Management of dementia-related psychosis, agitation and aggression: a review of the pharmacology and clinical effects of potential drug candidates - Marcinkowska M, Śniecikowska J, Fajkis N, Paśko P, Franczyk W, Kołaczkowski M.
Along with cognitive decline, 90% of patients with dementia experience behavioral and psychological symptoms of dementia, such as psychosis, aggression, agitation, and depression. Atypical antipsychotics are commonly prescribed off-label to manage certain ... (Source: SafetyLit)
Source: SafetyLit - February 17, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Impact of deprescribing AChEIs on aggressive behaviors and antipsychotic prescribing - Niznik JD, Zhao X, He M, Aspinall SL, Hanlon JT, Nace D, Thorpe JM, Thorpe CT.
INTRODUCTION: We evaluated the impact of deprescribing acetylcholinesterase inhibitors (AChEIs) on aggressive behaviors and incident antipsychotic use in nursing home (NH) residents with severe dementia. METHODS: We conducted a retrospective study ... (Source: SafetyLit)
Source: SafetyLit - February 17, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Beta-arrestin-2 increases neurotoxic tau driving frontotemporal dementia
(University of South Florida (USF Health)) The proteinβ-arrestin-2 increases the accumulation of brain-damaging tau tangles, a cause several forms of dementia, by interfering with removal of excess tau from the brain, a new study by the University of South Florida Health (USF Health) Morsani College of Medicine found. The research suggests a new treatment approach that could be preventive for those at risk or with mild cognitive impairment, and also for those with Alzheimer's disease and other overt dementias caused by tau. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 17, 2020 Category: International Medicine & Public Health Source Type: news

'Dementia becomes UK's biggest killer': Here's how to keep your brain healthy
Dementia has become Britain's biggest killer - overtaking long-feared cancer and heart disease in the process. One in eight deaths in the UK is now due to the condition which, on average, strikes a new victim every three minutes. (Source: Daily Express - Health)
Source: Daily Express - Health - February 17, 2020 Category: Consumer Health News Source Type: news

Who is man's best friend? To some people with dementia, it's a robot dog
(Natural News) A California company is marketing a robotic dog they’re developing to be a best friend that can comfort people who are living with Alzheimer’s disease and other forms of dementia. The makers said that this robot dog will be able to provide companionship for people by responding to human voice and touch with “life-like motions.” Entrepreneur Tom... (Source: NaturalNews.com)
Source: NaturalNews.com - February 16, 2020 Category: Consumer Health News Source Type: news

Effect of dual-tasking on walking and cognitive demands in adults with Alzheimer's dementia experienced in using a 4-wheeled walker - Hunter SW, Omana H, Madou E, Wittich W, Hill KD, Johnson AM, Divine A, Holmes JD.
BACKGROUND: Learning to walk with a 4-wheeled walker increases cognitive demands in people with Alzheimer's dementia (AD). However, it is expected that experience will offset the increased cognitive demand. Current research has not yet evaluated gait in pe... (Source: SafetyLit)
Source: SafetyLit - February 15, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Pathological links between traumatic brain injury and dementia: Australian pre-clinical research - Collins JM, Woodhouse A, Bye N, Vickers J, King AE, Ziebell J.
Traumatic brain injury (TBI) can cause persistent cognitive changes and ongoing neurodegeneration in the brain. Accumulating epidemiological and pathological evidence implicates TBI in the development of Alzheimer's disease (AD), the most common cause of d... (Source: SafetyLit)
Source: SafetyLit - February 15, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

DR MAX PEMBERTON on how dementia sufferers with optimistic spouses suffer less memory loss 
DR MAX PEMBERTON: Being optimistic isn't about being in denial, it's about trying to find the positives in life, even in dire situations. (Source: the Mail online | Health)
Source: the Mail online | Health - February 15, 2020 Category: Consumer Health News Source Type: news

Dementia care: Study reveals how to reduce your partner’s risk of brain decline
DEMENTIA can cause a person to become detached from their surroundings which can be highly distressing for the person affected and their loved one. Watching your partner's dementia get progressively worse can be heartbreaking but new research suggests you can reduce your partner's risk of dementia in the first place. (Source: Daily Express - Health)
Source: Daily Express - Health - February 14, 2020 Category: Consumer Health News Source Type: news

Alzheimer's and dementia: Caregiver depression
(Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - February 14, 2020 Category: Consumer Health News Source Type: news

Can bilingualism protect the brain even with early stages of dementia?
A study by York University psychology researchers provides new evidence that bilingualism can delay symptoms of dementia. Alzheimer's disease is the most common form of dementia, making up 60 to 70 per cent of dementia cases. Of all activities with neuroplastic benefits, language use is the most sustained, consuming the largest proportion of time within a day. It also activates regions across the entire brain. (Source: World Pharma News)
Source: World Pharma News - February 13, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Can bilingualism protect the brain even with early stages of dementia?
(York University) A study by York University psychology researchers provides new evidence that bilingualism can delay symptoms of dementia. Researchers found bilingualism provides the brain with greater cognitive reserve, delaying onset of symptoms. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 13, 2020 Category: International Medicine & Public Health Source Type: news

Ceramides predict vascular brain injury and dementia
(Brigham and Women's Hospital) In a study published in Annals of Clinical and Translational Neurology, a team led by investigators from Brigham and Women's Hospital describes the role of plasma ceramides in dementia and Alzheimer's disease (AD) and their potential as a blood-based biomarker. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 13, 2020 Category: International Medicine & Public Health Source Type: news

Vitamin B12 deficiency: The dementia-related symptoms that may signal you lack the vitamin
VITAMIN B12 helps to preserve vital bodily processes so becoming deficient in the nutrient can trigger a number of physical changes. Perhaps more worryingly, lacking the vitamin can cause symptoms associated with dementia. (Source: Daily Express - Health)
Source: Daily Express - Health - February 12, 2020 Category: Consumer Health News Source Type: news

Being tall may cut the risk of dementia in men
University of Copenhagen found for every 2.5inches (6.5cm) in height above the average, risk of the memory-robbing disease reduced by 10 per cent. (Source: the Mail online | Health)
Source: the Mail online | Health - February 12, 2020 Category: Consumer Health News Source Type: news

Dementia symptoms: A change in this social norm could be an early sign of the condition
DEMENTIA does more than rob people of their memories - research continues to show that this complicated condition is marked by a range of symptoms, and for a person who shows certain changes in social norms, they could be at risk of developing the condition. (Source: Daily Express - Health)
Source: Daily Express - Health - February 12, 2020 Category: Consumer Health News Source Type: news

PET shows cardiac meds may reduce beta-amyloid buildup
Patients who were on cardiovascular medications like cholesterol-lowering drugs...Read more on AuntMinnie.comRelated Reading: Amyloid-PET advocates take their case to Congress PET/MRI sheds light on cerebral vascular risk factors PET model tracks beta amyloid, Alzheimer's risk Florbetapir-PET links lack of financial acumen to dementia Alzheimer's biomarkers could affect races differently (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 12, 2020 Category: Radiology Source Type: news

Experiencing Trauma In Childhood Linked To Increased Risk Of Developing Dementia
Researchers in Japan published a study this week that examined the connection between adverse childhood experiences, or ACEs, and dementia risk. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - February 12, 2020 Category: Pharmaceuticals Authors: Lecia Bushak, Contributor Source Type: news

People with optimistic spouses are less at-risk for dementia, study finds
Although everyone has some cognitive declines with age, researchers at the University of Michigan and Harvard University found optimists' partners were protected by their spouse's good habits. (Source: the Mail online | Health)
Source: the Mail online | Health - February 12, 2020 Category: Consumer Health News Source Type: news

An Alzheimer ’s Treatment Fails: ‘We Don’t Have Anything Now’
With high hopes, drugs to fight brain plaques were tested in people genetically destined to develop dementia. The drugs failed. (Source: NYT Health)
Source: NYT Health - February 11, 2020 Category: Consumer Health News Authors: Gina Kolata Tags: Alzheimer ' s Disease Elderly Drugs (Pharmaceuticals) Brain Clinical Trials Dominantly Inherited Alzheimer Network (DIAN) Eli Lilly and Company National Institute on Aging Roche Holding AG Washington University Source Type: news

Alzheimer ’s treatment led by Wash U researcher fails
A study of whether drugs could slow or stop cognitive decline in patients with a genetic mutation guaranteeing they'd develop dementia has failed. Dr. Randall Bateman, a neurologist at Washington University, told the New York Times he was “shocked” when he first saw the data: “It was really crushing,” he said. Still, the Times reports that the scientists believe the drugs may have been given at too low a dose or could be given to yo unger patients. Participating in the trial at Washington… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 11, 2020 Category: Pharmaceuticals Authors: Jacob Kirn Source Type: news

The four-year-old slowly dying of childhood dementia: Girl's parents reveal she won't live past 12
Violet Jones, of Crosby, Merseyside, has the incurable Batten disease, which causes dementia symptoms. Her parents, Michelle and Peter, described Violet's life as 'the worst form of torture'. (Source: the Mail online | Health)
Source: the Mail online | Health - February 11, 2020 Category: Consumer Health News Source Type: news

Study suggests taller young men may have lower dementia risk
(eLife) Men who are taller in young adulthood, as an indicator of early-life circumstances, may have a lower risk of dementia in old age, suggests a study published today in eLife. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 11, 2020 Category: International Medicine & Public Health Source Type: news

Scientists develop non-invasive method to predict onset of dementia
(Regenstrief Institute) Information gathered from routine visits to the doctor is enough to accurately predict a person's risk of developing Alzheimer's disease and related dementias, according to new research led by scientists from Regenstrief Institute, Indiana University and Merck. The researchers developed and tested machine learning algorithms using data from electronic medical records to identify patients who may be at risk for developing the dementia. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 11, 2020 Category: International Medicine & Public Health Source Type: news

An Alzheimer ’s Drug Trial Fails: ‘We Don’t Have Anything Now’
With high hopes, drugs to fight brain plaques were tested in people genetically destined to develop dementia. The drugs failed. (Source: NYT Health)
Source: NYT Health - February 11, 2020 Category: Consumer Health News Authors: Gina Kolata Tags: Alzheimer ' s Disease Elderly Drugs (Pharmaceuticals) Brain Clinical Trials Dominantly Inherited Alzheimer Network (DIAN) Eli Lilly and Company National Institute on Aging Roche Holding AG Washington University Source Type: news

Palliative care could benefit people with Parkinson ’s
Patients and caregivers both had better outcomes when palliative care was integrated into their care Related items fromOnMedica Fund specialist dementia training to improve care and save money Emergency admissions at end of life set to sky rocket One in two women and one in three men will develop neurological disease Poor people have worse end-of-life care Cannabinoids not recommended to treat cancer-related pain (Source: OnMedica Latest News)
Source: OnMedica Latest News - February 11, 2020 Category: UK Health Source Type: news

Icometrix nets FDA OK for epilepsy detection software
Artificial intelligence (AI) software developer Icometrix has received U.S....Read more on AuntMinnie.comRelated Reading: Icometrix adds $18M to coffers Icometrix, Invicro team up on core lab imaging services Icometrix to collaborate with Siemens on AI for MRI Icometrix wins FDA clearance for brain CT AI software FDA clears Icometrix's dementia diagnosis software (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 10, 2020 Category: Radiology Source Type: news

Which herbal treatments in TCM help boost memory?
(Natural News) Mild cognitive impairment (MCI) is defined as the transitional stage between cognitive decline caused by aging and severe cognitive decline caused by brain disorders, such as Alzheimer’s disease and dementia. Research suggests that the prevalence of MCI increases with age, affecting about 25.2 percent of adults between the ages of 80 and 84.... (Source: NaturalNews.com)
Source: NaturalNews.com - February 10, 2020 Category: Consumer Health News Source Type: news

Roche provides topline results from investigator-led Phase II/III trial with gantenerumab in rare inherited form of Alzheimer ’s disease
Basel, 10 February 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the gantenerumab arm of the Phase II/III DIAN-TU-001 study did not meet its primary endpoint in people who have an early-onset, inherited form of Alzheimer ’s disease (AD). This form of AD, known as autosomal dominant AD (ADAD), accounts for less than 1% of all cases of the disease.1 The study, sponsored by Washington University School of Medicine in St. Louis, US, did not show a significant slowing of the rate of cognitive decline in people treated with investigational medicine gantenerumab as measured by the novel DIAN Multivariate Co...
Source: Roche Investor Update - February 10, 2020 Category: Pharmaceuticals Source Type: news

Roche provides topline results from investigator-led Phase II/III trial with gantenerumab in rare inherited form of Alzheimer ’s disease
Basel, 10 February 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the gantenerumab arm of the Phase II/III DIAN-TU-001 study did not meet its primary endpoint in people who have an early-onset, inherited form of Alzheimer ’s disease (AD). This form of AD, known as autosomal dominant AD (ADAD), accounts for less than 1% of all cases of the disease.1 The study, sponsored by Washington University School of Medicine in St. Louis, US, did not show a significant slowing of the rate of cognitive decline in people treated with investigational medicine gantenerumab as measured by the novel DIAN Multivariate Co...
Source: Roche Media News - February 10, 2020 Category: Pharmaceuticals Source Type: news

A happy partner leads to a healthier future
(Michigan State University) Michigan State University research found that those who are optimistic contribute to the health of their partners, staving off the risk factors leading to Alzheimer's disease, dementia and cognitive decline as they grow old together. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 10, 2020 Category: International Medicine & Public Health Source Type: news

Dementia charity leads global initiative for wearables to revolutionize disease detection
(Alzheimer's Research UK) The UK's leading dementia research charity Alzheimer's Research UK has today launched a global initiative to revolutionize the early detection of neurodegenerative diseases like Alzheimer's. The project will harness and analyse a wealth of digital data to develop signatures of disease -- or 'fingerprints' -- that can be then detected using wearable technologies, such as smart watches. Initial funds towards the initiative have already been secured from Bill Gates and Iceland Foods Charitable Foundation. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 10, 2020 Category: International Medicine & Public Health Source Type: news

Dementia symptoms: Losing these items around the house may be a sign of Alzheimer’s diseas
DEMENTIA is a progressive disease that can be hard to spot when symptoms first begin. This is because forgetfulness - the first symptom of Alzheimer's - can be part and parcel with everyday life. (Source: Daily Express - Health)
Source: Daily Express - Health - February 9, 2020 Category: Consumer Health News Source Type: news

ALZHEIMER’S CAMPAIGN: I’m fortunate I get help coping with Barbara’s dementia
DAME Barbara Windsor's husband Scott Mitchell has spoken out about how social care is "broken" in this country because the NHS has nothing in place for people with dementia and their carers. (Source: Daily Express - Health)
Source: Daily Express - Health - February 9, 2020 Category: Consumer Health News Source Type: news

Dementia: This fun exercise could help prevent cognitive decline
DEMENTIA progressively gets worse and for most of us, the speed at which it progresses is, frankly, too fast for our liking. To help stave off the condition, one fun activity has been proven to prevent cognitive decline. (Source: Daily Express - Health)
Source: Daily Express - Health - February 8, 2020 Category: Consumer Health News Source Type: news

NICEimpact dementia
Around 460,000 people in England are diagnosed with dementia. And it is estimated that around 200,000 are undiagnosed. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 7, 2020 Category: Consumer Health News Source Type: news

Keeping people with dementia or mild cognitive impairment in employment: a literature review on its determinants - Silvaggi F, Leonardi M, Tiraboschi P, Muscio C, Toppo C, Raggi A.
Background: Approximately 10-20% of people with early onset dementias (EOD) or mild cognitive impairment (MCI) are aged under 65 and, due to extended working life and increasing prevalence of dementias, they more and more frequently will be present ... (Source: SafetyLit)
Source: SafetyLit - February 7, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Gene Variant Ups Dementia Risk in Parkinson's Patients: Study
Title: Gene Variant Ups Dementia Risk in Parkinson's Patients: StudyCategory: Health NewsCreated: 2/6/2020 12:00:00 AMLast Editorial Review: 2/7/2020 12:00:00 AM (Source: MedicineNet Alzheimer)
Source: MedicineNet Alzheimer - February 7, 2020 Category: Geriatrics Source Type: news

Gene Variant Ups Dementia Risk in Parkinson's Patients: Study
THURSDAY, Feb. 6, 2020 -- A genetic variant associated with Alzheimer's disease increases the risk of dementia in people with Parkinson's disease, researchers say. The finding could lead to new treatments for dementia in Parkinson's patients,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 6, 2020 Category: General Medicine Source Type: news

FDG-PET shows where exercise could stall Alzheimer's
People with sedentary lifestyles who exercised regularly over several months...Read more on AuntMinnie.comRelated Reading: AI algorithm predicts Alzheimer's disease progression New Alzheimer's definition relies on imaging biomarkers Flortaucipir-PET could lead in early Alzheimer's detection FDG-PET links physical activity to healthy brains MRI shows physical activity can slow dementia, Alzheimer's (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 6, 2020 Category: Radiology Source Type: news

UNH researchers find synchronization of memory cells critical for learning and forming memories
(University of New Hampshire) Researchers at the University of New Hampshire found that the neurons, or memory cells, involved in Pavlovian learning shift their behavior during the learning process and become more synchronized when a memory is formed -- a finding that helps better understand memory mechanisms and provides clues for the development of future therapies for memory-related diseases like dementia, autism and post-traumatic stress disorder (PTSD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 6, 2020 Category: International Medicine & Public Health Source Type: news

Normal resting heart rate varies widely
Normal resting heart rate can vary from person to person by up to 70 beats per minute Related items fromOnMedica Good midlife heart health linked to lower dementia risk later on Patients question GPs ’ motives for prescribing statins Papworth Hospital cleared to resume heart ops Marathon running can boost vascular age Migraine may be linked to heightened cardiovascular disease risk (Source: OnMedica Latest News)
Source: OnMedica Latest News - February 6, 2020 Category: UK Health Source Type: news

Parents of boy, four, with 'childhood dementia' say it's 'too late' to slow the disease
James Young, from South Shields, Tyne and Wear, has been robbed of the ability to walk, feed himself or talk. He received a diagnosis of the rare and incurable Batten disease in January. (Source: the Mail online | Health)
Source: the Mail online | Health - February 5, 2020 Category: Consumer Health News Source Type: news

Dementia care: Doing this type of exercise could ward off the degenerative condition
DEMENTIA care: While getting older is the biggest risk factor for dementia, studies have shown there are things you can to help reduce your risk of developing the condition. A certain type of exercise has been proven to fight off dementia. (Source: Daily Express - Health)
Source: Daily Express - Health - February 5, 2020 Category: Consumer Health News Source Type: news

High blood pressure: Working this many hours a week may increase risk of condition
HIGH blood pressure is risky business. Unnecessarily putting strain on the arteries, it can lead to aneurysms, dementia and heart failure. Now a study confirms working a certain number of hours per week could increase the chances of developing the condition. (Source: Daily Express - Health)
Source: Daily Express - Health - February 5, 2020 Category: Consumer Health News Source Type: news

Dementia may reduce likelihood of a 'good death' for patients with cancer
(Wiley) As the population ages, the number of cancer patients with dementia has increased. A recent study published in Geriatrics& Gerontology International found that cancer patients with dementia were less likely to achieve a 'good death' than those without. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 5, 2020 Category: Cancer & Oncology Source Type: news

The benefits of physical activity for older adults
(Wiley) New findings published in the Scandinavian Journal of Medicine& Science in Sports reveal how physically active older adults benefit from reduced risks of early death, breast and prostate cancer, fractures, recurrent falls, functional limitations, cognitive decline, dementia, Alzheimer's disease, and depression. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 5, 2020 Category: International Medicine & Public Health Source Type: news

Legal problems concerning drivers with dementia - Baba M.
In recent years, the number of elderly people involved in automobile accidents has increased. Persons with dementia (Alzheimer-type dementia, vascular dementia, Lewy body dementia, frontotemporal dementia) are not permitted to update their driver's lic... (Source: SafetyLit)
Source: SafetyLit - February 4, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Counterpoint: Links between traumatic brain injury and dementia remain poorly defined - Barr WB.
There has been considerable public interest in the topic of traumatic brain injury (TBI) as a risk factor for development of late-life dementia. A review was performed on empirical studies examining the relationship between these two conditions. Although r... (Source: SafetyLit)
Source: SafetyLit - February 4, 2020 Category: International Medicine & Public Health Tags: Commentary Source Type: news

Why Fruits and Vegetables May Lower Alzheimer ’s Risk
Flavonols, found in fruits and vegetables, were tied to a lower risk of Alzheimer ’s disease. (Source: NYT Health)
Source: NYT Health - February 4, 2020 Category: Consumer Health News Authors: Nicholas Bakalar Tags: Alzheimer ' s Disease Fruit Vegetables Diet and Nutrition Dementia Source Type: news