Gla-300 Comparable to IDeg-100 for Uncontrolled Type 2 Diabetes Gla-300 Comparable to IDeg-100 for Uncontrolled Type 2 Diabetes
A head-to-head study of glargine 300 units/mL (Gla-300) and degludec 100 units/mL (IDeg-100) showed that both of these second-generation basal insulin analogs were comparable for treating uncontrolled type 2 diabetes, although hypoglycemia rates were lower with Gla-300 during the titration period, researchers say.Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 25, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Anti-inflammatory protein may protect against obesity and insulin resistance
The anti-inflammatory protein, NLRP12, may protect against obesity and insulin resistance by influencing gut bacteria, according to a study published inCell Host& Microbe.Medical News Today (Source: Society for Endocrinology)
Source: Society for Endocrinology - September 21, 2018 Category: Endocrinology Source Type: news

Insulin shows great potential against chronic colitis
(University of Copenhagen The Faculty of Health and Medical Sciences) Diabetes is not the only disease on which insulin has an effect, it appears. In a new study that involved tests on mice researchers from the University of Copenhagen, among others, have discovered a new method for treating chronic colitis with regular insulin. The researchers have set up a company with a view to testing the treatment and hopefully making it available to patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 21, 2018 Category: International Medicine & Public Health Source Type: news

FDA: Hurricane Florence should not affect medtech supply chain
Though destructive, the effects of Hurricane Florence on the Eastern US are not currently affecting medical supply chains in the region, according to a post from FDA head Dr. Scott Gottlieb. The federal watchdog said it is actively engaged in monitoring firms that manufacture “critically important medical products” and is closely coordinating with them to prevent any potential shortage issues. “Flooding associated with a hurricane’s impact can be devastating. I am extremely proud of the many FDA employees who have already deployed to help North and South Carolina begin their recovery as quickly as p...
Source: Mass Device - September 20, 2018 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Source Type: news

SFC Fluidics wins $1.4m grant to develop dual-hormone patch pump
SFC Fluidics said today that it won a $1.4 million grant to support the development of a dual-hormone patch pump for people with diabetes. The company’s ePump system is designed to control the delivery of insulin and glucagon via a small patch pump. The technology will also feature a flow confirmation sensor to determine, in real-time, if drug delivery has occurred as expected, according to SFC Fluidics. Get the full story at our sister site, Drug Delivery Business News. The post SFC Fluidics wins $1.4m grant to develop dual-hormone patch pump appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - September 20, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Diabetes Drug-Device Combinations Featured Funding Roundup Pharmaceuticals sfcfluidics Source Type: news

Anti-inflammatory protein promotes healthy gut bacteria to curb obesity
(University of North Carolina Health Care) Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet. The researchers also reported that the NLRP12 gene is underactive in people who are obese, making it a potential therapeutic target for treating obesity and diabetes, both of which are risk factors for cardiovascular disease and other serious conditions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 19, 2018 Category: International Medicine & Public Health Source Type: news

Medical News Today: Non-insulin drugs for treating type 2 diabetes
Type 2 diabetes prevents the body from responding to insulin correctly, leading to high levels of blood sugar. Some people require insulin injections, but others can manage the condition with oral or other injectable medications. Learn more here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 18, 2018 Category: Consumer Health News Tags: Diabetes Type 2 Source Type: news

Pregnancy Weight Gain Tied to Kids' Cardiometabolic Risk Factors
(MedPage Today) -- Higher risks of hypertension, insulin resistance (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - September 18, 2018 Category: OBGYN Source Type: news

Pregnant women warned 'eating for two' increases diabetes risk
A survey of 900 women has found a link to children who developed insulin resistance – a key precursor of diabetes – at age seven. There was also a link to obesity and high blood pressure. (Source: the Mail online | Health)
Source: the Mail online | Health - September 18, 2018 Category: Consumer Health News Source Type: news

Ca2+ concentration-dependent premature death of igfbp5a-/- fish reveals a critical role of IGF signaling in adaptive epithelial growth
The phenotype gap is a challenge for genetically dissecting redundant endocrine signaling pathways, such as the six isoforms in the insulin-like growth factor binding protein (IGFBP) family. Although overexpressed IGFBPs can inhibit or potentiate IGF actions or have IGF-independent actions, mutant mice lacking IGFBP-encoding genes do not exhibit major phenotypes. We found that although zebrafish deficient in igfbp5a did not show overt phenotypes when raised in Ca2+-rich solutions, they died prematurely in low Ca2+ conditions. A group of epithelial cells expressing igfbp5a take up Ca2+ and proliferate under low Ca2+ conditi...
Source: Signal Transduction Knowledge Environment - September 18, 2018 Category: Science Authors: Liu, C., Xin, Y., Bai, Y., Lewin, G., He, G., Mai, K., Duan, C. Tags: STKE Research Articles Source Type: news

Midwives call for pregnancy weight targets after study highlights health risks
Eating for two is a myth, say researchers, with weight gain linked to insulin resistanceMidwives should be given guidelines on how to advise expectant mothers about managing their weight, their professional body has said, reacting to research that suggested the commonly held belief that pregnant women needed to eat for two was a myth.Gaining too much weight during pregnancy could put the future offspring at an increased risk of insulin resistance and affect their blood pressure in childhood, according to the study published in the journal,Diabetologia.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - September 17, 2018 Category: Science Authors: Nicola Davis and Kevin Rawlinson Tags: Pregnancy Parents and parenting Science Family Health & wellbeing Life and style Medical research Society Source Type: news

Lose Weight, Reverse Type 2 Diabetes: Why It Works
Type 2 diabetes is caused by excess fat in the digestive organs, says an English researcher and physician who has seen his patients go into remission. Losing a substantial amount of weight can kill off that fat, often allowing the organs to work again, including a return to normal insulin production by the pancreas. (Source: WebMD Health)
Source: WebMD Health - September 17, 2018 Category: Consumer Health News Source Type: news

Scientists document at the anti-obesity effects of tomato and broccoli
(Natural News) Increased levels of resistin, an adipocyte hormone that regulates glucose metabolism, may cause obesity leading to insulin resistance and Type 2 diabetes. A study published in the journal BMC Complementary and Alternative Medicine reveals that tomato and broccoli can reduce resistin levels and restores insulin sensitivity. Researchers at Helwan University and Modern Sciences... (Source: NaturalNews.com)
Source: NaturalNews.com - September 16, 2018 Category: Consumer Health News Source Type: news

After a century, insulin is STILL wildly expensive at $400 a month
Operating in a regulatory blind spot, DIYers could upset the status quo for drug production. It's risky but researchers say it's the only way to help struggling Americans to survive. (Source: the Mail online | Health)
Source: the Mail online | Health - September 16, 2018 Category: Consumer Health News Source Type: news

Obesity Still on the Rise; Divide Over BPA Safety; DIY Insulin?
(MedPage Today) -- News and commentary from the endocrinology world (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - September 14, 2018 Category: Endocrinology Source Type: news

After a century, insulin is STILL wildly expensive at $400 a month
Operating in a regulatory blind spot, DIYers could upset the status quo for drug production. It's risky but researchers say it's the only way to help struggling Americans to survive. (Source: the Mail online | Health)
Source: the Mail online | Health - September 14, 2018 Category: Consumer Health News Source Type: news

BPA exposure linked to insulin resistance
Research, published in the Journal of the Endocrine Society, suggests that exposure to BPA can change insulin response in adults without diabetes.MedicalXpress (Source: Society for Endocrinology)
Source: Society for Endocrinology - September 14, 2018 Category: Endocrinology Source Type: news

Immune cells in fat may contribute to type-2 diabetes
CD8+ T cells can cause inflammation in fatty tissue leading insulin resistance, according to a study published inDiabetes.MedicalXpress (Source: Society for Endocrinology)
Source: Society for Endocrinology - September 14, 2018 Category: Endocrinology Source Type: news

Macimorelin as a Diagnostic Test for Adult GH Deficiency Macimorelin as a Diagnostic Test for Adult GH Deficiency
The oral macimorelin test may be a safe and reliable alternative to the insulin tolerance test for the diagnosis of adult GH deficiency.Journal of Clinical Endocrinology & Metabolism (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 14, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

DIY Artificial Pancreas Users Tweet it'Changes Lives'DIY Artificial Pancreas Users Tweet it'Changes Lives '
Study based on use of the #OpenAPS Twitter hashtag suggests that users of the DIY hack of an insulin pump and continuous glucose monitor perceive it as effective, safe, and life changing.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 13, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Scientists Are Developing New Ways to Treat Disease With Cells, Not Drugs
When Nichelle Obar learned she was pregnant with her second child last year, she never expected that her pregnancy, or her baby, would make history. But when the 40-year-old food-and-beverage coordinator from Hawaii and her fiancé Christopher Constantino went to their 18-week ultrasound, they learned something was wrong. The heart was larger than it should have been, and there was evidence that fluid was starting to build up around the organ as well. Both were signs that the fetus was working extra hard to pump blood to its fast-growing body and that its heart was starting to fail. Obar’s doctor knew what coul...
Source: TIME: Science - September 13, 2018 Category: Science Authors: Alice Park Tags: Uncategorized medicine Source Type: news

Scientists Are Developing New Ways to Treat Disease With Cells, Not Drugs
When Nichelle Obar learned she was pregnant with her second child last year, she never expected that her pregnancy, or her baby, would make history. But when the 40-year-old food-and-beverage coordinator from Hawaii and her fiancé Christopher Constantino went to their 18-week ultrasound, they learned something was wrong. The heart was larger than it should have been, and there was evidence that fluid was starting to build up around the organ as well. Both were signs that the fetus was working extra hard to pump blood to its fast-growing body and that its heart was starting to fail. Obar’s doctor knew what coul...
Source: TIME: Health - September 13, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Innovation Health medicine Source Type: news

Open insulin, 'DIY bio' and the future of pharma
(Colorado State University) The development, manufacture and sale of pharmaceutical drugs in the United States is a complex landscape of intellectual property and federal regulation. The status quo of the US pharmaceutical market may soon be turned on its head. That's due in part to a growing community of do-it-yourself 'biohackers' who are disrupting business-as-usual for pharmaceutical discovery, development and distribution. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 13, 2018 Category: International Medicine & Public Health Source Type: news

BPA exposure in US-approved levels may alter insulin response in non-diabetic adults
(University of Missouri-Columbia) In a first study of its kind study, researchers have found that a common chemical consumers are exposed to several times a day may be altering insulin release. Results of the study, led by scientists at the University of Missouri, indicate that the Food and Drug Administration-approved 'safe' daily exposure amount of BPA may be enough to have implications for the development of Type 2 diabetes and other metabolic diseases. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 13, 2018 Category: Biology Source Type: news

Online resource to support and assist adults with Type 1 diabetes
NHS England ’s deputy national clinical director for diabetes, Dr Partha Kar, has written to colleagues to draw attention to the nhs.uk online diabetes resource which provides practical information at diagnosis, such as videos on how to inject insulin, how to check blood glucose levels and the check-ups and a ppointments they should attend. (Source: NHS Networks)
Source: NHS Networks - September 13, 2018 Category: UK Health Source Type: news

Anthocyanins, abundantly found in berries, treat insulin resistance while managing cholesterol levels
(Natural News) Two of the biggest, most common health problems people face as they age are diabetes and heart disease. Although their mechanisms are different, scientists have discovered that one natural compound found in food can be helpful in both conditions. Anthocyanins are a type of antioxidant that have been linked to several impressive health... (Source: NaturalNews.com)
Source: NaturalNews.com - September 12, 2018 Category: Consumer Health News Source Type: news

Gene tech ­ no ­ logy brings more pre ­ cise in ­ for ­ ma ­ tion on the causes of dia ­ betes
(University of Helsinki) Dysfunction in insulin-producing pancreatic cells is the ultimate cause of diabetes. A new doctoral study introduces a novel model to study the molecular mechanisms behind this dysfunction with the help of pluripotent stem cells and CRISPR-Cas9 gene editing. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 12, 2018 Category: International Medicine & Public Health Source Type: news

Diabetes Patients Beg, Ration Insulin in Cost Crisis Diabetes Patients Beg, Ration Insulin in Cost Crisis
The high cost of insulin is driving some patients to reuse supplies and hoard insulin, with serious health implications -- sometimes even death.Medscape Diabetes & Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 11, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Expert Column Source Type: news

H19 gene protects against obesity
Research, published inNature Communications, suggests that the H19 gene can protect against obesity and insulin resistance.MedicalXpress (Source: Society for Endocrinology)
Source: Society for Endocrinology - September 11, 2018 Category: Endocrinology Source Type: news

A new understanding in insulin signalling
Research, published iniScience, suggests that cells respond in different ways to a high or low concentration of insulin exposure. Science Daily (Source: Society for Endocrinology)
Source: Society for Endocrinology - September 11, 2018 Category: Endocrinology Source Type: news

Insulet names its female president as next CEO
Billerica-based Insulet Corp. has announced that its president and chief operating officer, Shacey Petrovic, will take over as CEO next year, likely becoming the state ’s largest company by market cap to be headed by a woman. Insulet’s current CEO, Patrick Sullivan, plans to retire from the role as of Jan. 1, 2019, according to the Monday announcement. Maker of the Omnipod insulin pump for patients with type 1 diabetes, Insulet (Nasdaq: PODD) employs about 1 ,000 people and is one of the most… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 11, 2018 Category: Biotechnology Authors: Don Seiffert Source Type: news

Insulet names its female president as next CEO
Billerica-based Insulet Corp. has announced that its president and chief operating officer, Shacey Petrovic, will take over as CEO next year, likely becoming the state ’s largest company by market cap to be headed by a woman. Insulet’s current CEO, Patrick Sullivan, plans to retire from the role as of Jan. 1, 2019, according to the Monday announcement. Maker of the Omnipod insulin pump for patients with type 1 diabetes, Insulet (Nasdaq: PODD) employs about 1 ,000 people and is one of the most… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - September 11, 2018 Category: Pharmaceuticals Authors: Don Seiffert Source Type: news

'Ground-breaking' diabetes insulin drug trialled in Cardiff
It is hoped that it will cut the reliance of diabetes sufferers on injecting insulin. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - September 10, 2018 Category: Consumer Health News Source Type: news

Medical News Today: Natural ways to improve insulin sensitivity
Low insulin sensitivity can cause blood sugar levels to become too high and may lead to type 2 diabetes. Natural ways of improving insulin sensitivity include exercising more, getting enough sleep, eating a diet rich in saturated fats and soluble fiber, and taking certain dietary supplements. Learn more here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 10, 2018 Category: Consumer Health News Tags: Diabetes Type 2 Source Type: news

Higher Aldosterone Levels Tied to Incident Type 2 Diabetes Risk
MONDAY, Sept. 10, 2018 -- Higher levels of aldosterone are associated with insulin resistance and incident type 2 diabetes mellitus among multiethnic individuals, according to a study published in the Sept. 4 issue of the Journal of the American... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 10, 2018 Category: Pharmaceuticals Source Type: news

Insulin’s high cost leads to deadly rationing
Diabetic ketoacidosis is a terrible way to die. It’s what happens when you don’t have enough insulin. (Source: ABC News: Health)
Source: ABC News: Health - September 7, 2018 Category: Consumer Health News Tags: Health Source Type: news

Mellitus Health, Smart Meter ink insulin titration deal
Mellitus Health and Smart Meter inked a partnership this week to combine real-time blood glucose data with insulin titration tech. According to the terms of the deal, healthcare providers using Mellitus Health’s Insulin Insights titration service will have access to real-time patient data from Smart Meter’s iGlucose Cellular Diabetes Care solution. Combining these offerings will help healthcare teams better manage patients’ insulin therapy regimens, according to the companies. Get the full story at our sister site, Drug Delivery Business News. The post Mellitus Health, Smart Meter ink ...
Source: Mass Device - September 7, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Diabetes Drug-Device Combinations Pharmaceuticals mellitushealth smartmeter Source Type: news

A study of ants provides information on the evolution of social insects
(Johannes Gutenberg Universitaet Mainz) A major characteristic of eusocial species is the division of labor between queens and. But what determines this distinction? And how did it come about during the course of evolution? Dr. Romain Libbrecht of Mainz University in cooperation with researchers at Rockefeller University in NYC has found a completely unexpected answer: One single gene called insulin-like peptide 2 (ILP2), which is probably activated by better nutrition, stimulates the ovaries and triggers reproduction. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 7, 2018 Category: International Medicine & Public Health Source Type: news

Leading insulin manufacturer is stockpiling FOUR MONTHS' supply to protect diabetics after Brexit
Novo Nordisk, a Danish company which supplies more than half of the UK's insulin, says it will stash a 16 week supply to make sure the millions of diabetics who rely on the drug aren't hit by Brexit. (Source: the Mail online | Health)
Source: the Mail online | Health - September 5, 2018 Category: Consumer Health News Source Type: news

Losing just six hours of sleep could increase diabetes risk, study finds
(American Physiological Society) Losing a single night's sleep may affect the liver's ability to produce glucose and process insulin, increasing the risk of metabolic diseases such as hepatic steatosis (fatty liver) and type 2 diabetes. The findings of the mouse study are published ahead of print in the American Journal of Physiology--Endocrinology and Metabolism. The research was chosen as an APSselect article for September. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 5, 2018 Category: International Medicine & Public Health Source Type: news

New Hormonal Link Suspected in Type 2 Diabetes
In type 2 diabetes, he said, aldosterone can affect how the body uses another hormone -- insulin. Insulin ushers sugar from foods into the body's cells so it can be used as fuel to provide energy. (Source: WebMD Health)
Source: WebMD Health - September 4, 2018 Category: Consumer Health News Source Type: news

Lethal Insulin Prices; Concussion Rays; New VA Questions
(MedPage Today) -- The latest in healthcare investigations (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - September 4, 2018 Category: Neurology Source Type: news

Adding Pharmacist to Team Can Improve Patient Outcomes
Pharmacist roles include helping with insulin treatment, virtual consults, diabetes management (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - September 4, 2018 Category: Respiratory Medicine Tags: Cardiology, Endocrinology, Family Medicine, Geriatrics, Gynecology, Internal Medicine, Allergy, Nursing, Pediatrics, Pharmacy, Psychiatry, Pulmonology, Institutional, Source Type: news

Medical News Today: What role does insulin play in immunity?
Insulin is key in regulating blood sugar levels. When this mechanism malfunctions, it can lead to diabetes. However, does insulin also stimulate immunity? (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 2, 2018 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Insulin's High Cost Leads To Lethal Rationing
(Source: NPR Health and Science)
Source: NPR Health and Science - September 1, 2018 Category: Consumer Health News Authors: Bram Sable-Smith Source Type: news

Insulin boosts the immune system to fight infection
Research, published inCell Metabolism, reveals a pathway connecting insulin signalling and the activity of T cells to boost immune response.Science Daily (Source: Society for Endocrinology)
Source: Society for Endocrinology - August 31, 2018 Category: Endocrinology Source Type: news

Amazonian fruit improves insulin sensitivity
Mice fed an extract of a fruit which only grows in the amazon, show improved glucose tolerance and insulin sensitivity, according to research published inGut. Science Alert (Source: Society for Endocrinology)
Source: Society for Endocrinology - August 31, 2018 Category: Endocrinology Source Type: news

Immune cell checkpoints implicated in type-1 diabetes
Research, published inFrontiers in Immunology, suggests that specific immune cells, which fail to respond to checkpoint molecules, attack insulin-producing cells in a model of type-1 diabetes.Science Daily (Source: Society for Endocrinology)
Source: Society for Endocrinology - August 30, 2018 Category: Endocrinology Source Type: news