University of Minnesota receives seed funding for clinical study of metformin to treat, prevent COVID-19
(University of Minnesota Medical School) University of Minnesota Medical School researchers received funding from the Parsemus Foundation to initiate research on the widely-used diabetes medication, metformin, available globally as an inexpensive generic drug for prevention and treatment for COVID-19. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 25, 2020 Category: International Medicine & Public Health Source Type: news

Diabetes Drug Metformin May Protect Aging Brains
Title: Diabetes Drug Metformin May Protect Aging BrainsCategory: Health NewsCreated: 9/23/2020 12:00:00 AMLast Editorial Review: 9/24/2020 12:00:00 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - September 24, 2020 Category: Endocrinology Source Type: news

Diabetes Drug Metformin May Protect Aging Brains
New research suggests that people taking the drug appear to have significantly slower declines in thinking and memory as they age. (Source: WebMD Health)
Source: WebMD Health - September 23, 2020 Category: Consumer Health News Source Type: news

Sun Pharmaceutical Industries, Inc. Issues Voluntary Nationwide Recall of RIOMET ER ™ (Metformin Hydrochloride for Extended-Release Oral Suspension) Due to N-Nitrosodimethylamine (NDMA) Content Above the Acceptable Daily Intake (ADI) Limit
Sun Pharmaceutical Industries, Inc. (SUN PHARMA), a wholly owned subsidiary of Sun Pharmaceutical Industries Ltd. is voluntarily recalling one lot of RIOMET ER ™ (metformin hydrochloride for extended-release oral suspension), 500 mg per 5 mL to the consumer level. The reason for the recall is due to (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 23, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Metformin May Slow Cognitive Decline in Seniors With T2DM
Cognitive decline slower, dementia risk reduced in seniors with diabetes receiving metformin (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - September 23, 2020 Category: Psychiatry Tags: Endocrinology, Family Medicine, Geriatrics, Internal Medicine, Neurology, Pharmacy, Psychiatry, Radiology, Journal, Source Type: news

Metformin May Slow Cognitive Decline in Seniors With T2DM
WEDNESDAY, Sept. 23, 2020 -- For older adults with type 2 diabetes, cognitive decline is slower and dementia risk reduced for those receiving metformin, according to a study published online Sept. 23 in Diabetes Care. Katherine Samaras, M.B.B.S.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 23, 2020 Category: Pharmaceuticals Source Type: news

Diabetes Drug Metformin May Protect the Aging Brain
WEDNESDAY, Sept. 23, 2020 -- A common type 2 diabetes drug called metformin may have an unexpected, but positive, side effect: New research suggests that people taking the drug appear to have significantly slower declines in thinking and memory as... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 23, 2020 Category: General Medicine Source Type: news

Three-drug combo reduces risk for lung cancer by 17%, study finds
Taking aspirin, statins and the drug metformin together reduces the risk for lung cancer by 17%, a study published Thursday by the Journal of Thoracic Oncology found. (Source: Health News - UPI.com)
Source: Health News - UPI.com - September 17, 2020 Category: Consumer Health News Source Type: news

Three common medications lower risk and mortality for lung cancer
(International Association for the Study of Lung Cancer) Combined use of aspirin, statins, and metformin is associated with decreased lung cancerincidence and mortality, according to a study published in the Journal of Thoracic Oncology (JTO). The JTO is the official journal of the International Association for the Study of Lung Cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

How to mete out metformin
(Source: ScienceNOW)
Source: ScienceNOW - September 17, 2020 Category: Science Authors: Charneski, C. A. Tags: twis Source Type: news

Common diabetes drug reverses inflammation in the liver
(Salk Institute) The diabetes drug metformin has been prescribed to hundreds of millions of people worldwide as the frontline treatment for type 2 diabetes. Now, researchers at the Salk Institute have shown the importance of specific enzymes in the body for metformin's function. In addition, the new work showed that the same proteins, regulated by metformin, controlled aspects of inflammation in mice, something the drug has not typically been prescribed for. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 9, 2020 Category: International Medicine & Public Health Source Type: news

Rigorous Detection of Nitrosamine Contaminants in Metformin Products: Balancing Product Safety and Product Accessibility
Nitrosamines are a class of chemicals that commonly occur as impurities in water, beverages, and foods (particularly in cured and grilled meats). Although nitrosamines are generally regarded to be carcinogenic, small amounts of exposure are not considered to be harmful. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 4, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

SGLT2 Inhibitors With Metformin Do Not Up Fracture Risk SGLT2 Inhibitors With Metformin Do Not Up Fracture Risk
The combination of SGLT-2 inhibitors and metformin is not associated with an increase in fracture risk among patients with type 2 diabetes, according to a meta-analysis of 25 randomized, controlled trials.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - August 21, 2020 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Bayshore Pharmaceuticals, LLC Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets USP, 500 mg and 750 mg Due to the Detection of N-Nitrosodimethylamine (NDMA) Impurity
Bayshore Pharmaceuticals, LLC, Short Hills, NJ is voluntarily recalling one (1) lot of Metformin Hydrochloride Extended-Release Tablets USP, 500 mg, 1000 count bottles and one (1) lot of Metformin Hydrochloride Extended-Release Tablets USP, 750 mg, 100 count bottles within expiry to the consumer lev (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 20, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Does Metformin Reduce Risk for Death in COVID-19? Does Metformin Reduce Risk for Death in COVID-19?
Observational study data suggest that metformin reduces the risk for death from severe COVID-19, but questions remain.Medscape Medical News (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - August 14, 2020 Category: Transplant Surgery Tags: Diabetes & Endocrinology News Source Type: news

Does Metformin Reduce Risk for Death in COVID 19
Does Metformin Reduce Risk for Death in COVID-19? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - August 14, 2020 Category: General Medicine Source Type: news

A rare case of metformin intoxication with mortal course - Osoydan Satici M, Algin A, Aksel G, Ero ğlu SE.
Metformin-associated lactic acidosis is a rare side effect in metformin poisoning. There is conflicting data about mortality rates changing from 3% to 83%. We aimed to discuss a case that developed lactic acidosis and acute renal failure progressing to mor... (Source: SafetyLit)
Source: SafetyLit - August 4, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Dapagliflozin as add-on to metformin may reduce T2DM burden in China
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - August 1, 2020 Category: Drugs & Pharmacology Source Type: news

Lupin, Granules India recall around 9.71 lakh bottles of diabetes drug in the US market
As per the latest Enforcement Report of the US Food and Drug Administration (USFDA), Lupin is recalling 4,92,858 bottles of Metformin Hydrochloride extended-release tablets in 500 mg and 1,000 strengths. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - July 26, 2020 Category: Pharmaceuticals Source Type: news

Search list of recalled metformin products
(Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 13, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Lupin Pharmaceuticals, Inc. Issues Voluntarily Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets, 500mg and 1000mg Due to the Detection of N-Nitrosodimethylamine (NDMA) Impurity
Lupin Pharmaceuticals Inc. is voluntarily recalling all batches of Metformin Hydrochloride Extended-Release Tablets USP, 500mg and 1000mg to the consumer level. As part of the ongoing assessment and continuation of the dialog with the FDA, additional analysis revealed that certain tested batches wer (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 8, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Lupin recalls diabetes treatment drug in US
Drug major Lupin Ltd on Wednesday said it is voluntarily recalling its diabetes treatment drug Metformin Hydrochloride extended-release tablets in the US market. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - July 8, 2020 Category: Pharmaceuticals Source Type: news

Granules Pharmaceuticals, Inc. Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets USP, 750 mg Due to the Detection of N-Nitrosodimethylamine (NDMA) Impurity
Granules Pharmaceuticals, Inc., Chantilly, VA is voluntarily recalling twelve (12) lots of Metformin Hydrochloride Extended-Release Tablets USP, 750 mg, 100 and 500 count bottles within expiry to the consumer level due to the detection of NNitrosodimethylamine (NDMA) levels above the Acceptable Dail (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 6, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Is Metformin the Best Therapy for Diabetes?
Is Metformin the Best First-Line Therapy for Those With Diabetes? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - June 30, 2020 Category: General Medicine Source Type: news

' Right Diabetes Med for the Right Patient for the Right Outcome'' Right Diabetes Med for the Right Patient for the Right Outcome '
A network meta-analysis of more than 400 trials of 21 drugs for type 2 diabetes sheds light on outcomes in patients who were drug-naive or on metformin and at low or high risk of cardiovascular disease.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - June 29, 2020 Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news

Is Metformin the Best First-Line Therapy for Those With Diabetes? Is Metformin the Best First-Line Therapy for Those With Diabetes?
A network meta-analysis of more than 400 trials of 21 drugs for type 2 diabetes sheds light on outcomes in patients who were drug-naive or on metformin and at low or high risk of cardiovascular disease.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - June 29, 2020 Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news

Diabetes Drug May Lower COVID-19 Death Risk in Women Diabetes Drug May Lower COVID-19 Death Risk in Women
Women taking the widely used oral diabetes medication metformin may be at lower risk for fatal COVID-19, according to a study that has not yet been peer-reviewed.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 24, 2020 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

DPPOS at 22 Years:'Diabetes Prevention Is Possible' Long Term DPPOS at 22 Years:'Diabetes Prevention Is Possible' Long Term
' Even after 22 years, adults at a high risk for [type 2] diabetes have continued to benefit from metformin, or prior intensive lifestyle modification, in preventing or delaying'disease development.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - June 24, 2020 Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news

Common medication may protect diabetic women from coronavirus 
In one of the world's largest coronavirus studies to-date, University of Minnesota researchers found that metformin may stem inflammation for diabetic and obese women to lower their death risks. (Source: the Mail online | Health)
Source: the Mail online | Health - June 24, 2020 Category: Consumer Health News Source Type: news

Lupin Pharmaceuticals, Inc. Issues Voluntarily Nationwide Recall of One Lot of Metformin Hydrochloride Extended-Release Tablets USP, 500mg Due to the Detection of N-Nitrosodimethylamine (NDMA)
Lupin Pharmaceuticals Inc. is voluntarily recalling Metformin Hydrochloride Extended-Release Tablets USP (generic equivalent of Fortamet ®), 500mg, lot G901203 to the consumer level. FDA analysis revealed that this lot exceeded the Acceptable Daily Intake Limit for the impurity N-Nitrosodimethylamine (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 13, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Metformin May Boost Glucose Excretion in Stool Metformin May Boost Glucose Excretion in Stool
A study of patients with diabetes who underwent scanning to detect cancer suggests that metformin causes glucose to be excreted in stool, which needs to be confirmed in more research.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - June 12, 2020 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Metformin May Boost Glucose Excretion in Stool
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - June 12, 2020 Category: General Medicine Source Type: news

Marksans Pharma recalls 11,279 bottles of diabetes drug due to cancer causing chemical
​​The company has issued voluntary recall of one batch of Metformin extended release tablets (USP 500 mg) due to detection of NDMA (N-nitrosodimethylamine), Marksans Pharma said in a regulatory filing. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 8, 2020 Category: Pharmaceuticals Source Type: news

Marksans Pharma Limited Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets, USP 500mg, Due to the Detection of N-Nitrosodimethylamine (NDMA)
Marksans Pharma Limited, India is voluntarily recalling Metformin Hydrochloride Extended-Release Tablets, USP 500mg, lot # XP9004, to the consumer level. FDA analysis has found the product to contain N-Nitrosodimethylamine (NDMA) levels in excess of the Acceptable Daily Intake Limit (ADI) of 96ng/da (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 5, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Teva Pharmaceuticals USA, Inc. Initiates Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets USP 500 mg and 750 mg Due to Detection of N-Nitrosodimethylamine (NDMA)
Teva Pharmaceuticals USA, Inc. is voluntarily recalling fourteen (14) lots of Metformin Hydrochloride Extended-Release Tablets, USP 500 mg and 750 mg, 100 and 1000 count bottles, in the United States to the consumer-level due to the detection of N-Nitrosodimethylamine (NDMA) levels in excess of the (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 5, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness
The purpose was to determine the role of AMPK activation in the renal metabolic response to sepsis, the development of sepsis-induced acute kidney injury (AKI) and on survival. In a prospective experimental study, 167 10- to 12-week-old C57BL/6 mice underwent cecal ligation and puncture (CLP) and human proximal tubule epithelial cells (TEC; HK2) were exposed to inflammatory mix (IM), a combination of lipopolysaccharide (LPS) and high mobility group box 1 (HMGB1). Renal/TEC metabolic fitness was assessed by monitoring the expression of drivers of oxidative phosphorylation (OXPHOS), the rates of utilization of OXPHOS/glycoly...
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Amneal Pharmaceuticals LLC Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended Release Tablets, USP, 500 mg and 750 mg, Due to Detection of N-Nitrosodimethylamine (NDMA) Impurity
Amneal Pharmaceuticals LLC Bridgewater, New Jersey (Amneal), is voluntarily recalling all lots of Metformin Hydrochloride Extended Release Tablets, USP, 500 mg and 750 mg, within expiry to the Retail Level. Amneal was notified by the U.S. FDA that the Agency ’s testing of seven lots of Metformin Hydr (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 1, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Metformin Recalled for Possible Cancerous Chemical
The recall for all lots of metformin hydrochloride extended-release tablets 500 mg from Apotex comes after one lot tested by the U.S. Food and Drug Administration had higher NDMA levels than allowed by the FDA. (Source: WebMD Health)
Source: WebMD Health - June 1, 2020 Category: Consumer Health News Source Type: news

FDA Issues Recall Alert for Metformin ER Products
The FDA is asking several pharmaceutical companies to voluntarily recall products containing extended-release formulations of metformin, a drug prescribed to millions of patients with type 2 diabetes. (Source: AAFP News)
Source: AAFP News - June 1, 2020 Category: Primary Care Source Type: news

FDA Finds Contamination In Several Brands Of Diabetes Drug
U.S. health regulators are telling five drugmakers to recall their versions of metformin, a widely used diabetes medication. (Source: Science - The Huffington Post)
Source: Science - The Huffington Post - May 29, 2020 Category: Science Source Type: news

Metformin Recalled Due to Potential Cancer-Causing Chemical
FRIDAY, May 29, 2020 -- A recall of the widely used diabetes drug metformin was announced by drug maker Apotex due to possible high levels of N-Nitrosodimethylamine (NDMA), which is believed to cause cancer in people. The recall for all lots of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 29, 2020 Category: Pharmaceuticals Source Type: news

Diabetes and COVID-19 Link
I have results from my clinic… Three of my diabetic patients went into remission after using hyperbaric oxygen therapy (HBOT). Two patients had type 1 diabetes… and another had type 2 diabetes. All three recovered with oxygen therapy. Most mainstream doctors would scoff at the idea… they “know” there’s no cure for diabetes. And to be treated for it with oxygen seems laughable. If you’re a regular reader, you know more about oxygen therapy than 99% of the general public, including most doctors. But the reason diabetes responds so well to oxygen may surprise you… It al...
Source: Al Sears, MD Natural Remedies - May 29, 2020 Category: Complementary Medicine Authors: Dr.A.Sears Tags: Health Source Type: news

Metformin Linked to Better Motor Function in Parkinson's Metformin Linked to Better Motor Function in Parkinson's
Patients with Parkinson's disease and diabetes treated with metformin experience better motor and nonmotor function than those not receiving the antihyperglycemic agent, pilot data suggest.Medscape Medical News (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - May 29, 2020 Category: Primary Care Tags: Neurology & Neurosurgery News Source Type: news

FDA Recall Extended-Release Metformin Due to NDMA Impurities FDA Recall Extended-Release Metformin Due to NDMA Impurities
The FDA advises voluntary recall of extended-release metformin made by five manufacturers after NDMA contamination found in some batches.News Alerts (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - May 29, 2020 Category: Primary Care Tags: Diabetes & Endocrinology News Alert Source Type: news

FDA Recalls Extended-Release Metformin Due to NDMA Impurities FDA Recalls Extended-Release Metformin Due to NDMA Impurities
The FDA advises voluntary recall of extended-release metformin made by five manufacturers after NDMA contamination found in some batches.News Alerts (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - May 29, 2020 Category: Drugs & Pharmacology Tags: Diabetes & Endocrinology News Alert Source Type: news

U.S. FDA asks five firms to recall diabetes drug with high levels of probable carcinogen
The U.S. Food and Drug Administration (FDA) said on Thursday it has recommended five pharmaceutical firms to voluntarily recall their diabetes drug metformin after the agency found high levels of a possible cancer-causing impurity in some versions of the medication. (Source: Reuters: Health)
Source: Reuters: Health - May 29, 2020 Category: Consumer Health News Tags: healthNews Source Type: news

Questions and Answers: NDMA impurities in metformin products
Answers to questions about NDMA impurities found in metformin and FDA ’s actions to address the issue (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 29, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Apotex Corp. Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets 500mg Due to the Detection of N-nitrosodimethylamine (NDMA)
Apotex Corp is voluntarily recalling all lots of Metformin Hydrochloride Extended-Release Tablets, USP 500mg within expiry to retail level. Apotex was notified by the U.S. Food and Drug Administration (US FDA) that one lot of Metformin Hydrochloride Extended-Release Tablets, USP was tested and showe (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 28, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

U.S. FDA finds high levels of carcinogen in diabetes drug metformin
The U.S Food and Drug Administration said on Wednesday it had found high levels of a possible cancer-causing impurity in some versions of the popular diabetes drug metformin. (Source: Reuters: Health)
Source: Reuters: Health - May 28, 2020 Category: Consumer Health News Tags: healthNews Source Type: news

An exploratory study of metformin and rapamycin as maintenance therapy
(Impact Journals LLC) Volume 11, Number 21 of @Oncotarget reported that eligible patients with stable or responding mPDA after 6 months on chemotherapy were randomized 1:1 to metformin alone or with rapamycin, stratified by prior treatment with FOLFIRINOX. Metformin +/ rapamycin maintenance for mPDA was well-tolerated and several patients achieved stable disease associated with exceptionally long survival. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 27, 2020 Category: Cancer & Oncology Source Type: news