NIH Director's Seminar Series: Neuronal-origin extracellular vesicles in the circulation as a source of biomarkers for brain diseases
Extracellular Vesicles enriched for neuronal origin (NEVs) can be isolated from plasma by immunoaffinity capture. NEVs provide biomarkers for diagnosis, prognosis, disease monitoring, and therapeutic response in Alzheimer ’ s disease and related dementias (AD/ADRD), and, increasingly, other neurologic and psychiatric disorders. NEV biomarkers for preclinical AD have been validated in large longitudinal cohorts, such as the Baltimore Longitudinal Study of Aging. Moreover, NEV biomarkers can identify clinical subgroups (e.g., Parkinson ’ s disease patients with cognitive impairment), facilitating the development of Preci...
Source: Videocast - All Events - March 29, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video

Changing the paradigm for people with diabetes
Finding a natural pathway to deliver insulin can transform the lives of patients who suffer from diabetes, while education and finance can drive innovation to improve outcomes, say Diabetology cofounders Glen Travers and Roger New. (Source: Healthcare ITNews Videos)
Source: Healthcare ITNews Videos - July 21, 2021 Category: Information Technology Source Type: video

ONC to give HIEs a monetary boost; Q2 sees big dip in healthcare M & A activity
This week ' s top stories include the ONC offering new funding for state and local HIE innovation, a decline in healthcare M&A transactions and Medtronic ' s plans to buy connected insulin pen startup Companion Medical. (Source: Healthcare ITNews Videos)
Source: Healthcare ITNews Videos - August 14, 2020 Category: Information Technology Tags: Health Information Exchange (HIE) Mergers & amp; Acquisitions Source Type: video

National Clinical Care Commission Advisory Committee Meeting - June 2019
The National Clinical Care Advisory Committee evaluates and provides recommendations on the coordination and leveraging of federal programs related to complex metabolic or autoimmune diseases that result from insulin-related issues and represent a significant disease burden in the United States, including complications due to such diseases.Air date: 6/27/2019 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - June 3, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

For diabetics, insulin injection may become as easy as taking a pill
An MIT-led research team has developed a drug capsule -- about the size of a blueberry -- that could be used to deliver oral doses of insulin, potentially replacing the injections that people with Type 1 diabetes have to give themselves every day. In tests in animals, the researchers showed that ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - February 22, 2019 Category: Science Source Type: video

Insulin injection by pill, climate game changer, how bees chill and reefs on the flip side
A new design for insulin that’s easy to swallow, deep-sea surprise game changer for climate, catching reefs on the flip side, and the physics of how bees chill. Undersea Gases ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - February 16, 2019 Category: Science Source Type: video

Surveillance of Core Cellular Pathways in C. elegans for Pathogen Assaults
CCR Eminent Lectures The Ruvkun lab uses C. elegans molecular genetics and genomics to study miRNA and RNAi pathways. Using genetic and RNA interference approaches, we have identified many genes that positively or negatively regulate RNAi and microRNA pathways. These genes reveal the trajectory of siRNAs and miRNAs as they target mRNAs, as well as components that may be developed as drug targets to enhance RNAi in mammals. Over the past decade, we discovered that like mammals, C. elegans uses an insulin signaling pathway to control its metabolism and longevity. This analysis has revealed striking congruence of molecular me...
Source: Videocast - All Events - October 18, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

National Clinical Care Commission Advisory Committee Meeting - October 2018
The 2018 National Clinical Care commission Advisory Committee evaluates and provides recommendations on the coordination and leveraging of federal programs related to complex metabolic or autoimmune diseases that result from insulin-related issues and represent a significant disease burden in the United States, including complications due to such diseases.Air date: 10/31/2018 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 16, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Sugar and the beating heart: the conundrum of heart failure in diabetes
NIH Director ’ s Wednesday Afternoon Lecture Series Dr. Abel's current research interests focus on elucidating the molecular mechanisms leading to cardiac dysfunction in diabetes and the regulation of myocardial growth and metabolism by insulin signaling.For more information go tohttps://oir.nih.gov/wals/2017-2018/sugar-beating-heart-conundrum-heart-failure-diabetesAir date: 2/7/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

The Contribution of Bone to Whole Organism Physiology
GeroScience Interest Group The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its spring seminar, featuring Dr. Gerard Karsenty, the Paul A. Marks M.D., Professor and Chair of the Department of Genetics and Development at Columbia University Medical Center, New York City. Dr. Karsenty's main interest is how organs interact with one another to regulate vertebrates' various physiological functions. His research focuses on bone and, through the use of genetics, he has discovered that this organ, in addition to making bone, has remarkable endocrine functions that include the regulation of insulin secreti...
Source: Videocast - All Events - May 1, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video

Group 1 innate lymphoid cells in metabolic disease
Immunology Interest Group Seminar Series Innate lymphoid cells (ILCs) are the most recently identified arm of the innate immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. Although ILCs can also promote pathology at mucosal sites such as the gut or lung, it remains unknown whether aberrant activation of tissue-resident ILCs can contribute to disease in non-barrier tissues. Here, we identify a subset of long-term adipose-resident ILC1 that are dependent on the transcription factors Nfil3 and T-bet, but phenotypically and functionally distinct from circulating mature...
Source: Videocast - All Events - January 17, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video

How to make pancreatic beta cells for diabetics
Wednesday Afternoon Lecture Series Dr. Melton is interested in the developmental biology of the pancreas and in understanding the stem cells that give rise to the pancreas. In the lecture, he will discuss the challenges of making stem-cell-derived pancreatic beta cells. A primary problem for insulin-dependent diabetics is the absence (in type 1 diabetes) or dysfunction (in type 2 diabetes) of pancreatic beta cells. The ability to direct the differentiation human stem cells into beta cells opens up the possibility of using these cells for research into the causes of beta-cell loss. In addition, stem-cell-derived beta cell...
Source: Videocast - All Events - January 22, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video

Insulin and Nutrient Sensing signaling pathways promote amyloid formation in Alzheimer's disease
Presented by: Lawrence Rajendran, Ph.D., University of Zurich, Neuroscience CenterCategory: NeuroscienceAired date: 09/14/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - September 15, 2015 Category: Journals (General) Tags: Past Events Source Type: video

Insulin and Nutrient Sensing signaling pathways promote amyloid formation in Alzheimer's disease
NIH Neuroscience Series SeminarAir date: 9/14/2015 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 10, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Contemporary Clinical Medicine: Great Teachers Twelfth Annual John Laws Decker Memorial Lecture: Impact of Selective Insulin Resistance on Cardiovascular Risk Reduction Strategies
Presented by: Ranganath Muniyappa, MD, PhD, Staff Clinician, Clinical Endocrinology Section, Diabetes, Endocrinology, and Obesity Branch, NIDDK, NIHCategory: Clinical Center Grand RoundsAired date: 06/10/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - June 11, 2015 Category: Journals (General) Tags: Past Events Source Type: video