More Games With U.S. Insulin Prices and Coupons
This week, I did something unplanned: I bought 2 vials of Lilly's " authorized generic " of its brand-name U-100 insulin analog branded as Humalog (insulin lispro rDNA origin) at my neighborhood Walgreens. The reason it was unplanned is because I already met the deductible for my insurance plan, so I hadn't expected to deal with this until it resets in January. But I had a script I last filled before I met the deductible, and the pharmacy sent a text telling me it was time to refill. In reality, I have insulin but its a different brand and a different pharmacy. But Walgreens wants a sale so it was telling me it i...
Source: Scott's Web Log - September 23, 2020 Category: Endocrinology Tags: Admelog Drug Channels drug prices GoodRx Humalog insulin Lilly prescriptions rebates Sanofi Source Type: blogs

Reviewing the Clinical Evidence for NAD+ Upregulation
I recently collaborated on a review paper covering the history of clinical work on upregulation of nicotinamide adenine dinucleotide (NAD) as an approach to therapy. This is of interest to the aging research community because NAD is important to mitochondrial function. NAD levels diminish with age, alongside a loss of mitochondrial function that is known to contribute to the onset and progression of many age-related conditions. Animal studies and a few clinical trials have indicated that increased NAD levels may improve, for example, cardiovascular function in older individuals, as a result of improved mitochondrial functi...
Source: Fight Aging! - September 22, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fasting Mimicking Diet Improves Chemotherapy Effectiveness and Reduces Side Effects
The fasting mimicking diet emerged from efforts to better define the dose-response curve for beneficial effects resulting from a reduced calorie intake. Fasting is beneficial, calorie restriction is beneficial, but where are the dividing lines? How much food can one eat and still obtain near all of the benefits of fasting? As a result of this work, the fasting mimicking diet has undergone clinical testing in cancer patients. Numerous benefits have been demonstrated, and the paper here is an example of the type. In this human trial, fasting mimicking reduced the negative short term impact of chemotherapy on health, and, fur...
Source: Fight Aging! - September 22, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, September 21st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Harvard Health Ad Watch: A feel-good message about a diabetes drug
This 60-second advertisement for Trulicity, a medication for diabetes, is one of the most feel-good medication commercials I’ve ever seen. The narrator never uses the scare tactic of so many other ads, listing the terrible things that could happen if you don’t take the treatment. Instead, from start to finish, music, images, and spoken words deliver empowering, encouraging messages focused on helping your body to do what it’s supposed to be doing despite having diabetes. There’s a lot of good information here, but as in most direct-to-consumer health marketing there’s also some that’s mi...
Source: Harvard Health Blog - September 16, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Diabetes Drugs and Supplements Health Source Type: blogs

Increased Insulin Receptor Expression Improves Memory in Old Rats
This is a interesting example of modulating the metabolism of the aging brain in order to improve its function, without any attempt to address the underlying cell and tissue damage that causes loss of function. Researchers delivered recombinant insulin receptor protein to the hippocampus of old rats, and demonstrated improved memory function as an outcome of this intervention. An age-related decline in insulin metabolism has been implicated in neurodegenerative conditions, but it is somewhat hard to pick this apart from reduced blood flow, blood-brain barrier dysfunction, and other related issues that contribute to the dec...
Source: Fight Aging! - September 14, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

How I was wrong about health care
An excerpt from Butchered by “Healthcare”: What to Do About Doctors, Big Pharma, and Corrupt Government Ruining Your Health and Medical Care. Doctors help patients, and they love us for it. We fix bones, replace joints, cure killer infections, and control diabetes with insulin. We use painless scans for diagnosis. Liver, ki dney, and heart transplants […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 5, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/robert-yoho" rel="tag" > Robert Yoho, MD < /a > < /span > Tags: Policy Public Health & Source Type: blogs

A patient with chest pain and ST Elevation in V1 and V2
A 56 year old male complained of chest pain and called 911.They recorded a prehospital ECG:As you can see, at the top it says ***Meet ST Elevation MI Criteria***The medics activated the cath lab prehospital.It is a pathognomonic ECG.What is it?This is hyperkalemia, severe.  Surprisingly, there appear to be P-waves, which are often extinguished when the K is so high.Severe hyperkalemia often presents with STE in V1 and V2, often with a Brugada-like morphology (tall R in V1, or rSR'; downsloping ST segment; negative T-wave.  There is a very wide QRS and very peaked T-waves.  Especially in V4 and V5, T-waves ar...
Source: Dr. Smith's ECG Blog - September 5, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs

The next Wheat Belly 10-Day Grain Detox Challenge begins Wed Sept 16th!
Yes, you may still be practicing social distancing  during the COVID-19 pandemic. But you can still begin the process of reclaiming health, losing weight, and emerging from this national crisis in far better shape than when it started. And ask any successful Wheat Belly follower: Do you get sick like other people with viral illnesses every year? You will receive a resounding “NO”: people living this lifestyle enjoy a huge reduction in viral infections that plague other people. We cannot claim that this makes you resistant to coronavirus, but it surely helps to achieve the higher levels of health that we ac...
Source: Wheat Belly Blog - September 1, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open Detox Inflammation Weight Loss wheat belly Source Type: blogs

Fight Aging! Newsletter, August 31st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 30, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Human Studies Link Calorie Restriction to Improved Cardiometabolic Status
The data noted here is not news to anyone who has followed calorie restriction research. It is well understood that the practice of calorie restriction is beneficial to long term health, reducing the impact of aging over time. It extends life by up to 40% in mice, but is nowhere near as effective as that in longer-lived mammals, such as our own species, even given similar short-term effects on metabolism. That said, it is interesting to note that enough robust studies of calorie restriction in humans have taken place over the past few decades to justify review papers on the topic. Uncertainty remains about the ri...
Source: Fight Aging! - August 28, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Public Cannot Distinguish Between Scientific versus Unscientific, Likely Good versus Likely Bad Approaches to Longevity
One of the challenges inherent in patient advocacy for greater human longevity, for more research into aging and rejuvenation, is that journalists and the public at large either cannot or will not put in the effort needed to distinguish between: (a) scientific, plausible, and likely useful projects, those with a good expectation of addressing aging to a meaningful degree; (b) scientific, plausible, and likely unhelpful projects, those that will do little to move the needle on life expectancy, and (c) products and programs that consist of marketing, lies, and little else. This last category is depressingly large, and the fi...
Source: Fight Aging! - August 20, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Does diet really matter when it comes to adult acne?
When I was a teenager, the advice I got about acne was clear and consistent: Avoid oily foods and chocolate because they trigger breakouts and make existing acne worse Wash your face often Try a topical, over-the-counter remedy such as those containing benzoyl peroxide (Clearasil) or salicylic acid (Stridex). By the time I got to medical school, the message had changed. I learned that the diet-acne connection was considered a myth, and that what we eat has little to do with making acne better or worse. But a new study has once again turned the tables. It suggests that diet might contribute to acne — at least in adu...
Source: Harvard Health Blog - August 19, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Healthy Eating Skin and Hair Care Source Type: blogs

Fight Aging! Newsletter, August 17th 2020
In this study, we sought to elucidate the role of VRK-1 in regulation of adult life span in C. elegans. We found that overexpression of VRK-1::GFP (green fluorescent protein), which was detected in the nuclei of cells in multiple somatic tissues, including the intestine, increased life span. Conversely, genetic inhibition of vrk-1 decreased life span. We further showed that vrk-1 was essential for the increased life span of mitochondrial respiratory mutants. We demonstrated that VRK-1 was responsible for increasing the level of active and phosphorylated form of AMPK, thus promoting longevity. A Fisetin Variant, C...
Source: Fight Aging! - August 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Should Rapamycin be Prescribed Ubiquitously as an Anti-Aging Supplement?
Should rapamycin be prescribed ubiquitously as an anti-aging supplement? That is the question the authors of this commentary ask after a short overview of what is known of the beneficial effects of rapamycin on mechanisms relevant to aging. Research into inhibition of the two mTOR complexes, mTORC1 and mTORC2, via compounds such as rapamycin, is well funded at the present time. Numerous companies are attempting to push mTOR inhibitors through clinical trials. It is perhaps the largest outgrowth of research into the slowing of aging produced by the practice of calorie restriction, in which benefits are largely mediated by a...
Source: Fight Aging! - August 13, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

IGF-1R Inhibition Reduces Neuroinflammation in an Alzheimer's Mouse Model
Chronic inflammation in brain tissue is an important component of the progression of neurodegenerative conditions such as Alzheimer's disease. It is important enough that some researchers propose inflammation resulting from persistent infection and cellular senescence to be the primary mechanism in Alzheimer's disease, and the characteristic accumulation of amyloid-β deposits only a side-effect. Given the failure to achieve meaningful benefits in patients through removal of amyloid-β, researchers are turning their eyes towards ways to suppress inflammatory signaling in the brain. Removal of senescent cells, the s...
Source: Fight Aging! - August 10, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Is exercise the new snake oil? or just a dirty word?
If you haven’t heard about the health benefits of exercise in the last 10 years or longer, then you’ve probably been a hermit! Exercise can do all these wonderful things – help you lose weight, reduce heart disease, moderate insulin and blood glucose levels, improve your mental health, and yes! reduce pain and disability when you’re sore. (check this list out) The claims sound suspiciously similar to the claims made by old snake oil merchants – or the amazing White Cross Electric Vibrator! Well perhaps there’s a little more research supporting claims for exercise… but a...
Source: HealthSkills Weblog - August 10, 2020 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Coping strategies Motivation Professional topics Resilience/Health Science in practice exercise movement persistent pain Source Type: blogs

Fight Aging! Newsletter, August 10th 2020
This study aimed to characterize the role of BDNF in age-related microglial activation. Initially, we found that degrees of microglial activation were especially evident in the substantia nigra (SN) across different brain regions of aged mice. The levels of BDNF and TrkB in microglia decreased with age and negatively correlated with their activation statuses in mice during aging. Interestingly, aging-related microglial activation could be reversed by chronic, subcutaneous perfusion of BDNF. Peripheral lipopolysaccharide (LPS) injection-induced microglial activation could be reduced by local supplement of BDNF, while shTrkB...
Source: Fight Aging! - August 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Microtubule Activity in Dopaminergic Neurons Affects the Pace of Aging in Flies
In an interesting discovery, researchers here note evidence for the behavior of dopamine generating neurons in the fly brain to have an sizable influence on the pace of aging and longevity in this species. This effect on aging appears to depend on microtubule activity in these cells, but the work leaves open the question of how exactly this change to a very specific population of neurons alters life span. Much more is left to accomplish in order to even begin to speculate on relevance to human biochemistry. Dopaminergic neurons, a critical modulatory system in the brain, are greatly affected by age, but it is uncl...
Source: Fight Aging! - August 5, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

GDF15 Helps to Resist Age-Related Chronic Inflammation
In this study, we identified a link between mitochondrial stress-induced GDF15 production and protection from tissue inflammation on aging in humans and mice. We observed an increase in serum levels and hepatic expression of GDF15 as well as pro-inflammatory cytokines in elderly subjects. Circulating levels of cell-free mitochondrial DNA were significantly higher in elderly subjects with elevated serum levels of GDF15. In the BXD mouse reference population, mice with metabolic impairments and shorter survival were found to exhibit higher hepatic Gdf15 expression. Mendelian randomization links reduced GDF15 expressio...
Source: Fight Aging! - August 5, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Health Insurance Needs to Grow Up
By KIM BELLARD I’ve been covered by private insurance my entire life.  Even more telling, I worked in the health insurance industry for — gasp! — some thirty years.  It’s not just paid for my healthcare, it’s financed my life. Today, though, for the first time in my life, I’m covered by public insurance — and I couldn’t be more relieved.   Now, I’m not going to go all Wendell Potter.  I know many people have their health insurance horror stories, but, sadly, people have them about pretty much every part of the healthcare industry. ...
Source: The Health Care Blog - August 3, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Health insurance Kim Bellard Premiums Source Type: blogs

Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the tr...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The next Wheat Belly 10-Day Grain Detox Challenge begins Wed Aug 12th!
Yes, you may still be practicing social distancing  during the COVID-19 pandemic. But you can still begin the process of reclaiming health, losing weight, and emerging from this national crisis in far better shape than when it started. And ask any successful Wheat Belly follower: Do you get sick like other people with viral illnesses every year? You will receive a resounding “NO”: people living this lifestyle enjoy a huge reduction in viral infections that plague other people. We cannot claim that this makes you resistant to coronavirus, but it surely helps to achieve the higher levels of health that we ac...
Source: Wheat Belly Blog - July 30, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open Detox gluten-free grain-free Inflammation Weight Loss wheat belly Source Type: blogs

An Age-Related Increase in CD47 Expression Impairs Vascular Function
Researchers here provide evidence to indicate that increased expression of CD47 in aged blood vessels impairs a range of functions, from maintenance of these tissues to the generation of new blood vessels. The latter point is interesting given that capillary networks become less dense with age. This is thought to impair blood flow to tissues and thus contribute to age-related loss of function. The animal evidence here suggests that inhibition of CD47 may be a viable strategy to reduce the impact of aging on the vasculature, and thus also many of the consequences of vascular aging throughout the body. The aged popu...
Source: Fight Aging! - July 30, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Long Term Low Dose Ethanol Intake Modestly Extends Life in Mice
In this study, we use ethanol, the common substance in all kinds of alcoholic beverages, as a single variable to explore its effects in vivo. Our data showed that the long-term 3.5% ethanol substitution for drinking water had beneficial effects in mice, the daily performance of ethanol-fed mice was enhanced, the athletic ability and healthspan of ethanol-fed mice drastically improved. Furthermore, the ethanol-fed mice showed the resistance to high-fat diet (HFD). When supplemented with 3.5% ethanol, the HFD mice showed reduced multiple organ pathogenicity, increased insulin sensitivity, and decreased NF-kB activation and i...
Source: Fight Aging! - July 29, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Systematic review finds ten lifestyle factors that clearly impact the probability of developing Alzheimer ’s disease (AD)
This study offers a complex picture of how we can combat the onset of Alzheimer’s – as well as ten areas that scientists need to concentrate on researching in the future. Though the findings may seem bleak, there is some promise in that many of these risk factors can be managed or modified through lifestyle changes, including diet and exercise. – Mark Dallas is an Associate Professor in Cellular Neuroscience at University of Reading. This article is republished from The Conversation under a Creative Commons license. News in Context: Brain scans show lower accumulation of tau and amyloid pathology am...
Source: SharpBrains - July 27, 2020 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Alzheimer’s Disease body mass index cognitive activity concussion depression diabetes head trauma High-blood-pressure Stress Source Type: blogs

Coronavirus and insulin resistance
The post Coronavirus and insulin resistance appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - July 24, 2020 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle coronavirus covid covid-19 Inflammation insulin respiratory undoctored viral Source Type: blogs

Nanogenerators Harvest Energy from Body, Monitor Heart Health
Wearable medical devices such as continuous heart rate monitors, insulin pumps, and neural stimulators usually need access to an electric power source in order to function. While there’s a great deal of wasted energy that our body emits that can be harvested to power such devices, making it actually happen using biocompatible materials has proven to be challenging. Now, a team of engineers at Purdue University has shown that polyvinyl alcohol (PVA), one of the most common polymers used in biomedicine, can be used to produce efficient triboelectric nanogenerators (TENGs) that can also act as cardiac activity monitors....
Source: Medgadget - July 22, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Cardiology Diagnostics Materials Medicine Nanomedicine Telemedicine Source Type: blogs

Fight Aging! Newsletter, July 13th 2020
In conclusion, sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol. Exercise Slows Inappropriate Growth of Blood Vessels in a Mouse Model of Macular Degeneration https://www.fightaging.org/archives/2020/07/exercise-slows-inappropriate-growth-of-blood-vessels-in-a-mouse-model-of-macular-degeneration/ Excessive growth of blood vessels beneath the retina is a proximate cause of blindness in conditions such as macular degeneration. Researchers here provide evidence for physical activity to be influential in the pace at which this process of tissue...
Source: Fight Aging! - July 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Sedentary Behavior Correlates with Raised Risk of Age-Related Disease
In conclusion, sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol. Link: https://doi.org/10.1155/2020/3859472 (Source: Fight Aging!)
Source: Fight Aging! - July 7, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The next Wheat Belly 10-Day Grain Detox Challenge begins Wed July 15th!
  Yes, you are still practicing social isolation and sheltering-in-place during the COVID-19 pandemic. But you can still begin the process of reclaiming health, losing weight, and emerging from this national crisis in far better shape than when it started. And ask any successful Wheat Belly follower: Do you get sick like other people with viral illnesses every year? You will receive a resounding “NO”: people living this lifestyle enjoy a huge reduction in viral infections that plague others. We cannot claim that this makes you resistant to coronavirus, but it surely helps to achieve the higher levels of he...
Source: Wheat Belly Blog - July 1, 2020 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Detox gluten-free grain-free Inflammation joint pain Weight Loss Source Type: blogs

Fight Aging! Newsletter, June 22nd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 21, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Going Diabetes Old-School During the Pandemic
During the recent pandemic (between March and June 2020, although we are still not completely out of quarantine, we are now in Phase II of reopening), I decided to go old-school on diabetes supplies.Specifically, I went back to one of the many old blood glucose meters I'd saved over the years. All of them still worked, although I discarded a few for which test strips are no longer sold or had leaked battery acid in the battery compartment.I made a notable exception for one particular meter model...Specifically, I had saved a few of theOneTouch Ultra (1) meters I had in my possession. I also had a few OneTouch Ultra 2 meter...
Source: Scott's Web Log - June 21, 2020 Category: Endocrinology Tags: 2020 Diabetes J & Johnson and Johnson old-school OneTouch testing supplies Source Type: blogs

Medtronic ’s MiniMed 780G with Artificial Pancreas Capabilities Cleared in EU
Medtronic won the EU CE Mark for its MiniMed 780G closed loop insulin pump that features both Medtronic’s own SmartGuard algorithm and MD-Logic, an algorithm developed by DreaMed Diabetes, a small Israeli firm. The system, indicated to be used by patients with type 1 diabetes between ages 7 and 80, automatically delivers both basal insulin and correcting boluses every five minutes, if necessary. Such close monitoring and control of blood glucose levels may help patients stay within a healthy range while reducing worry about forgetting to track every instance of food intake. Target glucose levels can be set to as ...
Source: Medgadget - June 18, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Informatics Medicine Telemedicine Source Type: blogs

A Potentially Safe Mitochondrial Uncoupling Drug Candidate
Mitochondrial uncoupling is the mechanism by which cells generate heat. Mitochondria are the power plants of the cell, a herd of bacteria-like structures that conduct energetic processes to generate the chemical energy store molecule adenosine triphosphate (ATP). ATP is used to power all of the vital biochemical machinery of a cell. Mitochondrial uncoupling is a regulatory mechanism that changes the operation of a mitochondrion such that the energy it accumulates is dissipated as heat rather than powering the chemical reactions needed to generate ATP. This uncoupling is how mammals regulate body temperature. Raised ...
Source: Fight Aging! - June 15, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, June 15th 2020
In this study, we used markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR-induced SG formation but not heat shock. Moreover, our data suggest that this AMPK-eEF2K pathway-mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced ...
Source: Fight Aging! - June 14, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Stress Granules are Required for Calorie Restriction Induced Longevity
In this study, we used markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR-induced SG formation but not heat shock. Moreover, our data suggest that this AMPK-eEF2K pathway-mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced ...
Source: Fight Aging! - June 12, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Lysosomal Activity is Positively Affected by Various Longevity Mutations in Nematodes
The cellular organelles known as lysosomes are packed full of enzymes, enabling the recycling of metabolic waste and damaged or unwanted proteins and structures by breaking them down into their component parts. Lysosomes are a vital part of the mechanisms of autophagy, working to keep cells from being overtaken by damaged and dysfunctional components. Unfortunately, lysosomal function declines with age, particularly in long-lived cells of the nervous system. Not all metabolic waste is easily broken down, and lysosomes become bloated with a mix of compounds known as lipofuscin. This degrades their performance, and cells suf...
Source: Fight Aging! - June 12, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Changes in Muscle Metabolism Cause Beneficial Changes in Fat Metabolism in Long-Lived Dwarf Mice
We report here that white (WAT) and brown (BAT) fat have elevated UCP1 in both kinds of mice, and that adipocytes in WAT depots turn beige/brown. These imply increased thermogenesis and are expected to lead to improved glucose control. Both kinds of long-lived mice show lower levels of inflammatory M1 macrophages and higher levels of anti-inflammatory M2 macrophages in BAT and WAT, with correspondingly lower levels of inflammatory cytokines. Experiments with mice with tissue-specific disruption of GHR showed that these adipocyte and macrophage changes were not due to hepatic IGF1 production nor to direct growth hormone (GH...
Source: Fight Aging! - June 12, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Studies Explore the Question: ‘Has My Insulin Gone Bad?’
Studies Explore the Quality of Insulin for Diabetics (Source: Diabetes Mine)
Source: Diabetes Mine - June 1, 2020 Category: Endocrinology Authors: Mike Hoskins Source Type: blogs

Fight Aging! Newsletter, June 1st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 31, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Five Things You May Not Realize Can Affect Your Mental Health
Did you know diabetes affects your mental health? From depression to relationship problems or mood swings, too much or too little glucose (sugar) circulating in the blood can trigger behavior and thought patterns that may seem unrelated to how much insulin is released by your pancreas. Out of control glucose levels influence how you feel and make decisions, your beliefs and, yes, your attitude, a very necessary component of your overall care.  The U.S. Centers for Disease Control and Prevention (CDC) states less than half the number of people with diabetes who have depression get treated, which leads to worsening stat...
Source: World of Psychology - May 30, 2020 Category: Psychiatry & Psychology Authors: Jan McDaniel Tags: Mental Health and Wellness Comorbidities Diabetes Drug Interactions Nutrition Source Type: blogs

The next Wheat Belly 10-Day Grain Detox Challenge begins Wed June 10th!
Yes, you are still practicing social isolation and sheltering-in-place during the COVID-19 pandemic. But you can still begin the process of reclaiming health, losing weight, and emerging from this national crisis in far better shape than when it started. And ask any successful Wheat Belly follower: Do you get sick like other people with viral illnesses every year? You will receive a resounding “NO”: people living this lifestyle enjoy a huge reduction in viral infections that plague others. We cannot claim that this makes you resistant to coronavirus, but it surely helps to achieve the higher levels of health th...
Source: Wheat Belly Blog - May 29, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open grain-free grains Inflammation Weight Loss wheat belly wheat belly detox Source Type: blogs

Reviewing the Prospects for Nicotinamide Mononucleotide Supplementation to Raise NAD+ Levels and Improve Health
A fair amount of effort is presently put towards the exploration of supplements derived from vitamin B3 compounds (nicotinamide, niacin, nicotinamide riboside) that act as precursors to enable the manufacture of nicotinamide adenine dinucleotide (NAD). NAD is an important component in mitochondrial activity, and levels decline with age. Some portion of the loss of mitochondrial function, implicated in the progression of many age-related conditions, is due to NAD insufficiency. There is a rich history of the use of high doses of vitamin B3 as an intervention, most of it predating modern understanding of the role of NAD in m...
Source: Fight Aging! - May 29, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Visceral Fat Behaves Differently in Long-Lived Dwarf Mice
A few varieties of dwarf mice exhibit considerable longevity. They are produced via forms of mutation that disable portions of growth hormone metabolism, such as via growth hormone receptor knockout. Most research has thus focused on insulin signaling, IGF-1, and other pathways closely tied to growth hormone. Here, scientists instead focus on the behavior of fat tissue in these long-lived mouse lineages, suggesting that the significant differences they observe in the metabolism of visceral fat may contribute to the impact on aging. It is well known that visceral fat is metabolically active, and excess amounts create...
Source: Fight Aging! - May 29, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

12 Diabetes Problems That New " Smart " Insulin Pens Can Solve
DiabetesMine explains exactly how new digitally connected insulin pens can improve life for people with diabetes. (Source: Diabetes Mine)
Source: Diabetes Mine - May 27, 2020 Category: Endocrinology Authors: Wil Dubois Source Type: blogs

Vaccination as a Limited Option for Removal of Senescent Cells
In today's open access paper, the authors demonstrate a form of vaccination against a surface marker that appears on a subset of senescent T cells that reside in fat tissue, thus directing the rest of the immune system to attack and destroy these cells. There is good evidence for excess fat tissue to result in an increased burden of senescent cells, which disrupt metabolism via the generation of inflammatory signals. A novel branch of medicine is under construction, based on senolytic therapies capable of selectively destroying senescent cells in aged tissues. The growing numbers of senescent cells in older people (and eve...
Source: Fight Aging! - May 26, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Secreted Stem Cell Factors as a Treatment for Male-Pattern Baldness
Both hair graying and hair loss with age are well researched topics, but there remains considerable uncertainty over which of the possible mechanisms involved are the most relevant, or most useful as targets for therapy. This state of affairs is well illustrated by the feverish interest that attends any possible advance towards reversing male and female pattern baldness. Also the sizable marketplaces devoted to treatments that work poorly, if at all. Today's trial results are interesting, in that I don't recall seeing stem cell factors being used topically before. There is of course a great deal of nonsense and unsc...
Source: Fight Aging! - May 25, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs