GLP-1 medications like Wegovy are effective metabolic health tools for teens with insulin resistance
Lizzie is a 13-year-old with a great sense of humor. She tells it like it is, especially to her Mom, Jackie, who admits to being a bit of an Almond Mom (the parent who is stuck in a weight-focused diet culture). Jackie leads a very healthy lifestyle and has never had to deal with being
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GLP-1 medications like Wegovy are effective metabolic health tools for teens with insulin resistance originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 17, 2024 Category: General Medicine Authors: Karla Lester, MD Tags: Meds Obesity Pediatrics Source Type: blogs
From Patent To Product: The Speed Of The Digital Health Evolution
We’re bombarded with mindblowing headlines of new medical miracles every day. BCI helps paralysed patients talk again! Robots in the stomach! Micro-organs on organ-on-chip technologies! But it is almost impossible to see through the hype and know if and when these will yield actual, patient-ready solutions. So let’s get into this maze and decipher how a new, revolutionary medical technology develops from an ingenious idea to a market-ready product with two real-life examples: the artificial pancreas and wireless ECG.
In early April, the UK’s NHS rolled out an artificial pancreas (APS) for Type 1 diabetes patients,...
Source: The Medical Futurist - April 16, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF artificial intelligence digital health Innovation patent analysis Medicine Source Type: blogs
Lilly's Carelessness in Discontinuing 3 mL vials of Humalog Causes Shortages in 10 mL vials of Humalog + Unbranded Lispro
Last week, the JDRF shared newshttps://x.com/JDRF/status/1770848177354137650 in a series of three Tweets about how Eli Lilly& Company, Inc. was reporting that 10 mL vials of Humalog and the company ' s identical, unbranded (meaning Lilly sells it using the generic drug name rather than brand-name Humalog) version of Humalog known as Lilly Insulin Lispro Injection could be facing temporary lack of availability in selected locations around the country. Lilly tried to reassure everyone that it was only a temporary issue. But while Lilly complains it cannot keep up with demand for Mounjaro/Zepbound, it is having its own su...
Source: Scott's Web Log - April 9, 2024 Category: Endocrinology Tags: Eli Lilly and Company 2024 Humalog lispro vials Source Type: blogs
Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Costco Weight-Loss Program: Omission of Critical Data Puts Patients at (Financial) Risk
This week, the world learned that Costco Wholesale would start selling Novo Nordisk ' s newest, but vastly overpriced GLP-1 inhibitor medicine known generically as semaglutide (sold under the brand names Ozempic and Rybelsus for Type 2 diabetes, and under the brand name of Wegovy for weight-loss for those with obesity without Type 2 diabetes). We learned of the Costco GLP-1 initiative from a press release from Costco ' s strategic partner known as Sesamehttps://sesamecare.com/ which is the entity which will connect patients with its network of thousands of outpatient healthcare providers nationwide who are more than w...
Source: Scott's Web Log - April 3, 2024 Category: Endocrinology Tags: 2024 biosimilars Costco GLP-1 inhibitor liraglutide semaglutide Sesame Source Type: blogs
A Stem Cell Secretome Treatment Improves Measures of Health in Old Mice
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 1, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Interview with Stefany Shaheen: Revolutionizing diabetes care through cell therapies
I had the extraordinary opportunity to chat with Stefany Shaheen, the Chief Strategy Officer of Advanced Regenerative Manufacturing Institute (ARMI) and BioFab USA, about the transformative potential of cell therapies for individuals living with diabetes. Stefany shared her remarkable journey, insights on cell therapies’ current status, approval challenges, and how the diabetes community can contribute to advancing research in this field.
A few months before this discussion with Stefany, I had the opportunity to hear Dean Kamen speak at the recent ...
Source: Scott's Diabetes Blog - April 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Human Exosomes Harvested from Stem Cells in Urine Produce Rejuvenation in Mice
In this study, we further analyzed these data and found that a class of USC-EVs-enriched proteins have been previously shown to possess anti-aging function, such as tissue inhibitor of metalloproteinases 1 (TIMP1), plasminogen activator urokinase (PLAU), insulin-like growth factor binding protein 5, senescence marker protein-30, and connective tissue growth factor. Thus, we hypothesized that USC-EVs might be capable of rejuvenating old organs from aging via transferring of anti-aging proteins.
Here, we tested the effects of USC-EVs on cellular senescence in vitro and on the aging-related phenotypes in different orga...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Will Americans Get PBM Reform in 2024? Maybe, But Many Things Need to Happen I Order to Get There. On the Upside: Insulin Has Opted Out of PBM Sales.
At the core of this post is a YouTube video which can be viewed in the middle of this blog post. The subject is about whether we ' ll get much-needed legislation passed into law to reform corrupt Pharmacy Benefit Managers (PBMs) which we know with absolute certainty were at fault for runaway insulin prices. At least that was true until March 2023, when the three largest insulin manufacturers, starting withLilly, followed byNovo Nordisk and shortly thereafter,Sanofi all announced major insulin list price reductions in the range of 70% to 78%. Think about that for a second: Imagine being able to instantly...
Source: Scott's Web Log - March 17, 2024 Category: Endocrinology Tags: 2024 Congress insulin prices PBM rebates reform Source Type: blogs
Will Americans Get PBM Reform in 2024? Maybe, But Many Things Need to Happen In Order to Get There. On the Upside: Insulin Has Opted Out of PBM Sales.
At the core of this post is a YouTube video which can be viewed in the middle of this blog post. The subject is about whether we ' ll get much-needed legislation passed into law to reform corrupt Pharmacy Benefit Managers (PBMs) which we know with absolute certainty were at fault for runaway insulin prices. At least that was true until March 2023, when the three largest insulin manufacturers, starting withLilly, followed byNovo Nordisk and shortly thereafter,Sanofi all announced major insulin list price reductions in the range of 70% to 78%. Think about that for a second: Imagine being able to instantly...
Source: Scott's Web Log - March 17, 2024 Category: Endocrinology Tags: 2024 Congress insulin prices PBM rebates reform Source Type: blogs
Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
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Considering the Mechanisms of Vascular Calcification
https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/
Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is It Worth Buying Dexcom CGM Sensors from Best Buy Health? The only way to know with certainty is to do the math!
Last autumn, on October 9, 2023, the electronics retailer Best Buy announced (seehttps://www.businesswire.com/news/home/20231009526652/en/Best-Buy-to-Sell-Continuous-Glucose-Monitoring-Systems/ for the press release) that it had started a mail order business called "Best Buy Health"https://wellness.bestbuyhealth.com/ which it said would sell CGM sensors among other products. Best Buy Health aims to sell more than just CGM sensors. Its LinkedIn page https://www.linkedin.com/company/best-buy-health/ describes the business this way:" Best Buy Health aims to enrich and save lives through technology and meaningful connections. ...
Source: Scott's Web Log - March 9, 2024 Category: Endocrinology Tags: 2023 2024 Best Buy Best Buy Health Costco Source Type: blogs
Restriction of RNA Polymerase I Activity Extends Life in Nematode Worms
RNA Polymerase I (Pol I) is prominent in the regulatory systems managing the nutrient-driven tradeoff between growth and longevity. It is responsible for producing a sizable fraction of RNA, reading from gene sequences and assembling corresponding RNA molecules. As such, it is responsible for initiating some of the most energetically expensive processes in the cell, including translation of messenger RNA into proteins. Suppression of the production of proteins is a consequence of low calorie intake, an intervention known to slow aging, and researchers have shown that interfering in RNA synthesis can also extend life in sho...
Source: Fight Aging! - March 4, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
