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Sulfonylureas, Pioglitazone Similarly Safe for Add-On Therapy in Type 2 Diabetes (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD For patients with type 2 diabetes inadequately controlled with metformin, add-on treatment with either a sulfonylurea or pioglitazone seems similarly safe over the long-term, according to an open-label, multicenter study in … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 14, 2017 Category: Primary Care Source Type: news

For Metformin Add-On, No Winner in Head-to-Head CVD Trial (CME/CE)
(MedPage Today) -- Pioglitazone largely similar to sulfonylurea in pragmatic TOSCA.IT trial (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - September 13, 2017 Category: Urology & Nephrology Source Type: news

Deals this week: Mundipharma Medical Company, Cooper Pharmal Sarl, Merck
Mundipharma Medical Company will exclusively distribute INVOKANA (canagliflozin) and VOKANAMET (canagliflozin and metformin) in the European Economic Area (EEA) and Switzerland, under an agreement signed with drug developer and manufacturer Janssen P … (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - September 7, 2017 Category: Pharmaceuticals Source Type: news

Janssen and Mundipharma sign distribution deal for type 2 diabetes treatments
Janssen Pharmaceutica has entered an exclusive distribution agreement with Mundipharma Medical Company for Invokana (canagliflozin) and Vokanamet (a fixed-dose combination therapy of canagliflozin and metformin) to treat patients with type 2 diabetes … (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - September 4, 2017 Category: Pharmaceuticals Source Type: news

Janumet (Sitagliptin Metformin HCL) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - August 28, 2017 Category: Drugs & Pharmacology Source Type: news

Metformin Still Cost-effective for Diabetes Prevention Metformin Still Cost-effective for Diabetes Prevention
Metformin plus vitamin B12 supplementation remains cost-effective for preventing progression to diabetes compared with placebo and lifestyle changes, researchers report.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 26, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

$820 million wasted in failing to attempt Type 2 diabetes prevention efforts
(University of South Florida (USF Health)) Lifestyle intervention is the best approach in preventing Type 2 diabetes. However, most patients don't follow through in having a balanced diet and exercise. Prescribing metformin can save $820 million annually in healthcare costs and reduce the number of Type 2 diabetes patients by 20%. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 4, 2017 Category: International Medicine & Public Health Source Type: news

FDA Drug Safety Communication: FDA requires removal of some prescribing and dispensing restrictions for rosiglitazone-containing diabetes medicines
The U.S. Food and Drug Administration (FDA) has determined that recent data for rosiglitazone-containing drugs, such as Avandia, Avandamet, Avandaryl, and generics, do not show an increased risk of heart attack compared to the standard type 2 diabetes medicines metformin and sulfonylurea. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 1, 2017 Category: Drugs & Pharmacology Source Type: news

A therapy for FXS?
The antidiabetic drug metformin might be repurposed to treat patients with fragile X syndrome. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 4, 2017 Category: Science Authors: Ferrarelli, L. K. Tags: STKE Editors ' Choice Source Type: news

Metformin Particularly Effective in Those With History of GDM Metformin Particularly Effective in Those With History of GDM
Women who have had diabetes during pregnancy appear to profit the most from metformin treatment to reduce the risk of developing type 2 diabetes, according to the latest findings from the DPP study.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 29, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Antioxidant in Broccoli May Help Fight Diabetes Antioxidant in Broccoli May Help Fight Diabetes
A study finds broccoli extract containing the antioxidant sulforaphane decreased HbA1c and fasting blood sugar in obese patients with type 2 diabetes taking metformin but who had uncontrolled glycemia.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 22, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Broccoli sprout extract can replace toxic metformin drugs in type-2 diabetes; sulforaphane found to control blood sugar levels
(Natural News) The American Diabetes Association reports that around 10 percent of the U.S. population has diabetes, most of whom have lifestyle-related type 2 diabetes. Around 1.4 million new diabetes diagnoses are made each year, and it remains the seventh leading cause of death in the U.S. This is also an incredibly expensive disease, costing... (Source: NaturalNews.com)
Source: NaturalNews.com - June 22, 2017 Category: Consumer Health News Source Type: news

Specific diabetes medications recommended to protect bone health
Research highlights treatment options for co-managing type 2 diabetes and osteoporosis Related items fromOnMedica Osteoporosis - treatment options Osteoporosis - primary prevention Metformin lowers cardiac deaths better than other drugs Drug could cut heart events by 26% in diabetics (Source: OnMedica Latest News)
Source: OnMedica Latest News - June 22, 2017 Category: UK Health Source Type: news

Metformin No Help for Atherosclerosis in T1D
(MedPage Today) -- Findings don't support metformin in long-standing type 1 diabetes (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - June 13, 2017 Category: Cardiology Source Type: news

Metformin for Obesity in Children: Questions Still Remain Metformin for Obesity in Children: Questions Still Remain
Metformin improved body mass index in nondiabetic obese prepubertal -- but not pubertal -- children, a new study has found.Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 13, 2017 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Novel SGLT-2 Inhibitor Boosts Glycemic Control
(MedPage Today) -- A1c reduced when paired with metformin monotherapy (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - June 12, 2017 Category: Cardiology Source Type: news

ADA 2017: Oral Agents Under Review
When to start screening for B12 deficiency in your diabetes patients taking metformin? We review a dose-response diet study plus 2 others on oral drugs. (Source: ConsultantLive)
Source: ConsultantLive - June 12, 2017 Category: Internal Medicine Authors: Kenneth J. Bender, PharmD Tags: Conferences/ADA 2017 Diabetes Diabetes Type 2 Source Type: news

REMOVAL: Mixed Data on CV Benefits of Metformin in Type 1 Diabetes REMOVAL: Mixed Data on CV Benefits of Metformin in Type 1 Diabetes
Results from REMOVAL trial suggest possible cardiovascular benefit, but minimal effect on glucose lowering, in type 1 diabetes patients at increased cardiovascular risk.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 12, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Lifestyle Intervention Benefits Latinas With Prediabetes
(MedPage Today) -- Trend toward HbA1c improvement compared with metformin (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - June 11, 2017 Category: Cardiology Source Type: news

Metformin vs Myoinositol in Obese PCOS Patients Metformin vs Myoinositol in Obese PCOS Patients
Which is the more effective treatment choice for obese patients with PCOS?Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 2, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Jentadueto (Linagliptin and Metformin Hydrochloride) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 31, 2017 Category: Drugs & Pharmacology Source Type: news

Long-term Metformin May Reduce Coronary Calcium Long-term Metformin May Reduce Coronary Calcium
At least in men with prediabetes, and independent of statins, suggests a cohort study that did not find a similar effect of metformin on coronary calcium scores in women.Heartwire from Medscape (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 30, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

UK NICE Elevates SGLT2 Inhibitors in Diabetes Guidance UK NICE Elevates SGLT2 Inhibitors in Diabetes Guidance
The sodium-glucose cotransporter 2 (SGLT2) inhibitor class is now listed clearly as a second-line option after metformin in type 2 diabetes.Heartwire from Medscape (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 26, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Common diabetes drug may work by changing gut bacteria
A group of diabetics taking metformin had drastic changes in their gut flora, found Swedish and Spanish researchers.A probiotic diet may be beneficial for people with diabetes, say scientists. (Source: the Mail online | Health)
Source: the Mail online | Health - May 23, 2017 Category: Consumer Health News Source Type: news

No Link to Cognition in Diabetes Prevention Program Study
Intensive lifestyle intervention, metformin not tied to cognition (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - May 22, 2017 Category: Psychiatry Tags: Endocrinology, Family Medicine, Geriatrics, Internal Medicine, Neurology, Nursing, Pharmacy, Psychiatry, Journal, Source Type: news

Long-term Metformin Use'Has No Cognitive Impact'Long-term Metformin Use'Has No Cognitive Impact '
Patients and clinicians can be reassured that long-term use of metformin does not lead to worsening cognitive performance, new results from prolonged follow-up of the large-scale diabetes-prevention program indicate.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 19, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Metformin Improves Outcomes in HER2+ Breast Cancer Patients With Diabetes
Treatment with metformin may improve outcomes in patients with HER2 –positive primary breast cancer and diabetes, according to an analysis of the phase III ALTTO trial. (Source: CancerNetwork)
Source: CancerNetwork - May 16, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Breast Cancer HER2-Positive Breast Cancer News Source Type: news

Diabetes drug may help symptoms of autism-associated condition
Metformin, the most widely used drug to treat type 2 diabetes, could potentially be used to treat symptoms of Fragile X syndrome, an inherited form of intellectual disability and a cause of some forms of autism. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 15, 2017 Category: Science Source Type: news

Medical News Today: Metformin shows promise as a potential treatment for fragile X syndrome
New study shows that treatment with the common type 2 diabetes drug metformin improves social, behavioral, and neuron deficits in mouse model of fragile X. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 15, 2017 Category: Consumer Health News Tags: Autism Source Type: news

Diabetes drug may help symptoms of autism-associated condition
Metformin, the most widely used drug to treat type 2 diabetes, could potentially be used to treat symptoms of Fragile X syndrome, an inherited form of intellectual disability and a cause of some forms of autism. A new study led by researchers at McGill University, the University of Edinburgh and Université de Montréal has found that metformin improves social, behavioural and morphological defects in Fragile X mice. (Source: World Pharma News)
Source: World Pharma News - May 15, 2017 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Diabetes drug may help symptoms of autism associated condition
(University of Edinburgh) A widely used diabetes medication could help people with a common inherited form of autism, research shows. Scientists found that a drug called metformin improves sociability and reduces symptomatic behaviors in adult mice with a form of Fragile X syndrome. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 15, 2017 Category: International Medicine & Public Health Source Type: news

Medical News Today: Is it safe to use metformin during pregnancy?
Metformin is commonly prescribed for managing type 2 diabetes. Although it effectively lowers blood sugar, is it safe for women to take during pregnancy? (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 12, 2017 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news

More Side Effects With CRT Plus Metformin in Head, Neck Cancer
Metformin group less likely to tolerate cisplatin, have grade ≥ 3 nausea/vomiting, hematologic toxicities (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 5, 2017 Category: Cancer & Oncology Tags: Endocrinology, Internal Medicine, Oncology, ENT, Pharmacy, Journal, Source Type: news

Medical News Today: Can you drink alcohol while taking metformin?
People with diabetes may use metformin to help manage their symptoms. In this article, we look at the risks of consuming alcohol while on this medication. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 5, 2017 Category: Consumer Health News Tags: Diabetes Source Type: news

More Support for Metformin Benefit in Breast Cancer (CME/CE)
(MedPage Today) -- Better outcomes but only in hormone receptor-positive disease (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - May 4, 2017 Category: Cardiology Source Type: news

Metformin Use Does Not Increase Prostate Cancer Survival
Drug given in combination with docetaxel chemotherapy in patients with metastatic disease (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 11, 2017 Category: Cancer & Oncology Tags: Endocrinology, Oncology, Pharmacy, Urology, Journal, Source Type: news

Merck Receives Complete Response Letter from the U.S. FDA for TECOS Study with Sitagliptin
Dateline City: KENILWORTH, N.J.KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has issued a Complete Response Letter regarding Merck ’s Supplemental New Drug Applications for JANUVIA®(sitagliptin), JANUMET® (sitagliptin and metformin HCl) and JANUMET XR® (sitagliptin and metformin HCl extended-release).Language: EnglishContact: MerckMedia:Pamela Eisele, 267-305-3558orKristen Drake, 908-236-4223orInvestors:Amy Klug, 908-740-1898Ticker Slug:Ticker:MRKExchange:NY...
Source: Merck.com - Corporate News - April 7, 2017 Category: Pharmaceuticals Tags: Corporate News Latest News #Merck #MRK $MRK MSD NYSE:MRK Source Type: news

Metformin Linked to Dementia, Parkinson's in Patients With T2DM Metformin Linked to Dementia, Parkinson's in Patients With T2DM
In 9300 patients with type 2 diabetes, those taking metformin were significantly more likely to develop Parkinson's disease, as well as all-cause, Alzheimer's, or vascular dementia.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 30, 2017 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Potential for metformin use in thyroid disease
A report published in theJournal of Endocrinology which reviewed the relationship between the anti-diabetic drug metformin and thyroid disease suggests that metformin may benefit be beneficial for the condition.Medical News Bulletin (Source: Society for Endocrinology)
Source: Society for Endocrinology - March 27, 2017 Category: Endocrinology Source Type: news

The Effects of B12 Deficiency
Metformin is Big Pharma's pride and joy when it comes to diabetes. Over 120 million diabetics take this drug to try to control their blood sugar. Even anti-aging doctors have gotten on the bandwagon. They think metformin is a wonder drug. My colleagues keep asking me when I'm going to start prescribing it. Short-term, drugs can be a lifesaver. But long-term, the track record is not so good. Long term, like so many of Big Pharma's "cures," metformin creates more problems than it solves… Patients often stay on this drug for 10 years… 20 years… and more. That's a long time to be ...
Source: Al Sears, MD Natural Remedies - March 22, 2017 Category: Complementary Medicine Authors: Cathy Card Tags: Anti-Aging Health Source Type: news

FDA Drug Safety Communication: FDA revises warnings regarding use of the diabetes medicine metformin in certain patients with reduced kidney function
[4-8-2016] The U.S. Food and Drug Administration (FDA) is requiring labeling changes regarding the recommendations for metformin-containing medicines for diabetes to expand metformin ’s use in certain patients with reduced kidney function. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 22, 2017 Category: Drugs & Pharmacology Source Type: news

Controlling Cancer: How To Boost Your NK Cells
If your doctor puts you on a statin for cholesterol, prepare to be on it for life. If you have high blood pressure, you can be sure you'll be filling that prescription forever. Diabetic? You can look forward to decades of metformin. Big Pharma seems to have a "treatment" for every disease. But they rarely have a "cure." You see, the longer you take their "medicine," the more money they make. And now they're trying to do the same thing with chemotherapy drugs. A group of researchers from Oregon and the U.K. just created a new drug delivery system for cancer. It's called "m...
Source: Al Sears, MD Natural Remedies - March 20, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Cancer Source Type: news

Study claims medical treatment can reverse type 2 diabetes
Intervention led to months of remission in 40% of trial participants Related items fromOnMedica Impaired glucose regulation (pre-diabetes) Metformin doesn ’t help HbA1c in teens with type 1 diabetes Unhealthy lifestyles and poor diets Intensive treatment of type 2 diabetes with microalbuminuria reaps benefits NICE approves extra ‘triple therapy’ drug for diabetes (Source: OnMedica Latest News)
Source: OnMedica Latest News - March 15, 2017 Category: UK Health Source Type: news

ADA: Use Metformin as 1st T2D Monotherapy (CME/CE)
(MedPage Today) -- Recommendation comes from group's 2017 Standards of Medical Care in Diabetes (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 13, 2017 Category: Primary Care Source Type: news

Kombiglyze XR (Saxagliptin and Metformin HCl Extended-Release) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 9, 2017 Category: Drugs & Pharmacology Source Type: news

Substance found in red wine 'helps fight ageing'
Conclusion Resveratrol has been of interest to anti-ageing scientists for many years and researchers have previously shown it may be linked to a slowing of the decline in thinking and movement, at least in rodents. This study suggests a possible way this might happen. But the results don't tell us anything about what happens in humans. They suggest this substance may be useful for further research in humans at some point. They certainly don't provide a reason to drink gallons of red wine, in the hope of seeing an anti-ageing effect. Drinking too much alcohol is a sure-fire way to speed up deterioration of thinking skills,...
Source: NHS News Feed - March 8, 2017 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise Neurology Source Type: news

Resveratrol preserves neuromuscular synapses, muscle fibers in aging mice
Red wine, and metformin, a drug often prescribed to fight type 2 diabetes, have many of the neuroprotective benefits of a low-calorie diet and exercise, say researchers. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 7, 2017 Category: Science Source Type: news

Riomet (Metformin Hcl) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 7, 2017 Category: Drugs & Pharmacology Source Type: news

Intellipharmaceutics Announces FDA Approval for 500 mg and 750 mg Generic Glucophage(R) XR
TORONTO, Feb. 24, 2017 -- (Healthcare Sales & Marketing Network) -- Intellipharmaceutics International Inc. (IPCI) (TSX:I) ("Intellipharmaceutics" or the "Company"), a pharmaceutical company specializing in the research, development an... Biopharmaceuticals, Generics, FDA Intellipharmaceutics, metformin, Glucophage, diabetes (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 24, 2017 Category: Pharmaceuticals Source Type: news

Fasting For Just Five Days A Month Linked To Health Improvements
(Reuters Health) – Following a diet that mimics fasting may reduce risk factors for disease in generally healthy people, according to a small study.  Dr. Min Wei of UCLA’s Longevity Institute and colleagues tested the effects of the fasting-mimicking diet on various risk factors for diabetes, heart disease, cancer or other conditions. The diet (FMD; brand name ProLon) is low in calories, sugars and protein but high in unsaturated fats. Forty-eight study participants ate normally for three months while 52 ate FMD for five days each month and ate normally the rest of the time. After three months, the groups ...
Source: Healthy Living - The Huffington Post - February 21, 2017 Category: Consumer Health News Source Type: news