angiography video interpolation methods to reduce x-ray exposure frequency based on deep learning. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 16, 2021 Category: International Medicine & Public Health Source Type: news

ST-segment depression in leads I and aVL: Artifactual or pathophysiological findings?
(Compuscript Ltd) In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2021.0013, Sharen Lee, Gary Tse, Xin Wang, Adrian Baranchuk and Tong Liu from Laboratory of Cardiovascular Physiology, Hong Kong, China, Second Hospital of Tianjin Medical University, Tianjin, China and Queen's University, Kingston, Ontario, Canada consider ST-segment depression in leads I and aVL. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 16, 2021 Category: International Medicine & Public Health Source Type: news

Financial Toxicity More Prevalent for ASCVD Than Cancer Patients
TUESDAY, June 15, 2021 -- Financial toxicity (FT) is more prevalent among individuals with atherosclerotic cardiovascular disease (ASCVD) than individuals with cancer, according to a study published in the June 1 issue of JACC:... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 15, 2021 Category: Pharmaceuticals Source Type: news

A1c Below Prediabetes Cutoff Linked to Subclinical Atherosclerosis A1c Below Prediabetes Cutoff Linked to Subclinical Atherosclerosis
Observational data suggest that A1c above 5% but below the prediabetes cutoff of 5.5% is an additional potential biomarker of subclinical atherosclerosis in people with low cardiovascular disease risk.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - June 15, 2021 Category: Cardiology Tags: Cardiology News Source Type: news

Plant-Centered Diet May Lower LDL Cholesterol, CVD Risk
TUESDAY, June 15, 2021 -- Dietary strategies aimed solely at lowering saturated fat intake may be less effective in reducing cardiovascular disease (CVD) than recommendations for a plant-centered diet, according to a study presented during Nutrition... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 15, 2021 Category: Pharmaceuticals Source Type: news

A Personalized Approach to CKD and Cardiovascular Disease A Personalized Approach to CKD and Cardiovascular Disease
Managing cardiovascular risk in patients with chronic kidney disease requires a collaborative approach.Journal of the American College of Cardiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 15, 2021 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Circle Cardiovascular, DiA Imaging Analysis to partner
Cardiac imaging software developer Circle Cardiovascular Imaging and DiA Imagin...Read more on AuntMinnie.comRelated Reading: Konica Minolta, DiA add echo AI analysis of COVID-19 FDA clears DiA's cardiac ultrasound AI DiA gets FDA nod, CE Mark for AI-based ultrasound tools Circle Cardiovascular buys Corstem, inks Galgo deal Circle Cardiovascular secures $16M in financing (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 14, 2021 Category: Radiology Source Type: news

Young Adults Who Restore Heart Health Cut Later CVD Risk
MONDAY, June 14, 2021 -- Poor cardiovascular health in young adulthood is associated with subsequent cardiovascular disease (CVD), but improving cardiovascular health over time can attenuate this risk, according to a research letter published online... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 14, 2021 Category: Pharmaceuticals Source Type: news

$7 million to advance cardiovascular research
(Max Delbr ü ck Center for Molecular Medicine in the Helmholtz Association) Diverse messenger RNAs are produced in cells by " alternative splicing. " The Leducq Foundation is now supporting a transatlantic network dedicated to investigating this process in heart muscle cells and how changes in this process contribute to disease. Professor Michael Gotthardt of the MDC and Professor Leslie Leinwand of the University of Colorado Boulder are coordinating the project. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 14, 2021 Category: Biology Source Type: news

How to lose visceral fat: The simple dietary trick to burn the belly fat
VISCERAL fat is packed between the abdominal organs, such as the stomach, liver and kidneys. This intra-abdominal belly fat, in excess amounts, can increase the risk of diabetes, cardiovascular disease, and cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - June 13, 2021 Category: Consumer Health News Source Type: news

New Phase 3 Study Results Show IMBRUVICA ® (ibrutinib)-Based Combination Regimen as an All-Oral Fixed-Duration Treatment Demonstrated Superior Progression-Free Survival in Adult Patients with Previously Untreated Chronic Lymphocytic Leukemia
Raritan, N.J., June 12, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced primary results from the pivotal Phase 3 GLOW study (NCT03462719) evaluating fixed-duration IMBRUVICA® plus venetoclax (I+V) compared to chlorambucil plus obinutuzumab (Clb+O) for first-line treatment of elderly or unfit patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study demonstrated superior progression-free survival (PFS) of a once-daily, all-oral, fixed-duration regimen of I+V versus Clb+O as first-line treatment of CLL; the study also showed improved duratio...
Source: Johnson and Johnson - June 12, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Announces Results from Phase 3 MAIA Study Showing Significant Overall Survival Benefits for Treatment with DARZALEX ® (daratumumab) in Patients with Newly Diagnosed Multiple Myeloma Who are Transplant Ineligible
Raritan, N.J., June 12, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced overall survival (OS) results from the Phase 3 MAIA (NCT02252172) study showing the addition of DARZALEX® (daratumumab) to lenalidomide and dexamethasone (D-Rd) resulted in a statistically significant survival benefit over lenalidomide and dexamethasone (Rd) alone in patients with newly diagnosed multiple myeloma (NDMM) who were ineligible for autologous stem cell transplant (ASCT) and were treated to progression.[1] These data were featured in the European Hematology Association (EHA) 2021 Virtual Press Briefin...
Source: Johnson and Johnson - June 12, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Obesity-Related Outcomes Up for Metabolically Healthy Obese
FRIDAY, June 11, 2021 -- " Metabolically healthy obesity " (MHO) is associated with an increased risk for obesity-related outcomes, including incident diabetes, atherosclerotic cardiovascular disease (ASCVD), and heart failure compared with... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 11, 2021 Category: Pharmaceuticals Source Type: news

More Than One in Four Adults With CVD Currently Smoke
FRIDAY, June 11, 2021 -- More than one in four adults with cardiovascular disease (CVD) report current tobacco use, according to a study published online June 9 in the Journal of the American Heart Association. Lindsay M. Reynolds, Ph.D., from the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 11, 2021 Category: Pharmaceuticals Source Type: news

High intensity exercises to boost your cardiovascular fitness if you hate running
If you're looking to launch your summer fitness kick, it'll come as a relief to hear that there are other cardiovascular-boosting exercises you can do to get your heart pumping, either at home or the gym. (Source: the Mail online | Health)
Source: the Mail online | Health - June 11, 2021 Category: Consumer Health News Source Type: news

Report shows Western European medical device market recovering post-COVID
Growth opportunities in agile and home-based healthcare as well as in new-age technologies will particularly benefit RASD, cardiovascular and orthopaedic devices.   (Source: mobihealthnews)
Source: mobihealthnews - June 10, 2021 Category: Information Technology Tags: < div class= entity entity-paragraphs-item paragraphs-item-enterprise-taxonomy about= typeof= > content /div Source Type: news

Vasopressor effects on venous return in septic patients: a review
This manuscript is intended to provide a holistically orientated, physiological review of the cardiovascular system on the choice of a vasopressor in septic patients. It discusses the pharmacological consequences of vasopressors not only on arteries/arterioles but also on other related circulatory components, such as the veins and the microcirculation to offer a broad picture for a rational decision. The manuscript is based on a literature search in PubMed using the keywords: sepsis, venous return, venous resistance, mean circulatory or mean systemic filling pressure, vasopressin, norepinephrine, vasopressor (conducted Nov...
Source: Current Awareness Service for Health (CASH) - June 9, 2021 Category: Consumer Health News Source Type: news

Education program for prevention of outdoor accidents in middle-high aged trekkers: monitoring of change in blood pressure and heart rate during exercise - Mieda R, Matsui Y, Tobe M, Kanamoto M, Suto T, Saito S.
This is an observational study to evaluate cardiovascular parameters during an educational trekking program. The number of alpine accidents involving elderly trekkers has been increasing in developed countries in recent years. Many middle-high aged trekker... (Source: SafetyLit)
Source: SafetyLit - June 9, 2021 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

SARS-CoV-2 protease cuts human proteins; possible link to COVID-19 symptoms
(American Chemical Society) The SARS-CoV-2 papain-like protease (PLpro) plays an essential role in processing viral proteins needed for replication. In addition, the enzyme can cut and inactivate some human proteins important for an immune response. Now, researchers reporting inACS Infectious Diseases have found other targets of PLpro in the human proteome, including proteins involved in cardiovascular function, blood clotting and inflammation, suggesting a link between the inactivation of these proteins and COVID-19 symptoms. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 9, 2021 Category: Infectious Diseases Source Type: news

Improving heart health may reduce the severity of COVID-19 disease
(European Society of Cardiology) High blood pressure, smoking, obesity, heart disease and diabetes are associated with worse outcomes in patients with COVID-19, according to a study published today in European Heart Journal - Quality of Care and Clinical Outcomes, a journal of the European Society of Cardiology (ESC). 'Many of the cardiovascular risk factors associated with more severe consequences from COVID-19 are potentially modifiable,' said study author Dr. Stephanie Harrison of the University of Liverpool, UK. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 9, 2021 Category: Infectious Diseases Source Type: news

Treating sleep apnea with CPAP therapy is associated with lower risk of heart problems
(American Academy of Sleep Medicine) Findings from a recent study show that patients with untreated, moderate to severe obstructive sleep apnea had a higher risk of experiencing a cardiovascular event, but the risk of incident heart problems was decreased in those who used CPAP therapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 9, 2021 Category: International Medicine & Public Health Source Type: news

Lipoprotein Apheresis Shows Durable Impact on CV Outcomes Lipoprotein Apheresis Shows Durable Impact on CV Outcomes
Giving very high-risk dyslipidemia patients lipoprotein apheresis dramatically reduces their risk for cardiovascular (CV) and noncardiovascular events, show'unique'7-year Germany registry data.Medscape Medical News (Source: Medscape Pulmonary Medicine Headlines)
Source: Medscape Pulmonary Medicine Headlines - June 8, 2021 Category: Respiratory Medicine Tags: Cardiology News Source Type: news

Attenuated cardiovascular reactivity is related to higher anxiety and fatigue symptoms in truck drivers - Guest AJ, Clemes SA, King JA, Chen YL, Ruettger K, Sayyah M, Sherry A, Varela-Mato V, Paine NJ.
Depression and anxiety have been linked with reduced stress-induced cardiovascular reactivity (CVR), which could be indicative of autonomic dysregulation. Less is known about the association between work-related fatigue and CVR. Truck drivers experience hi... (Source: SafetyLit)
Source: SafetyLit - June 7, 2021 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

Cardiovascular outcomes and rates of fractures and falls among patients with brand-name versus generic L-thyroxine use - Brito JP, Ross JS, Deng Y, Sangaralingham L, Graham DJ, Qiang Y, Wang Z, Yao X, Zhao L, Smallridge RC, Bernet V, Shah ND, Lipska KJ.
PURPOSE: To compare cardiovascular outcomes and rates of fractures and falls among patients with persistent brand-name versus generic L-thyroxine use. METHODS: Retrospective, 1:1 propensity-matched longitudinal study using a national administrative... (Source: SafetyLit)
Source: SafetyLit - June 7, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Neighborhood socioeconomic resources and crime-related psychosocial hazards, stroke risk, and cognition in older adults - Ruiz LD, Brown M, Li Y, Boots EA, Barnes LL, Jason L, Zenk S, Clarke P, Lamar M.
Living in neighborhoods with lower incomes, lower education/occupational levels, and/or higher crime increases one's risk of developing chronic health problems including cardiovascular disease risk factors and stroke. These cardiovascular health problems a... (Source: SafetyLit)
Source: SafetyLit - June 7, 2021 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

5 Ways to Keep Your Brain Sharp As You Age
Important parts of the brain tend to atrophy as we get older—yet brain scans of some 70-year-olds resemble those of 20 to 30-year-olds. Emerging research points to habits that may keep the mind sharp during the aging process. “Despite the stereotypes, cognitive decline is not inevitable as you age, and adopting healthy lifestyle habits can significantly reduce your risks for dementia later on in life,” says Sarah Lenz Lock, AARP’s senior vice president and executive director of the Global Council on Brain Health. Start socializing “Social isolation increases dementia risk by 50%” in old...
Source: TIME: Health - June 7, 2021 Category: Consumer Health News Authors: Matt Fuchs Tags: Uncategorized Source Type: news

Temple scientists take deep dive into molecular causes of abnormal clotting in CV disease
(Temple University Health System) Dr. Satya P. Kunapuli's research has given him extensive insight into the role of abnormal clot formation in cardiovascular disease. But the answer to one question has remained elusive: how do platelets become activated to form clots that ultimately lead to cardiovascular diseases like stroke and heart attack? Now, thanks to a new NIH grant, Dr. Kunapuli will be able to focus his research on this fundamental question. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 7, 2021 Category: Biology Source Type: news

How to lose visceral fat: The drink proven to get rid of harmful belly fat
VISCERAL fat is a health hazard; carrying too much of the harmful belly fat can lead to insulin resistance, diabetes, and cardiovascular disease. How can you get rid of it? (Source: Daily Express - Health)
Source: Daily Express - Health - June 5, 2021 Category: Consumer Health News Source Type: news

Demographic and cardiovascular risk factors associated with drug use in truck drivers in the state of S ão Paulo, Brazil: a cross-sectional study - Pereira MM, Mansur AP, Takada JY, Leyton V.
The aim of the study is to analyze the association between risk factors for the health of truck drivers and previous use of illicit drugs. A cross-sectional study examined the data from 2071 truck drivers between 2010 and 2016. Demographic variables, risk ... (Source: SafetyLit)
Source: SafetyLit - June 4, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Switching to Plant Protein for Dinner May Reduce CVD Risk
FRIDAY, June 4, 2021 -- Overconsuming low-quality carbohydrates and animal protein at dinner versus breakfast is associated with a significantly increased risk for cardiovascular disease (CVD), according to a study published online May 26 in the The... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 4, 2021 Category: Pharmaceuticals Source Type: news

Is the Risk of CVD Increased in Living Kidney Donors? Is the Risk of CVD Increased in Living Kidney Donors?
A new study examines the question of whether living kidney donors are at a greater risk for developing cardiovascular disease.American Journal of Transplantation (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - June 4, 2021 Category: Intensive Care Tags: Transplantation Journal Article Source Type: news

Spike proteins administered intravenously are engineered to cross the blood-brain barrier, can cause cerebral hemorrhage
(Natural News) A study from Nature Neuroscience finds the S1 spike protein of SARS-CoV-2 crosses the blood–brain barrier in mice and can cause damage to the cardiovascular and central nervous systems. The spike protein is readily cleared from the blood and taken up by peripheral tissues. SARS-CoV-2 RNA was recovered from cerebrospinal fluid, proving it... (Source: NaturalNews.com)
Source: NaturalNews.com - June 3, 2021 Category: Consumer Health News Source Type: news

Prediabetes Linked to Higher CVD and CKD Rates Prediabetes Linked to Higher CVD and CKD Rates
People with A1C levels short of frank type 2 diabetes still have an increased risk for atherosclerotic cardiovascular disease events and chronic kidney disease, new data from the UK Biobank database.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - June 3, 2021 Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news

Misconceptions about biking and driving: drivers understanding of Missouri bicycle laws - Grimes A, Subramaniam DP, Lightner J.
Introduction Bicycling has numerous health benefits, such as improvements in cardiorespiratory fitness, and significant risk reductions for cardiovascular disease, cancer, and obesity and has benefits to the environment. However, motorists' behavior has b... (Source: SafetyLit)
Source: SafetyLit - June 3, 2021 Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news

Pro-vaccine Canadian researcher warns covid vaccine spike proteins are killing people... "We made a big mistake."
(Natural News) “Terrifying” new research has found that the spike proteins contained in and manufactured by Wuhan coronavirus (Covid-19) “vaccines” are directly responsible for cardiovascular injury and death. Dr. Byram W. Bridle, Ph.D. says the he and several colleagues gained access to a first-of-its-kind “biodistribution” study out of Japan showing that even when injected in... (Source: NaturalNews.com)
Source: NaturalNews.com - June 3, 2021 Category: Consumer Health News Source Type: news

Athletic competition after COVID
(Le Bonheur Children's Hospital) Cardiovascular imaging demonstrated no evidence of myocardial injury or myocarditis in athletes after COVID-19 infection, according to a research letter published in Circulation by Le Bonheur Children's Hospital and the University of Tennessee Health Science Center cardiologists. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 3, 2021 Category: Infectious Diseases Source Type: news

New Phase 3b Psoriatic Arthritis (PsA) Data Show First-in-Class TREMFYA ® (guselkumab) Achieved Robust Joint Symptom Improvement and Complete Skin Clearance in Patients with Inadequate Response to Tumor Necrosis Factor Inhibition (TNFi-IR)
SPRING HOUSE, PENNSYLVANIA, June 2, 2021 – Today the Janssen Pharmaceutical Companies of Johnson & Johnson announced new efficacy and safety data for first-in-class TREMFYA® (guselkumab), including data from the first study evaluating a selective IL-23 inhibitor in adult patients with active PsA, all of whom had demonstrated inadequate response or intolerance to TNFi.1 In the COSMOS Phase 3b study, significantly higher proportions of patients treated with TREMFYA showed joint symptom improvement and complete skin clearance versus placebo at week 24 in this true TNFi-IRa patient population, which is often more...
Source: Johnson and Johnson - June 2, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

4 Ways Exercise Helps Fight Aging
Everyone knows that exercise is good for you. But it’s not just beneficial for the young, healthy and already fit. It’s also one of the best defenses against the toughest aspects of aging. Exercise not only improves heart and lung health, but research shows that even modest physical activity is good for the brain, bones, muscles and mood. Numerous studies have found that lifelong exercise may keep people healthier for longer; delay the onset of 40 chronic conditions or diseases; stave off cognitive decline; reduce the risk of falls; alleviate depression, stress and anxiety; and may even help people live longer....
Source: TIME: Health - June 1, 2021 Category: Consumer Health News Authors: Liz Seegert Tags: Uncategorized Source Type: news

Janssen Highlights Commitment to Advancing Transformative Innovations in Oncology with Scientific Updates from Deep, Diverse Pipeline and Portfolio at ASCO and EHA Virtual Scientific Programs
June 1, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 30 company-sponsored studies, including six oral presentations, will be featured during the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, June 4-8. Janssen presentations will include new data and updates for both approved and investigational therapeutics that are being studied for the treatment of various solid tumors and blood cancers. Immediately following ASCO, additional data will be featured during the European Hematology Association (EHA) Virtual Congress, June 9-17. A ...
Source: Johnson and Johnson - June 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Microvascular Angina Linked to Major Adverse CV Events
TUESDAY, June 1, 2021 -- Microvascular angina (MVA) is associated with major cardiovascular events (MACE), with a comparable incidence for men and women, according to a study published online May 26 in the European Heart Journal. Hiroaki Shimokawa,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 1, 2021 Category: Pharmaceuticals Source Type: news

Janssen Announces U.S. FDA Breakthrough Therapy Designation Granted for Teclistamab for the Treatment of Relapsed or Refractory Multiple Myeloma
June 1, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation (BTD) for teclistamab in the treatment of relapsed or refractory multiple myeloma. This distinction for teclistamab, an off-the-shelf, T-cell redirecting, bispecific antibody targeting both B-cell maturation antigen (BCMA) and CD3 receptors, follows a PRIME (PRIority MEdicines) designation from the European Medicines Agency (EMA) received earlier this year. Today’s BTD marks the 11th received by Janssen’s ...
Source: Johnson and Johnson - June 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Reports New Data for BCMA CAR-T, Cilta-Cel, Showing Deep and Durable Responses in Patients with Relapsed or Refractory Multiple Myeloma
June 1, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data for ciltacabtagene autoleucel (cilta-cel), an investigational B-cell maturation antigen (BCMA)-directed CAR-T therapy, demonstrated sustained efficacy and durable responses in heavily pretreated patients with relapsed/refractory multiple myeloma (RRMM). Updated results from the Phase 1b/2 CARTITUDE-1 study (n=97) with a longer-term follow-up at a median of 18 months showed an overall response rate (ORR) of 98 percent, with 80 percent of patients achieving a stringent complete response (sCR), highlight...
Source: Johnson and Johnson - June 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Infographic: Pathways from Noise to Cardiovascular Damage
Research in mice and humans points to oxidative stress and inflammation as likely drivers of noise-induced health effects such as hypertension and heart disease. (Source: The Scientist)
Source: The Scientist - June 1, 2021 Category: Science Tags: Infographics Magazine Issue Source Type: news

How Environmental Noise Harms the Cardiovascular System
Sound from cars, aircraft, trains, and other man-made machines is more than just annoying. It increases the risk of cardiovascular disease. (Source: The Scientist)
Source: The Scientist - June 1, 2021 Category: Science Tags: Features Source Type: news

Diet plays critical role in NASH progressing to liver cancer in mouse model
(University of California - San Diego) Researchers at University of California San Diego School of Medicine found in a mouse model that when fed a Western diet rich in calories, fat and cholesterol, the mice progressively became obese, diabetic and developed NASH, which progressed to HCC, chronic kidney and cardiovascular disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 1, 2021 Category: Cancer & Oncology Source Type: news