Molecules, Vol. 26, Pages 606: JAK2 Inhibition by Fedratinib Reduces Osteoblast Differentiation and Mineralisation of Human Mesenchymal Stem Cells
aad Alfayez Several signalling pathways, including the JAK/STAT signalling pathway, have been identified to regulate the differentiation of human bone marrow skeletal (mesenchymal) stem cells (hBMSCs) into bone-forming osteoblasts. Members of the JAK family mediate the intracellular signalling of various of cytokines and growth factors, leading to the regulation of cell proliferation and differentiation into bone-forming osteoblastic cells. Inhibition of JAK2 leads to decoupling of its downstream mediator, STAT3, and the subsequent inhibition of JAK/STAT signalling. However, the crucial role of JAK2 in hBMSCs biology h...
Source: Molecules - January 25, 2021 Category: Chemistry Authors: Nihal AlMuraikhi Hanouf Alaskar Sarah Binhamdan Amal Alotaibi Moustapha Kassem Musaad Alfayez Tags: Article Source Type: research

The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats
Publication date: Available online 23 January 2021Source: Life SciencesAuthor(s): Chunxia Wang, Chengliang Wang, Liying Ren, Shankang Chen, Wen-Hua Chen, Yuhao Li (Source: Life Sciences)
Source: Life Sciences - January 24, 2021 Category: Biology Source Type: research

Insulin resistance and the Adiponectin/Leptin Ratio as a surrogate measure of insulin resistance in Japanese collegiate baseball players.
Authors: Oda K, Kawate H, Ishibashi A, Imamura H PMID: 33480516 [PubMed - as supplied by publisher] (Source: Journal of Sports Medicine and Physical Fitness)
Source: Journal of Sports Medicine and Physical Fitness - January 24, 2021 Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research

Evaluation of the expression of hexokinase 1, glucokinase, and insulin by canine insulinoma cells maintained in short-term culture.
CONCLUSIONS AND CLINICAL RELEVANCE: Canine insulinomas expressed hexokinases responsible for glucose responsiveness. Insulinoma cells were successfully maintained in short-term culture; cultured cells remained functional for 10 weeks as evidenced by cellular insulin content and had detectable secretion of insulin into the culture medium for ≥ 5 weeks. Apparent glucokinase overexpression by insulinomas suggested a possible mechanism underlying excessive insulin release by these tumors. PMID: 33480281 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - January 24, 2021 Category: Veterinary Research Authors: Suwitheechon OU, Schermerhorn T Tags: Am J Vet Res Source Type: research

Long-term Health of Offspring of Women With Polycystic Ovarian Syndrome
Polycystic ovarian syndrome (PCOS) presents as a constellation of clinical manifestations that can be varied among patients; however, the hormonal derangement associated with PCOS is uniformly characterized by excess androgens and abnormal insulin activity. The alteration in the normal hormonal milieu in these patients and subsequently during their pregnancies is theorized to alter the normal development of the fetus. This in utero exposure and its relationship with behavioral development, metabolic disease, and reproductive outcomes in male and female offspring of mothers with PCOS are under investigation and remains cont...
Source: Clinical Obstetrics and Gynecology - January 24, 2021 Category: OBGYN Tags: Polycystic Ovary Disease Source Type: research

A Pragmatic Approach to the Treatment of Women With Type 2 Diabetes in Pregnancy
Type 2 diabetes mellitus (DM) is a growing problem among reproductive-aged women. Contemporary trends in obesity and delayed child-bearing are expected to result in an increasing number of pregnancies affected by type 2 DM. Women with known type 2 DM can greatly benefit from preconception care as improved periconception glycemic control and weight loss can decrease the neonatal and maternal risks associated with type 2 DM and pregnancy. Antenatal mainstays of management include frequent blood glucose monitoring, insulin therapy, optimization of coexisting medical conditions, and fetal surveillance. Careful attention to pos...
Source: Clinical Obstetrics and Gynecology - January 24, 2021 Category: OBGYN Tags: Diabesity: Type 2 Diabetes and Obesity Source Type: research

Use of insulin glargine during pregnancy: A review
Publication date: Available online 22 January 2021Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Pratap Jethwani, B. Saboo, L. Jethwani, R. Chawla, A. Maheshwari, S. Agarwal, S. Jaggi (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2021 Category: Endocrinology Source Type: research

Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet.
CONCLUSION: In conclusion, rice bran prevented renal disease by modulating risk factors. PMID: 33475676 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - January 23, 2021 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Metabolic cardio- and reno-protective effects of empagliflozin in a prediabetic rat model.
Authors: Huttl M, Markova I, Miklankova D, Oliyarnyk O, Trnovska J, Kucera J, Sedlacek R, Haluzik M, Malinska H Abstract The mechanisms behind the cardiovascular and renal benefits of empagliflozin is not fully understood. The positive impact of the medication on cardiovascular mortality can not be solely attributed to its antidiabetic effect, with a metabolic mechanism possibly involved. To investigate the metabolic effects of empagliflozin treatment (10 mg/kg/day for 6 weeks), we used an adult male rat model with serious vascular complications associated with metabolic syndrome and prediabetes. Impaired glucose t...
Source: Journal of Physiology and Pharmacology - January 23, 2021 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

Extracellular signal-regulated kinases, P38 and c-Jun N-terminal kinases phosphorylation changes in PC12 cells with diabetic disturbances and comorbid excitotoxicity - a preliminary report.
This study investigated ERK, p38 and JNK protein kinases phosphorylation changes in diabetic in vitro conditions with accompanying excitotoxicity reflected by high L-glutamate concentrations. An InstantOne ELISA test in cell lysates was performed to evaluate the intensity of phosphorylation of ERK, p38 and JNK occurring as a result of the incubation of undifferentiated PC12 cells with solutions of glucose (G1,G2), insulin (I1,I2) and L-glutamate (L1,L2). We observed increased phosphorylation of JNK (Thr183/Tyr185) and p38 (Thr180/Tyr182) kinases. For both these kinases, we have shown an increase in phosphorylation in case ...
Source: Journal of Physiology and Pharmacology - January 23, 2021 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

Inhibition of soluble epoxide hydrolase offers protection against fructose-induced diabetes and related metabolic complications in rats.
Authors: Shah SA, Mehmood MH, Khan M, Bukhari IA, Alorainey BI, Vohra F Abstract Stabilization of epoxyeicosatrienoic acids (EETs) levels via soluble epoxide hydrolase (sEH) deletion or its pharmacological inhibition have been shown to have beneficial effects on inflammation, ischemia, hypertension and diabetes. Owing to the diverse role of EETs, current study was designed to evaluate the therapeutic potential of 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl) urea (TPPU), a novel sEHI against fructose-induced diabetes and related complications in rats. Sprague-Dawley rats (200 - 230 g) were divided into fo...
Source: Journal of Physiology and Pharmacology - January 23, 2021 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

Can probiotics supplementation improve glycemic & renal status in Diabetic Nephropathy? A systematic review and meta-analysis of clinical trials.
Can probiotics supplementation improve glycemic & renal status in Diabetic Nephropathy? A systematic review and meta-analysis of clinical trials. Endocr Metab Immune Disord Drug Targets. 2021 Jan 21;: Authors: Tarrahi MJ, Namjoo I, Borzoo-Isfahani M, Ebdali H, Moravejolahkami AR Abstract BACKGROUND & AIMS: This meta-analysis was performed to quantify the effects of probiotics on renal and glycemic biomarkers among patients with Diabetic Nephropathy (DN). METHODS: Electronic databases were searched through May 10, 2020. All trials that investigated the effect of probiotics on serum glycemic ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 23, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Adipose tissue insulin resistance and decreased adiponectin are correlated with metabolic abnormalities in non-obese men.
CONCLUSIONS: In non-obese Japanese men with high ATIS, the AN level was not associated with metabolic characteristics. On the other hand, subjects with low ATIS showed reduced muscle insulin sensitivity and those with a decreased AN level demonstrated multiple metabolic abnormalities, represented by fatty liver and dyslipidemia. PMID: 33484562 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 23, 2021 Category: Endocrinology Authors: Kiya M, Tamura Y, Takeno K, Someya Y, Kakehi S, Sato M, Yamasaki N, Kadowaki S, Suzuki R, Furukawa Y, Sugimoto D, Kaga H, Funayama T, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Satoh H, Kawamori R, Watada H Tags: J Clin Endocrinol Metab Source Type: research

Glucose metabolism after pancreatectomy: opposite extremes between pancreaticoduodenectomy and distal pancreatectomy.
Abstract CONTEXT: The rate of glucose metabolism changes drastically after partial pancreatectomy. OBJECTIVES: To analyze the changes in patients' glucose metabolism and endocrine and exocrine function before and after partial pancreatectomy relative to different resection types (Kindai Prospective Study on Metabolism and Endocrinology after Pancreatectomy: KIP-MEP study). METHODS: A series of 278 consecutive patients with scheduled pancreatectomy were enrolled into our prospective study. Of them, 109 individuals without diabetes, who underwent partial pancreatectomy, were investigated. Data were compare...
Source: The Journal of Clinical Endocrinology and Metabolism - January 23, 2021 Category: Endocrinology Authors: Niwano F, Babaya N, Hiromine Y, Matsumoto I, Kamei K, Noso S, Taketomo Y, Takeyama Y, Kawabata Y, Ikegami H Tags: J Clin Endocrinol Metab Source Type: research

Fatty liver index is associated with the risk of testosterone deficiency in aging men without metabolic syndrome
AbstractObjectivesNonalcoholic fatty liver disease (NAFLD) is suggested to be a precursor of metabolic syndrome (MetS) and could influence the risk of testosterone deficiency (TD). Fatty liver index (FLI) is a simple and useful screening tool for NAFLD. We determined the association between the risk of NAFLD assessed by FLI and TD in aging Taiwanese men, especially those without MetS.Materials and MethodsA free health screening program was conducted for men (age:>40 years) in a medical center in Kaohsiung, Taiwan. All participants underwent a physical examination; answered a questionnaire assessing demographics, medical...
Source: Andrology - January 23, 2021 Category: Urology & Nephrology Authors: Chia ‐Chu Liu, Shu‐Pin Huang, Tusty‐Jiuan Hsieh, Cheng‐Hsueh Lee, Kai‐Hung Cheng, Tsung‐Yi Huang, Jiun‐Hung Geng, Ching‐Chia Li, Wen‐Jeng Wu, Yung‐Chin Lee Tags: ORIGINAL ARTICLE Source Type: research

Experimental dopaminergic neuron lesion at the area of the biological clock pacemaker, suprachiasmatic nuclei (SCN) induces metabolic syndrome in rats
The daily peak in dopaminergic neuronal activity at the area of the biological clock (hypothalamic suprachiasmatic nuclei [SCN]) is diminished in obese/insulin resistant vs lean/insulin sensitive animals. The ... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - January 23, 2021 Category: Endocrinology Authors: Shuqin Luo, Michael Ezrokhi, Nicholas Cominos, Tsung-Huang Tsai, Carl R. Stoelzel, Yelena Trubitsyna and Anthony H. Cincotta Tags: Research Source Type: research

Targeting Insulin Resistance to Treat Cognitive Dysfunction
AbstractDementia is a devastating disease associated with aging. Alzheimer ’s disease is the most common form of dementia, followed by vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has been reported in diabetic patients. Recent studies are now beginning to recognize type 2 diabetes mellitus, characterized by chronic hyperglycemia and insulin resistance, as a risk factor for Alzheimer’s disease and other cognitive disorders. While studies on insulin action have remained traditionally in the domain of peripheral tissues, the detrimental effects of insulin resistance in the...
Source: Molecular Neurobiology - January 23, 2021 Category: Neurology Source Type: research

Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry
AbstractAimsTo analyse the association between coeliac disease (CD) and depression in children, adolescents, and young adults with type 1 diabetes (T1D).MethodsWe included 79,067 T1D patients aged 6 –20 years, with at least six months of diabetes duration, and treatment data between 1995 and 2019 were documented in the diabetes patient follow-up registry. We categorized patients into four groups: T1D only (n  =  73,699), T1 + CD (n  =  3379), T1D + depression (n  =  1877), or T1D + CD + depression (n  = &thin...
Source: Acta Diabetologica - January 23, 2021 Category: Endocrinology Source Type: research

Analysis of genetic selection at insulin receptor substrate-2 gene loci
ConclusionThese findings indicate that genetic selection has occurred at theIRS2 locus, warranting further research into the adaptive evolution of metabolic disorder-associated genes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 23, 2021 Category: Endocrinology Source Type: research

Biomolecular assembly on interdigitated electrode nanosensor for selective detection of insulin-like growth factor-1.
Authors: Gu Y, Liu L, Guo J, Xiao S, Fang F, Yu X, Gopinath SCB, Wu J, Liu X Abstract This research is focussed to quantify IGF1 by electroanalytical analysis on InterDigitated electrode surface and characterized by the microscopic observations. For the detection, antibody and aptamer were used to analyze the level of IGF1. The sandwich pattern (aptamer-IGF1-antibody) was designed on the chemically modified IDE surface and reached the limit of detection to 10 fM with 100 folds enhancement in the sensitivity. Different control experiments (absence of IGF1, binding with IGF2 and with non-complementary aptamer)...
Source: Artificial Cells, Nanomedicine and Biotechnology - January 22, 2021 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Anti-tuberculotic thionamide antibiotics show antioxidative and neuronal cytoprotective nature by inhibiting amyloid formation in human insulin and amyloid β-42
Publication date: 15 March 2021Source: Journal of Molecular Liquids, Volume 326Author(s): Asra Nasir Khan, Kundlik Gadhave, Mohammad Furkan, Prateek Kumar, Mohammad Khursheed Siddiqi, Rajanish Giri, Rizwan Hasan Khan (Source: Journal of Molecular Liquids)
Source: Journal of Molecular Liquids - January 22, 2021 Category: Molecular Biology Source Type: research

Pluronic ® F127-mediated control of insulin release rates from NPH microcrystals and blood glucose depression in STZ-induced diabetic rats.
Conclusion: Our findings suggest that the undesirable kinetics of insulin release from NPH is significantly influenced by tissue enzyme activity and that the presence of PF127 provided a timely modulation of insulin release from NPH microcrystals in the STZ-induced diabetic rat model. PMID: 33469509 [PubMed] (Source: BioImpacts)
Source: BioImpacts - January 22, 2021 Category: Research Tags: Bioimpacts Source Type: research

Seaweed Extract Improves Carbohydrate Metabolism in Overweight and Obese Adults
Conclusion: Ingestion of seaweed extract over 10 weeks improves glucose metabolism without affecting measures of inflammation, liver function or renal function. (Source: Current Nutrition and Food Science)
Source: Current Nutrition and Food Science - January 22, 2021 Category: Nutrition Source Type: research

Using Iterative Learning for Insulin Dosage Optimization in Multiple-Daily-Injections Therapy for People With Type 1 Diabetes
Conclusions: Iterative learning shows potential to improve glycemic regulation over time by driving blood glucose closer to the recommended glycemic targets. Significance: Decision support systems (DSSs) and automated therapy advisors such as the one proposed here are expected to improve glycemic outcomes reducing the burden on patients on MDI therapy. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - January 22, 2021 Category: Biomedical Engineering Source Type: research

Insulin-Like Growth Factor-1 Enhances Motoneuron Survival and Inhibits Neuroinflammation After Spinal Cord Transection in Zebrafish.
In this study, we used the zebrafish spinal transection model to investigate whether IGF-1 plays an important role in the recovery of motor function. Unlike mammals, zebrafish can regenerate axons and restore mobility in remarkably short period after spinal cord transection. Quantitative real-time PCR and immunofluorescence showed decreased IGF-1 expression in the lesion site. Double immunostaining for IGF-1 and Islet-1 (motoneuron marker)/GFAP (astrocyte marker)/Iba-1 (microglia marker) showed that IGF-1 was mainly expressed in motoneurons and was surrounded by astrocyte and microglia. Following administration of IGF-1 mo...
Source: Cellular and Molecular Neurobiology - January 22, 2021 Category: Cytology Authors: Zhao L, Zhang B, Huang S, Zhou Z, Jia X, Qiao C, Wang F, Sun M, Shi Y, Yao L, Cui C, Shen Y Tags: Cell Mol Neurobiol Source Type: research

Acute hyperglycemia enhances both vascular endothelial function and cardiac and skeletal muscle microvascular function in healthy humans.
This article is protected by copyright. All rights reserved. PMID: 33481251 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 22, 2021 Category: Physiology Authors: Horton WB, Jahn LA, Hartline LM, Aylor KW, Patrie JT, Barrett EJ Tags: J Physiol Source Type: research

Effect of Everolimus with Low-Dose Tacrolimus on Development of New-Onset Diabetes After Transplantation and Allograft Function in Kidney Transplantation: A Multicenter, Open-Label, Randomized Trial.
CONCLUSIONS EVL-based immunosuppressive therapy with lower Tac exposure could be a safer alternative for maintenance treatment. PMID: 33479188 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - January 22, 2021 Category: Transplant Surgery Authors: Kim HD, Chang JY, Chung BH, Kim CD, Lee SH, Kim YH, Yang CW Tags: Ann Transplant Source Type: research

The Relationship between Glucose Control & Cognitive Function in People with Diabetes after a Lacunar Stroke.
CONCLUSION: This analysis of lacunar stroke patients with diabetes demonstrates a relationship between A1C and change in cognitive scores over time. Intervention studies are needed in order to delineate if better glucose control could slow the rate of cognitive decline in this high risk population. PMID: 33481011 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 22, 2021 Category: Endocrinology Authors: Cukierman-Yaffe T, McClure LA, Thomas R, Bosch J, Sharma M, Gerstein HC, Benavente O Tags: J Clin Endocrinol Metab Source Type: research

Protein Isolates from Raw and Cooked Foxtail Millet Attenuate Development of Type 2 Diabetes in Streptozotocin ‐Induced Diabetic Mice
ConclusionBoth raw and cooked foxtail millet protein isolates can exert hypoglycemic effects in diabetic mice through rewiring glucose homeostasis, mitigating diabetes ‐induced gut dysbiosis, and affecting the GLP‐1R/PI3K/AKT pathway. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - January 22, 2021 Category: Food Science Authors: Yongxia Fu, Ruiyang Yin, Erhu Guo, Ruhong Cheng, Xianmin Diao, Yong Xue, Qun Shen Tags: Food & Function Source Type: research

Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1d/ − mice
Type 2 diabetes (T2DM) is an age-associated disease characterized by hyperglycemia due to insulin resistance and decreased beta-cell function. DNA damage accumulation has been associated with T2DM, but whether DNA damage plays a role in the pathogenesis of the disease is unclear. Here, we used mice deficient for the DNA excision-repair gene Ercc1 to study the impact of persistent endogenous DNA damage accumulation on energy metabolism, glucose homeostasis and beta-cell function. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 22, 2021 Category: Biomedical Science Authors: Ana P. Huerta Guevara, Sara J. McGowan, Melissa Kazantzis, Tania Rozgaja Stallons, Tokio Sano, Niels L. Mulder, Angelika Jurdzinski, Theo H. van Dijk, Bart J.L. Eggen, Johan W. Jonker, Laura J. Niedernhofer, Janine K. Kruit Source Type: research

Teprotumumab (Tepezza): from the discovery and development of medicines to USFDA approval for active thyroid eye disease (TED) treatment
AbstractTeprotumumab (TPT) is a type I insulin-like growth factor receptor inhibitor, marketed as Tepezza; recently USFDA approved it for the treatment of thyroid eye disease (thyroid-associated ophthalmopathy (TAO), Graves ophthalmopathy/orbitopathy) in the USA. It is a monoclonal antibody although it was initially developed in collaboration with Genmab and Roche for the treatment of the tumour, but later it was investigated by River Vision Development Corporation and Horizon Therapeutics for its ophthalmic use. The drug has been designated as an orphan drug, breakthrough designation and fast-track designation. This revie...
Source: International Ophthalmology - January 22, 2021 Category: Opthalmology Source Type: research

Branched-Chain Amino Acids in relation to Food Preferences and Insulin Resistance in Obese Subjects Consuming Walnuts: A Cross-Over, Randomized, Double-Blind, Placebo-Controlled inpatient physiology study
To assess whether the concentrations of circulating Branched-Chain Amino Acids (BCAAs) change after walnut consumption and, whether these changes are associated with alterations in markers of insulin resistance and food preferences. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 22, 2021 Category: Nutrition Authors: Dario Tuccinardi, Nikolaos Perakakis, Olivia M. Farr, Jagriti Upadhyay, Christos S. Mantzoros Tags: Randomized Control Trials Source Type: research

The relationship between different C-peptide level and insulin dose of insulin pump
Nutrition & Diabetes, Published online: 22 January 2021; doi:10.1038/s41387-020-00148-7The relationship between different C-peptide level and insulin dose of insulin pump (Source: Nutrition and Diabetes)
Source: Nutrition and Diabetes - January 22, 2021 Category: Nutrition Authors: Yihan Wei Li Quan Ting Zhou Guoli Du Sheng Jiang Source Type: research

Impact of glucagon response on early postprandial glucose excursions irrespective of residual β‐cell function in type 1 diabetes: A cross‐sectional study using a mixed meal tolerance test
We investigated the glucagon response to mixed ‐meal in type 1 diabetes. Hyperglucagonemia after mixed‐meal ingestion was associated with early‐postprandial glucose excursions. AbstractAims/IntroductionControlling postprandial glucose levels in patients with type  1 diabetes is challenging even under the adequate treatment of insulin injection. Recent studies showed that dysregulated glucagon secretion exacerbates hyperglycemia in type 2 diabetes patients, but little is known in type 1 diabetes patients. We investigated whether the glucagon response to a meal ingestion could influence the postprandial ...
Source: Journal of Diabetes Investigation - January 22, 2021 Category: Endocrinology Authors: Ayako Ito, Ichiro Horie, Masaki Miwa, Ayaka Sako, Tetsuro Niri, Yomi Nakashima, Riyoko Shigeno, Ai Haraguchi, Shoko Natsuda, Satoru Akazawa, Akie Kamada, Atsushi Kawakami, Norio Abiru Tags: Original Article Source Type: research

Serum insulin-like factor 3 quantification by LC –MS/MS in male patients with hypogonadotropic hypogonadism and Klinefelter syndrome
ConclusionsThe dichotomy between lower INSL3 and higher testosterone concentrations, particularly observed in hCG-treated patients with HH, confirms that INSL3 is a different marker of Leydig cell function than testosterone. However, the clinical application of INSL3 in males with hypogonadism remains unclear. (Source: Endocrine)
Source: Endocrine - January 22, 2021 Category: Endocrinology Source Type: research

Novel Genetic Variants of PPAR γ2 Promoter in Gestational Diabetes Mellitus and its Molecular Regulation in Adipogenesis
In conclusion, a novel -807A/C in PPARγ2 promoter was identified in Chinese women with GDM and the mutation affected GRβ binding and transcription of PPARγ2 for adipogenesis. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 22, 2021 Category: Endocrinology Source Type: research

A High Triglyceride-Glucose Index Is Associated With Contrast-Induced Acute Kidney Injury in Chinese Patients With Type 2 Diabetes Mellitus
This study enrolled 928 patients with suspected coronary artery disease who underwent coronary angiology or percutaneous coronary intervention in Zhongda hospital. Patient data were divided into quartiles according to the TyG index: group 1: TyG ≤ 8.62; group 2: 8.62
Source: Frontiers in Endocrinology - January 22, 2021 Category: Endocrinology Source Type: research

Correlation Between Daily Energy Intake from Fat with Insulin Resistance in Patients with Polycystic Ovary Syndrome
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - January 21, 2021 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

Adropin - potential link in cardiovascular protection for obese male type 2 diabetes mellitus patients treated with liraglutide.
ADROPIN - POTENTIAL LINK IN CARDIOVASCULAR PROTECTION FOR OBESE MALE TYPE 2 DIABETES MELLITUS PATIENTS TREATED WITH LIRAGLUTIDE. Acta Clin Croat. 2020 Jun;59(2):344-350 Authors: Tičinović Kurir T, Miličević T, Novak A, Vilović M, Božić J Abstract The aim of this study was to determine plasma adropin concentration and parameters of insulin resistance in obese male type 2 diabetes mellitus (T2DM) patients before and after 3-month liraglutide treatment. In this interventional study, we enrolled 15 obese male T2DM patients with body mass index (BMI)>35 kg/m2, uncontrolled disease and HbA1c>7.5...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The Prevalence and Trend of Metabolic Syndrome in the South-East of Iran.
Authors: Farmanfarma KK, Kaykhaei MA, Mohammadi M, Adineh HA, Ansari-Moghaddam A Abstract Metabolic syndrome (Mets) is a set of metabolic disorders including abdominal obesity, insulin resistance or disorders of glucose absorption and metabolism, lipid disorders, and hypertension, which increases the risk of chronic diseases including type 2 diabetes, cardiovascular diseases, cancer, and mortality. Therefore, the present study aimed to determine the trend of Mets and its components in Zahedan, a city located in South-East of Iran, from 2009 to 2017. A total of 761 individuals aged>20 years were followed from 200...
Source: Journal of Medicine and Life - January 21, 2021 Category: General Medicine Tags: J Med Life Source Type: research

Association between insulin resistance and aspirin or clopidogrel resistance in Chinese patients with recent ischemic stroke/TIA.
This study aims to discover whether insulin resistance is an independent predictor for antiplatelet drug resistance in patients with ischemic cerebrovascular disease. Methods: This study used a prospective cohort method. Patients diagnosed as minor ischemic stroke or transient ischemic attack (TIA) were enrolled successively. All patients have been administrated aspirin and/or clopidogrel and were tested for fasting glucose and insulin and platelet aggregation inhibition tests which was detected by light transmission aggregometry (LTA). The maximum platelet aggregation rate (AA) of ≥20% or the maximum platelet aggr...
Source: Neurological Research - January 21, 2021 Category: Neurology Tags: Neurol Res Source Type: research

A critical review of the effects of vitamin K on glucose and lipid homeostasis: its potential role in the prevention and management of type 2 diabetes.
In conclusion, vitamin K possibly improves glucose and lipid metabolism and could be an emerging target in the context of prevention and control of T2DM, insulin resistance, and dyslipidemia. PMID: 33454929 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - January 21, 2021 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

GSE162288 The comparative methylome and transcriptome after change of direction compared to straight line running exercise in human skeletal muscle
Contributor : Adam P SharplesSeries Type : Methylation profiling by arrayOrganism : Homo sapiensThe methylome and transcriptome signatures following exercise that are physiologically and metabolically relevant to sporting contexts such as team sports or health prescription scenarios (e.g. high intensity interval training/HIIT) has not been investigated. To explore this, we performed two different sport/exercise relevant high-intensity running protocols in 5 male sport team members using a repeated measures design of: 1) Change of direction (COD) versus; 2) straight line (ST) exercise with a wash-out period of at least 2 we...
Source: GEO: Gene Expression Omnibus - January 21, 2021 Category: Genetics & Stem Cells Tags: Methylation profiling by array Homo sapiens Source Type: research

Previous preeclampsia and its association with the future development of cardiovascular diseases: a systematic review and meta-analysis
Preeclampsia is a multifactorial disease. Among these factors, untreated hypertension during pregnancy can result in high morbidity and mortality rates and may also be related to the future development of cardiovascular diseases.Therefore, this systematic review aimed to determine the association of previous preeclampsia with the future development of cardiovascular diseases. Studies on the association between preeclampsia and future cardiovascular diseases published in the last 10 years (2009-2019) were identified from the PubMed/Medline (207 articles), Embase (nine articles), and Cochrane (three articles) databases using...
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research

Islet function and insulin sensitivity in latent autoimmune diabetes in adults taking sitagliptin: A randomized trial.
Abstract CONTEXT: The long-term effects of dipeptidyl peptidase-4 inhibitors on β-cell function and insulin sensitivity in latent autoimmune diabetes in adults (LADA) are unclear. OBJECTIVE: To investigate the effects of sitagliptin on β-cell function and insulin sensitivity in LADA patients receiving insulin. DESIGN AND SETTING: A randomized controlled trial at the Second Xiangya Hospital. PATIENTS AND INTERVENTIONS: Fifty-one patients with LADA were randomized to sitagliptin + insulin group (SITA group) or insulin alone group (CONT group) for 24 months. MAIN OUTCOME MEASURES: Fastin...
Source: The Journal of Clinical Endocrinology and Metabolism - January 21, 2021 Category: Endocrinology Authors: Yang L, Liang H, Liu X, Wang X, Cheng Y, Zhao Y, Liu L, Huang G, Wang X, Zhou Z Tags: J Clin Endocrinol Metab Source Type: research

Insulin acutely activates metabolism of primary human monocytes and promotes a proinflammatory phenotype.
Abstract Increased glycolysis is a metabolic trait of activated innate immune cells and supports functional changes including cytokine production. Insulin drives glycolysis in nonimmune cells, yet its metabolic effects on human innate immune cells remain unexplored. Potential effects of insulin on immune cell metabolism may occur acutely after a postprandial increase in plasma insulin levels or as a consequence of chronically elevated insulin levels as observed in obese insulin-resistant individuals and patients with diabetes. Here, we investigated the effects of acute and chronic exposure to insulin on metabolism...
Source: Journal of Leukocyte Biology - January 21, 2021 Category: Hematology Authors: Ratter JM, van Heck JIP, Rooijackers HMM, Jansen HJ, van Poppel PCM, Tack CJ, Stienstra R Tags: J Leukoc Biol Source Type: research

Closed-Loop Insulin Therapy Improves Glycemic Control in Adolescents and Young Adults: Outcomes from the International Diabetes Closed-Loop Trial
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology)
Source: Diabetes Technology - January 21, 2021 Category: Endocrinology Authors: Elvira Isganaitis Dan Raghinaru Louise Ambler-Osborn Jordan E. Pinsker Bruce A. Buckingham R. Paul Wadwa Laya Ekhlaspour Yogish C. Kudva Carol J. Levy Gregory P. Forlenza Roy W. Beck Craig Kollman John W. Lum Sue A. Brown Lori M. Laffel Source Type: research

Closed-Loop Insulin Therapy Improves Glycemic Control in Adolescents and Young Adults: Outcomes from the International Diabetes Closed-Loop Trial
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology and Therapeutics)
Source: Diabetes Technology and Therapeutics - January 21, 2021 Category: Endocrinology Authors: Elvira Isganaitis Dan Raghinaru Louise Ambler-Osborn Jordan E. Pinsker Bruce A. Buckingham R. Paul Wadwa Laya Ekhlaspour Yogish C. Kudva Carol J. Levy Gregory P. Forlenza Roy W. Beck Craig Kollman John W. Lum Sue A. Brown Lori M. Laffel Source Type: research

Impact of insulin resistance on subclinical left ventricular dysfunction in normal weight and overweight/obese japanese subjects in a general community
Insulin resistance carries increased risk of heart failure, although the pathophysiological mechanisms remain unclear. LV global longitudinal strain (LVGLS) assessed by speckle-tracking echocardiography has em... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 21, 2021 Category: Cardiology Authors: Kazutoshi Hirose, Koki Nakanishi, Masao Daimon, Naoko Sawada, Yuriko Yoshida, Kentaro Iwama, Yuko Yamamoto, Jumpei Ishiwata, Megumi Hirokawa, Katsuhiro Koyama, Tomoko Nakao, Hiroyuki Morita, Marco R. Di Tullio, Shunichi Homma and Issei Komuro Tags: Original investigation Source Type: research

Efficacy and safety of glucagon ‐like peptide‐1/glucagon receptor co‐agonist JNJ‐64565111 in individuals with type 2 diabetes mellitus and obesity: A randomized dose‐ranging study
SummaryWeight loss has been shown to improve metabolic parameters and cardiovascular risk in people with type 2 diabetes mellitus (T2DM). This phase 2 study evaluated the safety and efficacy of JNJ ‐64565111, a dual agonist of GLP‐1 and glucagon receptors, in individuals with T2DM and class II/III obesity. In this randomized, double‐blind study, participants with T2DM (HbA1c 6.5%‐9.5%), body mass index of 35 to 50 kg/m2 and stable weight were randomly assigned (1:1:1:1) to placebo or JNJ ‐64565111 (5.0 mg, 7.4 mg or 10.0 mg). The primary endpoint was percent change from baseline in body weight at week 12. ...
Source: Clinical Obesity - January 21, 2021 Category: Eating Disorders & Weight Management Authors: Nicholas A. Di Prospero, Jaqueline Yee, Mary E. Frustaci, Mahesh N. Samtani, Maria Alba, Penny Fleck Tags: Original Research Article Source Type: research