Skin Barrier in Atopic Dermatitis
A compromised permeability barrier is a hallmark of atopic dermatitis (AD). Localized to the outermost skin layer, the stratum corneum (SC) is critically dependent on terminal differentiation of epidermal keratinocytes, which transform into protein-rich corneocytes surrounded by extracellular lamellae of unique epidermal lipids, conferring permeability barrier function. These structures are disrupted in AD. A leaky barrier is prone to environmental insult, which in AD elicits type 2 –dominant inflammation, in turn resulting in a vicious cycle further impairing the SC structure. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Authors: Matthias Schmuth, Sonja Eckmann, Verena Moosbrugger-Martinz, Daniela Ortner-Tobider, Stefan Blunder, Thomas Trafoier, Robert Gruber, Peter M. Elias Tags: Atopic Dermatitis Spotlight Source Type: research
Clinical Snippets
Schuler et al penned an in-depth review of atopic dermatitis (AD) to describe the intersection between the genetic features, immunopathogenesis, environmental influences, and relationship to other atopic diseases. Heritability of this disease is as high as 80%, stemming from null sequence variants in the ski n barrier protein FLG as well as other epidermis-related factors. Dysfunction of immune cells (T helper [Th]2 cells, dendritic cells, mast cells, basophils, and keratinocytes) and cytokines (IL-2, IL-4, and IL-13) has also been rigorously explored in AD. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Tags: Clinical Snippets Source Type: research
Palliative Care in Cancer Alley: A Discussion on Environmental Racism
1. Understand environmental racism as a contributor to existential suffering at the end of life.2. Use principles of trauma-informed care to engage in conversation with patients about their experiences with environmental racism. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Pallavi Ana Mishra, Sonia Malhotra Source Type: research
Factors Impacting Serious Illness: A Mixed Methods Case Study of 4 Alabama Health Systems
1. The attendees will be able to describe factors that impact availability of hospital palliative care.2. The attendees will be able to describe environmental factors and hospital characteristics that are common and different across hospitals with and without palliative care. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Amy M. Beasley, Marie A. Bakitas, Nataliya Ivankova, Dio Kavalieratos, James Nicholas Odom, Rodney O. Tucker Source Type: research
Partners in Healing, Part II: Adapting & Disseminating An Interdisciplinary Curriculum on Spirituality & Medicine
1. Drawing on a brand new curriculum syllabus, this poster presentation will enable participants to demonstrate the goals, methods and outcomes of an interdisciplinary curriculum focused on spiritual care in the hospital setting, and equip them to implement it at their specific institutions.2. Equip participants to evaluate the benefits of a creative, reflective, multi-discipline learning environment, and its relevance to clinical care. By investigating the connection between being present to another's humanity and being present in their own, participants will gain recognition of the need for holistic spiritual care -for p...
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: TJ Douglas, Rachel Rim, Ronald D. Adelman, Jon Overvold, Jean Walsh Source Type: research
A Validated EMR-Based Algorithm to Detect and Quantify Palliative Care Needs in Seriously Ill Hospitalized Patients
1. Participants will describe how population-based methods to systematically identify palliative care need make access to palliative care services more equitable by mitigating clinician bias, ensure limited resources are provided to those most likely to benefit, and allow programs to quantify population need to argue for additional resources.2. Participants will analyze the criteria included in our validated algorithm, identify those criteria that can be directly applied in their own clinical setting, and propose changes to criteria that require tailoring to maximize their utility in their local environment. (Source: Journ...
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Joanna Sharpless, Yuika Goto, David L. O'Riordan, Steven Pantilat, Laura A. Schoenherr Source Type: research
Dignity in Diversity: Navigating End-of-Life Care for a Transgender Woman in an Inpatient Hospice Unit
1. Understand the unique healthcare needs and challenges faced by transgender individuals in end-of-life care settings, including the importance of addressing gender identity and pronoun preferences to provide culturally competent and compassionate care.2. Explore strategies and best practices for providing culturally competent and compassionate end-of-life care to transgender patients within an inpatient hospice setting, with an emphasis on communication, respect for gender identity, and fostering a supportive and affirming environment for both patients and their families. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Tyler Murphy Source Type: research
Palliative Care Consults May Reduce Readmission Rates: A Comparison Cohort Study in a Southeastern Academic Center
1. Upon review of the findings, participants will be able to characterize palliative care consultation utilization in a southeastern, academic medical center in a post-pandemic environment.2. Participants will be able to implement similar techniques in analyzing palliative care consultation utilization at other facilities, controlling for similar pathologies, to describe how palliative care consultations affect patient length of stays and readmission rates. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Adam Tyson, Heather Reed-Day, Hillary Davis, Robert Heidel, Erin W. Jackson, Veera Motashaw, Justin Wolfe Source Type: research
Factors Impacting Serious Illness Care: A Mixed Methods Case Study of 4 Alabama Health Systems (RP302)
1. The attendees will be able to describe factors that impact availability of hospital palliative care.2. The attendees will be able to describe environmental factors and hospital characteristics that are common and different across hospitals with and without palliative care. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Amy M. Beasley, Marie A. Bakitas, Nataliya Ivankova, Dio Kavalieratos, James Nicholas Odom, Rodney O. Tucker Source Type: research
Mid-Career Breakout Session (CAR402)
1. Identify approaches for efficient team and grant management.2. Compare and contrast team management and communication techniques.3. Outline team member accountability and conflict management strategiesThe mid-career breakout session will focus on grant management and leading research teams. T hree mid/senior investigators will share their multi-disciplinary perspectives about research team and grant management strategies and lessons learned. During this moderated session, the presenters will relay successes and challenges in stepping into a leadership role, maintaining an environment of inclusion and effective co...
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Jessica Merlin, Areej A. El-Jawahri, Stephanie White, Jill M. Steiner, Daniel David Source Type: research
IJERPH, Vol. 21, Pages 501: Sexually Transmitted Infections in Adolescents and Young Adults: A Cross Section of Public Health
Conclusions. The literature for other countries reports the need for comprehensive, culturally and developmentally sensitive care to address sexuality-related issues in adolescents and young adults, a need that also applies to Italy. These data will be of great importance in adopting evidence-based STI control programs in Marche Region. This study could, indeed, represent a landmark for public health officials and professionals, with the aim of promoting adolescents’ access to sexual health services to receive useful information, strengthening preventive measures in younger age groups, and designing sexual ed...
Source: International Journal of Environmental Research and Public Health - April 19, 2024 Category: Environmental Health Authors: Nunzia Cannovo Elena Bianchini Luciana Gironacci Elisabetta Garbati Filiberto Di Prospero Mariano Cingolani Roberto Scendoni Piergiorgio Fedeli Tags: Article Source Type: research
Anonymizing research funding applications could reduce ‘prestige privilege’
For research funders seeking to minimize bias in their selection process, removing applicants’ institutional affiliations from their submissions could help address a common disparity: disproportionate funding going to those at the most prestigious places. That’s the finding from researchers at the Arnold and Mabel Beckman Foundation, who reported last month in
eLife
that
anonymized applications partially reduced the effects of reputational bias and evened the playing field for early-career faculty at lesser known institutions
applying for their Beckman Young Investigator (BYI) awards.
T...
Source: Science of Aging Knowledge Environment - April 18, 2024 Category: Geriatrics Source Type: research
Salinity and pH effect on water-oil-calcite interfaces by molecular dynamics
In this study, the individual effect... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 18, 2024 Category: Chemistry Authors: Anderson Arboleda-Lamus Source Type: research
Electrochemically Driven Green Synthesis to Unlock Sustainable Routes to β-Keto Spirolactones
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Ian MacLean, Monta ña J García, Silvia Cabrera, Leyre Marzo, Jose Aleman In this work we present a sustainable and environmentally bening electrochemical method for the synthesis of β-keto spirolactones. The reaction is carried out using green solvents such as acetone and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - April 18, 2024 Category: Chemistry Authors: Ian MacLean Source Type: research
Unrecognized volatile and semi-volatile organic compounds from brake wear
This study shows that volatile and semi-volatile organic gases are emitted during light and heavy braking. These emissions will remain as we transition to zero exhaust emission vehicles and must be included in air pollution and climate assessments. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Environ. Monit. latest articles)
Source: RSC - J. Environ. Monit. latest articles - April 18, 2024 Category: Environmental Health Authors: V. Perraud Source Type: research
