Nasal Spray Lowered Coronavirus Levels In Animal Study, Researchers Say
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 28, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Healthwatch Syndicated Local Coronavirus Dr. Mallika Marshall Source Type: news

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy
The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the respiratory tract of aged BALB/c mice. The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to interstitial pneumonia and inflammatory responses in both young and aged mice after intranasal inoculation. Deep sequencing revealed a panel of adaptive mutations potentially associated with the increased virulence. In parti...
Source: ScienceNOW - September 24, 2020 Category: Science Authors: Gu, H., Chen, Q., Yang, G., He, L., Fan, H., Deng, Y.-Q., Wang, Y., Teng, Y., Zhao, Z., Cui, Y., Li, Y., Li, X.-F., Li, J., Zhang, N.-N., Yang, X., Chen, S., Guo, Y., Zhao, G., Wang, X., Luo, D.-Y., Wang, H., Yang, X., Li, Y., Han, G., He, Y., Zhou, X., G Tags: Microbiology r-articles Source Type: news

The science and medicine of human immunology
Although the development of effective vaccines has saved countless lives from infectious diseases, the basic workings of the human immune system are complex and have required the development of animal models, such as inbred mice, to define mechanisms of immunity. More recently, new strategies and technologies have been developed to directly explore the human immune system with unprecedented precision. We discuss how these approaches are advancing our mechanistic understanding of human immunology and are facilitating the development of vaccines and therapeutics for infection, autoimmune diseases, and cancer. (Source: ScienceNOW)
Source: ScienceNOW - September 24, 2020 Category: Science Authors: Pulendran, B., Davis, M. M. Tags: Immunology, Online Only review Source Type: news

New $5.4 million study to advance understanding of severe coronavirus infection
(University of Liverpool) The University of Liverpool is leading a major new international project to improve our understanding of severe coronavirus infection in humans.Researchers will sequence and analyse samples from humans and animals to create profiles of various coronaviruses, including SARS-CoV-2, which causes COVID-19. The results will help inform the development of new treatments and vaccines to tackle coronavirus infections. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 14, 2020 Category: Infectious Diseases Source Type: news

The Great Vaccine Race: Inside the Unprecedented Scramble to Immunize the World Against COVID-19
The cleverest of enemies thrive on surprise attacks. Viruses—and coronaviruses in particular—know this well. Remaining hidden in animal hosts for decades, they mutate steadily, sometimes serendipitously morphing into more effective and efficient infectious agents. When a strain with just the right combination of genetic codes that spell trouble for people makes the leap from animal to human, the ambush begins. Such was the case with SARS-CoV-2, the coronavirus behind COVID-19, and the attack was mostly silent and insidious at first. Many people infected with SARS-CoV-2 remained oblivious as they served as the v...
Source: TIME: Health - September 10, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Magazine Source Type: news

Biopharma Leaders Unite To Stand With Science
NEW YORK, September 8, 2020 — The CEOs of AstraZeneca (LSE/STO/NYSE: AZN), BioNTech (NASDAQ: BNTX), GlaxoSmithKline plc (LSE/NYSE: GSK), Johnson & Johnson (NYSE: JNJ), Merck (NYSE: MRK), known as MSD outside the United States and Canada, Moderna, Inc. (Nasdaq: MRNA), Novavax, Inc. (Nasdaq: NVAX), Pfizer Inc. (NYSE: PFE), and Sanofi (NASDAQ: SNY), today announced a historic pledge, outlining a united commitment to uphold the integrity of the scientific process as they work towards potential global regulatory filings and approvals of the first COVID-19 vaccines. All nine CEOs signed the following pledge: We, the un...
Source: Johnson and Johnson - September 8, 2020 Category: Pharmaceuticals Tags: Our Company Source Type: news

Novel vaccine that blunts fentanyl effects and sequesters ultrapotent fentanyl analogues - Barrientos RC, Bow EW, Whalen C, Torres OB, Sulima A, Beck Z, Jacobson AE, Rice KC, Matyas GR.
In this study, we described the design, synthesis, formulation, and animal testing of an e fficacious vaccine against fentanyl. The vaccine formulation ... (Source: SafetyLit)
Source: SafetyLit - September 4, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Johnson & Johnson Announces that Janssen ’s COVID-19 Investigational Vaccine Candidate Prevents Severe Clinical Disease in Pre-clinical Studies
Janssen’s lead SARS-CoV-2 investigational vaccine candidate, Ad26.COV2.S, prevented severe clinical disease in Syrian golden hamsters, upon challenge with SARS-CoV-2, the virus that causes COVID-19 in people. The data, published today in Nature Medicine, demonstrated that the Company’s investigational adenovirus serotype 26 (Ad26) vector-based vaccine elicited an immune response as demonstrated by “neutralizing antibodies” and prevented severe clinical disease – including weight loss, pneumonia and mortality – in Syrian golden hamsters upon challenge.This publication follows Johnson &...
Source: Johnson and Johnson - September 3, 2020 Category: Pharmaceuticals Tags: Our Company Source Type: news

Investigational COVID-19 vaccine candidate prevents severe clinical disease in animals
(Beth Israel Deaconess Medical Center) In new research published in Nature Medicine, Beth Israel Deaconess Medical Center immunologist Dan H. Barouch, MD, PhD, and colleagues demonstrated that the optimal vaccine elicited robust immune response in Syrian golden hamsters and prevented severe clinical disease -- including weight loss, pneumonia and death. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 3, 2020 Category: International Medicine & Public Health Source Type: news

NIDCR's Fall 2020 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Fall 2020 E-Newsletter In this issue: NIDCR News Funding Opportunities NIH/HHS News Funding Notices Science Advances Subscribe to NICDR News Grantee News   NIDCR News NIDCR Announces Availability of COVID-19 Research Funding On May 5, NIDCR issued two Notices of Special Interest highlighting the urgent need for research on coronavirus disease 2019. This research may be conducted either via the National Dental PBRN infrastructu...
Source: NIDCR Science News - September 1, 2020 Category: Dentistry Source Type: news

White House Announces 2022 R & D Budget Priorities
On August 14, 2020, the White House Office of Science and Technology Policy (OSTP) and the White House Office of Management and Budget (OMB), issued its annual science and technology priorities memorandum. The document guides federal agency priority-setting in the coming budget cycle. The directive identified public health security and innovation, industrial leadership, national security, energy and environmental leadership, and space exploration as priorities for the fiscal year (FY) 2022 budget. The Administration’s memo asserts that the federal government “serves as a catalyst for innovation by investing i...
Source: Public Policy Reports - September 1, 2020 Category: Biology Authors: AIBS Source Type: news

American Animal Hospital Association and American Association of Feline Practitioners release new Feline Vaccination Guidelines
(SAGE) The American Animal Hospital Association (AAHA) and the American Association of Feline Practitioners (AAFP) convened a panel of experts to update the 2013 AAFP Feline Vaccination Advisory Panel Report. The release of the 2020 AAHA/AAFP Feline Vaccination Guidelines provides updated recommendations and the most current information for feline vaccinations. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 1, 2020 Category: International Medicine & Public Health Source Type: news

Preclinical study of COVID-19 vaccine candidate shows potent T-cell responses
(University of Alabama at Birmingham) Preclinical studies of a COVID-19 vaccine candidate at the University of Alabama at Birmingham show positive results that appear to distinguish this vaccine candidate from other vaccine candidates currently in advanced stages of clinical development, the Maryland-based Altimmune Inc. announced today. In animal models at UAB, a single intranasal dose resulted in a potent T-cell response at the mucus layer of the lungs, including killer CD8+ T-cells, which can recognize and kill virally infected cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 25, 2020 Category: International Medicine & Public Health Source Type: news

How Convalescent Plasma Could Help Fight COVID-19
The last time most of us gave any thought to antibodies was probably in high school biology, but we’re getting a crash refresher course thanks to COVID-19. They are, after all, the key to our best defenses against SARS-CoV-2, the virus that’s caused the global pandemic. People who have been infected likely rely on antibodies to recover, and antibodies are what vaccines are designed to produce. Or at least that’s what infectious-disease and public-health experts assume for now. Because SARS-CoV-2 is such a new virus, even the world’s best authorities aren’t yet sure what it will take to build p...
Source: TIME: Health - August 24, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Small change makes cancer vaccine more effective in animal tests
(Thomas Jefferson University) Tweaking the adenovirus spike protein induces a more robust immune reaction for a cancer vaccine against gastric, pancreatic, esophageal and colon malignancies in animal models. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 24, 2020 Category: International Medicine & Public Health Source Type: news

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–recovered participants, developed neutralization assays to investigate antibody responses, adapted our high-throughput antibody generation pipeline to rapidly screen more than 1800 antibodies, and established an animal model to test protection. We isolated potent neutralizing antibodies (nAbs) to two epitopes on the receptor binding domain (RBD) and to distinct non-RBD epitopes on the spike (S) protein. As indicated by maintained we...
Source: ScienceNOW - August 20, 2020 Category: Science Authors: Rogers, T. F., Zhao, F., Huang, D., Beutler, N., Burns, A., He, W.-t., Limbo, O., Smith, C., Song, G., Woehl, J., Yang, L., Abbott, R. K., Callaghan, S., Garcia, E., Hurtado, J., Parren, M., Peng, L., Ramirez, S., Ricketts, J., Ricciardi, M. J., Rawlings, Tags: Immunology, Microbiology r-articles Source Type: news

Kenya: Lessons From a Community-Driven Rabies Vaccination Campaign
[The Conversation Africa] Every year, approximately 60,000 people die from rabies. Most of these deaths are children - who are often less able to defend themselves from animals - in sub-Saharan Africa and Asia. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - August 17, 2020 Category: African Health Source Type: news

Jeremy Farrar: ‘Viruses know no borders. Until every country is protected, we are all at risk’
There is no future in narrow nationalism. The only way out of this crisis is by working together• Time to reset:more brilliant ideas to remake the worldMake no mistake, we are still only at the start of the Covid-19 pandemic. My hope is that the world is now finally waking up, and will do all that is needed to bring the crisis to an end, and be better prepared for inevitable future outbreaks.For many years, scientists have warned of the likelihood of a rapidly spreading new virus, crossing from animals to humans – and the urgent need for governments to prepare. Unfortunately, the world ignored these warnings. In...
Source: Guardian Unlimited Science - August 15, 2020 Category: Science Authors: Jeremy Farrar Tags: Coronavirus outbreak Infectious diseases Medical research Microbiology Science World news Vaccines and immunisation Health Society Life and style Source Type: news

'They've jumped the gun': scientists worry about Russia's Covid-19 vaccine
Rising chorus of concern over Sputnik V vaccine stems from opaque development and lack of mass testingCoronavirus – latest updatesSee all our coronavirus coverageIn 1977, Scott Halstead, a virologist at the University of Hawaii, was studying dengue fever when he noticed a now well-known but then unexpected feature of the disease.Animals that had already been exposed to one of the four closely related viruses that cause dengue and produced antibodies to it, far from being protected against other versions, became sicker when infected a second time, and it was the antibodies produced by the first infection that were res...
Source: Guardian Unlimited Science - August 13, 2020 Category: Science Authors: Peter Beaumont Tags: Medical research Coronavirus outbreak Science World news Russia Europe Source Type: news

DNA vaccine protection against SARS-CoV-2 in rhesus macaques
In this study, we developed a series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 spike (S) protein and evaluated them in 35 rhesus macaques. Vaccinated animals developed humoral and cellular immune responses, including neutralizing antibody titers at levels comparable to those found in convalescent humans and macaques infected with SARS-CoV-2. After vaccination, all animals were challenged with SARS-CoV-2, and the vaccine encoding the full-length S protein resulted in>3.1 and>3.7 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa, respectively, as compared wit...
Source: ScienceNOW - August 13, 2020 Category: Science Authors: Yu, J., Tostanoski, L. H., Peter, L., Mercado, N. B., McMahan, K., Mahrokhian, S. H., Nkolola, J. P., Liu, J., Li, Z., Chandrashekar, A., Martinez, D. R., Loos, C., Atyeo, C., Fischinger, S., Burke, J. S., Slein, M. D., Chen, Y., Zuiani, A., Lelis, F. J. Tags: Immunology, Microbiology r-articles Source Type: news

SARS-CoV-2 infection protects against rechallenge in rhesus macaques
An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global coronavirus disease 2019 (COVID-19) pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against reexposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia. After the initial viral clearance, animals were recha...
Source: ScienceNOW - August 13, 2020 Category: Science Authors: Chandrashekar, A., Liu, J., Martinot, A. J., McMahan, K., Mercado, N. B., Peter, L., Tostanoski, L. H., Yu, J., Maliga, Z., Nekorchuk, M., Busman-Sahay, K., Terry, M., Wrijil, L. M., Ducat, S., Martinez, D. R., Atyeo, C., Fischinger, S., Burke, J. S., Sle Tags: Immunology, Microbiology r-articles Source Type: news

These Scientists Are Sewer-Diving in an Attempt to Detect Silent COVID-19 Outbreaks
Wearing face shields, masks, two layers of gloves and navy cotton overalls, two scientists carefully lift off a metal manhole cover to reveal the cumulative waste of some 400 migrant workers. As one of them lowers a yellow rubber tube into the fetid sewer outside a dormitory in central Singapore, a third explains how samples of the brownish liquid provide a crude snapshot of how the city-state is trying to keep a step ahead of the coronavirus. Wastewater surveillance — which Dutch scientists showed in March can identify evidence of the pathogen earlier than testing patients — is one of a handful of strategies a...
Source: TIME: Health - August 3, 2020 Category: Consumer Health News Authors: Bloomberg Tags: Uncategorized COVID-19 overnight wire Source Type: news

J&J Covid-19 vaccine performs well in early tests
Experimental inoculation elicits ‘robust’ immune response when used on animals (Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - July 30, 2020 Category: Pharmaceuticals Source Type: news

Moderna Coronavirus Vaccine Test in Monkeys Shows Promise
This coronavirus vaccine developed by government researchers and Moderna enabled the animals to quickly clear the infection from their lungs. (Source: NYT Health)
Source: NYT Health - July 29, 2020 Category: Consumer Health News Authors: Denise Grady Tags: Vaccination and Immunization Moderna Inc Clinical Trials Tests (Medical) Research Monkeys and Apes National Institute of Allergy and Infectious Diseases New England Journal of Medicine Vaccine (Journal) your-feed-healthcare Coronavirus Source Type: news

MRIGlobal works with animal vaccine company on human Covid-19 vaccine
MBF Therapeutics, which to date has focused on developing DNA-based vaccines for animals, said Thursday it has formed a collaboration with four life science industry partners to work on a Covid-19 vaccine for humans. The collaboration with MRIGlobal, Rymedi, SSI Strategy and Aldevron will seek to advance MBF Therapeutics’ SARS CoV-2 vaccine candidate COVE-001. Financial terms of the partnership are being kept confidential. “Our goal is a better long-term solution to the current global pandemic,"… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - July 24, 2020 Category: Biotechnology Authors: John George Source Type: news

Another mRNA-based vaccine candidate protects animals against SARS-CoV-2
An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell. Two injections of the vaccine were sufficient to induce robust immunity, completely preventing SARS-CoV-2 infection in mice. (Source: World Pharma News)
Source: World Pharma News - July 24, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Another mRNA-based vaccine candidate protects animals against SARS-CoV-2
(Cell Press) An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell. Two injections of the vaccine were sufficient to induce robust immunity, completely preventing SARS-CoV-2 infection in mice. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 24, 2020 Category: Infectious Diseases Source Type: news

Can an animal vaccine developer be the one to tame Covid-19? MBF Therapeutics places its bet
MBF Therapeutics, which to date has focused on developing DNA-based vaccines for animals, said Thursday it has formed a collaboration with four life science industry partners to work on a Covid-19 vaccine for humans. The collaboration with MRIGlobal, Rymedi, SSI Strategy and Aldevron will seek to advance MBF Therapeutics’ SARS CoV-2 vaccine candidate COVE-001. Financial terms of the partnership are being kept confidential. “Our goal is a better long-term solution to the current global pandemic,"… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 23, 2020 Category: Pharmaceuticals Authors: John George Source Type: news

Inside the Global Quest to Trace the Origins of COVID-19 —and Predict Where It Will Go Next
It wasn’t greed, or curiosity, that made Li Rusheng grab his shotgun and enter Shitou Cave. It was about survival. During Mao-era collectivization of the early 1970s, food was so scarce in the emerald valleys of southwestern China’s Yunnan province that farmers like Li could expect to eat meat only once a year–if they were lucky. So, craving protein, Li and his friends would sneak into the cave to hunt the creatures they could hear squeaking and fluttering inside: bats. Li would creep into the gloom and fire blindly at the vaulted ceiling, picking up any quarry that fell to the ground, while his companion...
Source: TIME: Health - July 23, 2020 Category: Consumer Health News Authors: Charlie Campbell/ Yuxi, Yunnan and Alice Park Tags: Uncategorized COVID-19 feature Magazine Source Type: news

Bovine TB vaccine trials get go-ahead in England and Wales
Scientific breakthrough could lead to phasing out of badger culling to tackle diseaseField trials of a cattle vaccine for bovine tuberculosis have been given the go-ahead as part of moves to phase out badger culling to tackle the disease.The trials are due to get under way in England and Wales to accelerate deployment of a cattle vaccine for TB by 2025, the government announced on Wednesday.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - July 22, 2020 Category: Science Authors: PA Media Tags: Bovine tuberculosis Animal welfare Animals Environment Farming Rural affairs UK news Badgers Science Source Type: news

Research Provides the Bricks and Mortar for Our Food Systems to ‘Build Back Better’
Elwyn Grainger-Jones is the Executive Director of the CGIAR System Organization.By Elwyn Grainger-JonesMONTPELLIER, France, Jul 22 2020 (IPS) The COVID-19 pandemic has exposed the structural weaknesses of today’s food systems, showing how quickly global networks of food production, trade and supply can waver under the impact of a single disease. By compromising access to safe, nutritious food through enforced restrictions on distribution and labour resulting in shortages and price rises, the coronavirus outbreak has shaken the foundations of global wellbeing, with repercussions for health, livelihoods, and equality....
Source: IPS Inter Press Service - Health - July 22, 2020 Category: International Medicine & Public Health Authors: Elwyn Grainger-Jones Tags: Climate Change Development & Aid Economy & Trade Featured Food & Agriculture Food Security and Nutrition Global Headlines Health Humanitarian Emergencies TerraViva United Nations Source Type: news

How Extremophile Bacteria Living In Nuclear Reactors Might Help Us Make Vaccines
Extremophiles like the bacterium  D. radiodurans that can withstand levels of radiation thousands of times what most animals can, are able to help us make vaccines faster, cheaper and safer. They use special molecular protectors to shield their repair proteins but not their DNA or RNA. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - July 21, 2020 Category: Pharmaceuticals Authors: James Conca, Contributor Tags: Energy /energy Business /business Innovation /innovation Healthcare /healthcare Editors' Pick editors-pick Source Type: news

COVID-19 replicating RNA vaccine has robust response in nonhuman primates
(University of Washington Health Sciences/UW Medicine) A replicating RNA vaccine, formulated with a lipid-based nanoparticle emulsion, produces antibodies against the COVID-19 coronavirus in mice and primates with a single immunization. These antibodies potently neutralize the virus in young and old animals. The antibody levels induced are comparable to those in recovered COVID-19 patients. This formulation is shelf-stable, with mass-production and distribution advantages. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 20, 2020 Category: Infectious Diseases Source Type: news

Zydus Cadila begins human trials of its COVID-19 vaccine, aims for an early 2021 launch
The company said in the preclinical stage the vaccine was found to be safe, immunogenic and well-tolerated. It was also able to produce neutralising antibodies in animal studies, a key requirement for a vaccine. In the phase-I and II trials, the company will assess the safety, tolerability and immunogenicity of the vaccine. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - July 16, 2020 Category: Pharmaceuticals Source Type: news

How Koalas With an S.T.D. Could Help Humanity
When it comes to finding a vaccine for chlamydia, the world ’s most common sexually transmitted infection, koalas may prove a key ally. (Source: NYT Health)
Source: NYT Health - July 13, 2020 Category: Consumer Health News Authors: Rachel E. Gross Tags: Chlamydia Koalas Animals Sexually Transmitted Diseases Endangered and Extinct Species Antibiotics Vaccination and Immunization Bacteria Veterinary Medicine Queensland (Australia) your-feed-science Source Type: news

International regulators align positions on phase 3 COVID-19 vaccine trials, EMA
During the second workshop on Covid-19 vaccine development, participants agreed regulatory positions on: 1) data needed from lab, animal and human studies to allow initiation of Phase III clinical trials, and 2) considerations for Phase III study design. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 13, 2020 Category: Consumer Health News Source Type: news

Salmonella biofilm protein causes autoimmune responses -- Possible link with Alzheimer's
(University of Saskatchewan) Scientists from the Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac) at the University of Saskatchewan (USask) and Temple University (Philadelphia, US) have demonstrated that a Salmonella biofilm protein can cause autoimmune responses and arthritis in animals. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 9, 2020 Category: International Medicine & Public Health Source Type: news

UN Chief Warns of Deadly Germs as Potential Bioterrorist Weapons
Credit: United NationsBy Thalif DeenUNITED NATIONS, Jul 8 2020 (IPS) The coronavirus—which has claimed the lives of over 538,000 people and infected more than 11.6 million worldwide—has destabilized virtually every facet of human life ever since its outbreak in late December. Providing a grim economic scenario of the devastation caused by the pandemic– including rising poverty, hunger and unemployment– UN Secretary-General Antonio Guterres warned last week of the possibility of an even worse disaster: the risks of bioterrorist attacks deploying deadly germs. He said it has already shown some of the...
Source: IPS Inter Press Service - Health - July 8, 2020 Category: International Medicine & Public Health Authors: Thalif Deen Tags: Armed Conflicts Featured Global Global Geopolitics Global Governance Headlines Health IPS UN: Inside the Glasshouse Peace TerraViva United Nations Source Type: news

Study: New Form Of Coronavirus Spreads Faster, But Doesn ’ t Make People Sicker
(CNN) — A global study has found strong evidence that a new form of the coronavirus has spread from Europe to the US. The new mutation makes the virus more likely to infect people but does not seem to make them any sicker than earlier variations of the virus, an international team of researchers reported Thursday. “It is now the dominant form infecting people,” Erica Ollmann Saphire of the La Jolla Institute for Immunology and the Coronavirus Immunotherapy Consortium, who worked on the study, told CNN. “This is now the virus.” The study, published in the journal Cell, builds on some earlier wo...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - July 3, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston CNN Coronavirus Source Type: news

COVID-19 vaccine by Ahmedabad-based Zydus Cadila gets DCGI nod for human clinical trials
The assent for human trials was given after the company submitted data of clinical trial on animals to the DCGI, in which the vaccine candidate was found to be successful with respect to safety and immunogenicity, sources said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - July 3, 2020 Category: Pharmaceuticals Source Type: news

Merck Animal Health announces $100M investment in De Soto plant
Merck Animal Health will invest $100 million to expand its De Soto facility. The company said Monday that it is spending $34 million to expand and improve its vaccine production operation at the plant. Those improvements, some of which already have begun, are set to come online this year, said Tom Schad director of North American animal health communications for Merck Anim al Health. The division of Merck& Co. Inc. (NYSE: MRK) said its investment in its De Soto facility includes $66 million for … (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - June 29, 2020 Category: Pharmaceuticals Authors: Brian Kaberline Source Type: news

How Deforestation Helps Deadly Viruses Jump from Animals to Humans
This article is republished from The Conversation under a Creative Commons license. Read the original article. The post How Deforestation Helps Deadly Viruses Jump from Animals to Humans appeared first on Inter Press Service. (Source: IPS Inter Press Service - Health)
Source: IPS Inter Press Service - Health - June 26, 2020 Category: International Medicine & Public Health Authors: External Source Tags: Environment Global Headlines Health TerraViva United Nations Source Type: news

Promising Results Mean Coronavirus Vaccine Trial Could Start by August
THURSDAY, June 25, 2020 -- Animal studies of a potential COVID-19 vaccine have been so encouraging that researchers plan to speed up testing of the vaccine in humans. Initially, the next phase of the trial was expected to begin in September, but... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 25, 2020 Category: General Medicine Source Type: news

Entos Pharmaceuticals announces selection of lead DNA vaccine candidates for COVID-19
(Entos Pharmaceuticals) In preclinical studies, two lead Fusogenix DNA vaccine (Covigenix) candidates demonstrated high immunogenicity and efficacy.Lead candidates to be evaluated in SARS-CoV-2 animal challenge studies and advanced to human clinical trials during summer 2020.Canadian Institutes of Health Research (CIHR) awards $4.2M grant to John Lewis, PhD., to be used for development of COVID-19 DNA vaccine. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 25, 2020 Category: Biology Source Type: news

Off-the-shelf tool for making mouse models of COVID-19
(University of Iowa Health Care) Researchers at the University of Iowa and Medical University, Guangzhou, in China, have created a gene therapy vector that is essentially an off-the-shelf tool that allows labs to create their own COVID-19 mouse model within a matter of days. This simple tool could help overcome a major research hurdle -- the lack of good, widely available animal models for developing and testing new anti-viral therapies and vaccines for COVID-19. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 16, 2020 Category: Infectious Diseases Source Type: news

Potential COVID-19 vaccine from China shows promise in animal tests
A potential COVID-19 vaccine being developed by Chinese researchers showed promise in trials in monkeys, triggering antibodies and raising no safety issues, researchers said, and a human trial with more than 1,000 participants is under way. (Source: Reuters: Health)
Source: Reuters: Health - June 10, 2020 Category: Consumer Health News Tags: healthNews Source Type: news

Coronavirus Vaccine: Here Are The Latest Developments
(CNN) — While coronavirus keeps spreading and killing with impunity, the world waits for a vaccine that could quash the pandemic. But details and timelines keep shifting. Here’s the latest on where we stand in the race for a vaccine: When will a Covid-19 vaccine be available to the public? No one’s sure yet, but the target is sometime in early 2021. Vaccines in development around the world are in various stages of testing. Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said he’s confident one of the vaccine candidates will be proven safe and effective by th...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - June 8, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Closures Covid-19 Boston, MA Health Healthcare Status Coronavirus Coronavirus Vaccine Moderna Therapeutics Source Type: news

COVID-19 Is a Symptom of a Bigger Problem: Our Planet ’s Ailing Health
The COVID-19 outbreak is a global tragedy. Hundreds of thousands have died, healthcare systems are buckling, and the future is uncertain for millions of people whose livelihoods are collapsing. It is absolutely right that the focus today is on saving lives here and now. In the same spirit of doing what we can to safeguard people’s wellbeing, we must not content ourselves with containing the acute crisis. We must also look ahead to what we can learn from this crisis to prevent future risks. COVID-19 is a reminder of how vulnerable even our modern, technologically advanced societies are. The biggest lesson is that COVI...
Source: TIME: Health - June 5, 2020 Category: Consumer Health News Authors: Inger Andersen and Johan Rockström Tags: Uncategorized COVID-19 Source Type: news

COVID-19 Is a Symptom of a Bigger Problem: Our Planet ’s Ailing Health
The COVID-19 outbreak is a global tragedy. Hundreds of thousands have died, healthcare systems are buckling, and the future is uncertain for millions of people whose livelihoods are collapsing. It is absolutely right that the focus today is on saving lives here and now. In the same spirit of doing what we can to safeguard people’s wellbeing, we must not content ourselves with containing the acute crisis. We must also look ahead to what we can learn from this crisis to prevent future risks. COVID-19 is a reminder of how vulnerable even our modern, technologically advanced societies are. The biggest lesson is that COVI...
Source: TIME: Science - June 5, 2020 Category: Science Authors: Inger Andersen and Johan Rockström Tags: Uncategorized COVID-19 Source Type: news

NIDCR's Summer 2020 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Summer 2020 E-Newsletter In this issue: NIDCR News Funding Opportunities NIH/HHS News Funding Notices Science Advances Subscribe to NICDR News Grantee News   NIDCR News NIDCR Announces Availability of COVID-19 Research Funding On May 5, NIDCR issued two Notices of Special Interest highlighting the urgent need for research on coronavirus disease 2019. This research may be conducted either via the National Dental PBRN infrastruc...
Source: NIDCR Science News - June 4, 2020 Category: Dentistry Source Type: news