Reef scientist Terry Hughes awarded prize for standing up to political ‘smears’
Coral reef scientist jointly awarded John Maddox prize weeks after his research centre lost government fundingJudges have awarded an Australian scientist a prestigious international prize, saying he has battled political smears and public attempts to discredit his work in order to shine a light on the devastating effects of climate change on coral reefs.Prof Terry Hughes was jointly awarded the John Maddox prize on Wednesday for bringing public attention to coral bleaching.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - November 15, 2018 Category: Science Authors: Lisa Cox Tags: Great Barrier Reef Science Australia news Climate change Environment Source Type: news

Draft EPA study finds newer nonstick compound may be harmful
Draft report by the Environmental Protection Agency says long-term exposure to a chemical compound currently used for making nonstick coatings appears to be dangerous, even in minute amounts (Source: ABC News: Health)
Source: ABC News: Health - November 14, 2018 Category: Consumer Health News Tags: Health Source Type: news

EPA flags new fears about nonstick coatings
The Environmental Protection Agency says long-term exposure to a chemical compound used in nonstick coatings appears to be dangerous even in minute amounts (Source: ABC News: Health)
Source: ABC News: Health - November 14, 2018 Category: Consumer Health News Tags: Health Source Type: news

Virtual Reality Could Transform Prototyping
Medical errors are the third leading cause of death in the United States, with some studies citing numbers as high as 250,000 annually. Many studies have begun to increasingly look at misuse and adverse events associated with medical devices. While these new advances typically allow for less-invasive procedures or the ability to treat conditions that previously had limited options, these modern procedures are dependent on technically proficient users dedicated to learning and mastering them. One qualitative study assessing device use errors and the prevention of adverse events found “the top three reporte...
Source: MDDI - November 14, 2018 Category: Medical Devices Authors: Justin Barad Tags: Design Source Type: news

Impact crater 19 miles wide found beneath Greenland glacier
Crater may have been caused by mile-wide iron meteorite just 12,000 years agoA huge impact crater has been discovered under a half-mile-thick Greenland ice sheet.The enormous bowl-shaped dent appears to be the result of a mile-wide iron meteorite slamming into the island at a speed of 12 miles per second as recently as 12,000 years ago.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - November 14, 2018 Category: Science Authors: Ian Sample Science editor Tags: Science Greenland Glaciers Space Polar regions Environment Geology World news Source Type: news

Former naturopath and scientist share John Maddox prize
Scientist documenting coral reef decline and whistleblower on alternative therapy industry share awardA scientist who is documenting thedevastating decline of the world ’s coral reefs and aformer naturopath turned whistleblower on the alternative therapy industry have been jointly awarded a prestigious prize for championing science in the face of hostility and legal threats.Prof Terry Hughes, the director of the ARC Centre of Excellence for Coral Reef Studies in Australia and a world expert on the Great Barrier Reef, was awarded the John Maddox prize for bringing to the world ’s attention the catastrophic coral...
Source: Guardian Unlimited Science - November 14, 2018 Category: Science Authors: Hannah Devlin Science correspondent Tags: Science World news Australia news US news Coral Environment Marine life Source Type: news

John Large obituary
Consulting engineer known for his work on nuclear safety who was never afraid to take on such a powerful industryJohn Large ’s working life was split into two halves, the first spent designing civil and military nuclear reactors and the second trying to make sure the industry was kept safe from accidents, nuclear waste and security threats. In this later role as a consulting engineer John was a dangerous opponent for t he secretive nuclear establishment because his inside knowledge gave him the ability to ask difficult questions and expose weaknesses. He was never afraid to speak truth to power, although it took cour...
Source: Guardian Unlimited Science - November 14, 2018 Category: Science Authors: Paul Brown Tags: Nuclear power Physics Bees Energy industry Environment Engineering Kursk submarine tragedy London Source Type: news

What are the most important factors for pedestrian level-of-service estimation? A systematic review of the literature - Raad N, Burke MI.
Pedestrian environments are becoming more important in an urbanizing world where walking is increasingly being encouraged. Engineers and planners determine a link's performance using measures codified as level-of-service, which provide guidance on acceptab... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Bicycling simulator calibration: proposed framework - Horne D, Abadi MG, Hurwitz DS.
Bicycling simulation allows for the low-risk experimental study of human factors within transportation environments. A cyclist pedals on a stationary bike trainer, which is instrumented to detect the speed of the wheel and the steering angle of the bicycle... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Influence of automation on mind wandering frequency in sustained attention - Gouraud J, Delorme A, Berberian B.
There is accumulating evidence which shows that mind wandering may be increased within automated environments. This is particularly concerning when considering the negative effect of mind wandering on short-term performance. Seventeen participants performe... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

Assessing driving simulator validity: a comparison of multi-modal smartphone interactions across simulated and field environments - McWilliams T, Ward N, Mehler B, Reimer B.
The use of a driving simulator as a tool to evaluate secondary task performance elicits the question of simulator validity. After upgrading an existing driving simulator from a medium-fidelity to a high-fidelity configuration with a new software environmen... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

Biking to ride: investigating the challenges and barriers of integrating cycling with regional rail transit - Ravensbergen L, Buliung R, Mendonca M, Garg N.
Integrating bicycling with public transport can potentially benefit cyclists and transit operators. Successfully coordinating these transport modes, however, can be a difficult task when so little is known about the social and environmental barriers to thi... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Pedestrians and Bicycles Source Type: news

Sun glare: network characterization and safety effects - Sun D, El-Basyouny K, Kwon TJ.
This research conducted a two-stage assessment to investigate sun glare effects on road safety in Edmonton. The first stage developed a methodology to model sun glare occurrence, aiming to identify when and where drivers are most likely to be exposed to su... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Environmental Issues, Climate, Geophysics Source Type: news

Snow and ice removal route optimization in Kentucky - Blandford B, Lammers E, Green E.
This research describes a geographic information system-based methodology developed for the Kentucky Transportation Cabinet (KYTC) to improve the efficiency of Kentucky's snow and ice removal program. The state's program uses a system of snowplow routes th... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Environmental Issues, Climate, Geophysics Source Type: news

Traffic calming and environmental justice: New York City's Neighborhood Slow Zones - Hagen JX.
This paper examines New York City's Neighborhood Slow Zones (NSZ) program in terms of environmental justice. The paper uses both quantitative and qualitative methods. Quantitative analyses show that the areas where the zones are implemented are well repres... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Walkability in the connected and automated vehicle era: a U.S. perspective on research needs - Shay E, Khattak AJ, Wali B.
Walkability and walking activity are of interest to planners, engineers, and health practitioners for their potential to improve safety, promote environmental and public health, and increase social equity. Connected and automated vehicles (CAVs) will resha... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Commentary Source Type: news

Incorporating the effect of special events into continuous count site selection for pedestrian traffic - Olfert C, Poapst R, Montufar J.
This paper presents results from pedestrian monitoring research conducted in a dense urban environment in Winnipeg, Canada. Pedestrian counts were conducted in downtown Winnipeg using infrared pedestrian counters. Count sites were assigned to traffic patte... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Pedestrians and Bicycles Source Type: news

Developing a pre-task safety briefing tool for Kentucky maintenance personnel - Al-Shabbani Z, Sturgill R, Dadi GB.
The dangerous work environment in the construction industry and the inherent high risks associated with its work make it the focus of safety training and regulations. Highway construction and maintenance has unique hazards but seemingly less directly appli... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news

Safety evaluation of the advanced stop assist system in connected vehicle environment - Njobelo G, Sando T, Sajjadi S, Mtoi E, Ozguven EE, Sobanjo J.
Although traffic signals are installed to reduce the overall number of collisions at intersections, certain types, in particular, rear-end collisions are increasing due to signalization. One dominant factor associated with rear-end crashes is the indecisiv... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Predictive dynamic speed limit in a connected environment for a weather affected traffic network: a case study of Chicago - Mittal A, Kim E, Mahmassani HS, Hong Z.
Dynamic speed limits (DSLs) are used to improve safety and mobility on freeways in unfavorable traffic conditions due to recurring congestion, roadworks, incidents, or adverse weather. The evaluation of in-field deployment reveals that the effectiveness of... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Influence of the built environment on the spatiotemporal variation of pedestrian collision in Seoul: an application of big data - Kim D, Chanchlani HM.
Although it is reasonable to hypothesize that the spatial pattern of pedestrian collisions changes by the time of day, there has been a lack of research that addresses this spatiotemporal variation because of a shortage of pedestrian volume data by time of... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Impact of built environment on first- and last-mile travel mode choice - Mo B, Shen Y, Zhao J.
The paper studies the impacts of built environment (BE) on the first- and last-mile travel modal choice. We select Singapore as a case study. The data used for this work is extracted from the first- and last-mile trips to mass rapid transit (MRT) stations ... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Assistive system to improve pedestrians' safety and mobility in a connected vehicle technology environment - Khosravi S, Beak B, Head KL, Saleem F.
Conflicts between vehicles and vulnerable road users (VRUs) often result in injuries and fatalities. This paper presents a vehicle-to-infrastructure and Wi-Fi based pedestrian conflict avoidance system to improve VRUs' safety. Compared with the vision base... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Train-level and car-level modeling of hazardous materials release in railroad incidents - Iranitalab A, Khattak A.
This paper quantifies the impacts of incident, railroad, environment. and train/car characteristics on the probability of hazardous material (hazmat) release in a hazmat-carrying train incident and provides a prediction tool for hazmat release. Two sets of... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

Modeling the probability of hazardous materials release in crashes at highway-rail grade crossings - Iranitalab A, Kang Y, Khattak A.
Crashes at Highway-Rail Grade Crossings (HRGCs) that involve a truck or a train carrying hazardous materials (hazmat) expose people and the environment to potentially severe consequences of hazmat release. This research involved statistical modeling of the... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

How can cities adapt to a multi-disaster environment? Empirical research in Guangzhou (China) - Shi Y, Zhai G, Zhou S, Lu Y, Chen W, Liu H.
Urban disaster risk assessment is the most basic and important part of urban safety development. Conducting disaster prevention and mitigation on the basis of urban disaster risk assessment requires an understanding of the relationship between the city and... (Source: SafetyLit)
Source: SafetyLit - November 14, 2018 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

South Africa: Diabetes Is Linked to Food Insecurity, and Needs Co-Ordinated, Multisectoral Intervention
[Daily Maverick] Evidence shows that the risk of developing chronic diseases in adulthood is influenced not only by genetic and adult lifestyle factors; the environment during early life also plays a very important role. People living in unfavourable environments and facing difficult socio-economic situations may begin life with increased vulnerability to diabetes and many other non-communicable diseases. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 14, 2018 Category: African Health Source Type: news

Breeding corn for water-use efficiency may have just gotten easier
(University of Illinois College of Agricultural, Consumer and Environmental Sciences) With approximately 80 percent of our nation's water supply going towards agriculture, it's fair to say it takes a lot of water to grow crops. In a climate with less predictable rainfall patterns and more intense droughts, scientists at the University of Illinois are working to reduce water consumption by developing more efficient crops. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 14, 2018 Category: International Medicine & Public Health Source Type: news

A world without brick-and-mortar stores? Even avid online shoppers say, 'no, thanks'
(University of Arizona) The majority of consumers, even those who prefer online shopping, think the extinction of brick-and-mortar stores would be bad for society, according to a new University of Arizona-led study that explores consumers' perceptions of today's transforming retail environment. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 14, 2018 Category: International Medicine & Public Health Source Type: news

TGen North partners with NARBHA Institute to promote human health
(The Translational Genomics Research Institute) Microbial pathogens -- the bacteria, viruses, fungi and parasites that can make you sick and even kill you -- often know no particular biological boundaries. TGen North, the Pathogen and Microbiome Division of the Translational Genomics Research Institute (TGen), has partnered with the non-profit NARBHA Institute to advance human health through the new TGen One Health Collaborative, an initiative that recognizes the interdependence of people, animals and plants in both the human-built and natural environments. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 14, 2018 Category: Infectious Diseases Source Type: news

How exercise could help fight drug addiction
(American Chemical Society) The siren call of addictive drugs can be hard to resist, and returning to the environment where drugs were previously taken can make resistance that much harder. However, addicts who exercise appear to be less vulnerable to the impact of these environmental cues. Now, research with mice suggests that exercise might strengthen a drug user's resolve by altering the production of peptides in the brain, according to a study in the journal ACS Omega. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 14, 2018 Category: International Medicine & Public Health Source Type: news

Scientists divided over new research method to combat malaria
Work on engineered gene used to modify DNA of mosquitoes ‘could be stifled’ by perceived risk to environmentResearch on a radical new way to combat malaria and other devastating diseases could be knocked off track if a UN biodiversity conference imposes a moratorium on the work, a group of scientists have said.Some scientists believe the different approach has the potential to transform the battle against malaria. It involves engineered gene drives which are used to modify the DNA of wild organisms on a mass scale. In the case of mosquitoes the method would have the potential to wipe out populations of certain ...
Source: Guardian Unlimited Science - November 14, 2018 Category: Science Authors: Ian Sample Science editor Tags: Malaria Biodiversity Science Health World news United Nations Insects Wildlife Conservation Environment Source Type: news

FDA clears Spinal Elements ’ surface coating technology
Spinal Elements’ Lucent XP expandable lumbar interbody system with Ti-Bond coating. (Image courtesy of Spinal Elements) Spinal Elements said that the FDA has issued 510(K) clearance for the macro-, micro-, and nano-surface structure of its Ti-Bond surface coating technology. The Carlsbad, Calif. company said that a number of products in its portfolio use Ti-Bond, including the most recently introduced Lucent XP height- and lordosis-expandable interbody device. Interbody fusion products with Ti-Bond technology are comprised of a PEEK body designed to provide a favorable modulus and imaging characteristics while the mu...
Source: Mass Device - November 13, 2018 Category: Medical Devices Authors: Nancy Crotti Tags: Blog Food & Drug Administration (FDA) Implants Orthopedics Spinal Spinal Elements Source Type: news

Botanists find natural farming methods effectively manage soil-borne fungus
(Natural News) The pathogenic soil fungus Verticillium dahliae has caused significant economic losses to farmers who grow spinach and lettuce in California. Chemical means of combating the infection are either ineffective or too toxic for the environment. Researchers therefore detailed natural means of protecting valuable crops from the increasingly widespread fungal disease. Verticillium dahliae first... (Source: NaturalNews.com)
Source: NaturalNews.com - November 13, 2018 Category: Consumer Health News Source Type: news

Mesothelioma Patients Can Benefit from Genetic Testing
All patients diagnosed with malignant mesothelioma should undergo genetic testing to better identify the most appropriate treatment plan, according to Dr. Michele Carbone, the director of thoracic oncology at the University of Hawaii Cancer Center. Genetic testing also could lead to a more accurate prognosis and help family members determine if they are more susceptible to the cancer. Carbone estimates only one-third of all mesothelioma patients today have undergone the testing. “Some of these patients could definitely benefit from genetic testing,” Carbone told The Mesothelioma Center at Asbestos.com. Carbon...
Source: Asbestos and Mesothelioma News - November 13, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news

13.11.18: Third quarter of 2018
Bayer: Good performance in a challenging environment, Group outlook confirmedGroup sales increase by 1.9 percent (Fx & portfolio adj.) to 9.905 billion euros / EBITDA before special items level year on year at 2.202 billion euros / Business performance at Pharmaceuticals remains strong / Consumer Health with increase in sales (Fx & portfolio adj.), while currency effects weigh on earnings / Crop Science posts substantial rise in sales and earnings due to acquisition - successful start to integration process / Sales and earnings of Animal Health decline following a strong second quarter / One-time gain (before taxes...
Source: Bayer IR Newsfeed: Events - November 13, 2018 Category: Pharmaceuticals Source Type: news

Heatwaves can 'wipe out' male insect fertility
Study of beetles could explain global decline – and also be a warning to humankindHeatwaves severely damage the fertility of male beetles and consecutive hot spells leave them virtually sterilised, according to research.Global warming ismaking heatwaves more common andwildlife is being annihilated, and the study may reveal a way in which these two trends are linked. The scientists behind the findings said there could also be some relevance for humans: the sperm counts of western men havehalved in the last 40 years.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - November 13, 2018 Category: Science Authors: Damian Carrington Environment editor Tags: Insects Reproduction Biology Climate change Animals Environment World news Science Source Type: news

Safety is Third, Not First, and We All Know It Should Be
It’s about 4:00 a.m. on your first overnight shift of the cycle. You had a busy day running errands, watching your child’s Christmas play, sitting down for dinner with the family before arriving to shift at 7:00 p.m. You’ve had a busy night with back-to-back calls, and haven’t made it back to the station since checking your truck at shift change. You almost make it back to the station when you’re dispatched to yet another call: a reported single motor vehicle crash (MVC) in a rural part of your district. You and your partner are the first unit to arrive on scene of an overturned vehicle on a b...
Source: JEMS Operations - November 13, 2018 Category: Emergency Medicine Authors: Christopher Davis, MD, NRP, FAWM Tags: Exclusive Articles Operations Source Type: news

Bayer: Good performance in a challenging environment, Group outlook confirmed
Group sales increase by 1.9 percent (Fx& portfolio adj.) to 9.905 billion euros / EBITDA before special items level year on year at 2.202 billion euros / Business performance at Pharmaceuticals remains strong / Consumer Health with increase in sales (Fx& portfolio adj.), while currency effects weigh on earnings / Crop Science posts substantial rise in sales and earnings due to acquisition– successful start to integration process / Sales and earnings of Animal Health decline following a strong second quarter / One-time gain (before taxes) of roughly 3.9 billion euros from divestments / Net income 2.886 billion...
Source: Bayer Company News - November 13, 2018 Category: Pharmaceuticals Source Type: news

Visualizing 'unfurling' microtubule growth
(University of California - Davis) Living cells depend absolutely on microtubules that form a scaffolding for moving materials inside the cell. Microtubule fibers are hollow rods made of much smaller tubulin subunits that spontaneously assemble at one end of the rod, but exactly how they do this inside the crowded environment of living cells has been a mystery. Now researchers at UC Davis have uncovered the mechanism that puts these blocks in place, illustrated in a new animation. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 13, 2018 Category: Biology Source Type: news

Robotics Flagship, a program for the sustainable development of future robots in Europe
(Istituto Italiano di Tecnologia - IIT) The Robotics Flagship aims to develop robots and artificial intelligence that are economically, socially and environmentally sustainable. It brings together over 800 European participants, and has broad international support including 370 endorsements from around the world. The Robotics Flagship wants to be a long-term and structured development plan, where science, economy and society are contemplated as a whole in order to make breakthroughs in the real-world. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 13, 2018 Category: International Medicine & Public Health Source Type: news

Emotional intelligence: A new criterion for hiring?
(Universit é de Gen è ve) The cognitive skills of a future employee are examined during a job interview. However, qualifications and a nice character don't necessarily mean that the interviewee will be a competent colleague. The individual's emotional intelligence has to be factored in, that is, his capacity to understand, regulate and manage emotions in the specific context of the work environment. Researchers at the UNIGE and UNIBE have devised an emotional intelligence test that measures emotional competences at work. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 13, 2018 Category: International Medicine & Public Health Source Type: news

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence
Defective mitochondrial dynamics through aberrant interactions between mitochondria and actin cytoskeleton is increasingly recognized as a key determinant of cardiac fragility after myocardial infarction (MI). Dynamin-related protein 1 (Drp1), a mitochondrial fission–accelerating factor, is activated locally at the fission site through interactions with actin. Here, we report that the actin-binding protein filamin A acted as a guanine nucleotide exchange factor for Drp1 and mediated mitochondrial fission–associated myocardial senescence in mice after MI. In peri-infarct regions characterized by mitochondrial hy...
Source: Signal Transduction Knowledge Environment - November 13, 2018 Category: Science Authors: Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga-Tomita, T., Yasuda, S., Sato, Y., Kuwahara, K., Kumagai, Y., Akaike, T., Ide, T., Ojida, A., Mori, Y., Nishida, M. Tags: STKE Research Articles Source Type: news

The transmembrane adaptor protein NTAL limits mast cell chemotaxis toward prostaglandin E2
Chemotaxis of mast cells is one of the crucial steps in their development and function. Non–T cell activation linker (NTAL) is a transmembrane adaptor protein that inhibits the activation of mast cells and B cells in a phosphorylation-dependent manner. Here, we studied the role of NTAL in the migration of mouse mast cells stimulated by prostaglandin E2 (PGE2). Although PGE2 does not induce the tyrosine phosphorylation of NTAL, unlike IgE immune complex antigens, we found that loss of NTAL increased the chemotaxis of mast cells toward PGE2. Stimulation of mast cells that lacked NTAL with PGE2 enhanced the phosphorylat...
Source: Signal Transduction Knowledge Environment - November 13, 2018 Category: Science Authors: Halova, I., Bambouskova, M., Draberova, L., Bugajev, V., Draber, P. Tags: STKE Research Articles Source Type: news

A cytoskeletal anchor connects ischemic mitochondrial fission to myocardial senescence
The interplay between the actin cytoskeleton and mitochondria has been implicated in cell and tissue homeostasis and physiological function. In this issue of Science Signaling, Nishimura et al. demonstrate that inhibiting the interaction of filamin A, an actin cytoskeleton regulator, with Drp1, a modulator of mitochondrial dynamics, attenuates mitochondrial hyperfission and cardiomyocyte senescence after myocardial infarction. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 13, 2018 Category: Science Authors: Boyer, M. J., Eguchi, S. Tags: STKE Focus Source Type: news

The basics of mechanotransduction
Basic residues in the transmembrane domain of the T cell receptor α chain promote its association with CD3 signaling chains. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 13, 2018 Category: Science Authors: Williams, E. R. Tags: STKE Editors ' Choice Source Type: news

Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2
The circadian clock relies on posttranslational modifications to set the timing for degradation of core regulatory components, which drives clock progression. Ubiquitin-modifying enzymes that target clock components for degradation mainly recognize phosphorylated substrates. Degradation of the circadian clock component PERIOD 2 (PER2) is mediated by its phospho-specific recognition by β-transducin repeat–containing proteins (β-TrCPs), which are F-box–containing proteins that function as substrate recognition subunits of the SCFβ-TRCP ubiquitin ligase complex. However, this mode of regulating PER2...
Source: Signal Transduction Knowledge Environment - November 13, 2018 Category: Science Authors: Liu, J., Zou, X., Gotoh, T., Brown, A. M., Jiang, L., Wisdom, E. L., Kim, J. K., Finkielstein, C. V. Tags: STKE Research Articles Source Type: news

Blood Pressure Drug Recall Expands Again; Meds May Be Tainted With Cancer-Causing Chemical
(CNN) — The US Food and Drug Administration says another heart medicine is being voluntarily recalled after tests showed that it was tainted with a potential cancer-causing chemical. The recall includes one lot of Sandoz’s losartan potassium hydrochlorothiazide 100 milligram/25 milligram tablets with the lot number JB8912. Patients use these drugs to keep their high blood pressure in check. The drug is being recalled because the active ingredient has tested positive for N-Nitrosodiethylamine or NDEA, a suspected human and animal carcinogen that is used in gasoline as a stabilizer for industry materials and as a...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 12, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Consumer Health News Local TV Valsartan Source Type: news

Enhance your Interdisciplinary and Team Science Skills
Reports abound from professional societies, the Academies, government agencies, and researchers calling attention to the fact that science is increasingly an inter-disciplinary, transdisciplinary, inter-institutional, and international endeavor. In short, science has become a “team sport.” There is a real and present need to better prepare scientists for success in this new collaborative environment. The American Institute of Biological Sciences is responding to this call with a new program for scientists, educators, and individuals who work with or participate in scientific teams. Team science is increasingl...
Source: Public Policy Reports - November 12, 2018 Category: Biology Authors: AIBS Source Type: news

Triggered Doctors Fire Back at NRA: This Is Our Lane
The National Rifle Association's ruffled an awful lot of feathers last week on Twitter by telling doctors to "stay in their lane" rather than to publish studies pushing for gun control. The medical community is certainly not taking the comment laying down, however. Within a matter of days, a new Twitter account was born using the handle @ThisIsOurLane, and the account already has more than 8,000 followers. It all started with this NRA editorial accompanied by the organization's tweet that says, "Someone should tell self-important anti-gun doctors to stay in their lane. Half of the art...
Source: MDDI - November 12, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Business Source Type: news