Insulin-induced conformational transition of fluorescent copolymer: A perspective of self-assembly between protein and micellar solution of smart copolymer
Phys. Chem. Chem. Phys., 2020, Accepted Manuscript DOI: 10.1039/D0CP00645A, PaperKrishan Kumar, Navin Kumar Kumar Mogha, Ritu Yadav, Pannuru Venkatesu Synthesizing and understanding phase transition behavior of novel block copolymers is very crucial for fabricating next generation of smart materials with foreseeable applications. In this regard, we synthesized three random... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 2, 2020 Category: Chemistry Authors: Krishan Kumar Source Type: research

Association between adherence to the Mediterranean Diet and circulating Vitamin D levels.
This study argues that a closer adherence to Med-Diet is independently associated with an increase of 25(OH)D suggesting that higher vitamin D levels may contribute to the protective effect of the Med-Diet on osteoporosis. PMID: 32223463 [PubMed - as supplied by publisher] (Source: International Journal of Food Sciences and Nutrition)
Source: International Journal of Food Sciences and Nutrition - April 2, 2020 Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research

[ASAP] Oleanane Triterpenoids from the Leaves of < italic toggle="yes" > Gymnema inodorum < /italic > and Their Insulin Mimetic Activities
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.0c00051 (Source: Journal of Natural Products)
Source: Journal of Natural Products - April 2, 2020 Category: Biochemistry Authors: Jin-Pyo An †, Eun Jin Park†, Byeol Ryu†, Ba Wool Lee†, Hyo Moon Cho†, Thi Phuong Doan†, Ha Thanh Tung Pham‡, and Won Keun Oh*† Source Type: research

Catalog of exogenous risk factors for bladder carcinogenesis
Purpose of review The aim of this article is to provide an overview of recent findings regarding the risk factors for bladder cancer. Recent findings Most of the available data derive from retrospective analysis. Smoking represents the most common and important risk factor. Occupational, dietary, and environmental exogenic carcinogen exposure, as well as several lifestyle factors, can increase the risk of developing bladder cancer. Summary Bladder cancer is a common malignancy worldwide. Cigarette smoking, exposure to aromatic amines and arsenic are known risk factors for bladder cancer. Evidence on other modifiabl...
Source: Current Opinion in Urology - April 1, 2020 Category: Urology & Nephrology Tags: BLADDER CANCER: Edited by Juan Palou and Óscar Rodríguez Faba Source Type: research

Use of Insulin Syringes for Precision Filler in Periocular and Rhinoplasty Procedures
No abstract available (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - April 1, 2020 Category: Dermatology Tags: Letters and Communications Source Type: research

[ASAP] Bound Phenolics Ensure the Antihyperglycemic Effect of Rice Bran Dietary Fiber in < italic toggle="yes" > db < /italic > / < italic toggle="yes" > db < /italic > Mice via Activating the Insulin Signaling Pathway in Skeletal Muscle and Altering Gut Microbiota
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.0c00584 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - April 1, 2020 Category: Food Science Authors: Xinwen Zhang †‡, Lihong Dong†, Xuchao Jia†, Lei Liu†, Jianwei Chi†, Fei Huang†, Qin Ma†, Mingwei Zhang*†‡, and Ruifen Zhang*† Source Type: research

Insulin Autoimmune Syndrome (Hirata Disease): A Comprehensive Review Fifty Years After Its First Description
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 1, 2020 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

Use of SGLT2 Inhibitors in Older Adults: Scientific Evidence and Practical Aspects
AbstractDiabetes mellitus (DM) is an increasingly prevalent condition that has a significant impact on health systems worldwide, particularly in older people. It is estimated that 30% of people aged  >  65 years fulfil the diagnostic criteria for DM, with 90% having type 2 DM (T2DM). Generally, specific guidelines for the treatment of T2DM in older people address in a very limited manner the use of more recent therapies, such as sodium–glucose co-transporter-2 inhibitors (SGLT2i), which have important benefits for older people, such as a low risk of hypoglycemia, reduction of cardiovascular and ...
Source: Drugs and Aging - April 1, 2020 Category: Geriatrics Source Type: research

Provision of Bidirectional Remote Patient Care With an Unmanned Aerial Vehicle
We report the world ’s first medication delivery with return blood sample collection from a patient living in an island community, using an unmanned aerial vehicle (UAV), commonly known as drone technology. Medical drones have shown potential to deliver life-saving supplies (eg, blood, vaccines, defibrillators) to un derdeveloped areas of the world and during emergencies.1,2 We recently employed a vertical takeoff and landing (VTOL) Wingcopter 178 drone under beyond visual line of sight (BVLOS) conditions to deliver insulin and glucagon to the Aran Islands (Inis Mór Aerodrome, IATA: IOR / ICAO:EIIM) from ...
Source: Mayo Clinic Proceedings - April 1, 2020 Category: Internal Medicine Authors: Derek T. O ’Keeffe, Kevin Johnson, Spyridoula Maraka Tags: Letter to the editor Source Type: research

IJERPH, Vol. 17, Pages 2404: Contact Allergy —Emerging Allergens and Public Health Impact
IJERPH, Vol. 17, Pages 2404: Contact Allergy—Emerging Allergens and Public Health Impact International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072404 Authors: Uter Werfel Lepoittevin White Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science&amp;trade;; additionally, all available issues of the journals &amp;ldquo;Contact Dermatitis&amp;rdquo; and &amp;ldquo;Dermatitis&a...
Source: International Journal of Environmental Research and Public Health - April 1, 2020 Category: Environmental Health Authors: Uter Werfel Lepoittevin White Tags: Review Source Type: research

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic {beta}-cells in vitro by activation of Smoothened [Research Articles]
In conclusion, the protective effect of HDL to counter ER stress and β-cell death involves the transport, generation, and mobilization of oxysterols for activation of the Hh signaling receptor SMO (Source: The Journal of Lipid Research)
Source: The Journal of Lipid Research - April 1, 2020 Category: Lipidology Authors: Yalcinkaya, M., Kerksiek, A., Gebert, K., Annema, W., Sibler, R., Radosavljevic, S., Lütjohann, D., Rohrer, L., von Eckardstein, A. Tags: Research Articles Source Type: research

PET Imaging of Pancreatic Dopamine D2 and D3 Receptor Density with 11C-(+)-PHNO in Type 1 Diabetes
Conclusion: Thirty-minute scan durations and SUVR-1 provide quantitative outcome measures for 11C-(+)-PHNO, a dopamine D3 receptor–preferring agonist PET radioligand, to differentiate BCM in T1DM and HCs. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Authors: Bini, J., Sanchez-Rangel, E., Gallezot, J.-D., Naganawa, M., Nabulsi, N., Lim, K., Najafzadeh, S., Shirali, A., Ropchan, J., Matuskey, D., Huang, Y., Herold, K. C., Harris, P. E., Sherwin, R. S., Carson, R. E., Cline, G. W. Tags: Clinical Source Type: research

An Experimental Series Investigating the Effects of Hyperinsulinemic Euglycemia on Myocardial Blood Flow Reserve in Healthy Individuals and on Myocardial Perfusion Defect Size following ST-Segment Elevation Myocardial Infarction
Incomplete restoration of myocardial blood flow (MBF) is reported in up to 30% of ST-segment elevation myocardial infarction (STEMI) despite prompt mechanical revascularization. Experimental hyperinsulinemic euglycemia (HE) increases MBF reserve (MBFR). If fully exploited, this effect may also improve MBF to ischemic myocardium. Using insulin-dextrose infusions to induce HE, we conducted four experiments to determine (1) how insulin infusion duration, dose, and presence of insulin resistance affect MBFR response; and (2) the effect of an insulin-dextrose infusion given immediately following revascularization of STEMI on my...
Source: Journal of the American Society of Echocardiography - April 1, 2020 Category: Cardiology Authors: Michael C.Y. Nam, Annelise L. Meneses, Christopher D. Byrne, Tuppence Richman, Jing Xian Quah, Tom G. Bailey, Ingrid Hickman, Chris Anstey, Christopher D. Askew, Roxy Senior, Tony Stanton, Anthony W. Russell, Kim Greaves Source Type: research

Associations of birthweight and history of childhood obesity with beta cell mass in Japanese adults
AbstractAims/hypothesisLow birthweight is associated with a high risk of diabetes, but there are no reports discussing birthweight and pancreatic tissues in humans. The purpose of this study was to examine the correlation between birthweight and beta and alpha cell mass in humans.MethodsSixty-four Japanese adults with and without diabetes who underwent pancreatectomy and were able to recall their weight history including birthweight were included. Pancreatic tissues were stained for insulin and glucagon, and fractional beta cell area (BCA) and alpha cell area (ACA) were quantified. Islet size and density and beta cell repl...
Source: Diabetologia - April 1, 2020 Category: Endocrinology Source Type: research

Insulin resistance is related with liver fibrosis in type 2 diabetic patients with non-alcoholic fatty liver disease proven biopsy and Mediterranean diet pattern as a protective factor
This study was conducted among 160 diabetic patients with NAFLD proven biopsy. Anthropometric assessments, laboratory test, liver histological features and follow-up of a Mediterranean diet were evaluated.ResultsDiabetic patients with liver fibrosis showed a greater number of positive metabolic criteria than diabetic patients without liver fibrosis. Patients with hepatic fibrosis have a lower score on the PREDIMED test (9.0 (2.4) vs. 6.2 (2.3);p 
Source: Endocrine - April 1, 2020 Category: Endocrinology Source Type: research

Medicare Part D and Insulin Affordability — The Devil Is in the Details
New England Journal of Medicine, Ahead of Print. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - April 1, 2020 Category: Internal Medicine Authors: Stacie B. Dusetzina Haiden A. Huskamp Laura M. Keohane Nancy L. Keating Source Type: research

Medtronic MiniMed 600 Series Insulin Pumps
No abstract available (Source: Biomedical Safety and Standards)
Source: Biomedical Safety and Standards - March 31, 2020 Category: Medical Devices Tags: RECALLS & FIELD CORRECTIONS—CLASS I Source Type: research

Analysis of Prevalence, Magnitude and Timing of the Dawn Phenomenon in Adults and Adolescents With Type 1 Diabetes: Descriptive Analysis of 2 Insulin Pump Trials
Publication date: April 2020Source: Canadian Journal of Diabetes, Volume 44, Issue 3Author(s): Ilia Ostrovski, Leif E. Lovblom, Daniel Scarr, Alanna Weisman, Nancy Cardinez, Andrej Orszag, C. Marcelo Falappa, Émilie D'Aoust, Ahmad Haidar, Rémi Rabasa-Lhoret, Laurent Legault, Bruce A. Perkins (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 31, 2020 Category: Endocrinology Source Type: research

New perspectives on the insulin therapy
AbstractInsulin was discovered by Banting and Best in 1921, and was subsequently applied for the treatment of diabetes. Porcine or bovine insulin purified from their pancreas had been used clinically for more than 50 years until the development of the methods to produce recombinant human insulin by genetical engineering techniques. The Diabetes Control and Complications Trial (DCCT) (1) and our Kumamoto Study (2) provided the evidences that better glycemic control could be obtained by intensive insulin therapy consisted of the supplementation of both basal and postprandial insulin, which in turn resulted in the prevention ...
Source: Journal of Diabetes Investigation - March 31, 2020 Category: Endocrinology Authors: Eiichi Araki, Hirotaka Araki, Takafumi Senokuchi, Hiroyuki Motoshima Tags: UPDATES Source Type: research

The role of carbohydrate counting in glycemic control and oxidative stress in patients with type 1 diabetes mellitus (T1DM).
CONCLUSION: Proper insulin dosing based on carbohydrate counting (CC) may have an impact on the antioxidant defensive mechanisms of patients with T1DM through the attainment of a better glycemic profile. There are also indications that it may reduce MDA, an important biomarker of oxidative stress and a significant mediator of complications in T1DM. Therefore, prompt dietetic intervention using CC as early as possible after the diagnosis of T1DM is important for achieving optimal glycemic control and improved oxidative status. PMID: 32221838 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - March 31, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Metabolomic effects of androgen deprivation therapy treatment for prostate cancer
ADT is standard therapy for advanced and metastatic PC with negative metabolic consequences. We determined the metabolomic effects of ADT during the PC treatments. Such analysis identify the unexpected reduced ketogenesis and microbiome ‐associated metabolites during ADT AbstractAndrogen deprivation therapy (ADT) is the main treatment strategy for men with metastatic prostate cancer (PC). However, ADT is associated with various metabolic disturbances, including impaired glucose tolerance, insulin resistance and weight gain, increasing risk of diabetes and cardiovascular death. Much remains unknown about the metabolic pat...
Source: Cancer Medicine - March 31, 2020 Category: Cancer & Oncology Authors: Jen ‐Tsan Chi, Pao‐Hwa Lin, Vladimir Tolstikov, Taofik Oyekunle, Emily Y. Chen, Valerie Bussberg, Bennett Greenwood, Rangaprasad Sarangarajan, Niven R. Narain, Michael A. Kiebish, Stephen J. Freedland Tags: ORIGINAL RESEARCH Source Type: research

Characteristics associated with elevated 1 ‐h plasma glucose levels during a 75‐g oral glucose tolerance test in non‐obese Japanese men
Characteristics of non ‐obese Asians with elevated 1‐h plasma glucose are unknown. Individuals with elevated 1‐h plasma glucose have lower insulinogenic index and adiponectin. Insulin sensitivity was similar between the low and high 1‐h plasma glucose groups. AbstractElevated 1 ‐h plasma glucose (1h‐PG; ≥155 mg/dL) during an oral glucose tolerance test is a risk factor for type 2 diabetes. However, the metabolic characteristics of non‐obese Asians with elevated 1h‐PG are unknown. Thus, we studied 59 non‐obese Japanese men with normal glucose tolerance. We div ided study participants into the Low 1h‐PG group (
Source: Journal of Diabetes Investigation - March 31, 2020 Category: Endocrinology Authors: Motonori Sato, Yoshifumi Tamura, Yuki Someya, Kageumi Takeno, Hideyoshi Kaga, Satoshi Kadowaki, Daisuke Sugimoto, Saori Kakehi, Takashi Funayama, Yasuhiko Furukawa, Ruriko Suzuki, Takashi Nakagata, Miho Nishitani ‐Yokoyama, Kazunori Shimada Tags: Short Report Source Type: research

Alcohol ‐induced impaired insulin secretion in a Japanese population: Five‐year follow‐up in the Gifu Diabetes Study
AbstractAims/IntroductionWhile moderate alcohol consumption lowers the risk of type 2 diabetes in European populations, the same cannot be assumed for Japanese patients with diabetes related to low insulin secretion rather than resistance. We aimed to evaluate the effects of daily alcohol consumption on glucose tolerance and diabetes development risk in Japanese populations.Materials and MethodsThis retrospective study randomly enrolled 452 men and 659 women aged 40 –78 years in 2005 (Gifu, Japan). The participants completed a 75‐g oral glucose tolerance test and medical questionnaire. The homeostasis model assessm...
Source: Journal of Diabetes Investigation - March 31, 2020 Category: Endocrinology Authors: Natsumi Ueda, Mayumi Yamamoto, Mitsuhiro Nakamura, Yumi Motooka, Yoko Nakayama, Yukiko Nonoyama, Shino Oba, Yukio Horikawa, Chisato Nagata, Daisuke Yabe, Gifu Diabetes Study Group Tags: ORIGINAL ARTICLE Source Type: research

Pharmacokinetics and Pharmacodynamics of Ursodeoxycholic Acid in an Overweight Population With Abnormal Liver Function
AbstractUrsodeoxycholic acid (UDCA) is a secondary bile acid that is used to treat primary biliary cholangitis. Although UDCA has a hepatoprotective effect in some diseases, its benefit in nonalcoholic fatty liver disease (NAFLD) remains controversial. We aimed to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of UDCA in overweight subjects with elevated liver enzymes after multiple administrations of UDCA and compare these changes with vitamin E treatment. Overweight subjects (body mass index, 25 ‐30 kg/m2) with elevated alanine aminotransferase (ALT) level (40 ‐200 IU/L) were enrolled. Subject...
Source: Clinical Pharmacology in Drug Development - March 31, 2020 Category: Drugs & Pharmacology Authors: Seonghae Yoon, Heechan Lee, Sang ‐Chun Ji, Seo Hyun Yoon, Joo‐Youn Cho, Jae‐Yong Chung Tags: Original Manuscript Source Type: research

Acute Effects of Three Different Meal Patterns on Postprandial Metabolism in Older Individuals with a Risk Phenotype for Cardiometabolic Diseases: a Randomized Controlled Crossover Trial
ConclusionsEnergy ‐rich meals induced hyperglycemia, hyperlipemia, an inflammatory response and a decrease in antioxidant markers. A meal typical for the Mediterranean diet resulted in favorable effects on glycemic, insulinemic and lipemic responses.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - March 31, 2020 Category: Food Science Authors: Yannik B Sch önknecht, Silke Crommen, Birgit Stoffel‐Wagner, Martin Coenen, Rolf Fimmers, Jens J Holst, Marie‐Christine Simon, Peter Stehle, Sarah Egert Tags: Research Article Source Type: research

Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells
Oxidative stress induced by free fatty acid overload in pancreatic β-cells is a potential contributory factor to dysfunction of insulin secretion and apoptotic cell death. Perilipin 5 (Plin5) has been reported to ameliorate oxidative stress-mediated damage in non-insulin-secreting tissues. We tested the hypothesis that Plin5 plays a similar role in pancreatic β-cells, which are extremely sensitive to oxidative stress. Here, our in vitro data showed that Plin5-mediated alleviation of palmitate-triggered apoptosis involves the mitochondrial pathway. And the protective role of Plin5 on β-cells was partially dep...
Source: Frontiers in Endocrinology - March 31, 2020 Category: Endocrinology Source Type: research

Caloric restriction induces anabolic resistance to resistance exercise
ConclusionDuring caloric restriction, there is considerable endocrine anabolic resistance to a single bout of resistance exercise which persists in the presence of post-exercise whey protein supplementation. Alternative strategies to restore the sensitivity of insulin-like growth factor-1 to growth hormone need to be explored. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - March 31, 2020 Category: Physiology Source Type: research

Vitamin D Deficiency Is Associated With Metabolic Risk Factors in Women With Polycystic Ovary Syndrome: A Cross-Sectional Study in Shaanxi China
This study aimed to investigate the vitamin D status, and analyze the relationship between vitamin D deficiency and metabolic risk factors in PCOS women in Shaanxi China.Methods: A cross-sectional study included 169 women diagnosed with PCOS and 114 control women without PCOS. The serum 25(OH)D and metabolic markers were measured. Vitamin D deficiency was defined as serum 25(OH)D concentration less than 20 ng/mL. The primary outcome was the difference in vitamin D status between the PCOS and control groups, the secondary outcomes were correlations between serum 25(OH)D concentration and metabolic risk factors in women with...
Source: Frontiers in Endocrinology - March 31, 2020 Category: Endocrinology Source Type: research

Characterization of Insulin and Glucagon Genes and Their Producing Endocrine Cells From Pygmy Sperm Whale (Kogia breviceps)
Insulin and glucagon are hormones secreted by pancreatic β and α cells, respectively, which together regulate glucose homeostasis. Dysregulation of insulin or glucagon can result in loss of blood glucose control, characterized by hyperglycemia or hypoglycemia. To better understand the endocrine physiology of cetaceans, we cloned and characterized the insulin and glucagon genes from pygmy sperm whale (Kogia breviceps). We obtained the complete coding sequences of the preproinsulin and preproglucagon genes, which encodes the preproinsulin protein of 110 amino acid (aa) residues and encodes the preproglucagon prote...
Source: Frontiers in Endocrinology - March 31, 2020 Category: Endocrinology Source Type: research

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease [Medical Sciences]
Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite increasing circulating nonesterified fatty acids (NEFA), the main substrate for synthesis of intrahepatic triglycerides (IHTG). To explore the underlying mechanism, we quantified hepatic mitochondrial fluxes... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - March 31, 2020 Category: Science Authors: Panu K. Luukkonen, Sylvie Dufour, Kun Lyu, Xian–Man Zhang, Antti Hakkarainen, Tiina E. Lehtimaki, Gary W. Cline, Kitt Falk Petersen, Gerald I. Shulman, Hannele Yki–Jarvinen Tags: Biological Sciences Source Type: research

Maternal Metabolic Biomarkers are Associated with Obesity and Excess Gestational Weight Gain
Conclusion Maternal metabolic biomarkers at delivery vary significantly with both obesity and GWG. Taken together, these findings suggest that GWG (with and without comorbid obesity) is an important mediator of measurable metabolites in pregnancy but is not necessarily accompanied by inflammatory measures in serum. These findings are consistent with GWG being an independent risk factor for metabolic disturbances during pregnancy. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (...
Source: American Journal of Perinatology - March 31, 2020 Category: Perinatology & Neonatology Authors: Antony, Kathleen M. Romezi, Mona Lindgren, Kourtnee Mitchell, Kristen B. Venable, Susan F. Racusin, Diana A. Suter, Melissa A. Aagaard, Kjersti M. Tags: Original Article Source Type: research

Safety, Immunogenicity, and Glycemic Control of Insulin Aspart Biosimilar SAR341402 Versus Originator Insulin Aspart in People with Diabetes Also Using Insulin Glargine: 12-Month Results from the GEMELLI 1 Trial
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology)
Source: Diabetes Technology - March 31, 2020 Category: Endocrinology Authors: Satish K. Garg Karin Wernicke-Panten Marek Wardecki Daniel Kramer Francois Delalande Edward Franek Karita Sadeharju Travis Monchamp Patrick Miossec Bhaswati Mukherjee Viral N. Shah Source Type: research

Safety, Immunogenicity, and Glycemic Control of Insulin Aspart Biosimilar SAR341402 Versus Originator Insulin Aspart in People with Diabetes Also Using Insulin Glargine: 12-Month Results from the GEMELLI 1 Trial
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology and Therapeutics)
Source: Diabetes Technology and Therapeutics - March 31, 2020 Category: Endocrinology Authors: Satish K. Garg Karin Wernicke-Panten Marek Wardecki Daniel Kramer Francois Delalande Edward Franek Karita Sadeharju Travis Monchamp Patrick Miossec Bhaswati Mukherjee Viral N. Shah Source Type: research

Fibroblast growth factor 21 alleviates acute pancreatitis via activation of the Sirt1-autophagy signalling pathway.
Abstract Fibroblast growth factor 21 (FGF21), a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity, alleviates the process of acute pancreatitis (AP). However, its mechanism remains elusive. The pathological and physiological characteristics of FGF21 are observed in both patients with AP and cerulein-induced AP models, and the mechanisms of FGF21 in response to AP are investigated by evaluating the impact of autophagy in FGF21-treated mice and cultured pancreatic cells. Circulating levels of FGF21 significantly increase in both AP patients and cerulein-induced AP mic...
Source: J Cell Mol Med - March 31, 2020 Category: Molecular Biology Authors: Chen Q, Li J, Ma J, Yang X, Ni M, Zhang Y, Li X, Lin Z, Gong F Tags: J Cell Mol Med Source Type: research

Blueberry proanthocyanidins and anthocyanins improve metabolic health through a gut microbiota-dependent mechanism in diet-induced obese mice.
ude VP, Marette A Abstract Blueberry consumption can prevent obesity-linked metabolic diseases and it has been proposed that its polyphenol content may contribute to these effects. Polyphenols have been shown to favourably impact metabolic health, but the role of specific polyphenol classes, and whether the gut microbiota is linked to these effects remains unclear. We aimed to evaluate the impact of whole blueberry and blueberry polyphenols against the development of obesity and insulin resistance, and to determine the potential role of gut microbes in these effects by using fecal microbiota transplantation (FMT)....
Source: American Journal of Physiology. Endocrinology and Metabolism - March 31, 2020 Category: Physiology Authors: Morissette A, Kropp C, Songpadith JP, Junges Moreira R, Costa J, Mariné Casadó R, Pilon G, Varin TV, Dudonné S, Boutekrabt L, St-Pierre P, Levy E, Roy D, Desjardins Y, Raymond F, Houde VP, Marette A Tags: Am J Physiol Endocrinol Metab Source Type: research

Downregulated microRNA-130b-5p Prevents Lipid Accumulation and Insulin Resistance in a Murine model of Nonalcoholic Fatty Liver Disease.
Abstract Nonalcoholic fatty liver disease (NAFLD) amplifies the risk of various liver diseases, ranging from simple steatosis to non-alcoholic steatohepatitis, fibrosis and cirrhosis, and ultimately hepatocellular carcinoma. Accumulating evidence suggests the involvement of aberrant microRNAs (miRNAs or miRs) in the activation of cellular stress, inflammation and fibrogenesis in hepatic cells at different stages of NAFLD and liver fibrosis. Here, we explored the potential role of miR-130b-5p in the pathogenesis of NAFLD, including lipid accumulation and insulin resistance as well as the underlying mechanism. Initi...
Source: American Journal of Physiology. Endocrinology and Metabolism - March 31, 2020 Category: Physiology Authors: Liu X, Chen S, Zhang L Tags: Am J Physiol Endocrinol Metab Source Type: research

Plasmatic lipocalin ‐2 levels in chronic low‐grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency
AbstractLipocalin ‐2 (LCN2) is a secreted glycoprotein involved in several chronic inflammatory processes. Metabolic syndrome (MetS) and adult growth hormone deficiency (GHD) are known as chronic inflammatory conditions. The primary objective of this observational cross‐sectional study was to compare LCN2 plasmat ic levels in these clinical settings, whereas the secondary objective was to investigate any possible correlation between LCN2 and BMI and/or indexes of insulin sensitivity/resistance. Seventy‐four patients were divided as follows: Group A, MetS (18 patients, 13 females and 5 males, mean ±&thin...
Source: BioFactors - March 30, 2020 Category: Biochemistry Authors: Diego Curr ò, Edoardo Vergani, Carmine Bruno, Simone Comi, Claudia D'Abate, Antonio Mancini Tags: Research Communication Source Type: research

Molecular characteristics and abundance of insulin-like androgenic gland hormone and effects of RNA interference in Eriocheir sinensis.
In this study, there was cloning of the full-length sequence of IAG from Eriocheir sinensis (Es-IAG). The full-length Es-IAG gene was 1392 base pairs long and encoded a protein of 151 amino acid residues. The precursor peptide included a signal peptide, and the protein was a protein that is secreted from the cell in which it is produced with no transmembrane domain. Amino acid sequence alignment indicated there was the greatest homology between E. sinensis and Chaceon quinquedens (47 %), followed by Callinectes sapidus (44 %). Results from analysis of the relative abundances of Es-IAG mRNA transcript at different developme...
Source: Animal Reproduction Science - March 30, 2020 Category: Zoology Authors: Fu C, Li F, Wang L, Wu F, Wang J, Fan X, Liu T Tags: Anim Reprod Sci Source Type: research

Estradiol-17 β regulates proliferation and apoptosis of sheep endometrial epithelial cells by regulating the relative abundance of YAP1.
Estradiol-17β regulates proliferation and apoptosis of sheep endometrial epithelial cells by regulating the relative abundance of YAP1. Anim Reprod Sci. 2020 Apr;215:106328 Authors: An SY, Gao XX, Wang ZB, Liang YX, Wang ST, Xiao SH, Xia JT, You PH, Wang F, Zhang GM Abstract Yes-associated protein 1 (YAP1) transcription regulator of the Hippo protein kinase pathway, serves as a key regulator of tissue growth and organ size by regulating cell proliferation and apoptosis. Effects of YAP1 on proliferation and apoptosis of sheep endometrial epithelial cells (EEC) as a result of estradiol-17β (E2...
Source: Animal Reproduction Science - March 30, 2020 Category: Zoology Authors: An SY, Gao XX, Wang ZB, Liang YX, Wang ST, Xiao SH, Xia JT, You PH, Wang F, Zhang GM Tags: Anim Reprod Sci Source Type: research

Effectiveness and Safety of Preoperative Oral Carbohydrates in Enhanced Recovery after Surgery Protocols for Patients with Diabetes Mellitus: A Systematic Review.
Abstract To evaluate the necessity and safety of preoperative oral carbohydrates in enhanced recovery after surgery (ERAS) protocols for diabetes mellitus patients. We searched PubMed, EMBASE, the Cochrane Library, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, and WANFANG databases for articles published through September 2018. We used the Cochrane risk-of-bias tool to assess the methodological quality of included studies. Literature screening, data extraction, and quality evaluation were performed independently by two investigators. Of the 6328 retrieved articles, five eligible ...
Source: Biomed Res - March 30, 2020 Category: Research Authors: Ge LN, Wang L, Wang F Tags: Biomed Res Int Source Type: research

Inflammatory Markers in Women with Polycystic Ovary Syndrome.
Abstract Several studies have reported the association between polycystic ovary syndrome (PCOS) and low-grade chronic inflammation to be of uncertain cause: obesity, insulin resistance, or PCOS itself. The aim of the study was to investigate the WBC (white blood cell) count and CRP (C-reactive protein) concentration in women with PCOS and to determine the factors that affect their concentration. The study included 200 women aged 18-40 with PCOS and 105 healthy women as the control group, recruited in the Department of Gynaecological Endocrinology of Medical University in Warsaw from 2016 to 2018. Each patient unde...
Source: Biomed Res - March 30, 2020 Category: Research Authors: Rudnicka E, Kunicki M, Suchta K, Machura P, Grymowicz M, Smolarczyk R Tags: Biomed Res Int Source Type: research

GSE147687 Insulin-Induced Serine 22 Phosphorylation of Retinoid X Receptor Alpha Is Dispensable For Adipogenesis in Brown Adipocytes
Contributors : Jacob Ardenkj ær-Larsen ; Kaja Rupar ; Goda Sinkevičiūtė ; Patricia S Petersen ; Julia Villarroel ; Morthen Lundh ; Romain Barrès ; Atefeh Rabiee ; Brice EmanuelliSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInsulin action initiates a series of phosphorylation events regulating cellular differentiation, growth and metabolism. We have previously discovered, in a mass spectrometry-based phosphoproteomic study, that insulin/IGF-1 signaling induces phosphorylation of retinoid x receptor alpha (RXR α) at S22 in mouse brown pre-adipocytes. Here, we sh...
Source: GEO: Gene Expression Omnibus - March 30, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Targeting < i > mir128-3p < /i > alleviates myocardial insulin resistance and prevents ischemia-induced heart failure
In conclusion, we reveal that targetingmir128-3p mitigates myocardial insulin resistance, thereafter slowing down the progression of heart failure post-ischemia. (Source: eLife)
Source: eLife - March 30, 2020 Category: Biomedical Science Tags: Biochemistry and Chemical Biology Cell Biology Source Type: research

Effects of body condition on the insulin resistance, lipid metabolism and oxidative stress of lactating dairy cows
Overconditioned dairy cows are prone to greater insulin resistance in transition to successfully adapt to negative energy balance. The associations among body condition score (BCS), insulin resistance, lipid m... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 30, 2020 Category: Lipidology Authors: Jiajin Wu, Jianxin Liu and Diming Wang Tags: Research Source Type: research

Optimizing beta cell function through mesenchymal stromal cell ‐mediated mitochondria transfer
This study aimed to determine whether the improved islet function is associated with mitochondrial transfer from MSCs to cocultured islets. We have demonstrated mitochondrial transfer from human adipose MSCs to human islet β‐cells in coculture. Fluorescence imaging showed that mitochondrial transfer occurs , at least partially, through tunneling nanotube (TNT)‐like structures. The extent of mitochondrial transfer to clinically relevant human islets was greater than that to experimental mouse islets. Human islets are subjected to more extreme cellular stressors than mouse islets, which may induce “ danger sig...
Source: Stem Cells - March 30, 2020 Category: Stem Cells Authors: Chloe L. Rackham, Ella L. Hubber, Anna Czajka, Afshan N. Malik, Aileen J. F. King, Peter M. Jones Tags: TISSUE ‐SPECIFIC STEM CELLS Source Type: research

Vaccines For Type 1 Diabetes: Prevention Or Reversal?
Abstract Type 1 diabetes mellitus (T1DM) is an autoimmune disease which leads to destruction of pancreatic β-cells, thereby causing insufficient insulin production. Globally, around 98, 200 children and adolescents below 15 years of age and almost 128,900 subjects below 20 years of age develop T1DM annually, along with severe complications deteriorating their quality of life. In India alone, around 15,900 incident cases below 15 years have reported annually. Hence, its prevention and reversal are significant. Unlike other chronic diseases, T1DM involves the presence of various autoantigens which can be target...
Source: Current Diabetes Reviews - March 30, 2020 Category: Endocrinology Authors: Desai S, Buchade S, Chitlange S, Sharma H, Bhombe D, Shewale S, Pujari P Tags: Curr Diabetes Rev Source Type: research

Optimizing beta cell function through mesenchymal stromal cell ‐mediated mitochondria transfer
This study aimed to determine whether the improved islet function is associated with mitochondrial transfer from MSCs to cocultured islets. We have demonstrated mitochondrial transfer from human adipose MSCs to human islet β‐cells in coculture. Fluorescence imaging showed that mitochondrial transfer occurs , at least partially, through tunneling nanotube (TNT)‐like structures. The extent of mitochondrial transfer to clinically relevant human islets was greater than that to experimental mouse islets. Human islets are subjected to more extreme cellular stressors than mouse islets, which may induce “ danger sig...
Source: Stem Cells - March 30, 2020 Category: Stem Cells Authors: Chloe L. Rackham, Ella L. Hubber, Anna Czajka, Afshan N. Malik, Aileen J. F. King, Peter M. Jones Tags: TISSUE ‐SPECIFIC STEM CELLS Source Type: research

Intuitive eating is associated with glycemic control in type 2 diabetes.
CONCLUSION: Eating intuitively, especially in accordance with body needs may be associated with lower chances of type 2 diabetics having inadequate glycemic control. LEVEL OF EVIDENCE: Level V, cross-sectional descriptive study. PMID: 32232778 [PubMed - as supplied by publisher] (Source: Eating and weight disorders : EWD)
Source: Eating and weight disorders : EWD - March 30, 2020 Category: Eating Disorders & Weight Management Authors: Soares FLP, Ramos MH, Gramelisch M, de Paula Pego Silva R, da Silva Batista J, Cattafesta M, Salaroli LB Tags: Eat Weight Disord Source Type: research

Creatinine/(cystatin C × body weight) ratio is associated with skeletal muscle mass index.
Creatinine/(cystatin C × body weight) ratio is associated with skeletal muscle mass index. Endocr J. 2020 Mar 26;: Authors: Nishida K, Hashimoto Y, Kaji A, Okamura T, Sakai R, Kitagawa N, Osaka T, Hamaguchi M, Fukui M Abstract We have previously reported that the creatinine (Cre) to cystatin C (CysC) ratio is associated with height-adjusted skeletal muscle mass index (SMI). However, weight-adjusted SMI is reported to be a more useful marker of insulin sensitivity than height-adjusted SMI. Thus, we hypothesized that the creatinine to (cystatin C × body weight [BW]) relationship (Cre/[CysC &t...
Source: Endocrine Journal - March 29, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Sicyos angulatus Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice.
Authors: Choi JH, Noh JR, Kim YH, Kim JH, Kang EJ, Choi DH, Choi JH, An JP, Oh WK, Lee CH Abstract Obesity is a medical condition in which excess body fat has accumulated to a serious extent. It is a chronic disease that can lead to dyslipidemia, insulin resistance, and type 2 diabetes. In the present study, we investigated the anti-obesity effects of Sicyos angulatus (SA) extract on a high-fat diet (HFD)-induced C57BL/6J obese mice. The mice were divided into vehicle and three SA groups (25, 50, and 100 mg/kg body weight). The mice were fed a HFD with or without SA for 12 weeks. The oral administration of SA reduc...
Source: International Journal of Medical Sciences - March 29, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research